Foods for Head And Neck Neuroendocrine Carcinoma!

Introduction

Foods for Head And Neck Neuroendocrine Carcinoma should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.

For Head And Neck Neuroendocrine Carcinoma does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Head And Neck Neuroendocrine Carcinoma does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Head And Neck Neuroendocrine Carcinoma?

For example does it matter if vegetable Brussel Sprouts is consumed more compared to Shallot? Does it make any difference if fruit Pummelo is preferred over Soursop? Also if similar choices are made for nuts/seeds like Black Walnut over Pumpkin Seeds and for pulses like Black-eyed Pea over Common Bean. And if what I eat matters – then how does one identify foods which are recommended for Head And Neck Neuroendocrine Carcinoma and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Head And Neck Neuroendocrine Carcinoma!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Pummelo contains active ingredients Curcumin, Apigenin, Catechol, Lupeol, Daidzein. And Soursop contains active ingredients Apigenin, Curcumin, Emodin, Catechol, Daidzein and possibly others.

A common mistake made when deciding and choosing foods to eat for Head And Neck Neuroendocrine Carcinoma – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Head And Neck Neuroendocrine Carcinoma.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Head And Neck Neuroendocrine Carcinoma?

Personalized nutrition for cancers like Head And Neck Neuroendocrine Carcinoma consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Head And Neck Neuroendocrine Carcinoma biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Characteristics of cancers like Head And Neck Neuroendocrine Carcinoma

All cancers like Head And Neck Neuroendocrine Carcinoma can be characterized by a unique set of biochemical pathways – the signature pathways of Head And Neck Neuroendocrine Carcinoma. Biochemical pathways like PI3K-AKT-MTOR Signaling, Growth Factor Signaling, Oncogenic Histone Methylation, Chromatin Remodeling are part of the signature definition of Head And Neck Neuroendocrine Carcinoma. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Head And Neck Neuroendocrine Carcinoma need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Head And Neck Neuroendocrine Carcinoma when taking cancer treatment Capecitabine, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

ERBB4, FGFR1, INPPL1, IRS1 and NSD1 are the top ranked reported genes for Head And Neck Neuroendocrine Carcinoma. ERBB4 is reported in 100.0 % of the representative patients across all clinical trials. And FGFR1 is reported in 100.0 %. The combined population patient data cover ages from to . 66.7 % of the patient data are identified as men. The Head And Neck Neuroendocrine Carcinoma biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Food and Supplements for Head And Neck Neuroendocrine Carcinoma

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable BRUSSEL SPROUTS or SHALLOT?

Vegetable Brussel Sprouts contains many active ingredients or bioactives such as Curcumin, Catechol, Lupeol, Daidzein, Formononetin. These active ingredients manipulate various biochemical pathways like MYC Signaling and PI3K-AKT-MTOR Signaling and others. Brussel Sprouts is recommended for Head And Neck Neuroendocrine Carcinoma when ongoing cancer treatment is Capecitabine. This is because Brussel Sprouts modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Capecitabine.

Some of the active ingredients or bioactives in vegetable Shallot are Apigenin, Curcumin, Catechol, Daidzein, Lupeol. These active ingredients manipulate various biochemical pathways like PI3K-AKT-MTOR Signaling and others. Shallot is not recommended for Head And Neck Neuroendocrine Carcinoma when ongoing cancer treatment is Capecitabine because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE BRUSSEL SPROUTS IS RECOMMENDED OVER SHALLOT FOR Head And Neck Neuroendocrine Carcinoma AND TREATMENT Capecitabine.

Choose Fruit SOURSOP or PUMMELO?

Fruit Soursop contains many active ingredients or bioactives such as Apigenin, Curcumin, Emodin, Catechol, Daidzein. These active ingredients manipulate various biochemical pathways like MYC Signaling and PI3K-AKT-MTOR Signaling and others. Soursop is recommended for Head And Neck Neuroendocrine Carcinoma when ongoing cancer treatment is Capecitabine. This is because Soursop modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Capecitabine.

Some of the active ingredients or bioactives in fruit Pummelo are Curcumin, Apigenin, Catechol, Lupeol, Daidzein. These active ingredients manipulate various biochemical pathways like PI3K-AKT-MTOR Signaling and others. Pummelo is not recommended for Head And Neck Neuroendocrine Carcinoma when ongoing cancer treatment is Capecitabine because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT SOURSOP IS RECOMMENDED OVER PUMMELO FOR Head And Neck Neuroendocrine Carcinoma AND TREATMENT Capecitabine.

Choose Nut BLACK WALNUT or PUMPKIN SEEDS?

Black Walnut contains many active ingredients or bioactives such as Apigenin, Curcumin, Catechol, Lupeol, Daidzein. These active ingredients manipulate various biochemical pathways like MYC Signaling and PI3K-AKT-MTOR Signaling and others. Black Walnut is recommended for Head And Neck Neuroendocrine Carcinoma when ongoing cancer treatment is Capecitabine. This is because Black Walnut modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Capecitabine.

Some of the active ingredients or bioactives in Pumpkin Seeds are Beta-sitosterol, Oleic Acid, Linolenic Acid, Stigmasterol, Salicylic Acid. These active ingredients manipulate various biochemical pathways like MYC Signaling and PI3K-AKT-MTOR Signaling and others. Pumpkin Seeds is not recommended for Head And Neck Neuroendocrine Carcinoma when ongoing cancer treatment is Capecitabine because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

BLACK WALNUT IS RECOMMENDED OVER PUMPKIN SEEDS FOR Head And Neck Neuroendocrine Carcinoma AND TREATMENT Capecitabine.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Head And Neck Neuroendocrine Carcinoma or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable GIANT BUTTERBUR or SPINACH?

Vegetable Giant Butterbur contains many active ingredients or bioactives such as Curcumin, Apigenin, Lycopene, Myricetin, Delphinidin. These active ingredients manipulate various biochemical pathways like MAPK Signaling, Insulin Signaling, RAS-RAF Signaling and PI3K-AKT-MTOR Signaling and others. Giant Butterbur is recommended for risk of Head And Neck Neuroendocrine Carcinoma when associated genetic risk is ERBB4. This is because Giant Butterbur increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Spinach are Curcumin, Apigenin, Quercetin, Myricetin, Delphinidin. These active ingredients manipulate various biochemical pathways like Oncogenic Histone Methylation and Insulin Signaling and others. Spinach is not recommended when risk of Head And Neck Neuroendocrine Carcinoma when associated genetic risk is ERBB4 because it increases the signature pathways of it.

VEGETABLE GIANT BUTTERBUR IS RECOMMENDED OVER SPINACH FOR ERBB4 GENETIC RISK OF CANCER.

Choose Fruit RED RASPBERRY or MALABAR PLUM?

Fruit Red Raspberry contains many active ingredients or bioactives such as Curcumin, Ellagic Acid, Quercetin, Delphinidin, Formononetin. These active ingredients manipulate various biochemical pathways like MAPK Signaling, RAS-RAF Signaling, Growth Factor Signaling and PI3K-AKT-MTOR Signaling and others. Red Raspberry is recommended for risk of Head And Neck Neuroendocrine Carcinoma when associated genetic risk is ERBB4. This is because Red Raspberry increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Malabar Plum are Curcumin, Apigenin, Lycopene, Myricetin, Delphinidin. These active ingredients manipulate various biochemical pathways like Cell Cycle Checkpoints and Oncogenic Histone Methylation and others. Malabar Plum is not recommended when risk of Head And Neck Neuroendocrine Carcinoma when associated genetic risk is ERBB4 because it increases the signature pathways of it.

FRUIT RED RASPBERRY IS RECOMMENDED OVER MALABAR PLUM FOR ERBB4 GENETIC RISK OF CANCER.

Choose Nut COMMON HAZELNUT or EUROPEAN CHESTNUT?

Common Hazelnut contains many active ingredients or bioactives such as Curcumin, Quercetin, Lycopene, Myricetin, Delphinidin. These active ingredients manipulate various biochemical pathways like MAPK Signaling, Insulin Signaling, RAS-RAF Signaling and PI3K-AKT-MTOR Signaling and others. Common Hazelnut is recommended for risk of Head And Neck Neuroendocrine Carcinoma when associated genetic risk is ERBB4. This is because Common Hazelnut increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in European Chestnut are Curcumin, Ellagic Acid, Apigenin, Quercetin, Myricetin. These active ingredients manipulate various biochemical pathways like Oncogenic Histone Methylation and Insulin Signaling and others. European Chestnut is not recommended when risk of Head And Neck Neuroendocrine Carcinoma when associated genetic risk is ERBB4 because it increases the signature pathways of it.

COMMON HAZELNUT IS RECOMMENDED OVER EUROPEAN CHESTNUT FOR ERBB4 GENETIC RISK OF CANCER.

In Conclusion

Foods and Supplements chosen are important decisions for cancers like Head And Neck Neuroendocrine Carcinoma. Head And Neck Neuroendocrine Carcinoma patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Head And Neck Neuroendocrine Carcinoma, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like Brussel Sprouts contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Head And Neck Neuroendocrine Carcinoma?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.

References

• Tmb Mskcc 2018
• Tumor mutational load predicts survival after immunotherapy across multiple cancer types.
• Daidzein exerts anti-tumor activity against bladder cancer cells via inhibition of FGFR3 pathway.
• Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH.
• Shikimic acid promotes estrogen receptor(ER)-positive breast cancer cells proliferation via activation of NF-κB signaling.
• Induction of colon and cervical cancer cell death by cinnamic acid derivatives is mediated through the inhibition of Histone Deacetylases (HDAC).
• Brassinin Combined with Capsaicin Enhances Apoptotic and Anti-metastatic Effects in PC-3 Human Prostate Cancer Cells.
• α-pinene regulates miR-221 and induces G₂/M phase cell cycle arrest in human hepatocellular carcinoma cells.