Which Foods are Recommended for Hemangiopericytoma?

Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Hemangiopericytoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Hemangiopericytoma because of BCOR and BTK gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Hemangiopericytoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Lingonberry” or “Include fruit Papaya in my diet” or “Should I reduce consumption of vegetable Chayote” or “Can I take Indole-3-carbinol and Bakuchi supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO HEMANGIOPERICYTOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Hemangiopericytoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR HEMANGIOPERICYTOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.

About Hemangiopericytoma

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Hemangiopericytoma from cBioPortal. 48.7% of males and 51.3% of females were the distribution of gender in these clinical studies. From a patient sample size of 78; the top genes with mutations and other abnormalities for Hemangiopericytoma include genes TERT, TP53, BCOR, BTK and KDM5C. The occurrence frequency distribution for these genes respectively is 46.2%, 30.8%, 3.8%, 3.8% and 3.8%. These tumor genetic details of Hemangiopericytoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Hemangiopericytoma.

Hemangiopericytoma is a rare type of tumor that can occur in various parts of the body, including the brain. Hemangiopericytomas are aggressive tumors with a high incidence of local recurrence and distant metastasis, even after a complete resection of the tumor. This tumor is characterized by an abnormal growth of blood vessels since these tumors arise from cells surrounding the blood vessels. Central nervous system hemangiopericytomas are uncommon and if present, usually occur in adults between 40-50 years of age. Symptoms of hemangiopericytomas can vary depending on the affected organs and tumor stage. While some patients remain without symptoms until advanced disease, many patients present with pain and mass-related symptoms including fever, urinary retention, and constipation. Surgery is the standard of care for the hemangiopericytoma patients, but radiotherapy or chemotherapy may be used in some cases. The life expectancy of individuals with hemangiopericytoma depends on the location and stage of the tumor. In addition to ongoing monitoring, supportive care with the optimal nutrition (foods and natural supplements) can help improve the patients’ well-being. (Ref: Wang K et al, Biomed Res Int., 2020; Huang L et al, Front. Oncol., 2021,)

Significance of Nutrition for Hemangiopericytoma

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Hemangiopericytoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Lingonberry includes active ingredients Quercetin, Resveratrol, Oleic Acid, Hyperoside, Linolenic Acid and others. And Papaya contains active ingredients Benzyl Isothiocyanate, Lycopene, Linalool, Oleic Acid, Beta-sitosterol and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Hemangiopericytoma, activation or inhibition of selected biochemical pathways like TGFB Signaling, Growth Factor Signaling, Apoptosis, Cell Cycle Checkpoints plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Hemangiopericytoma, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR HEMANGIOPERICYTOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Hemangiopericytoma undergoing chemotherapy treatment

In Hemangiopericytoma – the genes TERT, TP53, BCOR, BTK and KDM5C have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Hemangiopericytoma are TGFB Signaling, Growth Factor Signaling, PI3K-AKT-MTOR Signaling and others. Docetaxel is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers TGFB Signaling, Growth Factor Signaling, PI3K-AKT-MTOR Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Common Pea or Lima Bean?

Pulses are an important part of many diets. The active ingredients contained in Common Pea are Daidzein, Lupeol, Oleic Acid, Beta-sitosterol, Linolenic Acid among others. While the active ingredients contained in Lima Bean are Oleic Acid, Vitamin C, Linoleic Acid, Genistein, Vitamin A and others.

Beta-sitosterol can manipulate biochemical pathways MYC Signaling, NFKB Signaling and Apoptosis. Vitamin C has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, MYC Signaling and Apoptosis.

Linoleic Acid can manipulate biochemical pathways TGFB Signaling. Folic Acid has biological action on biochemical pathways MYC Signaling, Growth Factor Signaling and Apoptosis. And so on.

When treating Hemangiopericytoma with chemotherapy Docetaxel – Foods like Common Pea are recommended compared to Lima Bean. This is because the active ingredients Linoleic Acid and Folic Acid in Lima Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER LIMA BEAN FOR HEMANGIOPERICYTOMA ON TREATMENT WITH CHEMOTHERAPY DOCETAXEL FOR SOME CONDITIONS.

Eat more vegetables, Lettuce or Chayote?

Vegetables are an important part of many diets. The active ingredients contained in Lettuce are Quercetin, Oleic Acid, Beta-sitosterol, Linolenic Acid, Vitamin C among others. While the active ingredients contained in Chayote are Oleic Acid, Linolenic Acid, Vitamin C, Linoleic Acid, Folic Acid and others.

Vitamin A can manipulate biochemical pathways NFKB Signaling, Apoptosis and TGFB Signaling. Vitamin K has biological action on biochemical pathways MYC Signaling, PI3K-AKT-MTOR Signaling and NFKB Signaling.

Linoleic Acid can manipulate biochemical pathways TGFB Signaling. Folic Acid has biological action on biochemical pathways MYC Signaling, Growth Factor Signaling and Apoptosis. And so on.

When treating Hemangiopericytoma with chemotherapy Docetaxel – Foods like Lettuce are recommended compared to Chayote. This is because the active ingredients Linoleic Acid and Folic Acid in Chayote interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin A and Vitamin K contained in Lettuce support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: LETTUCE IS RECOMMENDED OVER CHAYOTE FOR HEMANGIOPERICYTOMA ON TREATMENT WITH CHEMOTHERAPY DOCETAXEL FOR SOME CONDITIONS.

Eat more fruits, Papaya or Lingonberry?

Fruits are an important part of many diets. The active ingredients contained in Papaya are Benzyl Isothiocyanate, Lycopene, Linalool, Oleic Acid, Beta-sitosterol among others. While the active ingredients contained in Lingonberry are Quercetin, Resveratrol, Oleic Acid, Hyperoside, Linolenic Acid and others.

Lycopene can manipulate biochemical pathways NFKB Signaling, Apoptosis and Growth Factor Signaling. Zeaxanthin has biological action on biochemical pathways MYC Signaling, PI3K-AKT-MTOR Signaling and NFKB Signaling.

Caffeic Acid can manipulate biochemical pathways TGFB Signaling. Linoleic Acid has biological action on biochemical pathways TGFB Signaling. And so on.

When treating Hemangiopericytoma with chemotherapy Docetaxel – Foods like Papaya are recommended compared to Lingonberry. This is because the active ingredients Caffeic Acid and Linoleic Acid in Lingonberry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Lycopene and Zeaxanthin contained in Papaya support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: PAPAYA IS RECOMMENDED OVER LINGONBERRY FOR HEMANGIOPERICYTOMA ON TREATMENT WITH CHEMOTHERAPY DOCETAXEL FOR SOME CONDITIONS.

Eat more nuts, Pecan Nut or Pumpkin Seeds?

Nuts are an important part of many diets. The active ingredients contained in Pecan Nut are Vitamin E, Oleic Acid, Linolenic Acid, Cianidanol, Linoleic Acid among others. While the active ingredients contained in Pumpkin Seeds are Oleic Acid, Beta-sitosterol, Linolenic Acid, Stigmasterol, Vitamin B3 and others.

Vitamin E can manipulate biochemical pathways MYC Signaling, NFKB Signaling and Apoptosis. Cianidanol has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, MYC Signaling and NFKB Signaling.

Lecithin can manipulate biochemical pathways MYC Signaling, NFKB Signaling and PI3K-AKT-MTOR Signaling. Cucurbitacin I has biological action on biochemical pathways MYC Signaling and NFKB Signaling. And so on.

When treating Hemangiopericytoma with chemotherapy Docetaxel – Foods like Pecan Nut are recommended compared to Pumpkin Seeds. This is because the active ingredients Lecithin and Cucurbitacin I in Pumpkin Seeds interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin E and Cianidanol contained in Pecan Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER PUMPKIN SEEDS FOR HEMANGIOPERICYTOMA ON TREATMENT WITH CHEMOTHERAPY DOCETAXEL FOR SOME CONDITIONS.

Foods for Genetic Risk of Hemangiopericytoma

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. BCOR and BTK are two genes whose abnormalities are risk factors for Hemangiopericytoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Hemangiopericytoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Hemangiopericytoma gene BCOR has causative impact on biological pathways like Oncogenic Histone Methylation, Oncogenic Histone Methylation and Oncogenic Cancer Epigenetics. And BTK has a causative impact on biological pathways like Apoptosis and Fc Receptor Signaling. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like BCOR and BTK should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes BCOR and BTK should be avoided.

Eat more pulses, Scarlet Bean or Soy Bean?

The active ingredients contained in Scarlet Bean are Beta-sitosterol, Linolenic Acid, Vitamin C, Oleic Acid, Stigmasterol among others. While the active ingredients contained in Soy Bean are Daidzein, Lupeol, Vitamin E, Beta-sitosterol, Quercetin and others.

Beta-sitosterol can manipulate biochemical pathways NFKB Signaling, Apoptosis and MYC Signaling. Vitamin C has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.

Aescin can manipulate biochemical pathways Cell Cycle Checkpoints. Lecithin has biological action on biochemical pathways MYC Signaling, NFKB Signaling and PI3K-AKT-MTOR Signaling. And so on.

For genetic risk of Hemangiopericytoma due to abnormalities in genes BCOR and BTK – Foods like Scarlet Bean are recommended compared to Soy Bean. This is because the active ingredients Aescin and Lecithin in Soy Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin C contained in Scarlet Bean together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER SOY BEAN FOR REDUCING THE GENETIC RISK OF HEMANGIOPERICYTOMA DUE TO GENES BCOR AND BTK

Eat more vegetables, Celeriac or Radish?

The active ingredients contained in Celeriac are Linolenic Acid, Vitamin C, Oleic Acid, Angelicin, Linoleic Acid among others. While the active ingredients contained in Radish are Beta-sitosterol, Quercetin, Linolenic Acid, Vitamin C, Oleic Acid and others.

Vitamin K can manipulate biochemical pathways MYC Signaling, NFKB Signaling and Cell Cycle Checkpoints. Vitamin C has biological action on biochemical pathways Apoptosis, P53 Signaling and PI3K-AKT-MTOR Signaling.

Pelargonidin can manipulate biochemical pathways MYC Signaling, NFKB Signaling and Cell Cycle Checkpoints. Folic Acid has biological action on biochemical pathways Apoptosis, P53 Signaling and PI3K-AKT-MTOR Signaling. And so on.

For genetic risk of Hemangiopericytoma due to abnormalities in genes BCOR and BTK – Foods like Celeriac are recommended compared to Radish. This is because the active ingredients Pelargonidin and Folic Acid in Radish further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin K and Vitamin C contained in Celeriac together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: CELERIAC IS RECOMMENDED OVER RADISH FOR REDUCING THE GENETIC RISK OF HEMANGIOPERICYTOMA DUE TO GENES BCOR AND BTK

Eat more fruits, Currant or Huckleberry?

The active ingredients contained in Currant are Beta-sitosterol, Quercetin, Linolenic Acid, Cianidanol, Vitamin C among others. While the active ingredients contained in Huckleberry are Resveratrol, Quercetin, Vitamin C, P-coumaric Acid, Ferulic Acid and others.

Cianidanol can manipulate biochemical pathways NFKB Signaling, Apoptosis and MYC Signaling. Vitamin C has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.

Resveratrol can manipulate biochemical pathways P53 Signaling. Pelargonidin has biological action on biochemical pathways MYC Signaling, NFKB Signaling and Cell Cycle Checkpoints. And so on.

For genetic risk of Hemangiopericytoma due to abnormalities in genes BCOR and BTK – Foods like Currant are recommended compared to Huckleberry. This is because the active ingredients Resveratrol and Pelargonidin in Huckleberry further promote the effects of genes on the biochemical pathways. While the active ingredients Cianidanol and Vitamin C contained in Currant together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: CURRANT IS RECOMMENDED OVER HUCKLEBERRY FOR REDUCING THE GENETIC RISK OF HEMANGIOPERICYTOMA DUE TO GENES BCOR AND BTK

Eat more nuts, Almond or Peanut?

The active ingredients contained in Almond are Vitamin E, Beta-sitosterol, Quercetin, Linolenic Acid, Oleic Acid among others. While the active ingredients contained in Peanut are Vitamin E, Beta-sitosterol, Quercetin, Linolenic Acid, Vitamin C and others.

Beta-sitosterol can manipulate biochemical pathways NFKB Signaling, Apoptosis and MYC Signaling. Vitamin E has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.

Lecithin can manipulate biochemical pathways MYC Signaling, NFKB Signaling and PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, P53 Signaling and Cell Cycle Checkpoints. And so on.

For genetic risk of Hemangiopericytoma due to abnormalities in genes BCOR and BTK – Foods like Almond are recommended compared to Peanut. This is because the active ingredients Lecithin and Folic Acid in Peanut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin E contained in Almond together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: ALMOND IS RECOMMENDED OVER PEANUT FOR REDUCING THE GENETIC RISK OF HEMANGIOPERICYTOMA DUE TO GENES BCOR AND BTK

In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Hemangiopericytoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

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