Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Richter Syndrome when undergoing chemotherapy or when you determine you have a genetic risk for developing Richter Syndrome because of MYC and BDKRB1 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Richter Syndrome which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Lingonberry” or “Include fruit Star Fruit in my diet” or “Should I reduce consumption of vegetable Beetroot” or “Can I take Thunder God and Artemisinine supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO RICHTER SYNDROME, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Richter Syndrome is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR RICHTER SYNDROME, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Richter Syndrome
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Richter Syndrome from cBioPortal. The top genes with mutations and other abnormalities for Richter Syndrome include genes MYC, NOTCH1, BDKRB1, BRAF and CDKN2A. The occurrence frequency distribution for these genes respectively is 57.1%, 35.7%, 35.7%, 35.7% and 35.7%. These tumor genetic details of Richter Syndrome are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Richter Syndrome.
Significance of Nutrition for Richter Syndrome
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Richter Syndrome. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Lingonberry includes active ingredients Vitamin C, Hyperoside, Quercetin, Linolenic Acid, Linoleic Acid and others. And Star Fruit contains active ingredients Beta-sitosterol, Vitamin C, Linolenic Acid, Linoleic Acid, Oleic Acid and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Richter Syndrome, activation or inhibition of selected biochemical pathways like Amino Acid Metabolism, Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling, Cell Cycle plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Richter Syndrome, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR RICHTER SYNDROME – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Richter Syndrome undergoing chemotherapy treatment
In Richter Syndrome – the genes MYC, NOTCH1, BDKRB1, BRAF and CDKN2A have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Richter Syndrome are Amino Acid Metabolism, Cell Cycle Checkpoints, Apoptosis and others. Doxorubicin is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Amino Acid Metabolism, Cell Cycle Checkpoints, Apoptosis so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Scarlet Bean or Common Bean?
Pulses are an important part of many diets. The active ingredients contained in Scarlet Bean are Beta-sitosterol, Vitamin C, Stigmasterol, Linolenic Acid, Linoleic Acid among others. While the active ingredients contained in Common Bean are Apigenin, Esculin, Vitamin C, P-coumaric Acid, Ferulic Acid and others.
Beta-sitosterol can manipulate biochemical pathways NFKB Signaling, Apoptosis and DNA Repair. Vitamin C has biological action on biochemical pathways MYC Signaling, P53 Signaling and Cell Cycle Checkpoints.
Apigenin can manipulate biochemical pathways Vitamin D Signaling and DNA Repair. Esculin has biological action on biochemical pathways DNA Repair. And so on.
When treating Richter Syndrome with chemotherapy Doxorubicin – Foods like Scarlet Bean are recommended compared to Common Bean. This is because the active ingredients Apigenin and Esculin in Common Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Scarlet Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER COMMON BEAN FOR RICHTER SYNDROME ON TREATMENT WITH CHEMOTHERAPY DOXORUBICIN FOR SOME CONDITIONS.
Eat more vegetables, Towel Gourd or Beetroot?
Vegetables are an important part of many diets. The active ingredients contained in Towel Gourd are Vitamin C, Vitamin B3, Linoleic Acid, Oleic Acid, Vitamin A among others. While the active ingredients contained in Beetroot are Vitamin E, Beta-sitosterol, Vitamin C, Linolenic Acid, Linoleic Acid and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin B3 has biological action on biochemical pathways NFKB Signaling, DNA Repair and Cell Cycle Checkpoints.
Linolenic Acid can manipulate biochemical pathways Vitamin D Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. And so on.
When treating Richter Syndrome with chemotherapy Doxorubicin – Foods like Towel Gourd are recommended compared to Beetroot. This is because the active ingredients Linolenic Acid and Folic Acid in Beetroot interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Vitamin B3 contained in Towel Gourd support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: TOWEL GOURD IS RECOMMENDED OVER BEETROOT FOR RICHTER SYNDROME ON TREATMENT WITH CHEMOTHERAPY DOXORUBICIN FOR SOME CONDITIONS.
Eat more fruits, Star Fruit or Lingonberry?
Fruits are an important part of many diets. The active ingredients contained in Star Fruit are Beta-sitosterol, Vitamin C, Linolenic Acid, Linoleic Acid, Oleic Acid among others. While the active ingredients contained in Lingonberry are Vitamin C, Hyperoside, Quercetin, Linolenic Acid, Linoleic Acid and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Beta-sitosterol has biological action on biochemical pathways NFKB Signaling, DNA Repair and Cell Cycle Checkpoints.
Resveratrol can manipulate biochemical pathways P53 Signaling and DNA Repair. Arbutin has biological action on biochemical pathways DNA Repair. And so on.
When treating Richter Syndrome with chemotherapy Doxorubicin – Foods like Star Fruit are recommended compared to Lingonberry. This is because the active ingredients Resveratrol and Arbutin in Lingonberry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Beta-sitosterol contained in Star Fruit support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: STAR FRUIT IS RECOMMENDED OVER LINGONBERRY FOR RICHTER SYNDROME ON TREATMENT WITH CHEMOTHERAPY DOXORUBICIN FOR SOME CONDITIONS.
Eat more nuts, Almond or Chestnut?
Nuts are an important part of many diets. The active ingredients contained in Almond are Vitamin E, Beta-sitosterol, Stigmasterol, Vitamin B3, Salicylic Acid among others. While the active ingredients contained in Chestnut are Vitamin C, Ellagic Acid, Quercetin, Linolenic Acid, Gallic Acid and others.
Beta-sitosterol can manipulate biochemical pathways NFKB Signaling, Apoptosis and DNA Repair. Vitamin E has biological action on biochemical pathways Notch Signaling, MYC Signaling and P53 Signaling.
Ellagic Acid can manipulate biochemical pathways MYC Signaling and Vitamin D Signaling. Gallic Acid has biological action on biochemical pathways Vitamin D Signaling. And so on.
When treating Richter Syndrome with chemotherapy Doxorubicin – Foods like Almond are recommended compared to Chestnut. This is because the active ingredients Ellagic Acid and Gallic Acid in Chestnut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin E contained in Almond support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: ALMOND IS RECOMMENDED OVER CHESTNUT FOR RICHTER SYNDROME ON TREATMENT WITH CHEMOTHERAPY DOXORUBICIN FOR SOME CONDITIONS.
Foods for Genetic Risk of Richter Syndrome
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. MYC and BDKRB1 are two genes whose abnormalities are risk factors for Richter Syndrome. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Richter Syndrome can be used as a guide for coming up with a recommended personalized nutrition plan. For Richter Syndrome gene MYC has causative impact on biological pathways like Noncoding RNA Signaling and MAPK Signaling. And BDKRB1 has a causative impact on biological pathways like Cytoskeletal Dynamics. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like MYC and BDKRB1 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes MYC and BDKRB1 should be avoided.
Eat more pulses, Yellow Wax Bean or Pigeon Pea?
The active ingredients contained in Yellow Wax Bean are Vitamin C, Palmitic Acid, Ferulic Acid, Cianidanol, Vitamin A among others. While the active ingredients contained in Pigeon Pea are Vitamin C, Linoleic Acid, Linolenic Acid, Oleic Acid, Vitamin A and others.
Palmitic Acid can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin A has biological action on biochemical pathways Vitamin D Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.
Linolenic Acid can manipulate biochemical pathways Vitamin D Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. And so on.
For genetic risk of Richter Syndrome due to abnormalities in genes MYC and BDKRB1 – Foods like Yellow Wax Bean are recommended compared to Pigeon Pea. This is because the active ingredients Linolenic Acid and Folic Acid in Pigeon Pea further promote the effects of genes on the biochemical pathways. While the active ingredients Palmitic Acid and Vitamin A contained in Yellow Wax Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: YELLOW WAX BEAN IS RECOMMENDED OVER PIGEON PEA FOR REDUCING THE GENETIC RISK OF RICHTER SYNDROME DUE TO GENES MYC AND BDKRB1
Eat more vegetables, Mexican Groundcherry or Bell Pepper?
The active ingredients contained in Mexican Groundcherry are Vitamin C, Vitamin B3 among others. While the active ingredients contained in Bell Pepper are Vitamin E, Vitamin C, P-coumaric Acid, Capsaicin, Linolenic Acid and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin B3 has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Apoptosis.
Linolenic Acid can manipulate biochemical pathways Vitamin D Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. And so on.
For genetic risk of Richter Syndrome due to abnormalities in genes MYC and BDKRB1 – Foods like Mexican Groundcherry are recommended compared to Bell Pepper. This is because the active ingredients Linolenic Acid and Folic Acid in Bell Pepper further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Vitamin B3 contained in Mexican Groundcherry together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: MEXICAN GROUNDCHERRY IS RECOMMENDED OVER BELL PEPPER FOR REDUCING THE GENETIC RISK OF RICHTER SYNDROME DUE TO GENES MYC AND BDKRB1
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Feijoa or Cranberry?
The active ingredients contained in Feijoa are Lycopene, Vitamin C, Casuarinin, Folic Acid among others. While the active ingredients contained in Cranberry are Vitamin C, P-coumaric Acid, Hyperoside, Resveratrol, Quercetin and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Lycopene has biological action on biochemical pathways Cell Cycle Checkpoints, Vitamin D Signaling and PI3K-AKT-MTOR Signaling.
Resveratrol can manipulate biochemical pathways P53 Signaling. Ellagic Acid has biological action on biochemical pathways MYC Signaling and Vitamin D Signaling. And so on.
For genetic risk of Richter Syndrome due to abnormalities in genes MYC and BDKRB1 – Foods like Feijoa are recommended compared to Cranberry. This is because the active ingredients Resveratrol and Ellagic Acid in Cranberry further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Lycopene contained in Feijoa together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: FEIJOA IS RECOMMENDED OVER CRANBERRY FOR REDUCING THE GENETIC RISK OF RICHTER SYNDROME DUE TO GENES MYC AND BDKRB1
Eat more nuts, Hazelnut or Cashew Nut?
The active ingredients contained in Hazelnut are Vitamin E, Linoleic Acid, Linolenic Acid, Oleic Acid, Quercetin among others. While the active ingredients contained in Cashew Nut are Beta-sitosterol, Vitamin C, Palmitic Acid, Butyric Acid, Gallic Acid and others.
Vitamin E can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Quercetin has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Apoptosis.
Lauric Acid can manipulate biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. Myristic Acid has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and Apoptosis. And so on.
For genetic risk of Richter Syndrome due to abnormalities in genes MYC and BDKRB1 – Foods like Hazelnut are recommended compared to Cashew Nut. This is because the active ingredients Lauric Acid and Myristic Acid in Cashew Nut further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin E and Quercetin contained in Hazelnut together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: HAZELNUT IS RECOMMENDED OVER CASHEW NUT FOR REDUCING THE GENETIC RISK OF RICHTER SYNDROME DUE TO GENES MYC AND BDKRB1
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Richter Syndrome by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
- Plant sterols as selective DNA polymerase beta lyase inhibitors and potentiators of bleomycin cytotoxicity.
- Vitamin C enhances epigenetic modifications induced by 5-azacytidine and cell cycle arrest in the hepatocellular carcinoma cell lines HLE and Huh7.
- Resveratrol, a remarkable inhibitor of ribonucleotide reductase.
- Effects of chemopreventive natural products on non-homologous end-joining DNA double-strand break repair.
- Concurrent acetylation of FoxO1/3a and p53 due to sirtuins inhibition elicit Bim/PUMA mediated mitochondrial dysfunction and apoptosis in berberine-treated HepG2 cells.
- Effects of folate deficiency on gene expression in the apoptosis and cancer pathways in colon cancer cells.
- Gamma- and delta-tocotrienols exert a more potent anticancer effect than alpha-tocopheryl succinate on breast cancer cell lines irrespective of HER-2/neu expression.
- Identification of ellagic acid as potent inhibitor of protein kinase CK2: a successful example of a virtual screening application.
- A redox-resistant sirtuin-1 mutant protects against hepatic metabolic and oxidant stress.
- Transcriptional activation of the cyclin-dependent kinase inhibitor p21 by PML/RARalpha.
- Lycopene metabolite, apo-10′-lycopenoic acid, inhibits diethylnitrosamine-initiated, high fat diet-promoted hepatic inflammation and tumorigenesis in mice.
- Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin.
- Clinical pharmacodynamics of antihistamines.
- Saturated fatty acids modulate cell response to DNA damage: implication for their role in tumorigenesis.
- HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.