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What Foods are Recommended for Cancer?
is a very common question. Personalized Nutrition Plans are foods and supplements which are personalized to a cancer indication, genes, any treatments and lifestyle conditions.

Which Foods are Recommended for Chronic Neutrophilic Leukemia?

Aug 16, 2022

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Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Chronic Neutrophilic Leukemia when undergoing chemotherapy or when you determine you have a genetic risk for developing Chronic Neutrophilic Leukemia because of ASXL1 and SRSF2 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Chronic Neutrophilic Leukemia which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Cherry” or “Include fruit Date in my diet” or “Should I reduce consumption of vegetable Endive” or “Can I take Artichoke and Modified Citrus Pectin supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO CHRONIC NEUTROPHILIC LEUKEMIA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Chronic Neutrophilic Leukemia is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR CHRONIC NEUTROPHILIC LEUKEMIA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.



About Chronic Neutrophilic Leukemia

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Chronic Neutrophilic Leukemia from cBioPortal. The top genes with mutations and other abnormalities for Chronic Neutrophilic Leukemia include genes ASXL1, TET2, SRSF2, CSF3R and GATA2. The occurrence frequency distribution for these genes respectively is 75.6%, 47.7%, 39.5%, 34.9% and 32.6%. These tumor genetic details of Chronic Neutrophilic Leukemia are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Chronic Neutrophilic Leukemia.

Significance of Nutrition for Chronic Neutrophilic Leukemia

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Chronic Neutrophilic Leukemia. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Cherry includes active ingredients Quercetin, Vitamin C, Beta-sitosterol, Chrysin, Glucaric Acid and others. And Date contains active ingredients Apigenin, Quercetin, Lupeol, Protocatechuic Acid, Vitamin C and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Chronic Neutrophilic Leukemia, activation or inhibition of selected biochemical pathways like Hypoxia, Apoptosis, Oncogenic Cancer Epigenetics, Suppressive Histone Methylation plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Chronic Neutrophilic Leukemia, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

For cancers like Chronic Neutrophilic Leukemia, activation or inhibition of selected biochemical pathways like Hypoxia, Apoptosis, Oncogenic Cancer Epigenetics, Suppressive Histone Methylation plays an important role in driving cancer growth.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR CHRONIC NEUTROPHILIC LEUKEMIA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Chronic Neutrophilic Leukemia undergoing chemotherapy treatment

In Chronic Neutrophilic Leukemia – the genes ASXL1, TET2, SRSF2, CSF3R and GATA2 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Chronic Neutrophilic Leukemia are Hypoxia, Apoptosis, Cell Cycle and others. Vinblastine is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Hypoxia, Apoptosis, Cell Cycle so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Mung Bean or Moth Bean?

Pulses are an important part of many diets. The active ingredients contained in Mung Bean are Quercetin, Kaempferol, Vitamin C, Glucaric Acid, Linolenic Acid among others. While the active ingredients contained in Moth Bean are Beta-sitosterol, Linolenic Acid, Stigmasterol, Oleic Acid, Linoleic Acid and others.

Quercetin can manipulate biochemical pathways RAS-RAF Signaling, Hypoxia and PI3K-AKT-MTOR Signaling. Kaempferol has biological action on biochemical pathways Cell Cycle, Hypoxia and RAS-RAF Signaling.

Folic Acid can manipulate biochemical pathways Apoptosis, RAS-RAF Signaling and PI3K-AKT-MTOR Signaling. And so on.

When treating Chronic Neutrophilic Leukemia with chemotherapy Vinblastine – Foods like Mung Bean are recommended compared to Moth Bean. This is because the active ingredients Folic Acid in Moth Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Quercetin and Kaempferol contained in Mung Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: MUNG BEAN IS RECOMMENDED OVER MOTH BEAN FOR CHRONIC NEUTROPHILIC LEUKEMIA ON TREATMENT WITH CHEMOTHERAPY VINBLASTINE FOR SOME CONDITIONS.

Eat more vegetables, Arugula or Endive?

Vegetables are an important part of many diets. The active ingredients contained in Arugula are Kaempferol, Esculin, Vitamin A, Vitamin K, Erysolin among others. While the active ingredients contained in Endive are Quercetin, Kaempferol, Vitamin C, Linolenic Acid, Oleic Acid and others.

Kaempferol can manipulate biochemical pathways Hypoxia, Cell Cycle and RAS-RAF Signaling. Vitamin A has biological action on biochemical pathways Apoptosis, PI3K-AKT-MTOR Signaling and Cell Cycle.

Folic Acid can manipulate biochemical pathways Apoptosis, RAS-RAF Signaling and PI3K-AKT-MTOR Signaling. And so on.

When treating Chronic Neutrophilic Leukemia with chemotherapy Vinblastine – Foods like Arugula are recommended compared to Endive. This is because the active ingredients Folic Acid in Endive interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Kaempferol and Vitamin A contained in Arugula support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: ARUGULA IS RECOMMENDED OVER ENDIVE FOR CHRONIC NEUTROPHILIC LEUKEMIA ON TREATMENT WITH CHEMOTHERAPY VINBLASTINE FOR SOME CONDITIONS.

Which Foods are Recommended for Chronic Neutrophilic Leukemia?

Eat more fruits, Date or Cherry?

Fruits are an important part of many diets. The active ingredients contained in Date are Apigenin, Quercetin, Lupeol, Protocatechuic Acid, Vitamin C among others. While the active ingredients contained in Cherry are Quercetin, Vitamin C, Beta-sitosterol, Chrysin, Glucaric Acid and others.

Apigenin can manipulate biochemical pathways RAS-RAF Signaling, Hypoxia and PI3K-AKT-MTOR Signaling. Quercetin has biological action on biochemical pathways Apoptosis, Cell Cycle and RAS-RAF Signaling.

Shikimic Acid can manipulate biochemical pathways Cell Cycle and PI3K-AKT-MTOR Signaling. Pelargonidin has biological action on biochemical pathways PI3K-AKT-MTOR Signaling. And so on.

When treating Chronic Neutrophilic Leukemia with chemotherapy Vinblastine – Foods like Date are recommended compared to Cherry. This is because the active ingredients Shikimic Acid and Pelargonidin in Cherry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Apigenin and Quercetin contained in Date support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: DATE IS RECOMMENDED OVER CHERRY FOR CHRONIC NEUTROPHILIC LEUKEMIA ON TREATMENT WITH CHEMOTHERAPY VINBLASTINE FOR SOME CONDITIONS.

Eat more nuts, Walnut or Macadamia Nut?

Nuts are an important part of many diets. The active ingredients contained in Walnut are Quercetin, Ellagic Acid, Myricetin, D-limonene, Protocatechuic Acid among others. While the active ingredients contained in Macadamia Nut are Beta-sitosterol, Palmitic Acid, Lauric Acid, Myristic Acid, Folic Acid and others.

Ellagic Acid can manipulate biochemical pathways RAS-RAF Signaling, Hypoxia and PI3K-AKT-MTOR Signaling. Myricetin has biological action on biochemical pathways Apoptosis, Cell Cycle and RAS-RAF Signaling.

Lauric Acid can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Myristic Acid has biological action on biochemical pathways Apoptosis, Cell Cycle and RAS-RAF Signaling. And so on.

When treating Chronic Neutrophilic Leukemia with chemotherapy Vinblastine – Foods like Walnut are recommended compared to Macadamia Nut. This is because the active ingredients Lauric Acid and Myristic Acid in Macadamia Nut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Ellagic Acid and Myricetin contained in Walnut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: WALNUT IS RECOMMENDED OVER MACADAMIA NUT FOR CHRONIC NEUTROPHILIC LEUKEMIA ON TREATMENT WITH CHEMOTHERAPY VINBLASTINE FOR SOME CONDITIONS.

Foods for Genetic Risk of Chronic Neutrophilic Leukemia

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. ASXL1 and SRSF2 are two genes whose abnormalities are risk factors for Chronic Neutrophilic Leukemia. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Chronic Neutrophilic Leukemia can be used as a guide for coming up with a recommended personalized nutrition plan. For Chronic Neutrophilic Leukemia gene ASXL1 has causative impact on biological pathways like Oncogenic Cancer Epigenetics and Suppressive Histone Methylation. And SRSF2 has a causative impact on biological pathways like mRNA Splicing. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like ASXL1 and SRSF2 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes ASXL1 and SRSF2 should be avoided.

Eat more pulses, Winged Bean or Common Bean?

The active ingredients contained in Winged Bean are Vitamin C, Betulinic Acid, Linolenic Acid, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Common Bean are Apigenin, Esculin, Vitamin C, Linolenic Acid, P-coumaric Acid and others.

Betulinic Acid can manipulate biochemical pathways Cell Cycle Checkpoints, P53 Signaling and MYC Signaling. Vitamin C has biological action on biochemical pathways Suppressive Histone Methylation, Oncogenic Cancer Epigenetics and Apoptosis.

Pelargonidin can manipulate biochemical pathways MYC Signaling and Cell Cycle Checkpoints. Folic Acid has biological action on biochemical pathways P53 Signaling, Apoptosis and MYC Signaling. And so on.

For genetic risk of Chronic Neutrophilic Leukemia due to abnormalities in genes ASXL1 and SRSF2 – Foods like Winged Bean are recommended compared to Common Bean. This is because the active ingredients Pelargonidin and Folic Acid in Common Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Betulinic Acid and Vitamin C contained in Winged Bean together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: WINGED BEAN IS RECOMMENDED OVER COMMON BEAN FOR REDUCING THE GENETIC RISK OF CHRONIC NEUTROPHILIC LEUKEMIA DUE TO GENES ASXL1 AND SRSF2

Eat more vegetables, Cassava or Chicory?

The active ingredients contained in Cassava are Vitamin C, Beta-sitosterol, Linolenic Acid, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Chicory are Apigenin, Esculin, Vitamin C, Lupeol, Betulinic Acid and others.

Vitamin C can manipulate biochemical pathways Cell Cycle Checkpoints, P53 Signaling and MYC Signaling. Beta-sitosterol has biological action on biochemical pathways Oncogenic Cancer Epigenetics, Apoptosis and Cell Cycle Checkpoints.

Luteolin can manipulate biochemical pathways MYC Signaling. Esculetin has biological action on biochemical pathways RUNX Signaling. And so on.

For genetic risk of Chronic Neutrophilic Leukemia due to abnormalities in genes ASXL1 and SRSF2 – Foods like Cassava are recommended compared to Chicory. This is because the active ingredients Luteolin and Esculetin in Chicory further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Cassava together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: CASSAVA IS RECOMMENDED OVER CHICORY FOR REDUCING THE GENETIC RISK OF CHRONIC NEUTROPHILIC LEUKEMIA DUE TO GENES ASXL1 AND SRSF2

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

Eat more fruits, Star Fruit or Huckleberry?

The active ingredients contained in Star Fruit are Vitamin C, Beta-sitosterol, Linolenic Acid, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Huckleberry are Vitamin C, P-coumaric Acid, Ferulic Acid, Quercetin, Resveratrol and others.

Vitamin C can manipulate biochemical pathways Cell Cycle Checkpoints, P53 Signaling and MYC Signaling. Beta-sitosterol has biological action on biochemical pathways Oncogenic Cancer Epigenetics, Apoptosis and Cell Cycle Checkpoints.

Resveratrol can manipulate biochemical pathways P53 Signaling. Pelargonidin has biological action on biochemical pathways MYC Signaling and Cell Cycle Checkpoints. And so on.

For genetic risk of Chronic Neutrophilic Leukemia due to abnormalities in genes ASXL1 and SRSF2 – Foods like Star Fruit are recommended compared to Huckleberry. This is because the active ingredients Resveratrol and Pelargonidin in Huckleberry further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Star Fruit together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: STAR FRUIT IS RECOMMENDED OVER HUCKLEBERRY FOR REDUCING THE GENETIC RISK OF CHRONIC NEUTROPHILIC LEUKEMIA DUE TO GENES ASXL1 AND SRSF2

Eat more nuts, Almond or Cashew Nut?

The active ingredients contained in Almond are Vitamin E, Beta-sitosterol, Stigmasterol, Linolenic Acid, Quercetin among others. While the active ingredients contained in Cashew Nut are Vitamin C, Beta-sitosterol, Palmitic Acid, Gallic Acid, Vitamin K and others.

Beta-sitosterol can manipulate biochemical pathways Cell Cycle Checkpoints, P53 Signaling and MYC Signaling. Vitamin E has biological action on biochemical pathways Apoptosis, P53 Signaling and MYC Signaling.

Palmitic Acid can manipulate biochemical pathways mRNA Splicing and Oncogenic Cancer Epigenetics. Lauric Acid has biological action on biochemical pathways MYC Signaling. And so on.

For genetic risk of Chronic Neutrophilic Leukemia due to abnormalities in genes ASXL1 and SRSF2 – Foods like Almond are recommended compared to Cashew Nut. This is because the active ingredients Palmitic Acid and Lauric Acid in Cashew Nut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin E contained in Almond together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: ALMOND IS RECOMMENDED OVER CASHEW NUT FOR REDUCING THE GENETIC RISK OF CHRONIC NEUTROPHILIC LEUKEMIA DUE TO GENES ASXL1 AND SRSF2


In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Chronic Neutrophilic Leukemia by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

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References

Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.


Scientifically Reviewed by: Dr. Cogle

Christopher R. Cogle, M.D. is a tenured professor at the University of Florida, Chief Medical Officer of Florida Medicaid, and Director of the Florida Health Policy Leadership Academy at the Bob Graham Center for Public Service.

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