Which Foods are Recommended for Gemistocytic Astrocytoma?

Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Gemistocytic Astrocytoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Gemistocytic Astrocytoma because of FOXO3 and FANCD2 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Gemistocytic Astrocytoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Peach” or “Include fruit Persimmon in my diet” or “Should I reduce consumption of vegetable Rhubarb” or “Can I take Dim and Birch supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO GEMISTOCYTIC ASTROCYTOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Gemistocytic Astrocytoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR GEMISTOCYTIC ASTROCYTOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.

About Gemistocytic Astrocytoma

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Gemistocytic Astrocytoma from cBioPortal. The top genes with mutations and other abnormalities for Gemistocytic Astrocytoma include genes IDH1, TP53, ATRX, FOXO3 and FANCD2. The occurrence frequency distribution for these genes respectively is 46.8%, 46.8%, 40.4%, 38.7% and 19.5%. These tumor genetic details of Gemistocytic Astrocytoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Gemistocytic Astrocytoma.

Significance of Nutrition for Gemistocytic Astrocytoma

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Gemistocytic Astrocytoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Peach includes active ingredients Fisetin, Caffeic Acid, Vitamin C, Beta-sitosterol, Modified Citrus Pectin and others. And Persimmon contains active ingredients Quercetin, Betulinic Acid, Fisetin, Lupeol, Vitamin C and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Gemistocytic Astrocytoma, activation or inhibition of selected biochemical pathways like DNA Repair, Angiogenesis, PI3K-AKT-MTOR Signaling, Hypoxia plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Gemistocytic Astrocytoma, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR GEMISTOCYTIC ASTROCYTOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Gemistocytic Astrocytoma undergoing chemotherapy treatment

In Gemistocytic Astrocytoma – the genes IDH1, TP53, ATRX, FOXO3 and FANCD2 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Gemistocytic Astrocytoma are DNA Repair, Angiogenesis, Hypoxia and others. Temozolomide is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers DNA Repair, Angiogenesis, Hypoxia so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Scarlet Bean or Lima Bean?

Pulses are an important part of many diets. The active ingredients contained in Scarlet Bean are Vitamin C, Beta-sitosterol, Oleic Acid, Linolenic Acid, Stigmasterol among others. While the active ingredients contained in Lima Bean are Vitamin C, Oleic Acid, Genistein, Vitamin A, Linoleic Acid and others.

Vitamin C can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Adherens junction and Growth Factor Signaling. Beta-sitosterol has biological action on biochemical pathways NFKB Signaling, Microtubule Dynamics and DNA Repair.

Genistein can manipulate biochemical pathways DNA Repair and Oxidative Stress. Vitamin A has biological action on biochemical pathways Extracellular Matrix Remodelling. And so on.

When treating Gemistocytic Astrocytoma with chemotherapy Temozolomide – Foods like Scarlet Bean are recommended compared to Lima Bean. This is because the active ingredients Genistein and Vitamin A in Lima Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Beta-sitosterol contained in Scarlet Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER LIMA BEAN FOR GEMISTOCYTIC ASTROCYTOMA ON TREATMENT WITH CHEMOTHERAPY TEMOZOLOMIDE FOR SOME CONDITIONS.

Eat more vegetables, Jicama or Rhubarb?

Vegetables are an important part of many diets. The active ingredients contained in Jicama are Vitamin C, Beta-carotene, Vitamin A, Vitamin B3, Folic Acid among others. While the active ingredients contained in Rhubarb are Quercetin, Vitamin E, Vitamin C, Chrysophanol, Linolenic Acid and others.

Vitamin C can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Adherens junction and Growth Factor Signaling. Beta-carotene has biological action on biochemical pathways NFKB Signaling, Microtubule Dynamics and DNA Repair.

Rutin can manipulate biochemical pathways WNT Beta Catenin Signaling, Oxidative Stress and Microtubule Dynamics. Quercetin has biological action on biochemical pathways Oxidative Stress. And so on.

When treating Gemistocytic Astrocytoma with chemotherapy Temozolomide – Foods like Jicama are recommended compared to Rhubarb. This is because the active ingredients Rutin and Quercetin in Rhubarb interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Beta-carotene contained in Jicama support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: JICAMA IS RECOMMENDED OVER RHUBARB FOR GEMISTOCYTIC ASTROCYTOMA ON TREATMENT WITH CHEMOTHERAPY TEMOZOLOMIDE FOR SOME CONDITIONS.

Eat more fruits, Persimmon or Peach?

Fruits are an important part of many diets. The active ingredients contained in Persimmon are Quercetin, Betulinic Acid, Fisetin, Lupeol, Vitamin C among others. While the active ingredients contained in Peach are Fisetin, Caffeic Acid, Vitamin C, Beta-sitosterol, Modified Citrus Pectin and others.

Vitamin C can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Adherens junction and Growth Factor Signaling. Lycopene has biological action on biochemical pathways NFKB Signaling, Microtubule Dynamics and JAK-STAT Signaling.

Citric Acid can manipulate biochemical pathways Oxidative Stress. Fisetin has biological action on biochemical pathways Epithelial to Mesenchymal Transition, TWEAK Signaling and MYC Signaling. And so on.

When treating Gemistocytic Astrocytoma with chemotherapy Temozolomide – Foods like Persimmon are recommended compared to Peach. This is because the active ingredients Citric Acid and Fisetin in Peach interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Lycopene contained in Persimmon support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: PERSIMMON IS RECOMMENDED OVER PEACH FOR GEMISTOCYTIC ASTROCYTOMA ON TREATMENT WITH CHEMOTHERAPY TEMOZOLOMIDE FOR SOME CONDITIONS.

Eat more nuts, Pine Nut or Acorn?

Nuts are an important part of many diets. The active ingredients contained in Pine Nut are Vitamin E, Beta-sitosterol, Oleic Acid, Linolenic Acid, Vitamin A among others. While the active ingredients contained in Acorn are Quercetin, Vitamin C, Beta-sitosterol, Beta-carotene, Gallic Acid and others.

Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Adherens junction. Vitamin K has biological action on biochemical pathways Cell Cycle, TWEAK Signaling and MYC Signaling.

Quercetin can manipulate biochemical pathways Oxidative Stress. Gallic Acid has biological action on biochemical pathways Vitamin D Signaling and Oxidative Stress. And so on.

When treating Gemistocytic Astrocytoma with chemotherapy Temozolomide – Foods like Pine Nut are recommended compared to Acorn. This is because the active ingredients Quercetin and Gallic Acid in Acorn interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin K contained in Pine Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: PINE NUT IS RECOMMENDED OVER ACORN FOR GEMISTOCYTIC ASTROCYTOMA ON TREATMENT WITH CHEMOTHERAPY TEMOZOLOMIDE FOR SOME CONDITIONS.

Foods for Genetic Risk of Gemistocytic Astrocytoma

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. FOXO3 and FANCD2 are two genes whose abnormalities are risk factors for Gemistocytic Astrocytoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Gemistocytic Astrocytoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Gemistocytic Astrocytoma gene FOXO3 has causative impact on biological pathways like MAPK Signaling and Autophagy. And FANCD2 has a causative impact on biological pathways like DNA Repair, DNA Repair and DNA Repair. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like FOXO3 and FANCD2 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes FOXO3 and FANCD2 should be avoided.

Eat more pulses, Common Pea or Fava Bean?

The active ingredients contained in Common Pea are Vitamin C, Lupeol, Daidzein, Beta-sitosterol, Linolenic Acid among others. While the active ingredients contained in Fava Bean are Vitamin C, Daidzein, Beta-sitosterol, Linolenic Acid, Stigmasterol and others.

Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Beta-sitosterol has biological action on biochemical pathways Cell Cycle Checkpoints, Oncogenic Cancer Epigenetics and Hypoxia.

Linoleic Acid can manipulate biochemical pathways FOXO Signaling. Folic Acid has biological action on biochemical pathways MYC Signaling, P53 Signaling and Cell Cycle Checkpoints. And so on.

For genetic risk of Gemistocytic Astrocytoma due to abnormalities in genes FOXO3 and FANCD2 – Foods like Common Pea are recommended compared to Fava Bean. This is because the active ingredients Linoleic Acid and Folic Acid in Fava Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Common Pea together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER FAVA BEAN FOR REDUCING THE GENETIC RISK OF GEMISTOCYTIC ASTROCYTOMA DUE TO GENES FOXO3 AND FANCD2

Eat more vegetables, Mexican Groundcherry or Heart Of Palm?

The active ingredients contained in Mexican Groundcherry are Vitamin C, Vitamin B3 among others. While the active ingredients contained in Heart Of Palm are Vitamin C, Palmitic Acid, Vitamin A, Folic Acid and others.

Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin B3 has biological action on biochemical pathways FOXO Signaling, Cell Cycle Checkpoints and Hypoxia.

Palmitic Acid can manipulate biochemical pathways Oncogenic Cancer Epigenetics and Energy Metabolism. Folic Acid has biological action on biochemical pathways MYC Signaling, P53 Signaling and Cell Cycle Checkpoints. And so on.

For genetic risk of Gemistocytic Astrocytoma due to abnormalities in genes FOXO3 and FANCD2 – Foods like Mexican Groundcherry are recommended compared to Heart Of Palm. This is because the active ingredients Palmitic Acid and Folic Acid in Heart Of Palm further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Vitamin B3 contained in Mexican Groundcherry together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: MEXICAN GROUNDCHERRY IS RECOMMENDED OVER HEART OF PALM FOR REDUCING THE GENETIC RISK OF GEMISTOCYTIC ASTROCYTOMA DUE TO GENES FOXO3 AND FANCD2

Eat more fruits, Feijoa or Lingonberry?

The active ingredients contained in Feijoa are Vitamin C, Lycopene, Casuarinin, Folic Acid among others. While the active ingredients contained in Lingonberry are Vitamin C, Hyperoside, Linolenic Acid, Quercetin, Quercitrin and others.

Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Lycopene has biological action on biochemical pathways FOXO Signaling, Cell Cycle Checkpoints and Hypoxia.

Resveratrol can manipulate biochemical pathways P53 Signaling and FOXO Signaling. Linoleic Acid has biological action on biochemical pathways FOXO Signaling. And so on.

For genetic risk of Gemistocytic Astrocytoma due to abnormalities in genes FOXO3 and FANCD2 – Foods like Feijoa are recommended compared to Lingonberry. This is because the active ingredients Resveratrol and Linoleic Acid in Lingonberry further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Lycopene contained in Feijoa together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: FEIJOA IS RECOMMENDED OVER LINGONBERRY FOR REDUCING THE GENETIC RISK OF GEMISTOCYTIC ASTROCYTOMA DUE TO GENES FOXO3 AND FANCD2

Eat more nuts, Pistachio or Peanut?

The active ingredients contained in Pistachio are Vitamin E, Beta-sitosterol, Linolenic Acid, Stigmasterol, Oleic Acid among others. While the active ingredients contained in Peanut are Vitamin C, Vitamin E, Beta-sitosterol, Linolenic Acid, Rhamnetin and others.

Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin E has biological action on biochemical pathways Cell Cycle Checkpoints, Hypoxia and Apoptosis.

Lecithin can manipulate biochemical pathways MYC Signaling. Linoleic Acid has biological action on biochemical pathways FOXO Signaling. And so on.

For genetic risk of Gemistocytic Astrocytoma due to abnormalities in genes FOXO3 and FANCD2 – Foods like Pistachio are recommended compared to Peanut. This is because the active ingredients Lecithin and Linoleic Acid in Peanut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin E contained in Pistachio together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: PISTACHIO IS RECOMMENDED OVER PEANUT FOR REDUCING THE GENETIC RISK OF GEMISTOCYTIC ASTROCYTOMA DUE TO GENES FOXO3 AND FANCD2

In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Gemistocytic Astrocytoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

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