Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Uterine Serous Carcinoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Uterine Serous Carcinoma because of PPP2R1A and ZFHX3 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Uterine Serous Carcinoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Gooseberry” or “Include fruit Mulberry in my diet” or “Should I reduce consumption of vegetable Swiss Chard” or “Can I take Cissus and Turmeric supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO UTERINE SEROUS CARCINOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Uterine Serous Carcinoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR UTERINE SEROUS CARCINOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Uterine Serous Carcinoma
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Uterine Serous Carcinoma from cBioPortal. The patients enrolled in the studies for Uterine Serous Carcinoma are in ages between 45 to 87 with an average age of 70.From a patient sample size of 460; the top genes with mutations and other abnormalities for Uterine Serous Carcinoma include genes TP53, PIK3CA, PPP2R1A, ZFHX3 and CHD4. The occurrence frequency distribution for these genes respectively is 12.9%, 6.9%, 4.8%, 2.1% and 2.1%. These tumor genetic details of Uterine Serous Carcinoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Uterine Serous Carcinoma.
Significance of Nutrition for Uterine Serous Carcinoma
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Uterine Serous Carcinoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Gooseberry includes active ingredients Gallic Acid, Modified Citrus Pectin, Linolenic Acid, Vitamin C, Beta-sitosterol and others. And Mulberry contains active ingredients Resveratrol, Morusin, Moracin P, Deoxynojirimycin and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Uterine Serous Carcinoma, activation or inhibition of selected biochemical pathways like Angiogenesis, Hypoxia, PI3K-AKT-MTOR Signaling, MAPK Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Uterine Serous Carcinoma, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR UTERINE SEROUS CARCINOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Uterine Serous Carcinoma undergoing chemotherapy treatment
In Uterine Serous Carcinoma – the genes TP53, PIK3CA, PPP2R1A, ZFHX3 and CHD4 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Uterine Serous Carcinoma are Angiogenesis, Hypoxia, Extracellular Matrix Remodelling and others. Bevacizumab is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Angiogenesis, Hypoxia, Extracellular Matrix Remodelling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Adzuki Bean or Moth Bean?
Pulses are an important part of many diets. The active ingredients contained in Adzuki Bean are Isoliquiritigenin, Glucaric Acid, Genistein, Folic Acid among others. While the active ingredients contained in Moth Bean are Linolenic Acid, Beta-sitosterol, Stigmasterol, Oleic Acid, Vitamin A and others.
Glucaric Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Extracellular Matrix Remodelling and MYC Signaling. Isoliquiritigenin has biological action on biochemical pathways Chemokine Signaling, Growth Factor Signaling and TGFB Signaling.
Vitamin A can manipulate biochemical pathways Extracellular Matrix Remodelling, Notch Signaling and Focal Adhesion. Oleic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition, Cytoskeletal Dynamics and Extracellular Matrix Remodelling. And so on.
When treating Uterine Serous Carcinoma with chemotherapy Bevacizumab – Foods like Adzuki Bean are recommended compared to Moth Bean. This is because the active ingredients Vitamin A and Oleic Acid in Moth Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Glucaric Acid and Isoliquiritigenin contained in Adzuki Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: ADZUKI BEAN IS RECOMMENDED OVER MOTH BEAN FOR UTERINE SEROUS CARCINOMA ON TREATMENT WITH CHEMOTHERAPY BEVACIZUMAB FOR SOME CONDITIONS.
Eat more vegetables, Kohlrabi or Swiss Chard?
Vegetables are an important part of many diets. The active ingredients contained in Kohlrabi are Kaempferol, Linolenic Acid, Vitamin C, Brassinin, Beta-sitosterol among others. While the active ingredients contained in Swiss Chard are Caffeic Acid, Kaempferol, Melatonin, Ferulic Acid, P-coumaric Acid and others.
Vitamin C can manipulate biochemical pathways Epithelial to Mesenchymal Transition, MYC Signaling and WNT Beta Catenin Signaling. Brassinin has biological action on biochemical pathways Extracellular Matrix Remodelling, Chemokine Signaling and MAPK Signaling.
Vitamin A can manipulate biochemical pathways Extracellular Matrix Remodelling, Notch Signaling and Focal Adhesion. Caffeic Acid has biological action on biochemical pathways TGFB Signaling. And so on.
When treating Uterine Serous Carcinoma with chemotherapy Bevacizumab – Foods like Kohlrabi are recommended compared to Swiss Chard. This is because the active ingredients Vitamin A and Caffeic Acid in Swiss Chard interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Brassinin contained in Kohlrabi support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: KOHLRABI IS RECOMMENDED OVER SWISS CHARD FOR UTERINE SEROUS CARCINOMA ON TREATMENT WITH CHEMOTHERAPY BEVACIZUMAB FOR SOME CONDITIONS.
Eat more fruits, Mulberry or Gooseberry?
Fruits are an important part of many diets. The active ingredients contained in Mulberry are Resveratrol, Morusin, Moracin P, Deoxynojirimycin among others. While the active ingredients contained in Gooseberry are Gallic Acid, Modified Citrus Pectin, Linolenic Acid, Vitamin C, Beta-sitosterol and others.
Morusin can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Extracellular Matrix Remodelling and Growth Factor Signaling. Deoxynojirimycin has biological action on biochemical pathways Epithelial to Mesenchymal Transition and Extracellular Matrix Remodelling.
Rutin can manipulate biochemical pathways WNT Beta Catenin Signaling and Focal Adhesion. Oleic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition, Cytoskeletal Dynamics and Extracellular Matrix Remodelling. And so on.
When treating Uterine Serous Carcinoma with chemotherapy Bevacizumab – Foods like Mulberry are recommended compared to Gooseberry. This is because the active ingredients Rutin and Oleic Acid in Gooseberry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Morusin and Deoxynojirimycin contained in Mulberry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: MULBERRY IS RECOMMENDED OVER GOOSEBERRY FOR UTERINE SEROUS CARCINOMA ON TREATMENT WITH CHEMOTHERAPY BEVACIZUMAB FOR SOME CONDITIONS.
Eat more nuts, Pine Nut or Peanut?
Nuts are an important part of many diets. The active ingredients contained in Pine Nut are Vitamin E, Linolenic Acid, Beta-sitosterol, Oleic Acid, Vitamin A among others. While the active ingredients contained in Peanut are Quercetin, Vitamin E, Linolenic Acid, Gamma-linolenic Acid, Vitamin C and others.
Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, MYC Signaling and WNT Beta Catenin Signaling. Vitamin K has biological action on biochemical pathways PI3K-AKT-MTOR Signaling and MYC Signaling.
Vitamin A can manipulate biochemical pathways Extracellular Matrix Remodelling, Notch Signaling and Focal Adhesion. Lecithin has biological action on biochemical pathways Chemokine Signaling, Cytoskeletal Dynamics and MYC Signaling. And so on.
When treating Uterine Serous Carcinoma with chemotherapy Bevacizumab – Foods like Pine Nut are recommended compared to Peanut. This is because the active ingredients Vitamin A and Lecithin in Peanut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin K contained in Pine Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PINE NUT IS RECOMMENDED OVER PEANUT FOR UTERINE SEROUS CARCINOMA ON TREATMENT WITH CHEMOTHERAPY BEVACIZUMAB FOR SOME CONDITIONS.
Foods for Genetic Risk of Uterine Serous Carcinoma
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. PPP2R1A and ZFHX3 are two genes whose abnormalities are risk factors for Uterine Serous Carcinoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Uterine Serous Carcinoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Uterine Serous Carcinoma gene PPP2R1A has causative impact on biological pathways like Nutrient sensing, PI3K-AKT-MTOR Signaling and DNA Repair. And ZFHX3 has a causative impact on biological pathways like . Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like PPP2R1A and ZFHX3 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes PPP2R1A and ZFHX3 should be avoided.
Eat more pulses, Scarlet Bean or Pigeon Pea?
The active ingredients contained in Scarlet Bean are Oleic Acid, Linolenic Acid, Genistein, Beta-sitosterol, Liquiritigenin among others. While the active ingredients contained in Pigeon Pea are Oleic Acid, Linolenic Acid, Genistein, Vitamin C, Linoleic Acid and others.
Genistein can manipulate biochemical pathways Growth Factor Signaling, Chromatin Remodeling and PI3K-AKT-MTOR Signaling. Beta-sitosterol has biological action on biochemical pathways RUNX Signaling and PI3K-AKT-MTOR Signaling.
Linoleic Acid can manipulate biochemical pathways Growth Factor Signaling. Folic Acid has biological action on biochemical pathways MAPK Signaling and PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Uterine Serous Carcinoma due to abnormalities in genes PPP2R1A and ZFHX3 – Foods like Scarlet Bean are recommended compared to Pigeon Pea. This is because the active ingredients Linoleic Acid and Folic Acid in Pigeon Pea further promote the effects of genes on the biochemical pathways. While the active ingredients Genistein and Beta-sitosterol contained in Scarlet Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER PIGEON PEA FOR REDUCING THE GENETIC RISK OF UTERINE SEROUS CARCINOMA DUE TO GENES PPP2R1A AND ZFHX3
Eat more vegetables, Artichoke or Yam?
The active ingredients contained in Artichoke are Naringenin, Apigenin, Chlorogenic Acid, Luteolin, Vitamin C among others. While the active ingredients contained in Yam are Oleic Acid, Linolenic Acid, Beta-sitosterol, Vitamin C, Dioscin and others.
Vitamin K can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Naringenin has biological action on biochemical pathways Growth Factor Signaling, MAPK Signaling and Extracellular Matrix Remodelling.
Linoleic Acid can manipulate biochemical pathways Growth Factor Signaling. Folic Acid has biological action on biochemical pathways MAPK Signaling and PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Uterine Serous Carcinoma due to abnormalities in genes PPP2R1A and ZFHX3 – Foods like Artichoke are recommended compared to Yam. This is because the active ingredients Linoleic Acid and Folic Acid in Yam further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin K and Naringenin contained in Artichoke together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: ARTICHOKE IS RECOMMENDED OVER YAM FOR REDUCING THE GENETIC RISK OF UTERINE SEROUS CARCINOMA DUE TO GENES PPP2R1A AND ZFHX3
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Bilberry or Apricot?
The active ingredients contained in Bilberry are Delphinidin, Resveratrol, Quercetin, Myricetin, Gallic Acid among others. While the active ingredients contained in Apricot are Oleic Acid, Linolenic Acid, Quercetin, Glucaric Acid, Beta-sitosterol and others.
Delphinidin can manipulate biochemical pathways Growth Factor Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. Chlorogenic Acid has biological action on biochemical pathways RUNX Signaling, Extracellular Matrix Remodelling and MAPK Signaling.
Rutin can manipulate biochemical pathways Extracellular Matrix Remodelling. Linoleic Acid has biological action on biochemical pathways Growth Factor Signaling. And so on.
For genetic risk of Uterine Serous Carcinoma due to abnormalities in genes PPP2R1A and ZFHX3 – Foods like Bilberry are recommended compared to Apricot. This is because the active ingredients Rutin and Linoleic Acid in Apricot further promote the effects of genes on the biochemical pathways. While the active ingredients Delphinidin and Chlorogenic Acid contained in Bilberry together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: BILBERRY IS RECOMMENDED OVER APRICOT FOR REDUCING THE GENETIC RISK OF UTERINE SEROUS CARCINOMA DUE TO GENES PPP2R1A AND ZFHX3
Eat more nuts, Pecan Nut or Acorn?
The active ingredients contained in Pecan Nut are Cianidanol, Delphinidin, Vitamin E, Oleic Acid, Linolenic Acid among others. While the active ingredients contained in Acorn are Quercetin, Gallic Acid, Beta-sitosterol, Vitamin C, Quercitrin and others.
Cianidanol can manipulate biochemical pathways Growth Factor Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. Delphinidin has biological action on biochemical pathways Growth Factor Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling.
Beta-carotene can manipulate biochemical pathways MAPK Signaling. Folic Acid has biological action on biochemical pathways PI3K-AKT-MTOR Signaling and MAPK Signaling. And so on.
For genetic risk of Uterine Serous Carcinoma due to abnormalities in genes PPP2R1A and ZFHX3 – Foods like Pecan Nut are recommended compared to Acorn. This is because the active ingredients Beta-carotene and Folic Acid in Acorn further promote the effects of genes on the biochemical pathways. While the active ingredients Cianidanol and Delphinidin contained in Pecan Nut together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER ACORN FOR REDUCING THE GENETIC RISK OF UTERINE SEROUS CARCINOMA DUE TO GENES PPP2R1A AND ZFHX3
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Uterine Serous Carcinoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
- Pan Origimed 2020
- Pan-cancer analysis of whole genomes.
- Preventive effects of butyric acid, nicotinamide, calcium glucarate alone or in combination during the 7, 12-dimethylbenz (a) anthracene induced mouse skin tumorigenesis via modulation of K-Ras-PI3K-AKTpathway and associated micro RNAs.
- Effects of isoliquiritigenin on ovarian cancer cells.
- Adhesion to the extracellular matrix is positively regulated by retinoic acid in HepG2 cells.
- Oleic acid-induced ANGPTL4 enhances head and neck squamous cell carcinoma anoikis resistance and metastasis via up-regulation of fibronectin.
- Lambda gt22S, a phage expression vector for the directional cloning of cDNA by the use of a single restriction enzyme SfiI.
- 1-Deoxynojirimycin inhibits metastasis of B16F10 melanoma cells by attenuating the activity and expression of matrix metalloproteinases-2 and -9 and altering cell surface glycosylation.
- Flavonoids suppress human glioblastoma cell growth by inhibiting cell metabolism, migration, and by regulating extracellular matrix proteins and metalloproteinases expression.
- Vitamin C decreases VEGF expression levels via hypoxia‑inducible factor‑1α dependent and independent pathways in lens epithelial cells.
- Brassinin inhibits STAT3 signaling pathway through modulation of PIAS-3 and SOCS-3 expression and sensitizes human lung cancer xenograft in nude mice to paclitaxel.
- Synthesis and structure-activity relationship analysis of caffeic acid amides as selective matrix metalloproteinase inhibitors.
- β-Sitosterol and Gemcitabine Exhibit Synergistic Anti-pancreatic Cancer Activity by Modulating Apoptosis and Inhibiting Epithelial-Mesenchymal Transition by Deactivating Akt/GSK-3β Signaling.
- Research progress on the anticancer effects of vitamin K2.
- New concepts in phospholipase D signaling in inflammation and cancer.
- Peroxisome proliferator-activated receptor gamma (PPARgamma ) as a molecular target for the soy phytoestrogen genistein.
- Role of phospholipase D in migration and invasion induced by linoleic acid in breast cancer cells.
- Folic Acid Supports Pluripotency and Reprogramming by Regulating LIF/STAT3 and MAPK/ERK Signaling.
- Delphinidin Inhibits LPS-Induced MUC8 and MUC5B Expression Through Toll-like Receptor 4-Mediated ERK1/2 and p38 MAPK in Human Airway Epithelial Cells.
- Chlorogenic acid reduces liver inflammation and fibrosis through inhibition of toll-like receptor 4 signaling pathway.
- Naringenin attenuates the progression of liver fibrosis via inactivation of hepatic stellate cells and profibrogenic pathways.
- Molecular docking analysis of Cianidanol fromGinkgo biloba with HER2+ breast cancer target.
- Growth stimulation of human pulmonary adenocarcinoma cells and small airway epithelial cells by beta-carotene via activation of cAMP, PKA, CREB and ERK1/2.
- Determination of 1-deoxynojirimycin in mulberry leaves using hydrophilic interaction chromatography with evaporative light scattering detection.
- 1-Deoxynojirimycin in Mulberry (Morus indica L.) Leaves Ameliorates Stable Angina Pectoris in Patients With Coronary Heart Disease by Improving Antioxidant and Anti-inflammatory Capacities.
- Effects of mulberry leaf extract rich in 1-deoxynojirimycin on blood lipid profiles in humans.
- Effect of sodium nitrate loading on electrolyte transport by the renal tubule.
- HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.