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What Foods are Recommended for Cancer?
is a very common question. Personalized Nutrition Plans are foods and supplements which are personalized to a cancer indication, genes, any treatments and lifestyle conditions.

Foods for Biliary Tract Carcinoma!

Aug 4, 2023

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Introduction

Foods for Biliary Tract Carcinoma should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.



For Biliary Tract Carcinoma does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Biliary Tract Carcinoma does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Biliary Tract Carcinoma?

For example does it matter if vegetable Garden Tomato is consumed more compared to Spinach? Does it make any difference if fruit Black Elderberry is preferred over Mango? Also if similar choices are made for nuts/seeds like Black Walnut over Chestnut and for pulses like Chickpea over Common Bean. And if what I eat matters – then how does one identify foods which are recommended for Biliary Tract Carcinoma and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Biliary Tract Carcinoma!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All cancers like Biliary Tract Carcinoma can be characterized by a unique set of biochemical pathways - the signature pathways of Biliary Tract Carcinoma. Biochemical pathways like RAS-RAF Signaling, mRNA Splicing, Oncogenic Cancer Epigenetics, DNA Repair are part of the signature definition of Biliary Tract Carcinoma.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Black Elderberry contains active ingredients Quercetin, Linalool, Caffeine, Lycopene, Protocatechuic Acid. And Mango contains active ingredients Quercetin, Protocatechuic Acid, Curcumin, Lupeol, Formononetin and possibly others.

A common mistake made when deciding and choosing foods to eat for Biliary Tract Carcinoma – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Biliary Tract Carcinoma.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Biliary Tract Carcinoma?

Personalized nutrition for cancers like Biliary Tract Carcinoma consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Biliary Tract Carcinoma biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

Characteristics of cancers like Biliary Tract Carcinoma

All cancers like Biliary Tract Carcinoma can be characterized by a unique set of biochemical pathways – the signature pathways of Biliary Tract Carcinoma. Biochemical pathways like RAS-RAF Signaling, mRNA Splicing, Oncogenic Cancer Epigenetics, DNA Repair are part of the signature definition of Biliary Tract Carcinoma. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Biliary Tract Carcinoma need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Biliary Tract Carcinoma when taking cancer treatment Radiation, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

DNMT3A, TET2, PPM1D, ASXL1 and CHEK2 are the top ranked reported genes for Biliary Tract Carcinoma. DNMT3A is reported in 36.1 % of the representative patients across all clinical trials. And TET2 is reported in 10.2 %. The combined population patient data cover ages from 21 to 89. 47.0 % of the patient data are identified as men. The Biliary Tract Carcinoma biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Foods for Biliary Tract Carcinoma!

Food and Supplements for Biliary Tract Carcinoma

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable GARDEN TOMATO or SPINACH?

Vegetable Garden Tomato contains many active ingredients or bioactives such as Quercetin, Lycopene, Protocatechuic Acid, Curcumin, Lupeol. These active ingredients manipulate various biochemical pathways like Angiogenesis, RAS-RAF Signaling, JAK-STAT Signaling and PI3K-AKT-MTOR Signaling and others. Garden Tomato is recommended for Biliary Tract Carcinoma when ongoing cancer treatment is Radiation. This is because Garden Tomato modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Radiation.

Some of the active ingredients or bioactives in vegetable Spinach are Quercetin, Protocatechuic Acid, Curcumin, Formononetin, Lupeol. These active ingredients manipulate various biochemical pathways like Notch Signaling, DNA Repair and MAPK Signaling and others. Spinach is not recommended for Biliary Tract Carcinoma when ongoing cancer treatment is Radiation because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE GARDEN TOMATO IS RECOMMENDED OVER SPINACH FOR Biliary Tract Carcinoma AND TREATMENT Radiation.

Choose Fruit MANGO or BLACK ELDERBERRY?

Fruit Mango contains many active ingredients or bioactives such as Quercetin, Protocatechuic Acid, Curcumin, Lupeol, Formononetin. These active ingredients manipulate various biochemical pathways like Angiogenesis, PI3K-AKT-MTOR Signaling, MAPK Signaling and RAS-RAF Signaling and others. Mango is recommended for Biliary Tract Carcinoma when ongoing cancer treatment is Radiation. This is because Mango modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Radiation.

Some of the active ingredients or bioactives in fruit Black Elderberry are Quercetin, Linalool, Caffeine, Lycopene, Protocatechuic Acid. These active ingredients manipulate various biochemical pathways like PI3K-AKT-MTOR Signaling and DNA Repair and others. Black Elderberry is not recommended for Biliary Tract Carcinoma when ongoing cancer treatment is Radiation because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT MANGO IS RECOMMENDED OVER BLACK ELDERBERRY FOR Biliary Tract Carcinoma AND TREATMENT Radiation.

Choose Nut BLACK WALNUT or CHESTNUT?

Black Walnut contains many active ingredients or bioactives such as Ellagic Acid, Quercetin, Protocatechuic Acid, Curcumin, Formononetin. These active ingredients manipulate various biochemical pathways like RAS-RAF Signaling, PI3K-AKT-MTOR Signaling, MAPK Signaling and MYC Signaling and others. Black Walnut is recommended for Biliary Tract Carcinoma when ongoing cancer treatment is Radiation. This is because Black Walnut modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Radiation.

Some of the active ingredients or bioactives in Chestnut are Ellagic Acid, Caffeine, Lycopene, Protocatechuic Acid, Curcumin. These active ingredients manipulate various biochemical pathways like PI3K-AKT-MTOR Signaling and DNA Repair and others. Chestnut is not recommended for Biliary Tract Carcinoma when ongoing cancer treatment is Radiation because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

BLACK WALNUT IS RECOMMENDED OVER CHESTNUT FOR Biliary Tract Carcinoma AND TREATMENT Radiation.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Biliary Tract Carcinoma or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable GIANT BUTTERBUR or AGAVE?

Vegetable Giant Butterbur contains many active ingredients or bioactives such as Apigenin, Curcumin, Lycopene, Lupeol, Protocatechuic Acid. These active ingredients manipulate various biochemical pathways like DNA Repair, PI3K-AKT-MTOR Signaling, Oncogenic Cancer Epigenetics and P53 Signaling and others. Giant Butterbur is recommended for risk of Biliary Tract Carcinoma when associated genetic risk is ASXL1. This is because Giant Butterbur increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Agave are Apigenin, Curcumin, Lupeol, Protocatechuic Acid, Daidzein. These active ingredients manipulate various biochemical pathways like DNA Repair and others. Agave is not recommended when risk of Biliary Tract Carcinoma when associated genetic risk is ASXL1 because it increases the signature pathways of it.

VEGETABLE GIANT BUTTERBUR IS RECOMMENDED OVER AGAVE FOR ASXL1 GENETIC RISK OF CANCER.

Choose Fruit NANCE or PUMMELO?

Fruit Nance contains many active ingredients or bioactives such as Apigenin, Curcumin, Lupeol, Protocatechuic Acid, Daidzein. These active ingredients manipulate various biochemical pathways like DNA Repair, PI3K-AKT-MTOR Signaling, Oncogenic Cancer Epigenetics and P53 Signaling and others. Nance is recommended for risk of Biliary Tract Carcinoma when associated genetic risk is ASXL1. This is because Nance increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Pummelo are Apigenin, Curcumin, Lycopene, Lupeol, Protocatechuic Acid. These active ingredients manipulate various biochemical pathways like DNA Repair and others. Pummelo is not recommended when risk of Biliary Tract Carcinoma when associated genetic risk is ASXL1 because it increases the signature pathways of it.

FRUIT NANCE IS RECOMMENDED OVER PUMMELO FOR ASXL1 GENETIC RISK OF CANCER.

Choose Nut COMMON HAZELNUT or PILI NUT?

Common Hazelnut contains many active ingredients or bioactives such as Curcumin, Lycopene, Lupeol, Protocatechuic Acid, Quercetin. These active ingredients manipulate various biochemical pathways like Apoptosis, PI3K-AKT-MTOR Signaling, DNA Repair and P53 Signaling and others. Common Hazelnut is recommended for risk of Biliary Tract Carcinoma when associated genetic risk is ASXL1. This is because Common Hazelnut increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in Pili Nut are Apigenin, Curcumin, Lycopene, Lupeol, Protocatechuic Acid. These active ingredients manipulate various biochemical pathways like DNA Repair and others. Pili Nut is not recommended when risk of Biliary Tract Carcinoma when associated genetic risk is ASXL1 because it increases the signature pathways of it.

COMMON HAZELNUT IS RECOMMENDED OVER PILI NUT FOR ASXL1 GENETIC RISK OF CANCER.


In Conclusion

Foods and Supplements chosen are important decisions for cancers like Biliary Tract Carcinoma. Biliary Tract Carcinoma patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Biliary Tract Carcinoma, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like Garden Tomato contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Biliary Tract Carcinoma?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.


Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.

References

Scientifically Reviewed by: Dr. Cogle

Christopher R. Cogle, M.D. is a tenured professor at the University of Florida, Chief Medical Officer of Florida Medicaid, and Director of the Florida Health Policy Leadership Academy at the Bob Graham Center for Public Service.

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