Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Inflammatory Breast Cancer when undergoing chemotherapy or when you determine you have a genetic risk for developing Inflammatory Breast Cancer because of CDH1 and ERBB2 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Inflammatory Breast Cancer which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Malus (crab Apple)” or “Include fruit Blackberry in my diet” or “Should I reduce consumption of vegetable Celeriac” or “Can I take Naringenin and Spirulina supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO INFLAMMATORY BREAST CANCER, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Inflammatory Breast Cancer is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR INFLAMMATORY BREAST CANCER, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Inflammatory Breast Cancer
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Inflammatory Breast Cancer from cBioPortal. From a patient sample size of 1; the top genes with mutations and other abnormalities for Inflammatory Breast Cancer include genes CDH1, ERBB2, RHOA, RUNX1 and TET2. The occurrence frequency distribution for these genes respectively is 100.0%, 100.0%, 100.0%, 100.0% and 100.0%. These tumor genetic details of Inflammatory Breast Cancer are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Inflammatory Breast Cancer.
Significance of Nutrition for Inflammatory Breast Cancer
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Inflammatory Breast Cancer. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Malus (crab Apple) includes active ingredients Linolenic Acid, Vitamin C, Oleic Acid, 7-4′-dihydroxyflavone, Linoleic Acid and others. And Blackberry contains active ingredients Ellagic Acid, Cianidanol, Quercetin, Myricetin, Scopoletin and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Inflammatory Breast Cancer, activation or inhibition of selected biochemical pathways like Epithelial to Mesenchymal Transition, PI3K-AKT-MTOR Signaling, Adherens junction, Growth Factor Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Inflammatory Breast Cancer, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR INFLAMMATORY BREAST CANCER – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Inflammatory Breast Cancer undergoing chemotherapy treatment
In Inflammatory Breast Cancer – the genes CDH1, ERBB2, RHOA, RUNX1 and TET2 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Inflammatory Breast Cancer are Epithelial to Mesenchymal Transition, PI3K-AKT-MTOR Signaling and others. Radiation is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Epithelial to Mesenchymal Transition, PI3K-AKT-MTOR Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Common Bean or Moth Bean?
Pulses are an important part of many diets. The active ingredients contained in Common Bean are Gamma-linolenic Acid, Linolenic Acid, Vitamin C, Oleic Acid, Apigenin among others. While the active ingredients contained in Moth Bean are Linolenic Acid, Beta-sitosterol, Oleic Acid, Stigmasterol, Vitamin A and others.
Vitamin A can manipulate biochemical pathways Epithelial to Mesenchymal Transition and PI3K-AKT-MTOR Signaling. Gamma-linolenic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition and PI3K-AKT-MTOR Signaling.
Oleic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition. Linoleic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition. And so on.
When treating Inflammatory Breast Cancer with chemotherapy Radiation – Foods like Common Bean are recommended compared to Moth Bean. This is because the active ingredients Oleic Acid and Linoleic Acid in Moth Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin A and Gamma-linolenic Acid contained in Common Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: COMMON BEAN IS RECOMMENDED OVER MOTH BEAN FOR INFLAMMATORY BREAST CANCER ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more vegetables, Cucumber or Celeriac?
Vegetables are an important part of many diets. The active ingredients contained in Cucumber are Linolenic Acid, Beta-sitosterol, Cucurbitacin E, Vitamin C, Oleic Acid among others. While the active ingredients contained in Celeriac are Linolenic Acid, Vitamin C, Oleic Acid, Vitamin K, Angelicin and others.
Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition and PI3K-AKT-MTOR Signaling. Cucurbitacin E has biological action on biochemical pathways Epithelial to Mesenchymal Transition and PI3K-AKT-MTOR Signaling.
Angelicin can manipulate biochemical pathways Epithelial to Mesenchymal Transition. Oleic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition. And so on.
When treating Inflammatory Breast Cancer with chemotherapy Radiation – Foods like Cucumber are recommended compared to Celeriac. This is because the active ingredients Angelicin and Oleic Acid in Celeriac interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Cucurbitacin E contained in Cucumber support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: CUCUMBER IS RECOMMENDED OVER CELERIAC FOR INFLAMMATORY BREAST CANCER ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more fruits, Blackberry or Malus (crab Apple)?
Fruits are an important part of many diets. The active ingredients contained in Blackberry are Ellagic Acid, Cianidanol, Quercetin, Myricetin, Scopoletin among others. While the active ingredients contained in Malus (crab Apple) are Linolenic Acid, Vitamin C, Oleic Acid, 7-4′-dihydroxyflavone, Linoleic Acid and others.
Cianidanol can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Scopoletin has biological action on biochemical pathways Epithelial to Mesenchymal Transition and PI3K-AKT-MTOR Signaling.
Oleic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition. Linoleic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition. And so on.
When treating Inflammatory Breast Cancer with chemotherapy Radiation – Foods like Blackberry are recommended compared to Malus (crab Apple). This is because the active ingredients Oleic Acid and Linoleic Acid in Malus (crab Apple) interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Cianidanol and Scopoletin contained in Blackberry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: BLACKBERRY IS RECOMMENDED OVER MALUS (CRAB APPLE) FOR INFLAMMATORY BREAST CANCER ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more nuts, Almond or Hazelnut?
Nuts are an important part of many diets. The active ingredients contained in Almond are Quercetin, Linolenic Acid, Beta-sitosterol, Vitamin E, Oleic Acid among others. While the active ingredients contained in Hazelnut are Quercetin, Linolenic Acid, Vitamin E, Oleic Acid, Vitamin A and others.
Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition and PI3K-AKT-MTOR Signaling. Quercetin has biological action on biochemical pathways Epithelial to Mesenchymal Transition and PI3K-AKT-MTOR Signaling.
Oleic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition. Linoleic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition. And so on.
When treating Inflammatory Breast Cancer with chemotherapy Radiation – Foods like Almond are recommended compared to Hazelnut. This is because the active ingredients Oleic Acid and Linoleic Acid in Hazelnut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Quercetin contained in Almond support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: ALMOND IS RECOMMENDED OVER HAZELNUT FOR INFLAMMATORY BREAST CANCER ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Foods for Genetic Risk of Inflammatory Breast Cancer
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. CDH1 and ERBB2 are two genes whose abnormalities are risk factors for Inflammatory Breast Cancer. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Inflammatory Breast Cancer can be used as a guide for coming up with a recommended personalized nutrition plan. For Inflammatory Breast Cancer gene CDH1 has causative impact on biological pathways like Adherens junction and Epithelial to Mesenchymal Transition. And ERBB2 has a causative impact on biological pathways like Growth Factor Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like CDH1 and ERBB2 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes CDH1 and ERBB2 should be avoided.
Eat more pulses, Common Pea or Pigeon Pea?
The active ingredients contained in Common Pea are Lupeol, Beta-sitosterol, Linolenic Acid, Daidzein, Delphinidin among others. While the active ingredients contained in Pigeon Pea are Linolenic Acid, Vitamin C, Oleic Acid, Genistein, Linoleic Acid and others.
Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Apoptosis and Adherens junction. Vitamin C has biological action on biochemical pathways WNT Beta Catenin Signaling, Growth Factor Signaling and MYC Signaling.
Oleic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition. Linoleic Acid has biological action on biochemical pathways Growth Factor Signaling and Epithelial to Mesenchymal Transition. And so on.
For genetic risk of Inflammatory Breast Cancer due to abnormalities in genes CDH1 and ERBB2 – Foods like Common Pea are recommended compared to Pigeon Pea. This is because the active ingredients Oleic Acid and Linoleic Acid in Pigeon Pea further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER PIGEON PEA FOR REDUCING THE GENETIC RISK OF INFLAMMATORY BREAST CANCER DUE TO GENES CDH1 AND ERBB2
Eat more vegetables, Cassava or Yardlong Bean?
The active ingredients contained in Cassava are Beta-sitosterol, Linolenic Acid, Vitamin C, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Yardlong Bean are Linolenic Acid, Vitamin C, Oleic Acid, Linoleic Acid, Vitamin A and others.
Vitamin C can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Apoptosis and Adherens junction. Beta-sitosterol has biological action on biochemical pathways WNT Beta Catenin Signaling, MYC Signaling and Cell Cycle Checkpoints.
Oleic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition. Linoleic Acid has biological action on biochemical pathways Growth Factor Signaling and Epithelial to Mesenchymal Transition. And so on.
For genetic risk of Inflammatory Breast Cancer due to abnormalities in genes CDH1 and ERBB2 – Foods like Cassava are recommended compared to Yardlong Bean. This is because the active ingredients Oleic Acid and Linoleic Acid in Yardlong Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Cassava together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: CASSAVA IS RECOMMENDED OVER YARDLONG BEAN FOR REDUCING THE GENETIC RISK OF INFLAMMATORY BREAST CANCER DUE TO GENES CDH1 AND ERBB2
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Kiwi or Raspberry?
The active ingredients contained in Kiwi are Quercetin, Vitamin C, Chlorogenic Acid, Fisetin, Vitamin A among others. While the active ingredients contained in Raspberry are Ellagic Acid, Quercetin, Vitamin C, Resveratrol, Gallic Acid and others.
Vitamin C can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Apoptosis and Adherens junction. Quercetin has biological action on biochemical pathways WNT Beta Catenin Signaling, Growth Factor Signaling and MYC Signaling.
Ellagic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition, WNT Beta Catenin Signaling and Cell Cycle Checkpoints. Rutin has biological action on biochemical pathways WNT Beta Catenin Signaling. And so on.
For genetic risk of Inflammatory Breast Cancer due to abnormalities in genes CDH1 and ERBB2 – Foods like Kiwi are recommended compared to Raspberry. This is because the active ingredients Ellagic Acid and Rutin in Raspberry further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Quercetin contained in Kiwi together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: KIWI IS RECOMMENDED OVER RASPBERRY FOR REDUCING THE GENETIC RISK OF INFLAMMATORY BREAST CANCER DUE TO GENES CDH1 AND ERBB2
Eat more nuts, Pecan Nut or Chestnut?
The active ingredients contained in Pecan Nut are Cianidanol, Linolenic Acid, Vitamin E, Delphinidin, Oleic Acid among others. While the active ingredients contained in Chestnut are Ellagic Acid, Linolenic Acid, Quercetin, Vitamin C, Oleic Acid and others.
Cianidanol can manipulate biochemical pathways Apoptosis, Growth Factor Signaling and MYC Signaling. Vitamin E has biological action on biochemical pathways Epithelial to Mesenchymal Transition, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.
Ellagic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition, WNT Beta Catenin Signaling and Cell Cycle Checkpoints. Oleic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition. And so on.
For genetic risk of Inflammatory Breast Cancer due to abnormalities in genes CDH1 and ERBB2 – Foods like Pecan Nut are recommended compared to Chestnut. This is because the active ingredients Ellagic Acid and Oleic Acid in Chestnut further promote the effects of genes on the biochemical pathways. While the active ingredients Cianidanol and Vitamin E contained in Pecan Nut together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER CHESTNUT FOR REDUCING THE GENETIC RISK OF INFLAMMATORY BREAST CANCER DUE TO GENES CDH1 AND ERBB2
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Inflammatory Breast Cancer by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
- Summit 2018
- HER kinase inhibition in patients with HER2- and HER3-mutant cancers.
- Retinol decreases beta-catenin protein levels in retinoic acid-resistant colon cancer cell lines.
- Gamma linolenic acid suppresses hypoxia-induced gastric cancer cell growth and epithelial-mesenchymal transition by inhibiting the Wnt/b-catenin signaling pathway.
- Oleic acid-induced ANGPTL4 enhances head and neck squamous cell carcinoma anoikis resistance and metastasis via up-regulation of fibronectin.
- Role of phospholipase D in migration and invasion induced by linoleic acid in breast cancer cells.
- Molecular docking analysis of Cianidanol fromGinkgo biloba with HER2+ breast cancer target.
- Scopoletin exerts anticancer effects on human cervical cancer cell lines by triggering apoptosis, cell cycle arrest, inhibition of cell invasion and PI3K/AKT signalling pathway.
- β-Sitosterol and Gemcitabine Exhibit Synergistic Anti-pancreatic Cancer Activity by Modulating Apoptosis and Inhibiting Epithelial-Mesenchymal Transition by Deactivating Akt/GSK-3β Signaling.
- Cucurbitacin-E inhibits multiple cancer cells proliferation through attenuation of Wnt/β-catenin signaling.
- Angelicin inhibits human lung carcinoma A549 cell growth and migration through regulating JNK and ERK pathways.
- Protein kinase and HDAC inhibitors from the endophytic fungus Epicoccum nigrum.
- Vitamin C enhances epigenetic modifications induced by 5-azacytidine and cell cycle arrest in the hepatocellular carcinoma cell lines HLE and Huh7.
- Identification of ellagic acid as potent inhibitor of protein kinase CK2: a successful example of a virtual screening application.
- Gamma-tocotrienol inhibits nuclear factor-kappaB signaling pathway through inhibition of receptor-interacting protein and TAK1 leading to suppression of antiapoptotic gene products and potentiation of apoptosis.
- HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.