Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Head And Neck Neuroendocrine Carcinoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Head And Neck Neuroendocrine Carcinoma because of ERBB4 and FGFR1 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Head And Neck Neuroendocrine Carcinoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Plum” or “Include fruit Partridgeberry in my diet” or “Should I reduce consumption of vegetable Chicory” or “Can I take Resveratrol and Mulberry supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO HEAD AND NECK NEUROENDOCRINE CARCINOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Head And Neck Neuroendocrine Carcinoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR HEAD AND NECK NEUROENDOCRINE CARCINOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Head And Neck Neuroendocrine Carcinoma
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Head And Neck Neuroendocrine Carcinoma from cBioPortal. 66.7% of males and 33.3% of females were the distribution of gender in these clinical studies. From a patient sample size of 3; the top genes with mutations and other abnormalities for Head And Neck Neuroendocrine Carcinoma include genes ERBB4, FGFR1, INPPL1, IRS1 and NSD1. The occurrence frequency distribution for these genes respectively is 100.0%, 100.0%, 100.0%, 100.0% and 100.0%. These tumor genetic details of Head And Neck Neuroendocrine Carcinoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Head And Neck Neuroendocrine Carcinoma.
Significance of Nutrition for Head And Neck Neuroendocrine Carcinoma
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Head And Neck Neuroendocrine Carcinoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Plum includes active ingredients Betulinic Acid, Beta-sitosterol, Vitamin C, Glucaric Acid, Cianidanol and others. And Partridgeberry contains active ingredients Resveratrol, Beta-sitosterol, Stigmasterol and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Head And Neck Neuroendocrine Carcinoma, activation or inhibition of selected biochemical pathways like PI3K-AKT-MTOR Signaling, Growth Factor Signaling, Oncogenic Histone Methylation, Chromatin Remodeling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Head And Neck Neuroendocrine Carcinoma, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR HEAD AND NECK NEUROENDOCRINE CARCINOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Head And Neck Neuroendocrine Carcinoma undergoing chemotherapy treatment
In Head And Neck Neuroendocrine Carcinoma – the genes ERBB4, FGFR1, INPPL1, IRS1 and NSD1 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Head And Neck Neuroendocrine Carcinoma are PI3K-AKT-MTOR Signaling and others. Radiation is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers PI3K-AKT-MTOR Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Mung Bean or Soy Bean?
Pulses are an important part of many diets. The active ingredients contained in Mung Bean are Oleic Acid, Vitamin C, Linolenic Acid, Vitexin, Glucaric Acid among others. While the active ingredients contained in Soy Bean are Lupeol, Daidzein, Vitamin E, Beta-sitosterol, Oleic Acid and others.
Vitamin C can manipulate biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. Vitexin has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling.
Lecithin can manipulate biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. Fisetin has biological action on biochemical pathways MYC Signaling. And so on.
When treating Head And Neck Neuroendocrine Carcinoma with chemotherapy Radiation – Foods like Mung Bean are recommended compared to Soy Bean. This is because the active ingredients Lecithin and Fisetin in Soy Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Vitexin contained in Mung Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: MUNG BEAN IS RECOMMENDED OVER SOY BEAN FOR HEAD AND NECK NEUROENDOCRINE CARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more vegetables, Arugula or Chicory?
Vegetables are an important part of many diets. The active ingredients contained in Arugula are Esculin, Kaempferol, Vitamin A, Vitamin K, Erysolin among others. While the active ingredients contained in Chicory are Apigenin, Esculin, Lupeol, Betulinic Acid, Protocatechuic Acid and others.
Kaempferol can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Vitamin A has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling.
Luteolin can manipulate biochemical pathways MYC Signaling. Folic Acid has biological action on biochemical pathways PI3K-AKT-MTOR Signaling and MYC Signaling. And so on.
When treating Head And Neck Neuroendocrine Carcinoma with chemotherapy Radiation – Foods like Arugula are recommended compared to Chicory. This is because the active ingredients Luteolin and Folic Acid in Chicory interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Kaempferol and Vitamin A contained in Arugula support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: ARUGULA IS RECOMMENDED OVER CHICORY FOR HEAD AND NECK NEUROENDOCRINE CARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more fruits, Partridgeberry or Plum?
Fruits are an important part of many diets. The active ingredients contained in Partridgeberry are Resveratrol, Beta-sitosterol, Stigmasterol among others. While the active ingredients contained in Plum are Betulinic Acid, Beta-sitosterol, Vitamin C, Glucaric Acid, Cianidanol and others.
Resveratrol can manipulate biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. Beta-sitosterol has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling.
Lauric Acid can manipulate biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. Myristic Acid has biological action on biochemical pathways MYC Signaling. And so on.
When treating Head And Neck Neuroendocrine Carcinoma with chemotherapy Radiation – Foods like Partridgeberry are recommended compared to Plum. This is because the active ingredients Lauric Acid and Myristic Acid in Plum interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Resveratrol and Beta-sitosterol contained in Partridgeberry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PARTRIDGEBERRY IS RECOMMENDED OVER PLUM FOR HEAD AND NECK NEUROENDOCRINE CARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more nuts, Pistachio or Brazil Nut?
Nuts are an important part of many diets. The active ingredients contained in Pistachio are Resveratrol, Vitamin E, Oleic Acid, Beta-sitosterol, Linolenic Acid among others. While the active ingredients contained in Brazil Nut are Vitamin E, Oleic Acid, Linolenic Acid, Lecithin, Folic Acid and others.
Beta-sitosterol can manipulate biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. Resveratrol has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling.
Lecithin can manipulate biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. And so on.
When treating Head And Neck Neuroendocrine Carcinoma with chemotherapy Radiation – Foods like Pistachio are recommended compared to Brazil Nut. This is because the active ingredients Lecithin and Folic Acid in Brazil Nut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Resveratrol contained in Pistachio support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PISTACHIO IS RECOMMENDED OVER BRAZIL NUT FOR HEAD AND NECK NEUROENDOCRINE CARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Foods for Genetic Risk of Head And Neck Neuroendocrine Carcinoma
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. ERBB4 and FGFR1 are two genes whose abnormalities are risk factors for Head And Neck Neuroendocrine Carcinoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Head And Neck Neuroendocrine Carcinoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Head And Neck Neuroendocrine Carcinoma gene ERBB4 has causative impact on biological pathways like Growth Factor Signaling and MAPK Signaling. And FGFR1 has a causative impact on biological pathways like Angiogenesis, MAPK Signaling and Growth Factor Signaling. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like ERBB4 and FGFR1 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes ERBB4 and FGFR1 should be avoided.
Eat more pulses, Common Pea or Pigeon Pea?
The active ingredients contained in Common Pea are Lupeol, Daidzein, Beta-sitosterol, Linolenic Acid, Vitamin C among others. While the active ingredients contained in Pigeon Pea are Linolenic Acid, Vitamin C, Oleic Acid, Linoleic Acid, Genistein and others.
Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin C has biological action on biochemical pathways Growth Factor Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.
Linoleic Acid can manipulate biochemical pathways Growth Factor Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. And so on.
For genetic risk of Head And Neck Neuroendocrine Carcinoma due to abnormalities in genes ERBB4 and FGFR1 – Foods like Common Pea are recommended compared to Pigeon Pea. This is because the active ingredients Linoleic Acid and Folic Acid in Pigeon Pea further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER PIGEON PEA FOR REDUCING THE GENETIC RISK OF HEAD AND NECK NEUROENDOCRINE CARCINOMA DUE TO GENES ERBB4 AND FGFR1
Eat more vegetables, Jicama or Chayote?
The active ingredients contained in Jicama are Vitamin C, Vitamin B3, Beta-carotene, Vitamin A, Folic Acid among others. While the active ingredients contained in Chayote are Linolenic Acid, Vitamin C, Oleic Acid, Linoleic Acid, Folic Acid and others.
Vitamin C can manipulate biochemical pathways Apoptosis, Growth Factor Signaling and MYC Signaling. Vitamin B3 has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.
Linoleic Acid can manipulate biochemical pathways Growth Factor Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. And so on.
For genetic risk of Head And Neck Neuroendocrine Carcinoma due to abnormalities in genes ERBB4 and FGFR1 – Foods like Jicama are recommended compared to Chayote. This is because the active ingredients Linoleic Acid and Folic Acid in Chayote further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Vitamin B3 contained in Jicama together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: JICAMA IS RECOMMENDED OVER CHAYOTE FOR REDUCING THE GENETIC RISK OF HEAD AND NECK NEUROENDOCRINE CARCINOMA DUE TO GENES ERBB4 AND FGFR1
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Kiwi or Pear?
The active ingredients contained in Kiwi are Vitamin C, Quercetin, Fisetin, Chlorogenic Acid, Vitamin A among others. While the active ingredients contained in Pear are Beta-sitosterol, Modified Citrus Pectin, Linolenic Acid, Vitamin C, Oleic Acid and others.
Vitamin C can manipulate biochemical pathways Apoptosis, Growth Factor Signaling and MYC Signaling. Quercetin has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.
Linoleic Acid can manipulate biochemical pathways Growth Factor Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. And so on.
For genetic risk of Head And Neck Neuroendocrine Carcinoma due to abnormalities in genes ERBB4 and FGFR1 – Foods like Kiwi are recommended compared to Pear. This is because the active ingredients Linoleic Acid and Folic Acid in Pear further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Quercetin contained in Kiwi together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: KIWI IS RECOMMENDED OVER PEAR FOR REDUCING THE GENETIC RISK OF HEAD AND NECK NEUROENDOCRINE CARCINOMA DUE TO GENES ERBB4 AND FGFR1
Eat more nuts, Pine Nut or Chestnut?
The active ingredients contained in Pine Nut are Beta-sitosterol, Vitamin E, Linolenic Acid, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Chestnut are Linolenic Acid, Ellagic Acid, Vitamin C, Oleic Acid, Quercetin and others.
Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin K has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and MYC Signaling.
Ellagic Acid can manipulate biochemical pathways MYC Signaling. Linoleic Acid has biological action on biochemical pathways Growth Factor Signaling. And so on.
For genetic risk of Head And Neck Neuroendocrine Carcinoma due to abnormalities in genes ERBB4 and FGFR1 – Foods like Pine Nut are recommended compared to Chestnut. This is because the active ingredients Ellagic Acid and Linoleic Acid in Chestnut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin K contained in Pine Nut together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: PINE NUT IS RECOMMENDED OVER CHESTNUT FOR REDUCING THE GENETIC RISK OF HEAD AND NECK NEUROENDOCRINE CARCINOMA DUE TO GENES ERBB4 AND FGFR1
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Head And Neck Neuroendocrine Carcinoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
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Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.