Foods for Gemistocytic Astrocytoma!

Introduction

Foods for Gemistocytic Astrocytoma should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.

Gemistocytic astrocytoma, a rare form of brain tumor, is classified into different grades, including grade 2, grade 3, and the more aggressive grade 4, each indicating the tumor’s level of aggressiveness and potential for progression. The pathology outlines and histology of gemistocytic astrocytoma reveal its distinctive cellular characteristics, essential for accurate diagnosis and treatment planning. Treatment strategies for gemistocytic astrocytoma vary depending on the tumor’s grade and may include surgery, radiation therapy, and chemotherapy. MRI plays a crucial role in the diagnosis and monitoring of gemistocytic astrocytoma, providing detailed images of the tumor’s size, location, and impact on surrounding brain tissue. The survival rate for patients with gemistocytic astrocytoma depends significantly on the tumor’s grade; lower grades like grade 2 often have a better prognosis compared to the more advanced grade 4 astrocytomas. Understanding the nature of gemistocytic astrocytoma and its progression is vital for developing effective treatment plans and improving patient outcomes.

For Gemistocytic Astrocytoma does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Gemistocytic Astrocytoma does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Gemistocytic Astrocytoma?

For example does it matter if vegetable Giant Butterbur is consumed more compared to Romaine Lettuce? Does it make any difference if fruit Elderberry is preferred over Nance? Also if similar choices are made for nuts/seeds like Common Hazelnut over Flaxseed and for pulses like Broad Bean over Pigeon Pea. And if what I eat matters – then how does one identify foods which are recommended for Gemistocytic Astrocytoma and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Gemistocytic Astrocytoma!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Elderberry contains active ingredients Quercetin, Curcumin, Apigenin, Phloretin, Myricetin. And Nance contains active ingredients Curcumin, Apigenin, Phloretin, Myricetin, Daidzein and possibly others.

A common mistake made when deciding and choosing foods to eat for Gemistocytic Astrocytoma – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Gemistocytic Astrocytoma.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Gemistocytic Astrocytoma?

Personalized nutrition for cancers like Gemistocytic Astrocytoma consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Gemistocytic Astrocytoma biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Characteristics of cancers like Gemistocytic Astrocytoma

All cancers like Gemistocytic Astrocytoma can be characterized by a unique set of biochemical pathways – the signature pathways of Gemistocytic Astrocytoma. Biochemical pathways like DNA Repair, Angiogenesis, PI3K-AKT-MTOR Signaling, Hypoxia are part of the signature definition of Gemistocytic Astrocytoma. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Gemistocytic Astrocytoma need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Gemistocytic Astrocytoma when taking cancer treatment Temozolomide, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

IDH1, TP53, ATRX, FOXO3 and FANCD2 are the top ranked reported genes for Gemistocytic Astrocytoma. IDH1 is reported in 46.8 % of the representative patients across all clinical trials. And TP53 is reported in 46.8 %. The combined population patient data cover ages from to . % of the patient data are identified as men. The Gemistocytic Astrocytoma biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Food and Supplements for Gemistocytic Astrocytoma

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable GIANT BUTTERBUR or ROMAINE LETTUCE?

Vegetable Giant Butterbur contains many active ingredients or bioactives such as Curcumin, Apigenin, Phloretin, Myricetin, Daidzein. These active ingredients manipulate various biochemical pathways like MAPK Signaling, DNA Repair, Microtubule Dynamics and Amino Acid Metabolism and others. Giant Butterbur is recommended for Gemistocytic Astrocytoma when ongoing cancer treatment is Temozolomide. This is because Giant Butterbur modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Temozolomide.

Some of the active ingredients or bioactives in vegetable Romaine Lettuce are Curcumin, Apigenin, Phloretin, Myricetin, Daidzein. These active ingredients manipulate various biochemical pathways like DNA Repair, Oncogenic Histone Methylation, TGFB Signaling and PI3K-AKT-MTOR Signaling and others. Romaine Lettuce is not recommended for Gemistocytic Astrocytoma when ongoing cancer treatment is Temozolomide because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE GIANT BUTTERBUR IS RECOMMENDED OVER ROMAINE LETTUCE FOR Gemistocytic Astrocytoma AND TREATMENT Temozolomide.

Choose Fruit NANCE or ELDERBERRY?

Fruit Nance contains many active ingredients or bioactives such as Curcumin, Apigenin, Phloretin, Myricetin, Daidzein. These active ingredients manipulate various biochemical pathways like MAPK Signaling, Hypoxia and Amino Acid Metabolism and others. Nance is recommended for Gemistocytic Astrocytoma when ongoing cancer treatment is Temozolomide. This is because Nance modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Temozolomide.

Some of the active ingredients or bioactives in fruit Elderberry are Quercetin, Curcumin, Apigenin, Phloretin, Myricetin. These active ingredients manipulate various biochemical pathways like Microtubule Dynamics, WNT Beta Catenin Signaling and Oxidative Stress and others. Elderberry is not recommended for Gemistocytic Astrocytoma when ongoing cancer treatment is Temozolomide because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT NANCE IS RECOMMENDED OVER ELDERBERRY FOR Gemistocytic Astrocytoma AND TREATMENT Temozolomide.

Choose Nut COMMON HAZELNUT or FLAXSEED?

Common Hazelnut contains many active ingredients or bioactives such as Quercetin, Curcumin, Phloretin, Myricetin, Daidzein. These active ingredients manipulate various biochemical pathways like MAPK Signaling, DNA Repair, Amino Acid Metabolism and NFKB Signaling and others. Common Hazelnut is recommended for Gemistocytic Astrocytoma when ongoing cancer treatment is Temozolomide. This is because Common Hazelnut modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Temozolomide.

Some of the active ingredients or bioactives in Flaxseed are Curcumin, Apigenin, Phloretin, Myricetin, Daidzein. These active ingredients manipulate various biochemical pathways like MAPK Signaling, Hypoxia, NFKB Signaling and Oxidative Stress and others. Flaxseed is not recommended for Gemistocytic Astrocytoma when ongoing cancer treatment is Temozolomide because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

COMMON HAZELNUT IS RECOMMENDED OVER FLAXSEED FOR Gemistocytic Astrocytoma AND TREATMENT Temozolomide.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Gemistocytic Astrocytoma or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable GREEN ZUCCHINI or RADISH?

Vegetable Green Zucchini contains many active ingredients or bioactives such as Curcumin, Apigenin, Myricetin, Lupeol, Vitamin D3. These active ingredients manipulate various biochemical pathways like Insulin Signaling and Hypoxia and others. Green Zucchini is recommended for risk of Gemistocytic Astrocytoma when associated genetic risk is ATRX. This is because Green Zucchini increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Radish are Curcumin, Apigenin, Quercetin, Myricetin, Lupeol. These active ingredients manipulate various biochemical pathways like Autophagy, Insulin Signaling, MYC Signaling and PI3K-AKT-MTOR Signaling and others. Radish is not recommended when risk of Gemistocytic Astrocytoma when associated genetic risk is ATRX because it increases the signature pathways of it.

VEGETABLE GREEN ZUCCHINI IS RECOMMENDED OVER RADISH FOR ATRX GENETIC RISK OF CANCER.

Choose Fruit SOUR CHERRY or PUMMELO?

Fruit Sour Cherry contains many active ingredients or bioactives such as Curcumin, Apigenin, Quercetin, Lupeol, Linalool. These active ingredients manipulate various biochemical pathways like MAPK Signaling, Hypoxia and PI3K-AKT-MTOR Signaling and others. Sour Cherry is recommended for risk of Gemistocytic Astrocytoma when associated genetic risk is ATRX. This is because Sour Cherry increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Pummelo are Curcumin, Apigenin, Quercetin, Lupeol, Lycopene. These active ingredients manipulate various biochemical pathways like Autophagy and Insulin Signaling and others. Pummelo is not recommended when risk of Gemistocytic Astrocytoma when associated genetic risk is ATRX because it increases the signature pathways of it.

FRUIT SOUR CHERRY IS RECOMMENDED OVER PUMMELO FOR ATRX GENETIC RISK OF CANCER.

Choose Nut BUTTERNUT or HICKORY NUT?

Butternut contains many active ingredients or bioactives such as Curcumin, Apigenin, Myricetin, Lupeol, Lycopene. These active ingredients manipulate various biochemical pathways like MAPK Signaling, Insulin Signaling and PI3K-AKT-MTOR Signaling and others. Butternut is recommended for risk of Gemistocytic Astrocytoma when associated genetic risk is ATRX. This is because Butternut increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in Hickory Nut are Curcumin, Apigenin, Myricetin, Lupeol, Lycopene. These active ingredients manipulate various biochemical pathways like Autophagy, Insulin Signaling and Oncogenic Cancer Epigenetics and others. Hickory Nut is not recommended when risk of Gemistocytic Astrocytoma when associated genetic risk is ATRX because it increases the signature pathways of it.

BUTTERNUT IS RECOMMENDED OVER HICKORY NUT FOR ATRX GENETIC RISK OF CANCER.

In Conclusion

Foods and Supplements chosen are important decisions for cancers like Gemistocytic Astrocytoma. Gemistocytic Astrocytoma patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Gemistocytic Astrocytoma, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like Giant Butterbur contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Gemistocytic Astrocytoma?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.

References

• Phloretin suppresses metastasis by targeting protease and inhibits cancer stemness and angiogenesis in human cervical cancer cells.
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• Isoliquiritigenin inhibits proliferation and metastasis of MKN28 gastric cancer cells by suppressing the PI3K/AKT/mTOR signaling pathway.
• In vitro and in vivo antitumor activity of neochlorogenic acid in human gastric carcinoma cells are complemented with ROS generation, loss of mitochondrial membrane potential and apoptosis induction.