Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Biliary Tract Carcinoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Biliary Tract Carcinoma because of PPM1D and ASXL1 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Biliary Tract Carcinoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Huckleberry” or “Include fruit Gooseberry in my diet” or “Should I reduce consumption of vegetable Radish” or “Can I take Boldo and Ginger supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO BILIARY TRACT CARCINOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Biliary Tract Carcinoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR BILIARY TRACT CARCINOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Biliary Tract Carcinoma
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Biliary Tract Carcinoma from cBioPortal. The patients enrolled in the studies for Biliary Tract Carcinoma are in ages between 21 to 89 with an average age of 64. 47.0% of males and 53.0% of females were the distribution of gender in these clinical studies. From a patient sample size of 508; the top genes with mutations and other abnormalities for Biliary Tract Carcinoma include genes DNMT3A, TET2, PPM1D, ASXL1 and CHEK2. The occurrence frequency distribution for these genes respectively is 36.1%, 10.2%, 8.8%, 6.8% and 3.4%. These tumor genetic details of Biliary Tract Carcinoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Biliary Tract Carcinoma.
Significance of Nutrition for Biliary Tract Carcinoma
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Biliary Tract Carcinoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Huckleberry includes active ingredients Quercetin, Resveratrol, Delphinidin, Chlorogenic Acid, Vitamin C and others. And Gooseberry contains active ingredients Modified Citrus Pectin, Oleic Acid, Gallic Acid, Linolenic Acid, Vitamin C and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Biliary Tract Carcinoma, activation or inhibition of selected biochemical pathways like RAS-RAF Signaling, mRNA Splicing, Oncogenic Cancer Epigenetics, DNA Repair plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Biliary Tract Carcinoma, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR BILIARY TRACT CARCINOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Biliary Tract Carcinoma undergoing chemotherapy treatment
In Biliary Tract Carcinoma – the genes DNMT3A, TET2, PPM1D, ASXL1 and CHEK2 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Biliary Tract Carcinoma are RAS-RAF Signaling, mRNA Splicing, Angiogenesis and others. Radiation is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers RAS-RAF Signaling, mRNA Splicing, Angiogenesis so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Mung Bean or Soy Bean?
Pulses are an important part of many diets. The active ingredients contained in Mung Bean are Quercetin, Oleic Acid, Glucaric Acid, Linolenic Acid, Stigmasterol among others. While the active ingredients contained in Soy Bean are Quercetin, Vitamin E, Lupeol, Oleic Acid, Daidzein and others.
Quercetin can manipulate biochemical pathways DNA Repair, JAK-STAT Signaling and MYC Signaling. Glucaric Acid has biological action on biochemical pathways RAS-RAF Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling.
Genistein can manipulate biochemical pathways DNA Repair. Lecithin has biological action on biochemical pathways MYC Signaling, JAK-STAT Signaling and MAPK Signaling. And so on.
When treating Biliary Tract Carcinoma with chemotherapy Radiation – Foods like Mung Bean are recommended compared to Soy Bean. This is because the active ingredients Genistein and Lecithin in Soy Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Quercetin and Glucaric Acid contained in Mung Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: MUNG BEAN IS RECOMMENDED OVER SOY BEAN FOR BILIARY TRACT CARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more vegetables, Asparagus or Radish?
Vegetables are an important part of many diets. The active ingredients contained in Asparagus are Quercetin, Oleic Acid, Isorhamnetin, Linolenic Acid, Vitamin C among others. While the active ingredients contained in Radish are Quercetin, Oleic Acid, Isorhamnetin, Linolenic Acid, Vitamin C and others.
Quercetin can manipulate biochemical pathways DNA Repair, JAK-STAT Signaling and MYC Signaling. Isorhamnetin has biological action on biochemical pathways RAS-RAF Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling.
Pelargonidin can manipulate biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways JAK-STAT Signaling, MAPK Signaling and RAS-RAF Signaling. And so on.
When treating Biliary Tract Carcinoma with chemotherapy Radiation – Foods like Asparagus are recommended compared to Radish. This is because the active ingredients Pelargonidin and Folic Acid in Radish interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Quercetin and Isorhamnetin contained in Asparagus support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: ASPARAGUS IS RECOMMENDED OVER RADISH FOR BILIARY TRACT CARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more fruits, Gooseberry or Huckleberry?
Fruits are an important part of many diets. The active ingredients contained in Gooseberry are Modified Citrus Pectin, Oleic Acid, Gallic Acid, Linolenic Acid, Vitamin C among others. While the active ingredients contained in Huckleberry are Quercetin, Resveratrol, Delphinidin, Chlorogenic Acid, Vitamin C and others.
Gallic Acid can manipulate biochemical pathways DNA Repair, MYC Signaling and MAPK Signaling. Vitamin C has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, Angiogenesis and RAS-RAF Signaling.
Resveratrol can manipulate biochemical pathways DNA Repair. Pelargonidin has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. And so on.
When treating Biliary Tract Carcinoma with chemotherapy Radiation – Foods like Gooseberry are recommended compared to Huckleberry. This is because the active ingredients Resveratrol and Pelargonidin in Huckleberry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Gallic Acid and Vitamin C contained in Gooseberry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: GOOSEBERRY IS RECOMMENDED OVER HUCKLEBERRY FOR BILIARY TRACT CARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more nuts, Pecan Nut or Acorn?
Nuts are an important part of many diets. The active ingredients contained in Pecan Nut are Vitamin E, Oleic Acid, Delphinidin, Linolenic Acid, Cianidanol among others. While the active ingredients contained in Acorn are Quercetin, Gallic Acid, Vitamin C, Beta-sitosterol, Beta-carotene and others.
Vitamin E can manipulate biochemical pathways DNA Repair, Notch Signaling and MYC Signaling. Delphinidin has biological action on biochemical pathways MAPK Signaling, PI3K-AKT-MTOR Signaling and Angiogenesis.
Beta-carotene can manipulate biochemical pathways MAPK Signaling and Notch Signaling. Folic Acid has biological action on biochemical pathways JAK-STAT Signaling, MYC Signaling and PI3K-AKT-MTOR Signaling. And so on.
When treating Biliary Tract Carcinoma with chemotherapy Radiation – Foods like Pecan Nut are recommended compared to Acorn. This is because the active ingredients Beta-carotene and Folic Acid in Acorn interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin E and Delphinidin contained in Pecan Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER ACORN FOR BILIARY TRACT CARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Foods for Genetic Risk of Biliary Tract Carcinoma
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. PPM1D and ASXL1 are two genes whose abnormalities are risk factors for Biliary Tract Carcinoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Biliary Tract Carcinoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Biliary Tract Carcinoma gene PPM1D has causative impact on biological pathways like DNA Repair. And ASXL1 has a causative impact on biological pathways like Oncogenic Cancer Epigenetics and Suppressive Histone Methylation. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like PPM1D and ASXL1 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes PPM1D and ASXL1 should be avoided.
Eat more pulses, Scarlet Bean or Common Bean?
The active ingredients contained in Scarlet Bean are Vitamin C, Beta-sitosterol, Linolenic Acid, Stigmasterol, Genistein among others. While the active ingredients contained in Common Bean are Apigenin, Esculin, Vitamin C, Linolenic Acid, Ferulic Acid and others.
Vitamin C can manipulate biochemical pathways Apoptosis, Suppressive Histone Methylation and MYC Signaling. Beta-sitosterol has biological action on biochemical pathways Oncogenic Cancer Epigenetics, Cell Cycle Checkpoints and Apoptosis.
Pelargonidin can manipulate biochemical pathways MYC Signaling and Cell Cycle Checkpoints. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and Cell Cycle Checkpoints. And so on.
For genetic risk of Biliary Tract Carcinoma due to abnormalities in genes PPM1D and ASXL1 – Foods like Scarlet Bean are recommended compared to Common Bean. This is because the active ingredients Pelargonidin and Folic Acid in Common Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Scarlet Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER COMMON BEAN FOR REDUCING THE GENETIC RISK OF BILIARY TRACT CARCINOMA DUE TO GENES PPM1D AND ASXL1
Eat more vegetables, Cassava or Heart Of Palm?
The active ingredients contained in Cassava are Vitamin C, Beta-sitosterol, Linolenic Acid, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Heart Of Palm are Vitamin C, Palmitic Acid, Vitamin A, Folic Acid and others.
Vitamin C can manipulate biochemical pathways Apoptosis, Suppressive Histone Methylation and MYC Signaling. Beta-sitosterol has biological action on biochemical pathways Oncogenic Cancer Epigenetics, Cell Cycle Checkpoints and Apoptosis.
Palmitic Acid can manipulate biochemical pathways Oncogenic Cancer Epigenetics and mRNA Splicing. Folic Acid has biological action on biochemical pathways MYC Signaling, Cell Cycle Checkpoints and Apoptosis. And so on.
For genetic risk of Biliary Tract Carcinoma due to abnormalities in genes PPM1D and ASXL1 – Foods like Cassava are recommended compared to Heart Of Palm. This is because the active ingredients Palmitic Acid and Folic Acid in Heart Of Palm further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Cassava together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: CASSAVA IS RECOMMENDED OVER HEART OF PALM FOR REDUCING THE GENETIC RISK OF BILIARY TRACT CARCINOMA DUE TO GENES PPM1D AND ASXL1
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Feijoa or Graviola?
The active ingredients contained in Feijoa are Lycopene, Vitamin C, Casuarinin, Folic Acid among others. While the active ingredients contained in Graviola are Emodin, Lycopene, Vitamin C, Beta-sitosterol, Daidzein and others.
Vitamin C can manipulate biochemical pathways Apoptosis, Suppressive Histone Methylation and MYC Signaling. Lycopene has biological action on biochemical pathways Cell Cycle Checkpoints, MYC Signaling and Apoptosis.
Fisetin can manipulate biochemical pathways MYC Signaling. Myricetin has biological action on biochemical pathways Oncogenic Cancer Epigenetics. And so on.
For genetic risk of Biliary Tract Carcinoma due to abnormalities in genes PPM1D and ASXL1 – Foods like Feijoa are recommended compared to Graviola. This is because the active ingredients Fisetin and Myricetin in Graviola further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Lycopene contained in Feijoa together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: FEIJOA IS RECOMMENDED OVER GRAVIOLA FOR REDUCING THE GENETIC RISK OF BILIARY TRACT CARCINOMA DUE TO GENES PPM1D AND ASXL1
Eat more nuts, Pistachio or Chestnut?
The active ingredients contained in Pistachio are Beta-sitosterol, Vitamin E, Stigmasterol, Linolenic Acid, Oleic Acid among others. While the active ingredients contained in Chestnut are Vitamin C, Linolenic Acid, Quercetin, Oleic Acid, Linoleic Acid and others.
Beta-sitosterol can manipulate biochemical pathways Apoptosis, Oncogenic Cancer Epigenetics and Cell Cycle Checkpoints. Vitamin E has biological action on biochemical pathways MYC Signaling, Cell Cycle Checkpoints and Apoptosis.
Ellagic Acid can manipulate biochemical pathways MYC Signaling and Cell Cycle Checkpoints. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and Cell Cycle Checkpoints. And so on.
For genetic risk of Biliary Tract Carcinoma due to abnormalities in genes PPM1D and ASXL1 – Foods like Pistachio are recommended compared to Chestnut. This is because the active ingredients Ellagic Acid and Folic Acid in Chestnut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin E contained in Pistachio together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: PISTACHIO IS RECOMMENDED OVER CHESTNUT FOR REDUCING THE GENETIC RISK OF BILIARY TRACT CARCINOMA DUE TO GENES PPM1D AND ASXL1
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Biliary Tract Carcinoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
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Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.