Foods for Mucinous Adenocarcinoma Of The Appendix!

Introduction

Foods for Mucinous Adenocarcinoma Of The Appendix should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.

Mucinous adenocarcinoma is a type of cancer that can occur in various organs, including the ovary, breast, lung, colon, pancreas, bladder, and appendix. Pathology outlines provide detailed information about the characteristics and cellular composition of mucinous adenocarcinoma. The staging and prognosis of mucinous adenocarcinoma depend on the location and stage of the cancer. Treatment options may include surgery, chemotherapy, and other targeted therapies. Careful monitoring and follow-up are essential to assess the response to treatment and increase the chances of survival. Understanding the symptoms and seeking early medical attention can aid in the timely detection and management of mucinous adenocarcinoma. Chemotherapy is often utilized as a key component of treatment for advanced cases of mucinous adenocarcinoma. Stay informed about the prognosis, pathology, and treatment options of mucinous adenocarcinoma to ensure comprehensive care and better outcomes for individuals facing this condition.

For Mucinous Adenocarcinoma Of The Appendix does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Mucinous Adenocarcinoma Of The Appendix does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Mucinous Adenocarcinoma Of The Appendix?

For example does it matter if vegetable Cauliflower is consumed more compared to Kohlrabi? Does it make any difference if fruit Malus (crab Apple) is preferred over Red Raspberry? Also if similar choices are made for nuts/seeds like Butternut over European Chestnut and for pulses like Adzuki Bean over Lima Bean. And if what I eat matters – then how does one identify foods which are recommended for Mucinous Adenocarcinoma Of The Appendix and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Mucinous Adenocarcinoma Of The Appendix!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Malus (crab Apple) contains active ingredients Curcumin, Caffeine, Delphinidin, Daidzein, Lycopene. And Red Raspberry contains active ingredients Quercetin, Ellagic Acid, Curcumin, Delphinidin, Daidzein and possibly others.

A common mistake made when deciding and choosing foods to eat for Mucinous Adenocarcinoma Of The Appendix – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Mucinous Adenocarcinoma Of The Appendix.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Mucinous Adenocarcinoma Of The Appendix?

Personalized nutrition for cancers like Mucinous Adenocarcinoma Of The Appendix consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Mucinous Adenocarcinoma Of The Appendix biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Characteristics of cancers like Mucinous Adenocarcinoma Of The Appendix

All cancers like Mucinous Adenocarcinoma Of The Appendix can be characterized by a unique set of biochemical pathways – the signature pathways of Mucinous Adenocarcinoma Of The Appendix. Biochemical pathways like RAS-RAF Signaling, Cell Cycle, PI3K-AKT-MTOR Signaling, MAPK Signaling are part of the signature definition of Mucinous Adenocarcinoma Of The Appendix. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Mucinous Adenocarcinoma Of The Appendix need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Mucinous Adenocarcinoma Of The Appendix when taking cancer treatment Radiation, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

KRAS, GNAS, TP53, SMAD2 and AKT1 are the top ranked reported genes for Mucinous Adenocarcinoma Of The Appendix. KRAS is reported in 56.9 % of the representative patients across all clinical trials. And GNAS is reported in 33.8 %. The combined population patient data cover ages from 73 to 73. 49.7 % of the patient data are identified as men. The Mucinous Adenocarcinoma Of The Appendix biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Food and Supplements for Mucinous Adenocarcinoma Of The Appendix

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable CAULIFLOWER or KOHLRABI?

Vegetable Cauliflower contains many active ingredients or bioactives such as Curcumin, Daidzein, Delphinidin, Lupeol, Cinnamaldehyde. These active ingredients manipulate various biochemical pathways like MAPK Signaling, MYC Signaling, NFKB Signaling and Cell Survival and others. Cauliflower is recommended for Mucinous Adenocarcinoma Of The Appendix when ongoing cancer treatment is Radiation. This is because Cauliflower modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Radiation.

Some of the active ingredients or bioactives in vegetable Kohlrabi are Quercetin, Curcumin, Delphinidin, Daidzein, Lupeol. These active ingredients manipulate various biochemical pathways like TGFB Signaling and NFKB Signaling and others. Kohlrabi is not recommended for Mucinous Adenocarcinoma Of The Appendix when ongoing cancer treatment is Radiation because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE CAULIFLOWER IS RECOMMENDED OVER KOHLRABI FOR Mucinous Adenocarcinoma Of The Appendix AND TREATMENT Radiation.

Choose Fruit RED RASPBERRY or MALUS (CRAB APPLE)?

Fruit Red Raspberry contains many active ingredients or bioactives such as Quercetin, Ellagic Acid, Curcumin, Delphinidin, Daidzein. These active ingredients manipulate various biochemical pathways like MAPK Signaling, RAS-RAF Signaling, NFKB Signaling and PI3K-AKT-MTOR Signaling and others. Red Raspberry is recommended for Mucinous Adenocarcinoma Of The Appendix when ongoing cancer treatment is Radiation. This is because Red Raspberry modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Radiation.

Some of the active ingredients or bioactives in fruit Malus (crab Apple) are Curcumin, Caffeine, Delphinidin, Daidzein, Lycopene. These active ingredients manipulate various biochemical pathways like DNA Repair, NFKB Signaling and TGFB Signaling and others. Malus (crab Apple) is not recommended for Mucinous Adenocarcinoma Of The Appendix when ongoing cancer treatment is Radiation because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT RED RASPBERRY IS RECOMMENDED OVER MALUS (CRAB APPLE) FOR Mucinous Adenocarcinoma Of The Appendix AND TREATMENT Radiation.

Choose Nut BUTTERNUT or EUROPEAN CHESTNUT?

Butternut contains many active ingredients or bioactives such as Curcumin, Caffeine, Daidzein, Delphinidin, Lycopene. These active ingredients manipulate various biochemical pathways like MAPK Signaling, DNA Repair, TGFB Signaling and PI3K-AKT-MTOR Signaling and others. Butternut is recommended for Mucinous Adenocarcinoma Of The Appendix when ongoing cancer treatment is Radiation. This is because Butternut modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Radiation.

Some of the active ingredients or bioactives in European Chestnut are Quercetin, Ellagic Acid, Curcumin, Delphinidin, Daidzein. These active ingredients manipulate various biochemical pathways like DNA Repair, NFKB Signaling and TGFB Signaling and others. European Chestnut is not recommended for Mucinous Adenocarcinoma Of The Appendix when ongoing cancer treatment is Radiation because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

BUTTERNUT IS RECOMMENDED OVER EUROPEAN CHESTNUT FOR Mucinous Adenocarcinoma Of The Appendix AND TREATMENT Radiation.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Mucinous Adenocarcinoma Of The Appendix or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable GIANT BUTTERBUR or SWAMP CABBAGE?

Vegetable Giant Butterbur contains many active ingredients or bioactives such as Curcumin, Delphinidin, Apigenin, Lycopene, Formononetin. These active ingredients manipulate various biochemical pathways like MAPK Signaling, PI3K-AKT-MTOR Signaling, TGFB Signaling and Oxidative Stress and others. Giant Butterbur is recommended for risk of Mucinous Adenocarcinoma Of The Appendix when associated genetic risk is AKT1. This is because Giant Butterbur increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Swamp Cabbage are Curcumin, Delphinidin, Lycopene, Formononetin, Daidzein. These active ingredients manipulate various biochemical pathways like MAPK Signaling and Oxidative Stress and others. Swamp Cabbage is not recommended when risk of Mucinous Adenocarcinoma Of The Appendix when associated genetic risk is AKT1 because it increases the signature pathways of it.

VEGETABLE GIANT BUTTERBUR IS RECOMMENDED OVER SWAMP CABBAGE FOR AKT1 GENETIC RISK OF CANCER.

Choose Fruit NANCE or PUMMELO?

Fruit Nance contains many active ingredients or bioactives such as Curcumin, Delphinidin, Apigenin, Formononetin, Daidzein. These active ingredients manipulate various biochemical pathways like MAPK Signaling, PI3K-AKT-MTOR Signaling, TGFB Signaling and Oxidative Stress and others. Nance is recommended for risk of Mucinous Adenocarcinoma Of The Appendix when associated genetic risk is AKT1. This is because Nance increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Pummelo are Curcumin, Quercetin, Delphinidin, Apigenin, Lycopene. These active ingredients manipulate various biochemical pathways like Oxidative Stress and others. Pummelo is not recommended when risk of Mucinous Adenocarcinoma Of The Appendix when associated genetic risk is AKT1 because it increases the signature pathways of it.

FRUIT NANCE IS RECOMMENDED OVER PUMMELO FOR AKT1 GENETIC RISK OF CANCER.

Choose Nut COMMON HAZELNUT or CASHEW NUT?

Common Hazelnut contains many active ingredients or bioactives such as Curcumin, Quercetin, Delphinidin, Lycopene, Formononetin. These active ingredients manipulate various biochemical pathways like MAPK Signaling, Cell Cycle Checkpoints, TGFB Signaling and PI3K-AKT-MTOR Signaling and others. Common Hazelnut is recommended for risk of Mucinous Adenocarcinoma Of The Appendix when associated genetic risk is AKT1. This is because Common Hazelnut increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in Cashew Nut are Curcumin, Quercetin, Delphinidin, Formononetin, Daidzein. These active ingredients manipulate various biochemical pathways like MAPK Signaling and PI3K-AKT-MTOR Signaling and others. Cashew Nut is not recommended when risk of Mucinous Adenocarcinoma Of The Appendix when associated genetic risk is AKT1 because it increases the signature pathways of it.

COMMON HAZELNUT IS RECOMMENDED OVER CASHEW NUT FOR AKT1 GENETIC RISK OF CANCER.

In Conclusion

Foods and Supplements chosen are important decisions for cancers like Mucinous Adenocarcinoma Of The Appendix. Mucinous Adenocarcinoma Of The Appendix patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Mucinous Adenocarcinoma Of The Appendix, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like Cauliflower contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Mucinous Adenocarcinoma Of The Appendix?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.

References

• Ntrk Msk 2019
• Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients.
• Brassinin inhibits STAT3 signaling pathway through modulation of PIAS-3 and SOCS-3 expression and sensitizes human lung cancer xenograft in nude mice to paclitaxel.
• Melatonin and vitamin D3 synergistically down-regulate Akt and MDM2 leading to TGFβ-1-dependent growth inhibition of breast cancer cells.
• Caffeine induces apoptosis of osteosarcoma cells by inhibiting AKT/mTOR/S6K, NF-κB and MAPK pathways.
• The O-methylated isoflavone, formononetin, inhibits human ovarian cancer cell proliferation by sub G0/G1 cell phase arrest through PI3K/AKT and ERK1/2 inactivation.