Foods for Uterine Serous Carcinoma!

Introduction

Foods for Uterine Serous Carcinoma should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.

Serous uterine carcinoma, a subtype of uterine cancer, is known for its aggressive nature and varying survival rates, which are significantly influenced by the cancer’s stage at diagnosis. The pathology of uterine serous carcinoma, detailed in pathology outlines, reveals its distinct cellular characteristics. Symptoms often resemble those of less aggressive uterine diseases, making early detection challenging. Staging is crucial; uterine serous carcinoma stage 1a indicates a localized tumor, while stages 3 and 4 signify advanced disease with a poorer prognosis. Treatment typically involves a combination of surgery, chemotherapy, and radiation, tailored to the individual’s stage and overall health. The ICD-10 classification for uterine serous carcinoma aids in standardizing diagnosis and treatment approaches. Understanding what causes uterine serous carcinoma is an area of ongoing research, focusing on identifying potential risk factors and preventive measures. Early detection and prompt treatment are essential for improving survival rates and managing this serious cancer effectively.

For Uterine Serous Carcinoma does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Uterine Serous Carcinoma does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Uterine Serous Carcinoma?

For example does it matter if vegetable New Zealand Spinach is consumed more compared to White Cabbage? Does it make any difference if fruit Pummelo is preferred over Red Raspberry? Also if similar choices are made for nuts/seeds like Butternut over European Chestnut and for pulses like Moth Bean over Pigeon Pea. And if what I eat matters – then how does one identify foods which are recommended for Uterine Serous Carcinoma and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Uterine Serous Carcinoma!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Pummelo contains active ingredients Quercetin, Curcumin, Catechol, Caffeic Acid, Apigenin. And Red Raspberry contains active ingredients Quercetin, Ellagic Acid, Curcumin, Catechol, Daidzein and possibly others.

A common mistake made when deciding and choosing foods to eat for Uterine Serous Carcinoma – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Uterine Serous Carcinoma.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Uterine Serous Carcinoma?

Personalized nutrition for cancers like Uterine Serous Carcinoma consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Uterine Serous Carcinoma biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Characteristics of cancers like Uterine Serous Carcinoma

All cancers like Uterine Serous Carcinoma can be characterized by a unique set of biochemical pathways – the signature pathways of Uterine Serous Carcinoma. Biochemical pathways like Apoptosis, RAS-RAF Signaling, PI3K-AKT-MTOR Signaling, MAPK Signaling are part of the signature definition of Uterine Serous Carcinoma. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Uterine Serous Carcinoma need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Uterine Serous Carcinoma when taking cancer treatment Lenvatinib, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

TP53, PIK3CA, PPP2R1A, ZFHX3 and CHD4 are the top ranked reported genes for Uterine Serous Carcinoma. TP53 is reported in 12.9 % of the representative patients across all clinical trials. And PIK3CA is reported in 6.9 %. The combined population patient data cover ages from 45 to 87. 0.0 % of the patient data are identified as men. The Uterine Serous Carcinoma biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Food and Supplements for Uterine Serous Carcinoma

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable NEW ZEALAND SPINACH or WHITE CABBAGE?

Vegetable New Zealand Spinach contains many active ingredients or bioactives such as Quercetin, Myricetin, Curcumin, Catechol, Caffeic Acid. These active ingredients manipulate various biochemical pathways like TGFB Signaling, Focal Adhesion and Chemokine Signaling and others. New Zealand Spinach is recommended for Uterine Serous Carcinoma when ongoing cancer treatment is Lenvatinib. This is because New Zealand Spinach modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Lenvatinib.

Some of the active ingredients or bioactives in vegetable White Cabbage are Quercetin, Curcumin, Catechol, Caffeic Acid, Benzyl Isothiocyanate. These active ingredients manipulate various biochemical pathways like TGFB Signaling and Oxidative Stress and others. White Cabbage is not recommended for Uterine Serous Carcinoma when ongoing cancer treatment is Lenvatinib because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE NEW ZEALAND SPINACH IS RECOMMENDED OVER WHITE CABBAGE FOR Uterine Serous Carcinoma AND TREATMENT Lenvatinib.

Choose Fruit RED RASPBERRY or PUMMELO?

Fruit Red Raspberry contains many active ingredients or bioactives such as Quercetin, Ellagic Acid, Curcumin, Catechol, Daidzein. These active ingredients manipulate various biochemical pathways like TGFB Signaling, Epithelial to Mesenchymal Transition, Angiogenesis and Focal Adhesion and others. Red Raspberry is recommended for Uterine Serous Carcinoma when ongoing cancer treatment is Lenvatinib. This is because Red Raspberry modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Lenvatinib.

Some of the active ingredients or bioactives in fruit Pummelo are Quercetin, Curcumin, Catechol, Caffeic Acid, Apigenin. These active ingredients manipulate various biochemical pathways like Oxidative Stress and others. Pummelo is not recommended for Uterine Serous Carcinoma when ongoing cancer treatment is Lenvatinib because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT RED RASPBERRY IS RECOMMENDED OVER PUMMELO FOR Uterine Serous Carcinoma AND TREATMENT Lenvatinib.

Choose Nut BUTTERNUT or EUROPEAN CHESTNUT?

Butternut contains many active ingredients or bioactives such as Myricetin, Curcumin, Catechol, Caffeic Acid, Apigenin. These active ingredients manipulate various biochemical pathways like TGFB Signaling, Growth Factor Signaling, Focal Adhesion and Cytoskeletal Dynamics and others. Butternut is recommended for Uterine Serous Carcinoma when ongoing cancer treatment is Lenvatinib. This is because Butternut modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Lenvatinib.

Some of the active ingredients or bioactives in European Chestnut are Quercetin, Ellagic Acid, Myricetin, Curcumin, Catechol. These active ingredients manipulate various biochemical pathways like TGFB Signaling and Oxidative Stress and others. European Chestnut is not recommended for Uterine Serous Carcinoma when ongoing cancer treatment is Lenvatinib because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

BUTTERNUT IS RECOMMENDED OVER EUROPEAN CHESTNUT FOR Uterine Serous Carcinoma AND TREATMENT Lenvatinib.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Uterine Serous Carcinoma or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable CALABASH or COMMON BEET?

Vegetable Calabash contains many active ingredients or bioactives such as Apigenin, Curcumin, Lupeol, Daidzein, Formononetin. These active ingredients manipulate various biochemical pathways like Cell Cycle, Stem Cell Signaling, P53 Signaling and MAPK Signaling and others. Calabash is recommended for risk of Uterine Serous Carcinoma when associated genetic risk is CHD4. This is because Calabash increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Common Beet are Apigenin, Curcumin, Lupeol, Daidzein, Formononetin. These active ingredients manipulate various biochemical pathways like Growth Factor Signaling and Insulin Signaling and others. Common Beet is not recommended when risk of Uterine Serous Carcinoma when associated genetic risk is CHD4 because it increases the signature pathways of it.

VEGETABLE CALABASH IS RECOMMENDED OVER COMMON BEET FOR CHD4 GENETIC RISK OF CANCER.

Choose Fruit WATERMELON or FIG?

Fruit Watermelon contains many active ingredients or bioactives such as Curcumin, Lupeol, Daidzein, Formononetin, Beta-sitosterol. These active ingredients manipulate various biochemical pathways like Cell Cycle, P53 Signaling and Insulin Signaling and others. Watermelon is recommended for risk of Uterine Serous Carcinoma when associated genetic risk is CHD4. This is because Watermelon increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Fig are Curcumin, Quercetin, Lupeol, Daidzein, Formononetin. These active ingredients manipulate various biochemical pathways like MAPK Signaling, Extracellular Matrix Remodelling and PI3K-AKT-MTOR Signaling and others. Fig is not recommended when risk of Uterine Serous Carcinoma when associated genetic risk is CHD4 because it increases the signature pathways of it.

FRUIT WATERMELON IS RECOMMENDED OVER FIG FOR CHD4 GENETIC RISK OF CANCER.

Choose Nut COMMON WALNUT or CHESTNUT?

Common Walnut contains many active ingredients or bioactives such as Curcumin, Quercetin, Ellagic Acid, Lupeol, Daidzein. These active ingredients manipulate various biochemical pathways like Cell Cycle, P53 Signaling and Insulin Signaling and others. Common Walnut is recommended for risk of Uterine Serous Carcinoma when associated genetic risk is CHD4. This is because Common Walnut increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in Chestnut are Apigenin, Curcumin, Ellagic Acid, Lupeol, Daidzein. These active ingredients manipulate various biochemical pathways like Extracellular Matrix Remodelling and Cell Cycle Checkpoints and others. Chestnut is not recommended when risk of Uterine Serous Carcinoma when associated genetic risk is CHD4 because it increases the signature pathways of it.

COMMON WALNUT IS RECOMMENDED OVER CHESTNUT FOR CHD4 GENETIC RISK OF CANCER.

In Conclusion

Foods and Supplements chosen are important decisions for cancers like Uterine Serous Carcinoma. Uterine Serous Carcinoma patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Uterine Serous Carcinoma, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like New Zealand Spinach contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Uterine Serous Carcinoma?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.

References

• Pan Origimed 2020
• Pan-cancer analysis of whole genomes.
• Modulation of HER2 expression by ferulic acid on human breast cancer MCF7 cells.