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What Foods are Recommended for Cancer?
is a very common question. Personalized Nutrition Plans are foods and supplements which are personalized to a cancer indication, genes, any treatments and lifestyle conditions.

Which Foods are Recommended for Liposarcoma?

Aug 16, 2022

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Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Liposarcoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Liposarcoma because of RYR1 and ARID1B gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Liposarcoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Huckleberry” or “Include fruit Feijoa in my diet” or “Should I reduce consumption of vegetable Swiss Chard” or “Can I take Birch and Silymarin supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO LIPOSARCOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Liposarcoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR LIPOSARCOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.



About Liposarcoma

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Liposarcoma from cBioPortal. 49.2% of males and 50.8% of females were the distribution of gender in these clinical studies. From a patient sample size of 52; the top genes with mutations and other abnormalities for Liposarcoma include genes TERT, MUC16, RYR1, ARID1B and PREX2. The occurrence frequency distribution for these genes respectively is 7.0%, 7.0%, 7.0%, 4.7% and 4.7%. These tumor genetic details of Liposarcoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Liposarcoma.

Significance of Nutrition for Liposarcoma

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Liposarcoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Huckleberry includes active ingredients Quercetin, Resveratrol, P-coumaric Acid, Ferulic Acid, Vitamin C and others. And Feijoa contains active ingredients Lycopene, Vitamin C, Casuarinin, Folic Acid and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Liposarcoma, activation or inhibition of selected biochemical pathways like Cell Cycle, C-type Lectin Receptor Signaling, PI3K-AKT-MTOR Signaling, MAPK Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Liposarcoma, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

For cancers like Liposarcoma, activation or inhibition of selected biochemical pathways like Cell Cycle, C-type Lectin Receptor Signaling, PI3K-AKT-MTOR Signaling, MAPK Signaling plays an important role in driving cancer growth.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR LIPOSARCOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Liposarcoma undergoing chemotherapy treatment

In Liposarcoma – the genes TERT, MUC16, RYR1, ARID1B and PREX2 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Liposarcoma are Cell Cycle, C-type Lectin Receptor Signaling, RUNX Signaling and others. Cisplatin is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Cell Cycle, C-type Lectin Receptor Signaling, RUNX Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Common Pea or Adzuki Bean?

Pulses are an important part of many diets. The active ingredients contained in Common Pea are Lupeol, Beta-sitosterol, Daidzein, Linolenic Acid, Vitamin C among others. While the active ingredients contained in Adzuki Bean are Isoliquiritigenin, Glucaric Acid, Genistein, Folic Acid and others.

Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Apoptosis. Vitamin C has biological action on biochemical pathways Cell Cycle, MYC Signaling and P53 Signaling.

Isoliquiritigenin can manipulate biochemical pathways Oxidative Stress. Genistein has biological action on biochemical pathways DNA Repair and Oxidative Stress. And so on.

When treating Liposarcoma with chemotherapy Cisplatin – Foods like Common Pea are recommended compared to Adzuki Bean. This is because the active ingredients Isoliquiritigenin and Genistein in Adzuki Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER ADZUKI BEAN FOR LIPOSARCOMA ON TREATMENT WITH CHEMOTHERAPY CISPLATIN FOR SOME CONDITIONS.

Eat more vegetables, Cassava or Swiss Chard?

Vegetables are an important part of many diets. The active ingredients contained in Cassava are Beta-sitosterol, Linolenic Acid, Vitamin C, Oleic Acid, Vitamin A among others. While the active ingredients contained in Swiss Chard are P-coumaric Acid, Ferulic Acid, Melatonin, Caffeic Acid, Kaempferol and others.

Vitamin C can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Apoptosis and Cell Cycle. Beta-sitosterol has biological action on biochemical pathways NFKB Signaling, Inositol Phosphate Signaling and Cell Survival.

Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. P-coumaric Acid has biological action on biochemical pathways Oxidative Stress. And so on.

When treating Liposarcoma with chemotherapy Cisplatin – Foods like Cassava are recommended compared to Swiss Chard. This is because the active ingredients Vitamin A and P-coumaric Acid in Swiss Chard interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Beta-sitosterol contained in Cassava support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: CASSAVA IS RECOMMENDED OVER SWISS CHARD FOR LIPOSARCOMA ON TREATMENT WITH CHEMOTHERAPY CISPLATIN FOR SOME CONDITIONS.

Which Foods are Recommended for Liposarcoma?

Eat more fruits, Feijoa or Huckleberry?

Fruits are an important part of many diets. The active ingredients contained in Feijoa are Lycopene, Vitamin C, Casuarinin, Folic Acid among others. While the active ingredients contained in Huckleberry are Quercetin, Resveratrol, P-coumaric Acid, Ferulic Acid, Vitamin C and others.

Vitamin C can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Apoptosis and Cell Cycle. Lycopene has biological action on biochemical pathways NFKB Signaling, JAK-STAT Signaling and Cell Survival.

Quercetin can manipulate biochemical pathways Oxidative Stress. Resveratrol has biological action on biochemical pathways P53 Signaling and DNA Repair. And so on.

When treating Liposarcoma with chemotherapy Cisplatin – Foods like Feijoa are recommended compared to Huckleberry. This is because the active ingredients Quercetin and Resveratrol in Huckleberry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Lycopene contained in Feijoa support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: FEIJOA IS RECOMMENDED OVER HUCKLEBERRY FOR LIPOSARCOMA ON TREATMENT WITH CHEMOTHERAPY CISPLATIN FOR SOME CONDITIONS.

Eat more nuts, Pecan Nut or Chestnut?

Nuts are an important part of many diets. The active ingredients contained in Pecan Nut are Vitamin E, Linolenic Acid, Oleic Acid, Cianidanol, Vitamin A among others. While the active ingredients contained in Chestnut are Quercetin, Ellagic Acid, Linolenic Acid, Vitamin C, Oleic Acid and others.

Vitamin E can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Apoptosis. Cianidanol has biological action on biochemical pathways DNA Repair, Cell Survival and MYC Signaling.

Ellagic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition and MYC Signaling. Gallic Acid has biological action on biochemical pathways Oxidative Stress. And so on.

When treating Liposarcoma with chemotherapy Cisplatin – Foods like Pecan Nut are recommended compared to Chestnut. This is because the active ingredients Ellagic Acid and Gallic Acid in Chestnut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin E and Cianidanol contained in Pecan Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER CHESTNUT FOR LIPOSARCOMA ON TREATMENT WITH CHEMOTHERAPY CISPLATIN FOR SOME CONDITIONS.

Foods for Genetic Risk of Liposarcoma

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. RYR1 and ARID1B are two genes whose abnormalities are risk factors for Liposarcoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Liposarcoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Liposarcoma gene RYR1 has causative impact on biological pathways like G-protein-coupled Receptor Signaling and G-protein-coupled Receptor Signaling. And ARID1B has a causative impact on biological pathways like Androgen Signaling and Chromatin Remodeling. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like RYR1 and ARID1B should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes RYR1 and ARID1B should be avoided.

Eat more pulses, Scarlet Bean or Fava Bean?

The active ingredients contained in Scarlet Bean are Beta-sitosterol, Vitamin C, Linolenic Acid, Oleic Acid, Stigmasterol among others. While the active ingredients contained in Fava Bean are Daidzein, Beta-sitosterol, Vitamin C, P-coumaric Acid, Linolenic Acid and others.

Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin C has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Apoptosis.

Ferulic Acid can manipulate biochemical pathways DNA Repair. Quercetin has biological action on biochemical pathways DNA Repair. And so on.

For genetic risk of Liposarcoma due to abnormalities in genes RYR1 and ARID1B – Foods like Scarlet Bean are recommended compared to Fava Bean. This is because the active ingredients Ferulic Acid and Quercetin in Fava Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin C contained in Scarlet Bean together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER FAVA BEAN FOR REDUCING THE GENETIC RISK OF LIPOSARCOMA DUE TO GENES RYR1 AND ARID1B

Eat more vegetables, Jicama or Chicory?

The active ingredients contained in Jicama are Vitamin C, Beta-carotene, Vitamin B3, Vitamin A, Folic Acid among others. While the active ingredients contained in Chicory are Apigenin, Esculin, Lupeol, Betulinic Acid, Vitamin C and others.

Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Beta-carotene has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Apoptosis.

Quercetin can manipulate biochemical pathways DNA Repair. Gallic Acid has biological action on biochemical pathways DNA Repair. And so on.

For genetic risk of Liposarcoma due to abnormalities in genes RYR1 and ARID1B – Foods like Jicama are recommended compared to Chicory. This is because the active ingredients Quercetin and Gallic Acid in Chicory further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-carotene contained in Jicama together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: JICAMA IS RECOMMENDED OVER CHICORY FOR REDUCING THE GENETIC RISK OF LIPOSARCOMA DUE TO GENES RYR1 AND ARID1B

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

Eat more fruits, Orange or Lemon?

The active ingredients contained in Orange are D-limonene, Linalool, Vitamin C, Hesperidin, Linolenic Acid among others. While the active ingredients contained in Lemon are D-limonene, Vitamin C, P-coumaric Acid, Hesperidin, Diosmetin and others.

D-limonene can manipulate biochemical pathways Small Molecule Transport, Apoptosis and MYC Signaling. Vitamin C has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.

Myrcene can manipulate biochemical pathways Small Molecule Transport and Extracellular Matrix Remodelling. Diosmetin has biological action on biochemical pathways DNA Repair. And so on.

For genetic risk of Liposarcoma due to abnormalities in genes RYR1 and ARID1B – Foods like Orange are recommended compared to Lemon. This is because the active ingredients Myrcene and Diosmetin in Lemon further promote the effects of genes on the biochemical pathways. While the active ingredients D-limonene and Vitamin C contained in Orange together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: ORANGE IS RECOMMENDED OVER LEMON FOR REDUCING THE GENETIC RISK OF LIPOSARCOMA DUE TO GENES RYR1 AND ARID1B

Eat more nuts, Hazelnut or Peanut?

The active ingredients contained in Hazelnut are Vitamin E, Linolenic Acid, Oleic Acid, Linoleic Acid, Quercetin among others. While the active ingredients contained in Peanut are Beta-sitosterol, Vitamin E, Vitamin C, Linolenic Acid, Oleic Acid and others.

Vitamin E can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Myricitrin has biological action on biochemical pathways PI3K-AKT-MTOR Signaling and MYC Signaling.

Quercetin can manipulate biochemical pathways DNA Repair. Lecithin has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. And so on.

For genetic risk of Liposarcoma due to abnormalities in genes RYR1 and ARID1B – Foods like Hazelnut are recommended compared to Peanut. This is because the active ingredients Quercetin and Lecithin in Peanut further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin E and Myricitrin contained in Hazelnut together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: HAZELNUT IS RECOMMENDED OVER PEANUT FOR REDUCING THE GENETIC RISK OF LIPOSARCOMA DUE TO GENES RYR1 AND ARID1B


In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Liposarcoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

sample-report


References

Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.


Scientifically Reviewed by: Dr. Cogle

Christopher R. Cogle, M.D. is a tenured professor at the University of Florida, Chief Medical Officer of Florida Medicaid, and Director of the Florida Health Policy Leadership Academy at the Bob Graham Center for Public Service.

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