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What Foods are Recommended for Cancer?
is a very common question. Personalized Nutrition Plans are foods and supplements which are personalized to a cancer indication, genes, any treatments and lifestyle conditions.

Which Foods are Recommended for Lung Squamous Cell Carcinoma?

Aug 16, 2022

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Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Lung Squamous Cell Carcinoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Lung Squamous Cell Carcinoma because of RYR2 and RYR3 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Lung Squamous Cell Carcinoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Watermelon” or “Include fruit Cherimoya in my diet” or “Should I reduce consumption of vegetable Spinach” or “Can I take Dim and Thunder God supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO LUNG SQUAMOUS CELL CARCINOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Lung Squamous Cell Carcinoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR LUNG SQUAMOUS CELL CARCINOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.



About Lung Squamous Cell Carcinoma

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Lung Squamous Cell Carcinoma from cBioPortal. The patients enrolled in the studies for Lung Squamous Cell Carcinoma are in ages between 39 to 90 with an average age of 68. 73.0% of males and 27.0% of females were the distribution of gender in these clinical studies. From a patient sample size of 2394; the top genes with mutations and other abnormalities for Lung Squamous Cell Carcinoma include genes TP53, RYR2, MUC16, RYR3 and CDH10. The occurrence frequency distribution for these genes respectively is 13.9%, 9.3%, 9.1%, 4.6% and 4.3%. These tumor genetic details of Lung Squamous Cell Carcinoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Lung Squamous Cell Carcinoma.

Significance of Nutrition for Lung Squamous Cell Carcinoma

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Lung Squamous Cell Carcinoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Watermelon includes active ingredients Lycopene, Linolenic Acid, Cucurbitacin E, Vitamin C, Oleic Acid and others. And Cherimoya contains active ingredients Beta-sitosterol, Linolenic Acid, Vitamin C, Stigmasterol, Oleic Acid and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Lung Squamous Cell Carcinoma, activation or inhibition of selected biochemical pathways like Post Translation Modification, RAS-RAF Signaling, Extracellular Matrix Remodelling, Focal Adhesion plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Lung Squamous Cell Carcinoma, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

For cancers like Lung Squamous Cell Carcinoma, activation or inhibition of selected biochemical pathways like Post Translation Modification, RAS-RAF Signaling, Extracellular Matrix Remodelling, Focal Adhesion plays an important role in driving cancer growth.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR LUNG SQUAMOUS CELL CARCINOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Lung Squamous Cell Carcinoma undergoing chemotherapy treatment

In Lung Squamous Cell Carcinoma – the genes TP53, RYR2, MUC16, RYR3 and CDH10 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Lung Squamous Cell Carcinoma are Post Translation Modification, RAS-RAF Signaling, mRNA Splicing and others. Radiation is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Post Translation Modification, RAS-RAF Signaling, mRNA Splicing so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Scarlet Bean or Pigeon Pea?

Pulses are an important part of many diets. The active ingredients contained in Scarlet Bean are Beta-sitosterol, Linolenic Acid, Genistein, Vitamin C, Stigmasterol among others. While the active ingredients contained in Pigeon Pea are Linolenic Acid, Genistein, Vitamin C, Oleic Acid, Linoleic Acid and others.

Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Glucocorticoid Signaling. Genistein has biological action on biochemical pathways Stem Cell Signaling, Microtubule Dynamics and Cell Cycle.

Vitamin C can manipulate biochemical pathways Heat Stress Response. Vitamin A has biological action on biochemical pathways Extracellular Matrix Remodelling, Notch Signaling and Focal Adhesion. And so on.

When treating Lung Squamous Cell Carcinoma with chemotherapy Radiation – Foods like Scarlet Bean are recommended compared to Pigeon Pea. This is because the active ingredients Vitamin C and Vitamin A in Pigeon Pea interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Genistein contained in Scarlet Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER PIGEON PEA FOR LUNG SQUAMOUS CELL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more vegetables, Kohlrabi or Spinach?

Vegetables are an important part of many diets. The active ingredients contained in Kohlrabi are Sulforaphane, Beta-sitosterol, Linolenic Acid, Brassinin, Kaempferol among others. While the active ingredients contained in Spinach are Quercetin, Apigenin, Beta-sitosterol, Linolenic Acid, Kaempferol and others.

Brassinin can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and JAK-STAT Signaling. Sulforaphane has biological action on biochemical pathways Glucocorticoid Signaling, Oxidative Stress and Microtubule Dynamics.

Apigenin can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Stem Cell Signaling and DNA Repair. Vitamin C has biological action on biochemical pathways Heat Stress Response. And so on.

When treating Lung Squamous Cell Carcinoma with chemotherapy Radiation – Foods like Kohlrabi are recommended compared to Spinach. This is because the active ingredients Apigenin and Vitamin C in Spinach interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Brassinin and Sulforaphane contained in Kohlrabi support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: KOHLRABI IS RECOMMENDED OVER SPINACH FOR LUNG SQUAMOUS CELL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Which Foods are Recommended for Lung Squamous Cell Carcinoma?

Eat more fruits, Cherimoya or Watermelon?

Fruits are an important part of many diets. The active ingredients contained in Cherimoya are Beta-sitosterol, Linolenic Acid, Vitamin C, Stigmasterol, Oleic Acid among others. While the active ingredients contained in Watermelon are Lycopene, Linolenic Acid, Cucurbitacin E, Vitamin C, Oleic Acid and others.

Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Glucocorticoid Signaling. Stigmasterol has biological action on biochemical pathways DNA Repair, JAK-STAT Signaling and Cell Cycle.

Lycopene can manipulate biochemical pathways Oncogenic Cancer Epigenetics and Oxidative Stress. Vitamin C has biological action on biochemical pathways Heat Stress Response. And so on.

When treating Lung Squamous Cell Carcinoma with chemotherapy Radiation – Foods like Cherimoya are recommended compared to Watermelon. This is because the active ingredients Lycopene and Vitamin C in Watermelon interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Stigmasterol contained in Cherimoya support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: CHERIMOYA IS RECOMMENDED OVER WATERMELON FOR LUNG SQUAMOUS CELL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more nuts, Pistachio or Peanut?

Nuts are an important part of many diets. The active ingredients contained in Pistachio are Resveratrol, Vitamin E, Beta-sitosterol, Linolenic Acid, Stigmasterol among others. While the active ingredients contained in Peanut are Quercetin, Vitamin E, Beta-sitosterol, Linolenic Acid, Rhamnetin and others.

Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Glucocorticoid Signaling. Resveratrol has biological action on biochemical pathways Microtubule Dynamics, JAK-STAT Signaling and Cell Cycle.

Quercetin can manipulate biochemical pathways Oxidative Stress. Vitamin A has biological action on biochemical pathways Extracellular Matrix Remodelling, Notch Signaling and Focal Adhesion. And so on.

When treating Lung Squamous Cell Carcinoma with chemotherapy Radiation – Foods like Pistachio are recommended compared to Peanut. This is because the active ingredients Quercetin and Vitamin A in Peanut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Resveratrol contained in Pistachio support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: PISTACHIO IS RECOMMENDED OVER PEANUT FOR LUNG SQUAMOUS CELL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Foods for Genetic Risk of Lung Squamous Cell Carcinoma

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. RYR2 and RYR3 are two genes whose abnormalities are risk factors for Lung Squamous Cell Carcinoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Lung Squamous Cell Carcinoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Lung Squamous Cell Carcinoma gene RYR2 has causative impact on biological pathways like G-protein-coupled Receptor Signaling and G-protein-coupled Receptor Signaling. And RYR3 has a causative impact on biological pathways like G-protein-coupled Receptor Signaling and G-protein-coupled Receptor Signaling. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like RYR2 and RYR3 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes RYR2 and RYR3 should be avoided.

Eat more pulses, Common Pea or Soy Bean?

The active ingredients contained in Common Pea are Lupeol, Daidzein, Beta-sitosterol, Linolenic Acid, Oleic Acid among others. While the active ingredients contained in Soy Bean are Lupeol, Quercetin, Daidzein, Vitamin E, Beta-sitosterol and others.

Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Lupeol has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and RAS-RAF Signaling.

Aescin can manipulate biochemical pathways Cell Cycle Checkpoints. Lecithin has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. And so on.

For genetic risk of Lung Squamous Cell Carcinoma due to abnormalities in genes RYR2 and RYR3 – Foods like Common Pea are recommended compared to Soy Bean. This is because the active ingredients Aescin and Lecithin in Soy Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Lupeol contained in Common Pea together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER SOY BEAN FOR REDUCING THE GENETIC RISK OF LUNG SQUAMOUS CELL CARCINOMA DUE TO GENES RYR2 AND RYR3

Eat more vegetables, Arugula or Parsnip?

The active ingredients contained in Arugula are Esculin, Kaempferol, Vitamin A, Vitamin K, Erysolin among others. While the active ingredients contained in Parsnip are Quercetin, Psoralen, Imperatorin, Linolenic Acid, Oleic Acid and others.

Kaempferol can manipulate biochemical pathways RAS-RAF Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling. Vitamin K has biological action on biochemical pathways MYC Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.

Imperatorin can manipulate biochemical pathways Small Molecule Transport. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. And so on.

For genetic risk of Lung Squamous Cell Carcinoma due to abnormalities in genes RYR2 and RYR3 – Foods like Arugula are recommended compared to Parsnip. This is because the active ingredients Imperatorin and Folic Acid in Parsnip further promote the effects of genes on the biochemical pathways. While the active ingredients Kaempferol and Vitamin K contained in Arugula together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: ARUGULA IS RECOMMENDED OVER PARSNIP FOR REDUCING THE GENETIC RISK OF LUNG SQUAMOUS CELL CARCINOMA DUE TO GENES RYR2 AND RYR3

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

Eat more fruits, Orange or Strawberry?

The active ingredients contained in Orange are D-limonene, Linalool, Modified Citrus Pectin, Linolenic Acid, Oleic Acid among others. While the active ingredients contained in Strawberry are Ellagic Acid, Lupeol, Beta-sitosterol, Cianidanol, Linolenic Acid and others.

D-limonene can manipulate biochemical pathways Small Molecule Transport, Apoptosis and MYC Signaling. Glucaric Acid has biological action on biochemical pathways RAS-RAF Signaling, PI3K-AKT-MTOR Signaling and MYC Signaling.

Fisetin can manipulate biochemical pathways MYC Signaling. Ellagic Acid has biological action on biochemical pathways MYC Signaling. And so on.

For genetic risk of Lung Squamous Cell Carcinoma due to abnormalities in genes RYR2 and RYR3 – Foods like Orange are recommended compared to Strawberry. This is because the active ingredients Fisetin and Ellagic Acid in Strawberry further promote the effects of genes on the biochemical pathways. While the active ingredients D-limonene and Glucaric Acid contained in Orange together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: ORANGE IS RECOMMENDED OVER STRAWBERRY FOR REDUCING THE GENETIC RISK OF LUNG SQUAMOUS CELL CARCINOMA DUE TO GENES RYR2 AND RYR3

Eat more nuts, Almond or Brazil Nut?

The active ingredients contained in Almond are Quercetin, Vitamin E, Beta-sitosterol, Linolenic Acid, Oleic Acid among others. While the active ingredients contained in Brazil Nut are Vitamin E, Linolenic Acid, Oleic Acid, Lecithin, Folic Acid and others.

Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin E has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Apoptosis.

Lecithin can manipulate biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, P53 Signaling and Cell Cycle Checkpoints. And so on.

For genetic risk of Lung Squamous Cell Carcinoma due to abnormalities in genes RYR2 and RYR3 – Foods like Almond are recommended compared to Brazil Nut. This is because the active ingredients Lecithin and Folic Acid in Brazil Nut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin E contained in Almond together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: ALMOND IS RECOMMENDED OVER BRAZIL NUT FOR REDUCING THE GENETIC RISK OF LUNG SQUAMOUS CELL CARCINOMA DUE TO GENES RYR2 AND RYR3


In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Lung Squamous Cell Carcinoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

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References

Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.


Scientifically Reviewed by: Dr. Cogle

Christopher R. Cogle, M.D. is a tenured professor at the University of Florida, Chief Medical Officer of Florida Medicaid, and Director of the Florida Health Policy Leadership Academy at the Bob Graham Center for Public Service.

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