Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Mit Family Translocation Renal Cell Carcinoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Mit Family Translocation Renal Cell Carcinoma because of LRP2 and PIK3CB gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Mit Family Translocation Renal Cell Carcinoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Apricot” or “Include fruit Mulberry in my diet” or “Should I reduce consumption of vegetable Kale” or “Can I take Cissus and Resveratrol supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO MIT FAMILY TRANSLOCATION RENAL CELL CARCINOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Mit Family Translocation Renal Cell Carcinoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR MIT FAMILY TRANSLOCATION RENAL CELL CARCINOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Mit Family Translocation Renal Cell Carcinoma
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Mit Family Translocation Renal Cell Carcinoma from cBioPortal. 36.4% of males and 63.6% of females were the distribution of gender in these clinical studies. From a patient sample size of 22; the top genes with mutations and other abnormalities for Mit Family Translocation Renal Cell Carcinoma include genes LRP2, PIK3CB, CDK6, EPHA7 and BAP1. The occurrence frequency distribution for these genes respectively is 12.5%, 12.5%, 6.2%, 6.2% and 6.2%. These tumor genetic details of Mit Family Translocation Renal Cell Carcinoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Mit Family Translocation Renal Cell Carcinoma.
Significance of Nutrition for Mit Family Translocation Renal Cell Carcinoma
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Mit Family Translocation Renal Cell Carcinoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Apricot includes active ingredients Quercetin, Beta-sitosterol, Oleic Acid, Vitamin C, Linolenic Acid and others. And Mulberry contains active ingredients Resveratrol, Morusin, Deoxynojirimycin, Moracin P and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Mit Family Translocation Renal Cell Carcinoma, activation or inhibition of selected biochemical pathways like mRNA Splicing, Angiogenesis, PI3K-AKT-MTOR Signaling, Cell Cycle plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Mit Family Translocation Renal Cell Carcinoma, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR MIT FAMILY TRANSLOCATION RENAL CELL CARCINOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Mit Family Translocation Renal Cell Carcinoma undergoing chemotherapy treatment
In Mit Family Translocation Renal Cell Carcinoma – the genes LRP2, PIK3CB, CDK6, EPHA7 and BAP1 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Mit Family Translocation Renal Cell Carcinoma are mRNA Splicing, Angiogenesis, PI3K-AKT-MTOR Signaling and others. Radiation is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers mRNA Splicing, Angiogenesis, PI3K-AKT-MTOR Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Scarlet Bean or Common Bean?
Pulses are an important part of many diets. The active ingredients contained in Scarlet Bean are Beta-sitosterol, Oleic Acid, Vitamin C, Linolenic Acid, Liquiritigenin among others. While the active ingredients contained in Common Bean are Apigenin, Oleic Acid, Esculin, Vitamin C, Linolenic Acid and others.
Beta-sitosterol can manipulate biochemical pathways MYC Signaling, Angiogenesis and PI3K-AKT-MTOR Signaling. Vitamin C has biological action on biochemical pathways MYC Signaling, Angiogenesis and PI3K-AKT-MTOR Signaling.
Pelargonidin can manipulate biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. Linoleic Acid has biological action on biochemical pathways Angiogenesis. And so on.
When treating Mit Family Translocation Renal Cell Carcinoma with chemotherapy Radiation – Foods like Scarlet Bean are recommended compared to Common Bean. This is because the active ingredients Pelargonidin and Linoleic Acid in Common Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Scarlet Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER COMMON BEAN FOR MIT FAMILY TRANSLOCATION RENAL CELL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more vegetables, Brussels Sprout or Kale?
Vegetables are an important part of many diets. The active ingredients contained in Brussels Sprout are Beta-sitosterol, Oleic Acid, Vitamin C, Brassinin, Indole-3-carbinol among others. While the active ingredients contained in Kale are Vitamin C, Brassinin, Indole-3-carbinol, Linolenic Acid, Sulforaphane and others.
Vitamin C can manipulate biochemical pathways MYC Signaling, Angiogenesis and PI3K-AKT-MTOR Signaling. Brassinin has biological action on biochemical pathways Cell Survival, MYC Signaling and Angiogenesis.
Linoleic Acid can manipulate biochemical pathways Angiogenesis. Folic Acid has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. And so on.
When treating Mit Family Translocation Renal Cell Carcinoma with chemotherapy Radiation – Foods like Brussels Sprout are recommended compared to Kale. This is because the active ingredients Linoleic Acid and Folic Acid in Kale interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Brassinin contained in Brussels Sprout support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: BRUSSELS SPROUT IS RECOMMENDED OVER KALE FOR MIT FAMILY TRANSLOCATION RENAL CELL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more fruits, Mulberry or Apricot?
Fruits are an important part of many diets. The active ingredients contained in Mulberry are Resveratrol, Morusin, Deoxynojirimycin, Moracin P among others. While the active ingredients contained in Apricot are Quercetin, Beta-sitosterol, Oleic Acid, Vitamin C, Linolenic Acid and others.
Morusin can manipulate biochemical pathways MYC Signaling, Angiogenesis and PI3K-AKT-MTOR Signaling. Deoxynojirimycin has biological action on biochemical pathways Cell Survival.
Epicatechin can manipulate biochemical pathways Angiogenesis. Linoleic Acid has biological action on biochemical pathways Angiogenesis. And so on.
When treating Mit Family Translocation Renal Cell Carcinoma with chemotherapy Radiation – Foods like Mulberry are recommended compared to Apricot. This is because the active ingredients Epicatechin and Linoleic Acid in Apricot interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Morusin and Deoxynojirimycin contained in Mulberry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: MULBERRY IS RECOMMENDED OVER APRICOT FOR MIT FAMILY TRANSLOCATION RENAL CELL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more nuts, Pecan Nut or Chestnut?
Nuts are an important part of many diets. The active ingredients contained in Pecan Nut are Vitamin E, Oleic Acid, Linolenic Acid, Cianidanol, Delphinidin among others. While the active ingredients contained in Chestnut are Quercetin, Oleic Acid, Vitamin C, Betulin, Ellagic Acid and others.
Vitamin E can manipulate biochemical pathways MYC Signaling, Angiogenesis and PI3K-AKT-MTOR Signaling. Cianidanol has biological action on biochemical pathways Cell Survival, MYC Signaling and Angiogenesis.
Ellagic Acid can manipulate biochemical pathways MYC Signaling. Linoleic Acid has biological action on biochemical pathways Angiogenesis. And so on.
When treating Mit Family Translocation Renal Cell Carcinoma with chemotherapy Radiation – Foods like Pecan Nut are recommended compared to Chestnut. This is because the active ingredients Ellagic Acid and Linoleic Acid in Chestnut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin E and Cianidanol contained in Pecan Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER CHESTNUT FOR MIT FAMILY TRANSLOCATION RENAL CELL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Foods for Genetic Risk of Mit Family Translocation Renal Cell Carcinoma
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. LRP2 and PIK3CB are two genes whose abnormalities are risk factors for Mit Family Translocation Renal Cell Carcinoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Mit Family Translocation Renal Cell Carcinoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Mit Family Translocation Renal Cell Carcinoma gene LRP2 has causative impact on biological pathways like . And PIK3CB has a causative impact on biological pathways like Hematopoiesis and Inositol Phosphate Signaling. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like LRP2 and PIK3CB should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes LRP2 and PIK3CB should be avoided.
Eat more pulses, Mung Bean or Yellow Wax Bean?
The active ingredients contained in Mung Bean are Quercetin, Kaempferol, Vitamin C, Oleic Acid, Linolenic Acid among others. While the active ingredients contained in Yellow Wax Bean are Ferulic Acid, Vitamin C, Butyric Acid, Cianidanol, Vitamin A and others.
Quercetin can manipulate biochemical pathways Small Molecule Transport, Cell Cycle and EPHRIN Signaling. Kaempferol has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Cell Cycle.
Palmitic Acid can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Mit Family Translocation Renal Cell Carcinoma due to abnormalities in genes LRP2 and PIK3CB – Foods like Mung Bean are recommended compared to Yellow Wax Bean. This is because the active ingredients Palmitic Acid and Folic Acid in Yellow Wax Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Quercetin and Kaempferol contained in Mung Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: MUNG BEAN IS RECOMMENDED OVER YELLOW WAX BEAN FOR REDUCING THE GENETIC RISK OF MIT FAMILY TRANSLOCATION RENAL CELL CARCINOMA DUE TO GENES LRP2 AND PIK3CB
Eat more vegetables, Artichoke or Jute?
The active ingredients contained in Artichoke are Apigenin, Luteolin, Cynaroside, Vitamin C, Chlorogenic Acid among others. While the active ingredients contained in Jute are Quercetin, Kaempferol, Vitamin C, Oleic Acid, Linolenic Acid and others.
Vitamin K can manipulate biochemical pathways Cell Cycle Checkpoints, Cell Cycle and PI3K-AKT-MTOR Signaling. Apigenin has biological action on biochemical pathways EPHRIN Signaling, PI3K-AKT-MTOR Signaling and Cell Cycle Checkpoints.
Vitamin B3 can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Oleic Acid has biological action on biochemical pathways Netrin Signaling. And so on.
For genetic risk of Mit Family Translocation Renal Cell Carcinoma due to abnormalities in genes LRP2 and PIK3CB – Foods like Artichoke are recommended compared to Jute. This is because the active ingredients Vitamin B3 and Oleic Acid in Jute further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin K and Apigenin contained in Artichoke together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: ARTICHOKE IS RECOMMENDED OVER JUTE FOR REDUCING THE GENETIC RISK OF MIT FAMILY TRANSLOCATION RENAL CELL CARCINOMA DUE TO GENES LRP2 AND PIK3CB
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Bilberry or Persimmon?
The active ingredients contained in Bilberry are Quercetin, Resveratrol, Myricetin, Caffeic Acid, P-coumaric Acid among others. While the active ingredients contained in Persimmon are Fisetin, Quercetin, Lupeol, Betulinic Acid, Vitamin C and others.
Chlorogenic Acid can manipulate biochemical pathways PI3K-AKT-MTOR Signaling and Extracellular Matrix Remodelling. Ursolic Acid has biological action on biochemical pathways Cell Cycle Checkpoints, Cell Cycle and PI3K-AKT-MTOR Signaling.
Lycopene can manipulate biochemical pathways Small Molecule Transport and Extracellular Matrix Remodelling. Folic Acid has biological action on biochemical pathways Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Mit Family Translocation Renal Cell Carcinoma due to abnormalities in genes LRP2 and PIK3CB – Foods like Bilberry are recommended compared to Persimmon. This is because the active ingredients Lycopene and Folic Acid in Persimmon further promote the effects of genes on the biochemical pathways. While the active ingredients Chlorogenic Acid and Ursolic Acid contained in Bilberry together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: BILBERRY IS RECOMMENDED OVER PERSIMMON FOR REDUCING THE GENETIC RISK OF MIT FAMILY TRANSLOCATION RENAL CELL CARCINOMA DUE TO GENES LRP2 AND PIK3CB
Eat more nuts, Pine Nut or Peanut?
The active ingredients contained in Pine Nut are Vitamin E, Beta-sitosterol, Oleic Acid, Linolenic Acid, Vitamin A among others. While the active ingredients contained in Peanut are Quercetin, Vitamin E, Beta-sitosterol, Ferulic Acid, Vitamin C and others.
Beta-sitosterol can manipulate biochemical pathways Cell Cycle Checkpoints, Cell Cycle and PI3K-AKT-MTOR Signaling. Vitamin K has biological action on biochemical pathways Cell Cycle Checkpoints, Cell Cycle and PI3K-AKT-MTOR Signaling.
Lecithin can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Vitamin B3 has biological action on biochemical pathways PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Mit Family Translocation Renal Cell Carcinoma due to abnormalities in genes LRP2 and PIK3CB – Foods like Pine Nut are recommended compared to Peanut. This is because the active ingredients Lecithin and Vitamin B3 in Peanut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin K contained in Pine Nut together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: PINE NUT IS RECOMMENDED OVER PEANUT FOR REDUCING THE GENETIC RISK OF MIT FAMILY TRANSLOCATION RENAL CELL CARCINOMA DUE TO GENES LRP2 AND PIK3CB
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Mit Family Translocation Renal Cell Carcinoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
- Pan Origimed 2020
- β-Sitosterol targets Trx/Trx1 reductase to induce apoptosis in A549 cells via ROS mediated mitochondrial dysregulation and p53 activation.
- Vitamin C decreases VEGF expression levels via hypoxia‑inducible factor‑1α dependent and independent pathways in lens epithelial cells.
- Pelargonidin reduces the TPA induced transformation of mouse epidermal cells -potential involvement of Nrf2 promoter demethylation.
- Linoleic acid enhances angiogenesis through suppression of angiostatin induced by plasminogen activator inhibitor 1.
- Lambda gt22S, a phage expression vector for the directional cloning of cDNA by the use of a single restriction enzyme SfiI.
- Intake of mulberry 1-deoxynojirimycin prevents colorectal cancer in mice.
- Effects of (-)-epicatechin and derivatives on nitric oxide mediated induction of mitochondrial proteins.
- Brassinin inhibits STAT3 signaling pathway through modulation of PIAS-3 and SOCS-3 expression and sensitizes human lung cancer xenograft in nude mice to paclitaxel.
- Effects of folate deficiency on gene expression in the apoptosis and cancer pathways in colon cancer cells.
- Anti-IL-1 alpha autoantibodies in patients with rheumatic diseases and in healthy subjects.
- (+)-Catechin inhibits tumour angiogenesis and regulates the production of nitric oxide and TNF-alpha in LPS-stimulated macrophages.
- Identification of ellagic acid as potent inhibitor of protein kinase CK2: a successful example of a virtual screening application.
- Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin.
- Chlorogenic acid reduces liver inflammation and fibrosis through inhibition of toll-like receptor 4 signaling pathway.
- Major triterpenoids in Chinese hawthorn Crataegus pinnatifida” and their effects on cell proliferation and apoptosis induction in MDA-MB-231 cancer cells.”
- Lycopene and bone: an in vitro investigation and a pilot prospective clinical study.
- Research progress on the anticancer effects of vitamin K2.
- Modulation of Sirt1 by resveratrol and nicotinamide alters proliferation and differentiation of pig preadipocytes.
- Oleic acid-induced ANGPTL4 enhances head and neck squamous cell carcinoma anoikis resistance and metastasis via up-regulation of fibronectin.
- New concepts in phospholipase D signaling in inflammation and cancer.
- Determination of 1-deoxynojirimycin in mulberry leaves using hydrophilic interaction chromatography with evaporative light scattering detection.
- 1-Deoxynojirimycin in Mulberry (Morus indica L.) Leaves Ameliorates Stable Angina Pectoris in Patients With Coronary Heart Disease by Improving Antioxidant and Anti-inflammatory Capacities.
- Effects of mulberry leaf extract rich in 1-deoxynojirimycin on blood lipid profiles in humans.
- Effect of sodium nitrate loading on electrolyte transport by the renal tubule.
- HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.