Which Foods are Recommended for Dermatofibrosarcoma Protuberans?

Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Dermatofibrosarcoma Protuberans when undergoing chemotherapy or when you determine you have a genetic risk for developing Dermatofibrosarcoma Protuberans because of FGFR1 and MED12 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Dermatofibrosarcoma Protuberans which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Fig” or “Include fruit Raspberry in my diet” or “Should I reduce consumption of vegetable Burdock” or “Can I take Banaba and Ellagic Acid supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO DERMATOFIBROSARCOMA PROTUBERANS, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Dermatofibrosarcoma Protuberans is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR DERMATOFIBROSARCOMA PROTUBERANS, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.

About Dermatofibrosarcoma Protuberans

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Dermatofibrosarcoma Protuberans from cBioPortal. 20.0% of males and 80.0% of females were the distribution of gender in these clinical studies. From a patient sample size of 5; the top genes with mutations and other abnormalities for Dermatofibrosarcoma Protuberans include genes FGFR1, MED12, NF1, SUZ12 and ATRX. The occurrence frequency distribution for these genes respectively is 33.3%, 33.3%, 33.3%, 33.3% and 33.3%. These tumor genetic details of Dermatofibrosarcoma Protuberans are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Dermatofibrosarcoma Protuberans.

Dermatofibrosarcoma protuberans is a rare type of skin cancer. It starts in the dermis, the middle layer of the skin. Dermatofibrosarcoma protuberans might initially look like a pimple or a rough patch of skin, but as it grows, lumps of tissue (protuberans) may form near the surface of the skin. The skin cancer often forms on arms, legs, and trunk. This is typically a slow growing cancer. A chromosomal translocation resulting in a fusion protein COL1A1-PDGFB is implicated as one of the causes of dermatofibrosarcoma protuberans and this aberration promotes tumor growth due to an over production of the platelet-derived growth factor (PDGF). Optimal treatment modality for dermatofibrosarcoma protuberans is Mohs micrographic surgery. Imatinib is a chemotherapeutic drug that is also approved for adults with unresectable, recurrent, or metastatic dermatofibrosarcoma protuberans. The overall prognosis for this rare skin cancer is good with a 5-year survival rate of 99.1%. Additionally, supportive care with the right nutrition (foods and natural supplements) with the right bioactives to counteract the underlying disease pathways can help improve patients’ well-being. (Ref: https://www.ncbi.nlm.nih.gov/books/NBK513305/ ; https://www.mayoclinic.org/diseases-conditions/dermatofibrosarcoma-protuberans/cdc-20352949 )

Significance of Nutrition for Dermatofibrosarcoma Protuberans

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Dermatofibrosarcoma Protuberans. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Fig includes active ingredients Lupeol, Angelicin, Psoralen, Palmitic Acid, Vitamin C and others. And Raspberry contains active ingredients Ellagic Acid, Quercetin, Resveratrol, Salicylic Acid, Vitamin C and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Dermatofibrosarcoma Protuberans, activation or inhibition of selected biochemical pathways like Growth Factor Signaling, PI3K-AKT-MTOR Signaling, RAS-RAF Signaling, TGFB Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Dermatofibrosarcoma Protuberans, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR DERMATOFIBROSARCOMA PROTUBERANS – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Dermatofibrosarcoma Protuberans undergoing chemotherapy treatment

In Dermatofibrosarcoma Protuberans – the genes FGFR1, MED12, NF1, SUZ12 and ATRX have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Dermatofibrosarcoma Protuberans are Growth Factor Signaling, PI3K-AKT-MTOR Signaling, RAS-RAF Signaling and others. Imatinib is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Growth Factor Signaling, PI3K-AKT-MTOR Signaling, RAS-RAF Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Mung Bean or Common Bean?

Pulses are an important part of many diets. The active ingredients contained in Mung Bean are Quercetin, Genistein, Kaempferol, Oleic Acid, Glucaric Acid among others. While the active ingredients contained in Common Bean are Ferulic Acid, Apigenin, Kaempferol, Genistein, Delphinidin and others.

Quercetin can manipulate biochemical pathways RAS-RAF Signaling, Growth Factor Signaling and PI3K-AKT-MTOR Signaling. Genistein has biological action on biochemical pathways RAS-RAF Signaling and PI3K-AKT-MTOR Signaling.

Apigenin can manipulate biochemical pathways TGFB Signaling. Pelargonidin has biological action on biochemical pathways PI3K-AKT-MTOR Signaling. And so on.

When treating Dermatofibrosarcoma Protuberans with chemotherapy Imatinib – Foods like Mung Bean are recommended compared to Common Bean. This is because the active ingredients Apigenin and Pelargonidin in Common Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Quercetin and Genistein contained in Mung Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: MUNG BEAN IS RECOMMENDED OVER COMMON BEAN FOR DERMATOFIBROSARCOMA PROTUBERANS ON TREATMENT WITH CHEMOTHERAPY IMATINIB FOR SOME CONDITIONS.

Eat more vegetables, Asparagus or Burdock?

Vegetables are an important part of many diets. The active ingredients contained in Asparagus are Quercetin, Kaempferol, Oleic Acid, Vitamin C, Isorhamnetin among others. While the active ingredients contained in Burdock are Lupeol, Oleic Acid, Chlorogenic Acid, Linolenic Acid, Dehydrocostus Lactone and others.

Quercetin can manipulate biochemical pathways RAS-RAF Signaling, Growth Factor Signaling and PI3K-AKT-MTOR Signaling. Kaempferol has biological action on biochemical pathways RAS-RAF Signaling and PI3K-AKT-MTOR Signaling.

Caffeic Acid can manipulate biochemical pathways TGFB Signaling. Arctigenin has biological action on biochemical pathways PI3K-AKT-MTOR Signaling. And so on.

When treating Dermatofibrosarcoma Protuberans with chemotherapy Imatinib – Foods like Asparagus are recommended compared to Burdock. This is because the active ingredients Caffeic Acid and Arctigenin in Burdock interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Quercetin and Kaempferol contained in Asparagus support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: ASPARAGUS IS RECOMMENDED OVER BURDOCK FOR DERMATOFIBROSARCOMA PROTUBERANS ON TREATMENT WITH CHEMOTHERAPY IMATINIB FOR SOME CONDITIONS.

Eat more fruits, Raspberry or Fig?

Fruits are an important part of many diets. The active ingredients contained in Raspberry are Ellagic Acid, Quercetin, Resveratrol, Salicylic Acid, Vitamin C among others. While the active ingredients contained in Fig are Lupeol, Angelicin, Psoralen, Palmitic Acid, Vitamin C and others.

Ellagic Acid can manipulate biochemical pathways RAS-RAF Signaling, Growth Factor Signaling and PI3K-AKT-MTOR Signaling. Vitamin C has biological action on biochemical pathways RAS-RAF Signaling and PI3K-AKT-MTOR Signaling.

Palmitic Acid can manipulate biochemical pathways Growth Factor Signaling and TGFB Signaling. Lauric Acid has biological action on biochemical pathways PI3K-AKT-MTOR Signaling. And so on.

When treating Dermatofibrosarcoma Protuberans with chemotherapy Imatinib – Foods like Raspberry are recommended compared to Fig. This is because the active ingredients Palmitic Acid and Lauric Acid in Fig interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Ellagic Acid and Vitamin C contained in Raspberry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: RASPBERRY IS RECOMMENDED OVER FIG FOR DERMATOFIBROSARCOMA PROTUBERANS ON TREATMENT WITH CHEMOTHERAPY IMATINIB FOR SOME CONDITIONS.

Eat more nuts, Walnut or Peanut?

Nuts are an important part of many diets. The active ingredients contained in Walnut are Ellagic Acid, Quercetin, D-limonene, Myricetin, Juglone among others. While the active ingredients contained in Peanut are Quercetin, Ferulic Acid, Oleic Acid, Vitamin C, Beta-sitosterol and others.

Ellagic Acid can manipulate biochemical pathways RAS-RAF Signaling, Growth Factor Signaling and PI3K-AKT-MTOR Signaling. D-limonene has biological action on biochemical pathways RAS-RAF Signaling, Growth Factor Signaling and PI3K-AKT-MTOR Signaling.

Lecithin can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Linoleic Acid has biological action on biochemical pathways TGFB Signaling. And so on.

When treating Dermatofibrosarcoma Protuberans with chemotherapy Imatinib – Foods like Walnut are recommended compared to Peanut. This is because the active ingredients Lecithin and Linoleic Acid in Peanut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Ellagic Acid and D-limonene contained in Walnut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: WALNUT IS RECOMMENDED OVER PEANUT FOR DERMATOFIBROSARCOMA PROTUBERANS ON TREATMENT WITH CHEMOTHERAPY IMATINIB FOR SOME CONDITIONS.

Foods for Genetic Risk of Dermatofibrosarcoma Protuberans

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. FGFR1 and MED12 are two genes whose abnormalities are risk factors for Dermatofibrosarcoma Protuberans. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Dermatofibrosarcoma Protuberans can be used as a guide for coming up with a recommended personalized nutrition plan. For Dermatofibrosarcoma Protuberans gene FGFR1 has causative impact on biological pathways like Angiogenesis, MAPK Signaling and Growth Factor Signaling. And MED12 has a causative impact on biological pathways like TGFB Signaling and Thyroid Hormone Signaling. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like FGFR1 and MED12 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes FGFR1 and MED12 should be avoided.

Eat more pulses, Scarlet Bean or Pigeon Pea?

The active ingredients contained in Scarlet Bean are Oleic Acid, Linolenic Acid, Vitamin C, Beta-sitosterol, Genistein among others. While the active ingredients contained in Pigeon Pea are Oleic Acid, Linolenic Acid, Vitamin C, Genistein, Linoleic Acid and others.

Beta-sitosterol can manipulate biochemical pathways MYC Signaling, P53 Signaling and Cell Cycle Checkpoints. Vitamin C has biological action on biochemical pathways Growth Factor Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling.

Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Linoleic Acid has biological action on biochemical pathways Growth Factor Signaling and TGFB Signaling. And so on.

For genetic risk of Dermatofibrosarcoma Protuberans due to abnormalities in genes FGFR1 and MED12 – Foods like Scarlet Bean are recommended compared to Pigeon Pea. This is because the active ingredients Vitamin A and Linoleic Acid in Pigeon Pea further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin C contained in Scarlet Bean together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER PIGEON PEA FOR REDUCING THE GENETIC RISK OF DERMATOFIBROSARCOMA PROTUBERANS DUE TO GENES FGFR1 AND MED12

Eat more vegetables, Jicama or Okra?

The active ingredients contained in Jicama are Vitamin C, Vitamin B3, Beta-carotene, Vitamin A, Folic Acid among others. While the active ingredients contained in Okra are Quercetin, Oleic Acid, Linolenic Acid, Vitamin C, Beta-sitosterol and others.

Vitamin C can manipulate biochemical pathways Growth Factor Signaling, MYC Signaling and P53 Signaling. Vitamin B3 has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and MYC Signaling.

Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Linoleic Acid has biological action on biochemical pathways Growth Factor Signaling and TGFB Signaling. And so on.

For genetic risk of Dermatofibrosarcoma Protuberans due to abnormalities in genes FGFR1 and MED12 – Foods like Jicama are recommended compared to Okra. This is because the active ingredients Vitamin A and Linoleic Acid in Okra further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Vitamin B3 contained in Jicama together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: JICAMA IS RECOMMENDED OVER OKRA FOR REDUCING THE GENETIC RISK OF DERMATOFIBROSARCOMA PROTUBERANS DUE TO GENES FGFR1 AND MED12

Eat more fruits, Feijoa or Peach?

The active ingredients contained in Feijoa are Lycopene, Vitamin C, Casuarinin, Folic Acid among others. While the active ingredients contained in Peach are Modified Citrus Pectin, Oleic Acid, Linolenic Acid, Beta-sitosterol, Vitamin C and others.

Vitamin C can manipulate biochemical pathways Growth Factor Signaling, MYC Signaling and P53 Signaling. Lycopene has biological action on biochemical pathways Cell Cycle Checkpoints, MAPK Signaling and PI3K-AKT-MTOR Signaling.

Caffeic Acid can manipulate biochemical pathways TGFB Signaling. Fisetin has biological action on biochemical pathways MYC Signaling. And so on.

For genetic risk of Dermatofibrosarcoma Protuberans due to abnormalities in genes FGFR1 and MED12 – Foods like Feijoa are recommended compared to Peach. This is because the active ingredients Caffeic Acid and Fisetin in Peach further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Lycopene contained in Feijoa together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: FEIJOA IS RECOMMENDED OVER PEACH FOR REDUCING THE GENETIC RISK OF DERMATOFIBROSARCOMA PROTUBERANS DUE TO GENES FGFR1 AND MED12

Eat more nuts, Almond or Acorn?

The active ingredients contained in Almond are Quercetin, Vitamin E, Oleic Acid, Linolenic Acid, Beta-sitosterol among others. While the active ingredients contained in Acorn are Quercetin, Vitamin C, Beta-sitosterol, Gallic Acid, Quercitrin and others.

Beta-sitosterol can manipulate biochemical pathways MYC Signaling, P53 Signaling and Cell Cycle Checkpoints. Quercetin has biological action on biochemical pathways Growth Factor Signaling, TGFB Signaling and MAPK Signaling.

Beta-carotene can manipulate biochemical pathways MAPK Signaling and PI3K-AKT-MTOR Signaling. Vitamin A has biological action on biochemical pathways PI3K-AKT-MTOR Signaling. And so on.

For genetic risk of Dermatofibrosarcoma Protuberans due to abnormalities in genes FGFR1 and MED12 – Foods like Almond are recommended compared to Acorn. This is because the active ingredients Beta-carotene and Vitamin A in Acorn further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Quercetin contained in Almond together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: ALMOND IS RECOMMENDED OVER ACORN FOR REDUCING THE GENETIC RISK OF DERMATOFIBROSARCOMA PROTUBERANS DUE TO GENES FGFR1 AND MED12

In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Dermatofibrosarcoma Protuberans by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

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