Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Anal Squamous Cell Carcinoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Anal Squamous Cell Carcinoma because of EP300 and FBXW7 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Anal Squamous Cell Carcinoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Date” or “Include fruit Persimmon in my diet” or “Should I reduce consumption of vegetable Spinach” or “Can I take Birch and Dim supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO ANAL SQUAMOUS CELL CARCINOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Anal Squamous Cell Carcinoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR ANAL SQUAMOUS CELL CARCINOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Anal Squamous Cell Carcinoma
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Anal Squamous Cell Carcinoma from cBioPortal. 41.9% of males and 58.1% of females were the distribution of gender in these clinical studies. From a patient sample size of 119; the top genes with mutations and other abnormalities for Anal Squamous Cell Carcinoma include genes KMT2D, PIK3CA, EP300, FBXW7 and PTEN. The occurrence frequency distribution for these genes respectively is 27.0%, 23.8%, 14.3%, 14.3% and 9.5%. These tumor genetic details of Anal Squamous Cell Carcinoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Anal Squamous Cell Carcinoma.
Significance of Nutrition for Anal Squamous Cell Carcinoma
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Anal Squamous Cell Carcinoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Date includes active ingredients Quercetin, Lupeol, Beta-sitosterol, Vitamin C, Protocatechuic Acid and others. And Persimmon contains active ingredients Quercetin, Betulinic Acid, Lupeol, Vitamin C, Lycopene and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Anal Squamous Cell Carcinoma, activation or inhibition of selected biochemical pathways like Amino Acid Metabolism, Angiogenesis, PI3K-AKT-MTOR Signaling, Oncogenic Histone Methylation plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Anal Squamous Cell Carcinoma, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR ANAL SQUAMOUS CELL CARCINOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Anal Squamous Cell Carcinoma undergoing chemotherapy treatment
In Anal Squamous Cell Carcinoma – the genes KMT2D, PIK3CA, EP300, FBXW7 and PTEN have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Anal Squamous Cell Carcinoma are Amino Acid Metabolism, Angiogenesis, PI3K-AKT-MTOR Signaling and others. Fluorouracil is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Amino Acid Metabolism, Angiogenesis, PI3K-AKT-MTOR Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Black-eyed Pea or Pigeon Pea?
Pulses are an important part of many diets. The active ingredients contained in Black-eyed Pea are Daidzein, Vitamin C, Oleic Acid, Linolenic Acid, Stigmasterol among others. While the active ingredients contained in Pigeon Pea are Vitamin C, Oleic Acid, Linolenic Acid, Linoleic Acid, Vitamin A and others.
Daidzein can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and MYC Signaling. Vitamin C has biological action on biochemical pathways Adherens junction, WNT Beta Catenin Signaling and P53 Signaling.
Vitamin A can manipulate biochemical pathways Focal Adhesion. Genistein has biological action on biochemical pathways DNA Repair and Oxidative Stress. And so on.
When treating Anal Squamous Cell Carcinoma with chemotherapy Fluorouracil – Foods like Black-eyed Pea are recommended compared to Pigeon Pea. This is because the active ingredients Vitamin A and Genistein in Pigeon Pea interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Daidzein and Vitamin C contained in Black-eyed Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: BLACK-EYED PEA IS RECOMMENDED OVER PIGEON PEA FOR ANAL SQUAMOUS CELL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY FLUOROURACIL FOR SOME CONDITIONS.
Eat more vegetables, Onion or Spinach?
Vegetables are an important part of many diets. The active ingredients contained in Onion are Quercetin, Isorhamnetin, Myricetin, Beta-sitosterol, Vitamin C among others. While the active ingredients contained in Spinach are Quercetin, Beta-sitosterol, Vitamin C, Oleic Acid, Apigenin and others.
Isorhamnetin can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Adherens junction. Myricetin has biological action on biochemical pathways DNA Repair, MYC Signaling and WNT Beta Catenin Signaling.
Apigenin can manipulate biochemical pathways Epithelial to Mesenchymal Transition, DNA Repair and Vitamin D Signaling. Quercetin has biological action on biochemical pathways Oxidative Stress. And so on.
When treating Anal Squamous Cell Carcinoma with chemotherapy Fluorouracil – Foods like Onion are recommended compared to Spinach. This is because the active ingredients Apigenin and Quercetin in Spinach interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Isorhamnetin and Myricetin contained in Onion support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: ONION IS RECOMMENDED OVER SPINACH FOR ANAL SQUAMOUS CELL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY FLUOROURACIL FOR SOME CONDITIONS.
Eat more fruits, Persimmon or Date?
Fruits are an important part of many diets. The active ingredients contained in Persimmon are Quercetin, Betulinic Acid, Lupeol, Vitamin C, Lycopene among others. While the active ingredients contained in Date are Quercetin, Lupeol, Beta-sitosterol, Vitamin C, Protocatechuic Acid and others.
Vitamin C can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Adherens junction and MYC Signaling. Lycopene has biological action on biochemical pathways NFKB Signaling, WNT Beta Catenin Signaling and P53 Signaling.
Quercetin can manipulate biochemical pathways Oxidative Stress. Protocatechuic Acid has biological action on biochemical pathways Oxidative Stress. And so on.
When treating Anal Squamous Cell Carcinoma with chemotherapy Fluorouracil – Foods like Persimmon are recommended compared to Date. This is because the active ingredients Quercetin and Protocatechuic Acid in Date interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Lycopene contained in Persimmon support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PERSIMMON IS RECOMMENDED OVER DATE FOR ANAL SQUAMOUS CELL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY FLUOROURACIL FOR SOME CONDITIONS.
Eat more nuts, Pecan Nut or Acorn?
Nuts are an important part of many diets. The active ingredients contained in Pecan Nut are Vitamin E, Oleic Acid, Cianidanol, Delphinidin, Linolenic Acid among others. While the active ingredients contained in Acorn are Quercetin, Beta-sitosterol, Vitamin C, Beta-carotene, Gallic Acid and others.
Vitamin E can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and DNA Repair. Cianidanol has biological action on biochemical pathways MYC Signaling, P53 Signaling and RUNX Signaling.
Quercetin can manipulate biochemical pathways Oxidative Stress. Beta-carotene has biological action on biochemical pathways MAPK Signaling and Notch Signaling. And so on.
When treating Anal Squamous Cell Carcinoma with chemotherapy Fluorouracil – Foods like Pecan Nut are recommended compared to Acorn. This is because the active ingredients Quercetin and Beta-carotene in Acorn interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin E and Cianidanol contained in Pecan Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER ACORN FOR ANAL SQUAMOUS CELL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY FLUOROURACIL FOR SOME CONDITIONS.
Foods for Genetic Risk of Anal Squamous Cell Carcinoma
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. EP300 and FBXW7 are two genes whose abnormalities are risk factors for Anal Squamous Cell Carcinoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Anal Squamous Cell Carcinoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Anal Squamous Cell Carcinoma gene EP300 has causative impact on biological pathways like G-protein-coupled Receptor Signaling and Immune Evasion Signaling. And FBXW7 has a causative impact on biological pathways like Antigen Presentation and Post Translation Modification. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like EP300 and FBXW7 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes EP300 and FBXW7 should be avoided.
Eat more pulses, Common Pea or Soy Bean?
The active ingredients contained in Common Pea are Lupeol, Daidzein, Beta-sitosterol, Vitamin C, Linolenic Acid among others. While the active ingredients contained in Soy Bean are Lupeol, Quercetin, Daidzein, Vitamin E, Beta-sitosterol and others.
Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin C has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Oncogenic Cancer Epigenetics.
Aescin can manipulate biochemical pathways Cell Cycle Checkpoints. Lecithin has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Anal Squamous Cell Carcinoma due to abnormalities in genes EP300 and FBXW7 – Foods like Common Pea are recommended compared to Soy Bean. This is because the active ingredients Aescin and Lecithin in Soy Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER SOY BEAN FOR REDUCING THE GENETIC RISK OF ANAL SQUAMOUS CELL CARCINOMA DUE TO GENES EP300 AND FBXW7
Eat more vegetables, Jicama or Radish?
The active ingredients contained in Jicama are Vitamin C, Beta-carotene, Vitamin B3, Vitamin A, Folic Acid among others. While the active ingredients contained in Radish are Quercetin, Beta-sitosterol, Vitamin C, Linolenic Acid, Salicylic Acid and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin B3 has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Apoptosis.
Pelargonidin can manipulate biochemical pathways MYC Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, P53 Signaling and RAS-RAF Signaling. And so on.
For genetic risk of Anal Squamous Cell Carcinoma due to abnormalities in genes EP300 and FBXW7 – Foods like Jicama are recommended compared to Radish. This is because the active ingredients Pelargonidin and Folic Acid in Radish further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Vitamin B3 contained in Jicama together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: JICAMA IS RECOMMENDED OVER RADISH FOR REDUCING THE GENETIC RISK OF ANAL SQUAMOUS CELL CARCINOMA DUE TO GENES EP300 AND FBXW7
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Kiwi or Cranberry?
The active ingredients contained in Kiwi are Quercetin, Vitamin C, Chlorogenic Acid, Fisetin, Vitamin A among others. While the active ingredients contained in Cranberry are Resveratrol, Ellagic Acid, Quercetin, Vitamin C, Hyperoside and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Chlorogenic Acid has biological action on biochemical pathways Oncogenic Cancer Epigenetics, PI3K-AKT-MTOR Signaling and MYC Signaling.
Resveratrol can manipulate biochemical pathways P53 Signaling. Ellagic Acid has biological action on biochemical pathways MYC Signaling. And so on.
For genetic risk of Anal Squamous Cell Carcinoma due to abnormalities in genes EP300 and FBXW7 – Foods like Kiwi are recommended compared to Cranberry. This is because the active ingredients Resveratrol and Ellagic Acid in Cranberry further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Chlorogenic Acid contained in Kiwi together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: KIWI IS RECOMMENDED OVER CRANBERRY FOR REDUCING THE GENETIC RISK OF ANAL SQUAMOUS CELL CARCINOMA DUE TO GENES EP300 AND FBXW7
Eat more nuts, Almond or Peanut?
The active ingredients contained in Almond are Quercetin, Vitamin E, Beta-sitosterol, Linolenic Acid, Salicylic Acid among others. While the active ingredients contained in Peanut are Quercetin, Vitamin E, Beta-sitosterol, Vitamin C, Linolenic Acid and others.
Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin E has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Apoptosis.
Lecithin can manipulate biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, P53 Signaling and Cell Cycle Checkpoints. And so on.
For genetic risk of Anal Squamous Cell Carcinoma due to abnormalities in genes EP300 and FBXW7 – Foods like Almond are recommended compared to Peanut. This is because the active ingredients Lecithin and Folic Acid in Peanut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin E contained in Almond together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: ALMOND IS RECOMMENDED OVER PEANUT FOR REDUCING THE GENETIC RISK OF ANAL SQUAMOUS CELL CARCINOMA DUE TO GENES EP300 AND FBXW7
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Anal Squamous Cell Carcinoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
- Mixed Allen 2018
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Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.