Foods for Chronic Neutrophilic Leukemia!

Introduction

Foods for Chronic Neutrophilic Leukemia should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.

Chronic neutrophilic leukemia (CNL) is a rare myeloproliferative disorder characterized by an increased number of neutrophils in the blood. The pathology outlines of CNL highlight the proliferation of mature neutrophils, often seen in a blood smear. Symptoms of CNL can include fatigue, weight loss, and splenomegaly, although some patients may be asymptomatic. Diagnostic criteria for CNL involve a combination of clinical findings, including an elevated white blood cell (WBC) count with a predominance of neutrophils, and the exclusion of other myeloproliferative disorders. The CBC (complete blood count) is a crucial diagnostic tool, showing an increased neutrophil count and other abnormalities. Treatment options for CNL are evolving, with current strategies focusing on managing symptoms and controlling the leukocyte count. The life expectancy and survival rate in CNL vary, with outcomes depending on factors such as response to treatment and disease progression. Chronic neutrophilic leukemia’s ICD-10 coding ensures standardized reporting and treatment monitoring. UpToDate and other medical resources offer comprehensive and current information about CNL, including advances in diagnosis and treatment. Understanding CNL’s clinical presentation, diagnostic criteria, and available treatments is essential for effective management and improving patient outcomes.

For Chronic Neutrophilic Leukemia does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Chronic Neutrophilic Leukemia does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Chronic Neutrophilic Leukemia?

For example does it matter if vegetable Radish is consumed more compared to Daikon Radish? Does it make any difference if fruit Alaska Blueberry is preferred over Evergreen Blackberry? Also if similar choices are made for nuts/seeds like Black Walnut over Flaxseed and for pulses like Alfalfa over Common Bean. And if what I eat matters – then how does one identify foods which are recommended for Chronic Neutrophilic Leukemia and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Chronic Neutrophilic Leukemia!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Alaska Blueberry contains active ingredients Apigenin, Isoliquiritigenin, Curcumin, Myricetin, Kaempferol. And Evergreen Blackberry contains active ingredients Myricetin, Ellagic Acid, Linalool, Geraniol, Eugenol and possibly others.

A common mistake made when deciding and choosing foods to eat for Chronic Neutrophilic Leukemia – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Chronic Neutrophilic Leukemia.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Chronic Neutrophilic Leukemia?

Personalized nutrition for cancers like Chronic Neutrophilic Leukemia consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Chronic Neutrophilic Leukemia biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Characteristics of cancers like Chronic Neutrophilic Leukemia

All cancers like Chronic Neutrophilic Leukemia can be characterized by a unique set of biochemical pathways – the signature pathways of Chronic Neutrophilic Leukemia. Biochemical pathways like Hypoxia, Apoptosis, Oncogenic Cancer Epigenetics, Suppressive Histone Methylation are part of the signature definition of Chronic Neutrophilic Leukemia. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Chronic Neutrophilic Leukemia need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Chronic Neutrophilic Leukemia when taking cancer treatment Vinblastine, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

ASXL1, TET2, SRSF2, CSF3R and GATA2 are the top ranked reported genes for Chronic Neutrophilic Leukemia. ASXL1 is reported in 75.6 % of the representative patients across all clinical trials. And TET2 is reported in 47.7 %. The combined population patient data cover ages from to . % of the patient data are identified as men. The Chronic Neutrophilic Leukemia biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Food and Supplements for Chronic Neutrophilic Leukemia

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable RADISH or DAIKON RADISH?

Vegetable Radish contains many active ingredients or bioactives such as Apigenin, Quercetin, Isoliquiritigenin, Curcumin, Myricetin. These active ingredients manipulate various biochemical pathways like Cell Cycle, PI3K-AKT-MTOR Signaling, Hypoxia and Apoptosis and others. Radish is recommended for Chronic Neutrophilic Leukemia when ongoing cancer treatment is Vinblastine. This is because Radish modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Vinblastine.

Some of the active ingredients or bioactives in vegetable Daikon Radish are Apigenin, Isoliquiritigenin, Curcumin, Myricetin, Luteolin. These active ingredients manipulate various biochemical pathways like PI3K-AKT-MTOR Signaling and others. Daikon Radish is not recommended for Chronic Neutrophilic Leukemia when ongoing cancer treatment is Vinblastine because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE RADISH IS RECOMMENDED OVER DAIKON RADISH FOR Chronic Neutrophilic Leukemia AND TREATMENT Vinblastine.

Choose Fruit EVERGREEN BLACKBERRY or ALASKA BLUEBERRY?

Fruit Evergreen Blackberry contains many active ingredients or bioactives such as Myricetin, Ellagic Acid, Linalool, Geraniol, Eugenol. These active ingredients manipulate various biochemical pathways like Cell Cycle, PI3K-AKT-MTOR Signaling, Hypoxia and Apoptosis and others. Evergreen Blackberry is recommended for Chronic Neutrophilic Leukemia when ongoing cancer treatment is Vinblastine. This is because Evergreen Blackberry modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Vinblastine.

Some of the active ingredients or bioactives in fruit Alaska Blueberry are Apigenin, Isoliquiritigenin, Curcumin, Myricetin, Kaempferol. These active ingredients manipulate various biochemical pathways like PI3K-AKT-MTOR Signaling and others. Alaska Blueberry is not recommended for Chronic Neutrophilic Leukemia when ongoing cancer treatment is Vinblastine because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT EVERGREEN BLACKBERRY IS RECOMMENDED OVER ALASKA BLUEBERRY FOR Chronic Neutrophilic Leukemia AND TREATMENT Vinblastine.

Choose Nut BLACK WALNUT or FLAXSEED?

Black Walnut contains many active ingredients or bioactives such as Apigenin, Quercetin, Isoliquiritigenin, Curcumin, Myricetin. These active ingredients manipulate various biochemical pathways like RAS-RAF Signaling, Cell Cycle and Apoptosis and others. Black Walnut is recommended for Chronic Neutrophilic Leukemia when ongoing cancer treatment is Vinblastine. This is because Black Walnut modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Vinblastine.

Some of the active ingredients or bioactives in Flaxseed are Apigenin, Isoliquiritigenin, Curcumin, Myricetin, Kaempferol. These active ingredients manipulate various biochemical pathways like PI3K-AKT-MTOR Signaling and others. Flaxseed is not recommended for Chronic Neutrophilic Leukemia when ongoing cancer treatment is Vinblastine because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

BLACK WALNUT IS RECOMMENDED OVER FLAXSEED FOR Chronic Neutrophilic Leukemia AND TREATMENT Vinblastine.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Chronic Neutrophilic Leukemia or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable GARDEN CRESS or OLIVE?

Vegetable Garden Cress contains many active ingredients or bioactives such as Curcumin, Genistein, Formononetin, Vitamin C, Protocatechuic Acid. These active ingredients manipulate various biochemical pathways like RAS-RAF Signaling, Stem Cell Signaling, PI3K-AKT-MTOR Signaling and MYC Signaling and others. Garden Cress is recommended for risk of Chronic Neutrophilic Leukemia when associated genetic risk is ASXL1. This is because Garden Cress increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Olive are Quercetin, Curcumin, Formononetin, Protocatechuic Acid, Bergapten. These active ingredients manipulate various biochemical pathways like Stem Cell Signaling and MYC Signaling and others. Olive is not recommended when risk of Chronic Neutrophilic Leukemia when associated genetic risk is ASXL1 because it increases the signature pathways of it.

VEGETABLE GARDEN CRESS IS RECOMMENDED OVER OLIVE FOR ASXL1 GENETIC RISK OF CANCER.

Choose Fruit PASSION FRUIT or PUMMELO?

Fruit Passion Fruit contains many active ingredients or bioactives such as Apigenin, Curcumin, Formononetin, Vitamin C, Protocatechuic Acid. These active ingredients manipulate various biochemical pathways like RAS-RAF Signaling, Stem Cell Signaling, PI3K-AKT-MTOR Signaling and MYC Signaling and others. Passion Fruit is recommended for risk of Chronic Neutrophilic Leukemia when associated genetic risk is ASXL1. This is because Passion Fruit increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Pummelo are Quercetin, Apigenin, Curcumin, Genistein, Formononetin. These active ingredients manipulate various biochemical pathways like Stem Cell Signaling and PI3K-AKT-MTOR Signaling and others. Pummelo is not recommended when risk of Chronic Neutrophilic Leukemia when associated genetic risk is ASXL1 because it increases the signature pathways of it.

FRUIT PASSION FRUIT IS RECOMMENDED OVER PUMMELO FOR ASXL1 GENETIC RISK OF CANCER.

Choose Nut BUTTERNUT or JAPANESE WALNUT?

Butternut contains many active ingredients or bioactives such as Apigenin, Curcumin, Genistein, Formononetin, Lycopene. These active ingredients manipulate various biochemical pathways like Stem Cell Signaling, JAK-STAT Signaling, PI3K-AKT-MTOR Signaling and Oncogenic Cancer Epigenetics and others. Butternut is recommended for risk of Chronic Neutrophilic Leukemia when associated genetic risk is ASXL1. This is because Butternut increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in Japanese Walnut are Apigenin, Curcumin, Genistein, Ellagic Acid, Formononetin. These active ingredients manipulate various biochemical pathways like Stem Cell Signaling and others. Japanese Walnut is not recommended when risk of Chronic Neutrophilic Leukemia when associated genetic risk is ASXL1 because it increases the signature pathways of it.

BUTTERNUT IS RECOMMENDED OVER JAPANESE WALNUT FOR ASXL1 GENETIC RISK OF CANCER.

In Conclusion

Foods and Supplements chosen are important decisions for cancers like Chronic Neutrophilic Leukemia. Chronic Neutrophilic Leukemia patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Chronic Neutrophilic Leukemia, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like Radish contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Chronic Neutrophilic Leukemia?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.

References

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• Myricetin suppresses p21-activated kinase 1 in human breast cancer MCF-7 cells through downstream signaling of the β-catenin pathway.
• α-Pinene Induces Apoptotic Cell Death via Caspase Activation in Human Ovarian Cancer Cells.
• New concepts in phospholipase D signaling in inflammation and cancer.
• Retinol decreases beta-catenin protein levels in retinoic acid-resistant colon cancer cell lines.
• Genistein inhibits DNA methylation and increases expression of tumor suppressor genes in human breast cancer cells.