Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Castration-resistant Prostate Cancer when undergoing chemotherapy or when you determine you have a genetic risk for developing Castration-resistant Prostate Cancer because of SPOP and DYNC1H1 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Castration-resistant Prostate Cancer which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Elderberry” or “Include fruit Persimmon in my diet” or “Should I reduce consumption of vegetable Endive” or “Can I take Baicalin and Alpha Lipoic Acid supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO CASTRATION-RESISTANT PROSTATE CANCER, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Castration-resistant Prostate Cancer is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR CASTRATION-RESISTANT PROSTATE CANCER, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Castration-resistant Prostate Cancer
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Castration-resistant Prostate Cancer from cBioPortal. From a patient sample size of 52; the top genes with mutations and other abnormalities for Castration-resistant Prostate Cancer include genes TP53, SPOP, DYNC1H1, AR and CDK12. The occurrence frequency distribution for these genes respectively is 17.3%, 11.5%, 9.6%, 9.6% and 7.7%. These tumor genetic details of Castration-resistant Prostate Cancer are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Castration-resistant Prostate Cancer.
Significance of Nutrition for Castration-resistant Prostate Cancer
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Castration-resistant Prostate Cancer. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Elderberry includes active ingredients Quercetin, Lupeol, Isorhamnetin, Betulinic Acid, Linolenic Acid and others. And Persimmon contains active ingredients Quercetin, Fisetin, Lycopene, Lupeol, Betulinic Acid and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Castration-resistant Prostate Cancer, activation or inhibition of selected biochemical pathways like Cell Cycle, Oncogenic Histone Methylation, PI3K-AKT-MTOR Signaling, Small Molecule Transport plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Castration-resistant Prostate Cancer, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR CASTRATION-RESISTANT PROSTATE CANCER – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Castration-resistant Prostate Cancer undergoing chemotherapy treatment
In Castration-resistant Prostate Cancer – the genes TP53, SPOP, DYNC1H1, AR and CDK12 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Castration-resistant Prostate Cancer are Cell Cycle, Oncogenic Histone Methylation, Oncogenic Cancer Epigenetics and others. Abiraterone Acetate is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Cell Cycle, Oncogenic Histone Methylation, Oncogenic Cancer Epigenetics so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Common Pea or Pigeon Pea?
Pulses are an important part of many diets. The active ingredients contained in Common Pea are Beta-sitosterol, Lupeol, Daidzein, Linolenic Acid, Vitamin C among others. While the active ingredients contained in Pigeon Pea are Linolenic Acid, Vitamin C, Oleic Acid, Genistein, Vitamin A and others.
Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Glucocorticoid Signaling. Vitamin C has biological action on biochemical pathways Suppressive Histone Methylation, Cell Cycle and MYC Signaling.
Genistein can manipulate biochemical pathways Oncogenic Cancer Epigenetics and DNA Repair. Vitamin A has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, Extracellular Matrix Remodelling and Oncogenic Cancer Epigenetics. And so on.
When treating Castration-resistant Prostate Cancer with chemotherapy Abiraterone Acetate – Foods like Common Pea are recommended compared to Pigeon Pea. This is because the active ingredients Genistein and Vitamin A in Pigeon Pea interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER PIGEON PEA FOR CASTRATION-RESISTANT PROSTATE CANCER ON TREATMENT WITH CHEMOTHERAPY ABIRATERONE ACETATE FOR SOME CONDITIONS.
Eat more vegetables, Cabbage or Endive?
Vegetables are an important part of many diets. The active ingredients contained in Cabbage are Quercetin, Beta-sitosterol, Benzyl Isothiocyanate, Sulforaphane, Isorhamnetin among others. While the active ingredients contained in Endive are Quercetin, Linolenic Acid, Vitamin C, Kaempferol, Oleic Acid and others.
Vitamin C can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Suppressive Histone Methylation and Cell Cycle. Glucaric Acid has biological action on biochemical pathways NFKB Signaling, MYC Signaling and PI3K-AKT-MTOR Signaling.
Vitamin A can manipulate biochemical pathways Oncogenic Cancer Epigenetics, PI3K-AKT-MTOR Signaling and Extracellular Matrix Remodelling. Quercetin has biological action on biochemical pathways Oncogenic Cancer Epigenetics. And so on.
When treating Castration-resistant Prostate Cancer with chemotherapy Abiraterone Acetate – Foods like Cabbage are recommended compared to Endive. This is because the active ingredients Vitamin A and Quercetin in Endive interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Glucaric Acid contained in Cabbage support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: CABBAGE IS RECOMMENDED OVER ENDIVE FOR CASTRATION-RESISTANT PROSTATE CANCER ON TREATMENT WITH CHEMOTHERAPY ABIRATERONE ACETATE FOR SOME CONDITIONS.
Eat more fruits, Persimmon or Elderberry?
Fruits are an important part of many diets. The active ingredients contained in Persimmon are Quercetin, Fisetin, Lycopene, Lupeol, Betulinic Acid among others. While the active ingredients contained in Elderberry are Quercetin, Lupeol, Isorhamnetin, Betulinic Acid, Linolenic Acid and others.
Lycopene can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Glucocorticoid Signaling. Vitamin C has biological action on biochemical pathways Suppressive Histone Methylation, Cell Cycle and MYC Signaling.
Rutin can manipulate biochemical pathways WNT Beta Catenin Signaling and Microtubule Dynamics. Quercetin has biological action on biochemical pathways Oncogenic Cancer Epigenetics. And so on.
When treating Castration-resistant Prostate Cancer with chemotherapy Abiraterone Acetate – Foods like Persimmon are recommended compared to Elderberry. This is because the active ingredients Rutin and Quercetin in Elderberry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Lycopene and Vitamin C contained in Persimmon support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PERSIMMON IS RECOMMENDED OVER ELDERBERRY FOR CASTRATION-RESISTANT PROSTATE CANCER ON TREATMENT WITH CHEMOTHERAPY ABIRATERONE ACETATE FOR SOME CONDITIONS.
Eat more nuts, Pecan Nut or Chestnut?
Nuts are an important part of many diets. The active ingredients contained in Pecan Nut are Vitamin E, Linolenic Acid, Cianidanol, Oleic Acid, Vitamin A among others. While the active ingredients contained in Chestnut are Quercetin, Ellagic Acid, Linolenic Acid, Gallic Acid, Vitamin C and others.
Vitamin E can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and DNA Repair. Cianidanol has biological action on biochemical pathways Glucocorticoid Signaling, Microtubule Dynamics and MYC Signaling.
Ellagic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition, MYC Signaling and WNT Beta Catenin Signaling. Vitamin A has biological action on biochemical pathways Oncogenic Cancer Epigenetics, PI3K-AKT-MTOR Signaling and Extracellular Matrix Remodelling. And so on.
When treating Castration-resistant Prostate Cancer with chemotherapy Abiraterone Acetate – Foods like Pecan Nut are recommended compared to Chestnut. This is because the active ingredients Ellagic Acid and Vitamin A in Chestnut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin E and Cianidanol contained in Pecan Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER CHESTNUT FOR CASTRATION-RESISTANT PROSTATE CANCER ON TREATMENT WITH CHEMOTHERAPY ABIRATERONE ACETATE FOR SOME CONDITIONS.
Foods for Genetic Risk of Castration-resistant Prostate Cancer
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. SPOP and DYNC1H1 are two genes whose abnormalities are risk factors for Castration-resistant Prostate Cancer. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Castration-resistant Prostate Cancer can be used as a guide for coming up with a recommended personalized nutrition plan. For Castration-resistant Prostate Cancer gene SPOP has causative impact on biological pathways like . And DYNC1H1 has a causative impact on biological pathways like Antigen Presentation. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like SPOP and DYNC1H1 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes SPOP and DYNC1H1 should be avoided.
Eat more pulses, Mung Bean or Lima Bean?
The active ingredients contained in Mung Bean are Vitexin, Vitamin C, Oleic Acid, Linolenic Acid, Stigmasterol among others. While the active ingredients contained in Lima Bean are Vitamin C, Oleic Acid, Genistein, Linoleic Acid, Vitamin A and others.
Vitexin can manipulate biochemical pathways Small Molecule Transport, Apoptosis and MYC Signaling. Vitamin C has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.
Linoleic Acid can manipulate biochemical pathways Extracellular Matrix Remodelling. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. And so on.
For genetic risk of Castration-resistant Prostate Cancer due to abnormalities in genes SPOP and DYNC1H1 – Foods like Mung Bean are recommended compared to Lima Bean. This is because the active ingredients Linoleic Acid and Folic Acid in Lima Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Vitexin and Vitamin C contained in Mung Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: MUNG BEAN IS RECOMMENDED OVER LIMA BEAN FOR REDUCING THE GENETIC RISK OF CASTRATION-RESISTANT PROSTATE CANCER DUE TO GENES SPOP AND DYNC1H1
Eat more vegetables, Giant Butterbur or Heart Of Palm?
The active ingredients contained in Giant Butterbur are Beta-sitosterol, Vitamin C, Vitamin B3, Melatonin, Vitamin A among others. While the active ingredients contained in Heart Of Palm are Vitamin C, Palmitic Acid, Vitamin A, Folic Acid and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Beta-sitosterol has biological action on biochemical pathways Calcium Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.
Palmitic Acid can manipulate biochemical pathways Oncogenic Cancer Epigenetics and PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. And so on.
For genetic risk of Castration-resistant Prostate Cancer due to abnormalities in genes SPOP and DYNC1H1 – Foods like Giant Butterbur are recommended compared to Heart Of Palm. This is because the active ingredients Palmitic Acid and Folic Acid in Heart Of Palm further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Giant Butterbur together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: GIANT BUTTERBUR IS RECOMMENDED OVER HEART OF PALM FOR REDUCING THE GENETIC RISK OF CASTRATION-RESISTANT PROSTATE CANCER DUE TO GENES SPOP AND DYNC1H1
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Feijoa or Cranberry?
The active ingredients contained in Feijoa are Vitamin C, Lycopene, Casuarinin, Folic Acid among others. While the active ingredients contained in Cranberry are Resveratrol, Vitamin C, Ellagic Acid, Hyperoside, P-coumaric Acid and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Lycopene has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Apoptosis.
Resveratrol can manipulate biochemical pathways P53 Signaling. Ellagic Acid has biological action on biochemical pathways MYC Signaling. And so on.
For genetic risk of Castration-resistant Prostate Cancer due to abnormalities in genes SPOP and DYNC1H1 – Foods like Feijoa are recommended compared to Cranberry. This is because the active ingredients Resveratrol and Ellagic Acid in Cranberry further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Lycopene contained in Feijoa together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: FEIJOA IS RECOMMENDED OVER CRANBERRY FOR REDUCING THE GENETIC RISK OF CASTRATION-RESISTANT PROSTATE CANCER DUE TO GENES SPOP AND DYNC1H1
Eat more nuts, Pine Nut or Peanut?
The active ingredients contained in Pine Nut are Beta-sitosterol, Vitamin E, Oleic Acid, Linolenic Acid, Linoleic Acid among others. While the active ingredients contained in Peanut are Beta-sitosterol, Vitamin E, Vitamin C, Oleic Acid, Linolenic Acid and others.
Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin K has biological action on biochemical pathways Calcium Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.
Lecithin can manipulate biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. Vitamin B3 has biological action on biochemical pathways PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Castration-resistant Prostate Cancer due to abnormalities in genes SPOP and DYNC1H1 – Foods like Pine Nut are recommended compared to Peanut. This is because the active ingredients Lecithin and Vitamin B3 in Peanut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin K contained in Pine Nut together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: PINE NUT IS RECOMMENDED OVER PEANUT FOR REDUCING THE GENETIC RISK OF CASTRATION-RESISTANT PROSTATE CANCER DUE TO GENES SPOP AND DYNC1H1
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Castration-resistant Prostate Cancer by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
- Nepc Wcm 2016
- Divergent clonal evolution of castration-resistant neuroendocrine prostate cancer.
- Paederia foetida induces anticancer activity by modulating chromatin modification enzymes and altering pro-inflammatory cytokine gene expression in human prostate cancer cells.
- The synergy of Vitamin C with decitabine activates TET2 in leukemic cells and significantly improves overall survival in elderly patients with acute myeloid leukemia.
- BRCA1 and BRCA2 as molecular targets for phytochemicals indole-3-carbinol and genistein in breast and prostate cancer cells.
- Vitamin A regulates Akt signaling through the phospholipid fatty acid composition.
- Lycopene metabolite, apo-10′-lycopenoic acid, inhibits diethylnitrosamine-initiated, high fat diet-promoted hepatic inflammation and tumorigenesis in mice.
- In vitro Cytotoxic Activities and Molecular Mechanisms of Angelica shikokiana Extract and its Isolated Compounds.
- Preventive effects of butyric acid, nicotinamide, calcium glucarate alone or in combination during the 7, 12-dimethylbenz (a) anthracene induced mouse skin tumorigenesis via modulation of K-Ras-PI3K-AKTpathway and associated micro RNAs.
- Gamma-tocotrienol inhibits nuclear factor-kappaB signaling pathway through inhibition of receptor-interacting protein and TAK1 leading to suppression of antiapoptotic gene products and potentiation of apoptosis.
- Cytotoxicity and apoptosis induction in human breast adenocarcinoma MCF-7 cells by (+)-cyanidan-3-ol.
- Identification of ellagic acid as potent inhibitor of protein kinase CK2: a successful example of a virtual screening application.
- Vitexin protects against cardiac hypertrophy via inhibiting calcineurin and CaMKII signaling pathways.
- Excess Linoleic Acid Increases Collagen I/III Ratio and Stiffens” the Heart Muscle Following High Fat Diets.”
- Effects of folate deficiency on gene expression in the apoptosis and cancer pathways in colon cancer cells.
- Resveratrol, a remarkable inhibitor of ribonucleotide reductase.
- Functional lipidomics: Palmitic acid impairs hepatocellular carcinoma development by modulating membrane fluidity and glucose metabolism.
- Research progress on the anticancer effects of vitamin K2.
- The recruitment of Raf-1 to membranes is mediated by direct interaction with phosphatidic acid and is independent of association with Ras.
- Modulation of Sirt1 by resveratrol and nicotinamide alters proliferation and differentiation of pig preadipocytes.
- HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.