Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Gastric Neuroendocrine Tumor when undergoing chemotherapy or when you determine you have a genetic risk for developing Gastric Neuroendocrine Tumor because of RB1 and COL1A1 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Gastric Neuroendocrine Tumor which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Peach” or “Include fruit Cherimoya in my diet” or “Should I reduce consumption of vegetable Kale” or “Can I take Diosmin and D-limonene supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO GASTRIC NEUROENDOCRINE TUMOR, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Gastric Neuroendocrine Tumor is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR GASTRIC NEUROENDOCRINE TUMOR, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Gastric Neuroendocrine Tumor
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Gastric Neuroendocrine Tumor from cBioPortal. 88.9% of males and 11.1% of females were the distribution of gender in these clinical studies. From a patient sample size of 9; the top genes with mutations and other abnormalities for Gastric Neuroendocrine Tumor include genes TP53, RB1, COL1A1, SMARCA4 and EPHB1. The occurrence frequency distribution for these genes respectively is 77.8%, 44.4%, 22.2%, 22.2% and 11.1%. These tumor genetic details of Gastric Neuroendocrine Tumor are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Gastric Neuroendocrine Tumor.
Significance of Nutrition for Gastric Neuroendocrine Tumor
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Gastric Neuroendocrine Tumor. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Peach includes active ingredients Beta-sitosterol, Vitamin C, Linolenic Acid, Modified Citrus Pectin, Oleic Acid and others. And Cherimoya contains active ingredients Beta-sitosterol, Vitamin C, Linolenic Acid, Oleic Acid, Stigmasterol and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Gastric Neuroendocrine Tumor, activation or inhibition of selected biochemical pathways like Nutrient sensing, DNA Repair, Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Gastric Neuroendocrine Tumor, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR GASTRIC NEUROENDOCRINE TUMOR – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Gastric Neuroendocrine Tumor undergoing chemotherapy treatment
In Gastric Neuroendocrine Tumor – the genes TP53, RB1, COL1A1, SMARCA4 and EPHB1 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Gastric Neuroendocrine Tumor are Nutrient sensing, DNA Repair, Extracellular Matrix Remodelling and others. Irinotecan is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Nutrient sensing, DNA Repair, Extracellular Matrix Remodelling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Common Pea or Common Bean?
Pulses are an important part of many diets. The active ingredients contained in Common Pea are Lupeol, Daidzein, Beta-sitosterol, Vitamin C, Linolenic Acid among others. While the active ingredients contained in Common Bean are Apigenin, Esculin, Vitamin C, Linolenic Acid, Oleic Acid and others.
Beta-sitosterol can manipulate biochemical pathways NFKB Signaling, Apoptosis and MYC Signaling. Vitamin C has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and Nutrient sensing.
Vitamin A can manipulate biochemical pathways TGFB Signaling and Extracellular Matrix Remodelling. Apigenin has biological action on biochemical pathways Nutrient sensing and TGFB Signaling. And so on.
When treating Gastric Neuroendocrine Tumor with chemotherapy Irinotecan – Foods like Common Pea are recommended compared to Common Bean. This is because the active ingredients Vitamin A and Apigenin in Common Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER COMMON BEAN FOR GASTRIC NEUROENDOCRINE TUMOR ON TREATMENT WITH CHEMOTHERAPY IRINOTECAN FOR SOME CONDITIONS.
Eat more vegetables, Kohlrabi or Kale?
Vegetables are an important part of many diets. The active ingredients contained in Kohlrabi are Beta-sitosterol, Vitamin C, Linolenic Acid, Brassinin, Oleic Acid among others. While the active ingredients contained in Kale are Vitamin C, Linolenic Acid, Brassinin, Indole-3-carbinol, Linoleic Acid and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Brassinin has biological action on biochemical pathways NFKB Signaling, Cell Cycle Checkpoints and MAPK Signaling.
Vitamin A can manipulate biochemical pathways TGFB Signaling and Extracellular Matrix Remodelling. Linoleic Acid has biological action on biochemical pathways Nutrient sensing and TGFB Signaling. And so on.
When treating Gastric Neuroendocrine Tumor with chemotherapy Irinotecan – Foods like Kohlrabi are recommended compared to Kale. This is because the active ingredients Vitamin A and Linoleic Acid in Kale interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Brassinin contained in Kohlrabi support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: KOHLRABI IS RECOMMENDED OVER KALE FOR GASTRIC NEUROENDOCRINE TUMOR ON TREATMENT WITH CHEMOTHERAPY IRINOTECAN FOR SOME CONDITIONS.
Eat more fruits, Cherimoya or Peach?
Fruits are an important part of many diets. The active ingredients contained in Cherimoya are Beta-sitosterol, Vitamin C, Linolenic Acid, Oleic Acid, Stigmasterol among others. While the active ingredients contained in Peach are Beta-sitosterol, Vitamin C, Linolenic Acid, Modified Citrus Pectin, Oleic Acid and others.
Beta-sitosterol can manipulate biochemical pathways NFKB Signaling, Apoptosis and MYC Signaling. Stigmasterol has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and MAPK Signaling.
Fisetin can manipulate biochemical pathways MYC Signaling. Caffeic Acid has biological action on biochemical pathways TGFB Signaling. And so on.
When treating Gastric Neuroendocrine Tumor with chemotherapy Irinotecan – Foods like Cherimoya are recommended compared to Peach. This is because the active ingredients Fisetin and Caffeic Acid in Peach interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Stigmasterol contained in Cherimoya support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: CHERIMOYA IS RECOMMENDED OVER PEACH FOR GASTRIC NEUROENDOCRINE TUMOR ON TREATMENT WITH CHEMOTHERAPY IRINOTECAN FOR SOME CONDITIONS.
Eat more nuts, Pine Nut or Chestnut?
Nuts are an important part of many diets. The active ingredients contained in Pine Nut are Beta-sitosterol, Vitamin E, Linolenic Acid, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Chestnut are Ellagic Acid, Vitamin C, Linolenic Acid, Oleic Acid, Quercetin and others.
Beta-sitosterol can manipulate biochemical pathways NFKB Signaling, Apoptosis and MYC Signaling. Vitamin K has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and MYC Signaling.
Ellagic Acid can manipulate biochemical pathways MYC Signaling. Vitamin A has biological action on biochemical pathways TGFB Signaling and Extracellular Matrix Remodelling. And so on.
When treating Gastric Neuroendocrine Tumor with chemotherapy Irinotecan – Foods like Pine Nut are recommended compared to Chestnut. This is because the active ingredients Ellagic Acid and Vitamin A in Chestnut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin K contained in Pine Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PINE NUT IS RECOMMENDED OVER CHESTNUT FOR GASTRIC NEUROENDOCRINE TUMOR ON TREATMENT WITH CHEMOTHERAPY IRINOTECAN FOR SOME CONDITIONS.
Foods for Genetic Risk of Gastric Neuroendocrine Tumor
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. RB1 and COL1A1 are two genes whose abnormalities are risk factors for Gastric Neuroendocrine Tumor. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Gastric Neuroendocrine Tumor can be used as a guide for coming up with a recommended personalized nutrition plan. For Gastric Neuroendocrine Tumor gene RB1 has causative impact on biological pathways like Cell Cycle Checkpoints, DNA Repair and Cell Cycle. And COL1A1 has a causative impact on biological pathways like Extracellular Matrix Remodelling, Epithelial to Mesenchymal Transition and Focal Adhesion. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like RB1 and COL1A1 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes RB1 and COL1A1 should be avoided.
Eat more pulses, Hyacinth Bean or Fava Bean?
The active ingredients contained in Hyacinth Bean are Vitamin C, Palmitic Acid, Genistein, Myristic Acid, Folic Acid among others. While the active ingredients contained in Fava Bean are Quercetin, Daidzein, Beta-sitosterol, Oleic Acid, Cianidanol and others.
Palmitic Acid can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin C has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and RAS-RAF Signaling.
Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Linoleic Acid has biological action on biochemical pathways Extracellular Matrix Remodelling. And so on.
For genetic risk of Gastric Neuroendocrine Tumor due to abnormalities in genes RB1 and COL1A1 – Foods like Hyacinth Bean are recommended compared to Fava Bean. This is because the active ingredients Vitamin A and Linoleic Acid in Fava Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Palmitic Acid and Vitamin C contained in Hyacinth Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: HYACINTH BEAN IS RECOMMENDED OVER FAVA BEAN FOR REDUCING THE GENETIC RISK OF GASTRIC NEUROENDOCRINE TUMOR DUE TO GENES RB1 AND COL1A1
Eat more vegetables, Jicama or Chicory?
The active ingredients contained in Jicama are Vitamin C, Vitamin B3, Beta-carotene, Vitamin A, Folic Acid among others. While the active ingredients contained in Chicory are Apigenin, Esculin, Lupeol, Quercetin, Betulinic Acid and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin B3 has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Apoptosis.
Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Luteolin has biological action on biochemical pathways MYC Signaling. And so on.
For genetic risk of Gastric Neuroendocrine Tumor due to abnormalities in genes RB1 and COL1A1 – Foods like Jicama are recommended compared to Chicory. This is because the active ingredients Vitamin A and Luteolin in Chicory further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Vitamin B3 contained in Jicama together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: JICAMA IS RECOMMENDED OVER CHICORY FOR REDUCING THE GENETIC RISK OF GASTRIC NEUROENDOCRINE TUMOR DUE TO GENES RB1 AND COL1A1
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Feijoa or Lingonberry?
The active ingredients contained in Feijoa are Lycopene, Vitamin C, Casuarinin, Folic Acid among others. While the active ingredients contained in Lingonberry are Quercetin, Resveratrol, Hyperoside, Oleic Acid, Vitamin C and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Lycopene has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and RAS-RAF Signaling.
Resveratrol can manipulate biochemical pathways P53 Signaling. Vitamin A has biological action on biochemical pathways PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Gastric Neuroendocrine Tumor due to abnormalities in genes RB1 and COL1A1 – Foods like Feijoa are recommended compared to Lingonberry. This is because the active ingredients Resveratrol and Vitamin A in Lingonberry further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Lycopene contained in Feijoa together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: FEIJOA IS RECOMMENDED OVER LINGONBERRY FOR REDUCING THE GENETIC RISK OF GASTRIC NEUROENDOCRINE TUMOR DUE TO GENES RB1 AND COL1A1
Eat more nuts, Hazelnut or Peanut?
The active ingredients contained in Hazelnut are Quercetin, Vitamin E, Oleic Acid, Linolenic Acid, Linoleic Acid among others. While the active ingredients contained in Peanut are Quercetin, Beta-sitosterol, Vitamin E, Oleic Acid, Vitamin C and others.
Quercetin can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin E has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Apoptosis.
Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Lecithin has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Gastric Neuroendocrine Tumor due to abnormalities in genes RB1 and COL1A1 – Foods like Hazelnut are recommended compared to Peanut. This is because the active ingredients Vitamin A and Lecithin in Peanut further promote the effects of genes on the biochemical pathways. While the active ingredients Quercetin and Vitamin E contained in Hazelnut together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: HAZELNUT IS RECOMMENDED OVER PEANUT FOR REDUCING THE GENETIC RISK OF GASTRIC NEUROENDOCRINE TUMOR DUE TO GENES RB1 AND COL1A1
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Gastric Neuroendocrine Tumor by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
- Pan Origimed 2020
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- Vitamin C enhances epigenetic modifications induced by 5-azacytidine and cell cycle arrest in the hepatocellular carcinoma cell lines HLE and Huh7.
- Vitamin A regulates Akt signaling through the phospholipid fatty acid composition.
- Flavones: an important scaffold for medicinal chemistry.
- Stigmasterol Causes Ovarian Cancer Cell Apoptosis by Inducing Endoplasmic Reticulum and Mitochondrial Dysfunction.
- Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin.
- Synthesis and structure-activity relationship analysis of caffeic acid amides as selective matrix metalloproteinase inhibitors.
- Brassinin inhibits STAT3 signaling pathway through modulation of PIAS-3 and SOCS-3 expression and sensitizes human lung cancer xenograft in nude mice to paclitaxel.
- Excess Linoleic Acid Increases Collagen I/III Ratio and Stiffens” the Heart Muscle Following High Fat Diets.”
- Research progress on the anticancer effects of vitamin K2.
- Identification of ellagic acid as potent inhibitor of protein kinase CK2: a successful example of a virtual screening application.
- Functional lipidomics: Palmitic acid impairs hepatocellular carcinoma development by modulating membrane fluidity and glucose metabolism.
- Lycopene metabolite, apo-10′-lycopenoic acid, inhibits diethylnitrosamine-initiated, high fat diet-promoted hepatic inflammation and tumorigenesis in mice.
- Resveratrol, a remarkable inhibitor of ribonucleotide reductase.
- Concurrent acetylation of FoxO1/3a and p53 due to sirtuins inhibition elicit Bim/PUMA mediated mitochondrial dysfunction and apoptosis in berberine-treated HepG2 cells.
- Gamma- and delta-tocotrienols exert a more potent anticancer effect than alpha-tocopheryl succinate on breast cancer cell lines irrespective of HER-2/neu expression.
- The recruitment of Raf-1 to membranes is mediated by direct interaction with phosphatidic acid and is independent of association with Ras.
- HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods.
- Fisetin: a dietary antioxidant for health promotion.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.