Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Urachal Adenocarcinoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Urachal Adenocarcinoma because of NFE2L2 and GNAS gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Urachal Adenocarcinoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Coconut” or “Include fruit Cloudberry in my diet” or “Should I reduce consumption of vegetable Cauliflower” or “Can I take Dim and Diosmin supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO URACHAL ADENOCARCINOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Urachal Adenocarcinoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR URACHAL ADENOCARCINOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Urachal Adenocarcinoma
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Urachal Adenocarcinoma from cBioPortal. From a patient sample size of 3; the top genes with mutations and other abnormalities for Urachal Adenocarcinoma include genes NFE2L2, TP53, GNAS, IKZF1 and KRAS. The occurrence frequency distribution for these genes respectively is 50.0%, 50.0%, 50.0%, 50.0% and 50.0%. These tumor genetic details of Urachal Adenocarcinoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Urachal Adenocarcinoma.
Significance of Nutrition for Urachal Adenocarcinoma
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Urachal Adenocarcinoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Coconut includes active ingredients Beta-sitosterol, Vitamin E, Palmitic Acid, Capric Acid, Lauric Acid and others. And Cloudberry contains active ingredients Vitamin C, Ellagic Acid, Urolithin B, Vitamin A and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Urachal Adenocarcinoma, activation or inhibition of selected biochemical pathways like Cell Cycle Checkpoints, Apoptosis, Oxidative Stress, PI3K-AKT-MTOR Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Urachal Adenocarcinoma, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR URACHAL ADENOCARCINOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Urachal Adenocarcinoma undergoing chemotherapy treatment
In Urachal Adenocarcinoma – the genes NFE2L2, TP53, GNAS, IKZF1 and KRAS have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Urachal Adenocarcinoma are Cell Cycle Checkpoints, Apoptosis, MAPK Signaling and others. Cisplatin is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Cell Cycle Checkpoints, Apoptosis, MAPK Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Scarlet Bean or Fava Bean?
Pulses are an important part of many diets. The active ingredients contained in Scarlet Bean are Beta-sitosterol, Vitamin C, Stigmasterol, Linolenic Acid, Oleic Acid among others. While the active ingredients contained in Fava Bean are Daidzein, Beta-sitosterol, Vitamin C, Stigmasterol, Ferulic Acid and others.
Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin C has biological action on biochemical pathways Cell Cycle Checkpoints, MAPK Signaling and PI3K-AKT-MTOR Signaling.
Cianidanol can manipulate biochemical pathways Oxidative Stress. P-coumaric Acid has biological action on biochemical pathways Oxidative Stress. And so on.
When treating Urachal Adenocarcinoma with chemotherapy Cisplatin – Foods like Scarlet Bean are recommended compared to Fava Bean. This is because the active ingredients Cianidanol and P-coumaric Acid in Fava Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Scarlet Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER FAVA BEAN FOR URACHAL ADENOCARCINOMA ON TREATMENT WITH CHEMOTHERAPY CISPLATIN FOR SOME CONDITIONS.
Eat more vegetables, Cassava or Cauliflower?
Vegetables are an important part of many diets. The active ingredients contained in Cassava are Beta-sitosterol, Vitamin C, Linolenic Acid, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Cauliflower are Beta-sitosterol, Vitamin C, Brassinin, Linolenic Acid, Oleic Acid and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Beta-sitosterol has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Oxidative Stress.
Brassinin can manipulate biochemical pathways Oxidative Stress. Citric Acid has biological action on biochemical pathways Oxidative Stress. And so on.
When treating Urachal Adenocarcinoma with chemotherapy Cisplatin – Foods like Cassava are recommended compared to Cauliflower. This is because the active ingredients Brassinin and Citric Acid in Cauliflower interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Beta-sitosterol contained in Cassava support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: CASSAVA IS RECOMMENDED OVER CAULIFLOWER FOR URACHAL ADENOCARCINOMA ON TREATMENT WITH CHEMOTHERAPY CISPLATIN FOR SOME CONDITIONS.
Eat more fruits, Cloudberry or Coconut?
Fruits are an important part of many diets. The active ingredients contained in Cloudberry are Vitamin C, Ellagic Acid, Urolithin B, Vitamin A among others. While the active ingredients contained in Coconut are Beta-sitosterol, Vitamin E, Palmitic Acid, Capric Acid, Lauric Acid and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin A has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Oxidative Stress.
Palmitic Acid can manipulate biochemical pathways MAPK Signaling. Lauric Acid has biological action on biochemical pathways MYC Signaling, PI3K-AKT-MTOR Signaling and MAPK Signaling. And so on.
When treating Urachal Adenocarcinoma with chemotherapy Cisplatin – Foods like Cloudberry are recommended compared to Coconut. This is because the active ingredients Palmitic Acid and Lauric Acid in Coconut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Vitamin A contained in Cloudberry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: CLOUDBERRY IS RECOMMENDED OVER COCONUT FOR URACHAL ADENOCARCINOMA ON TREATMENT WITH CHEMOTHERAPY CISPLATIN FOR SOME CONDITIONS.
Eat more nuts, Pistachio or Cashew Nut?
Nuts are an important part of many diets. The active ingredients contained in Pistachio are Beta-sitosterol, Vitamin E, Stigmasterol, Linolenic Acid, Oleic Acid among others. While the active ingredients contained in Cashew Nut are Beta-sitosterol, Vitamin C, Palmitic Acid, Butyric Acid, Lauric Acid and others.
Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin E has biological action on biochemical pathways Cell Cycle Checkpoints, MAPK Signaling and PI3K-AKT-MTOR Signaling.
Palmitic Acid can manipulate biochemical pathways MAPK Signaling. Lauric Acid has biological action on biochemical pathways MYC Signaling, PI3K-AKT-MTOR Signaling and MAPK Signaling. And so on.
When treating Urachal Adenocarcinoma with chemotherapy Cisplatin – Foods like Pistachio are recommended compared to Cashew Nut. This is because the active ingredients Palmitic Acid and Lauric Acid in Cashew Nut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin E contained in Pistachio support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PISTACHIO IS RECOMMENDED OVER CASHEW NUT FOR URACHAL ADENOCARCINOMA ON TREATMENT WITH CHEMOTHERAPY CISPLATIN FOR SOME CONDITIONS.
Foods for Genetic Risk of Urachal Adenocarcinoma
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. NFE2L2 and GNAS are two genes whose abnormalities are risk factors for Urachal Adenocarcinoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Urachal Adenocarcinoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Urachal Adenocarcinoma gene NFE2L2 has causative impact on biological pathways like Oxidative Stress and Immune Checkpoints. And GNAS has a causative impact on biological pathways like G-protein-coupled Receptor Signaling, Reproductive Hormone Signaling and Gonadotropin-releasing hormone. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like NFE2L2 and GNAS should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes NFE2L2 and GNAS should be avoided.
Eat more pulses, Hyacinth Bean or Soy Bean?
The active ingredients contained in Hyacinth Bean are Palmitic Acid, Vitamin C, Genistein, Myristic Acid, Folic Acid among others. While the active ingredients contained in Soy Bean are Lupeol, Daidzein, Beta-sitosterol, Vitamin E, Oleic Acid and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Genistein has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and MYC Signaling.
Aescin can manipulate biochemical pathways Cell Cycle Checkpoints. Lecithin has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Urachal Adenocarcinoma due to abnormalities in genes NFE2L2 and GNAS – Foods like Hyacinth Bean are recommended compared to Soy Bean. This is because the active ingredients Aescin and Lecithin in Soy Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Genistein contained in Hyacinth Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: HYACINTH BEAN IS RECOMMENDED OVER SOY BEAN FOR REDUCING THE GENETIC RISK OF URACHAL ADENOCARCINOMA DUE TO GENES NFE2L2 AND GNAS
Eat more vegetables, Giant Butterbur or Purslane?
The active ingredients contained in Giant Butterbur are Beta-sitosterol, Vitamin C, Vitamin B3, Melatonin, Vitamin A among others. While the active ingredients contained in Purslane are Oleic Acid, Vitamin C, Linolenic Acid, Linoleic Acid, Vitamin A and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Beta-sitosterol has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Oxidative Stress.
Citric Acid can manipulate biochemical pathways Oxidative Stress. Linolenic Acid has biological action on biochemical pathways Oxidative Stress. And so on.
For genetic risk of Urachal Adenocarcinoma due to abnormalities in genes NFE2L2 and GNAS – Foods like Giant Butterbur are recommended compared to Purslane. This is because the active ingredients Citric Acid and Linolenic Acid in Purslane further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Giant Butterbur together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: GIANT BUTTERBUR IS RECOMMENDED OVER PURSLANE FOR REDUCING THE GENETIC RISK OF URACHAL ADENOCARCINOMA DUE TO GENES NFE2L2 AND GNAS
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Naranjilla or Bilberry?
The active ingredients contained in Naranjilla are Zeaxanthin, Beta-carotene, Vitamin A among others. While the active ingredients contained in Bilberry are Resveratrol, P-coumaric Acid, Arbutin, Caffeic Acid, Ursolic Acid and others.
Beta-carotene can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin A has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Oxidative Stress.
Arbutin can manipulate biochemical pathways Oxidative Stress. Chlorogenic Acid has biological action on biochemical pathways Oxidative Stress. And so on.
For genetic risk of Urachal Adenocarcinoma due to abnormalities in genes NFE2L2 and GNAS – Foods like Naranjilla are recommended compared to Bilberry. This is because the active ingredients Arbutin and Chlorogenic Acid in Bilberry further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-carotene and Vitamin A contained in Naranjilla together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: NARANJILLA IS RECOMMENDED OVER BILBERRY FOR REDUCING THE GENETIC RISK OF URACHAL ADENOCARCINOMA DUE TO GENES NFE2L2 AND GNAS
Eat more nuts, Hazelnut or Walnut?
The active ingredients contained in Hazelnut are Vitamin E, Oleic Acid, Linolenic Acid, Linoleic Acid, Vitamin A among others. While the active ingredients contained in Walnut are D-limonene, Betulinic Acid, Protocatechuic Acid, Beta-sitosterol, Juglone and others.
Vitamin E can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin A has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Oxidative Stress.
D-limonene can manipulate biochemical pathways Oxidative Stress. Juglone has biological action on biochemical pathways Oxidative Stress. And so on.
For genetic risk of Urachal Adenocarcinoma due to abnormalities in genes NFE2L2 and GNAS – Foods like Hazelnut are recommended compared to Walnut. This is because the active ingredients D-limonene and Juglone in Walnut further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin E and Vitamin A contained in Hazelnut together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: HAZELNUT IS RECOMMENDED OVER WALNUT FOR REDUCING THE GENETIC RISK OF URACHAL ADENOCARCINOMA DUE TO GENES NFE2L2 AND GNAS
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Urachal Adenocarcinoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
- Msk Impact 2017
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- The recruitment of Raf-1 to membranes is mediated by direct interaction with phosphatidic acid and is independent of association with Ras.
- The effect of Pasteurella haemolytica cytotoxin on bovine polymorphonuclear leukocytes can be attenuated by beta-adrenoceptor antagonists.
- Decrease of intracellular ROS by arbutin is associated with apoptosis induction and downregulation of IL-1β and TNF-α in LNCaP; prostate cancer.
- Natural Polyphenol Chlorogenic Acid Protects Against Acetaminophen-Induced Hepatotoxicity by Activating ERK/Nrf2 Antioxidative Pathway.
- Alpha-linolenic acid confers protection on mice renal cells against cisplatin-induced nephrotoxicity.
- Protective Effect of D-Limonene against Oxidative Stress-Induced Cell Damage in Human Lens Epithelial Cells via the p38 Pathway.
- ROS -mediated p53 activation by juglone enhances apoptosis and autophagy in vivo and in vitro.
- HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.