Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Fibrolamellar Carcinoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Fibrolamellar Carcinoma because of EIF4A2 and EPHA5 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Fibrolamellar Carcinoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Elderberry” or “Include fruit Rowanberry in my diet” or “Should I reduce consumption of vegetable Chinese Mustard” or “Can I take Modified Citrus Pectin and D-limonene supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO FIBROLAMELLAR CARCINOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Fibrolamellar Carcinoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR FIBROLAMELLAR CARCINOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Fibrolamellar Carcinoma
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Fibrolamellar Carcinoma from cBioPortal. The patients enrolled in the studies for Fibrolamellar Carcinoma are in ages between 14 to 25 with an average age of 18. 48.1% of males and 51.9% of females were the distribution of gender in these clinical studies. From a patient sample size of 27; the top genes with mutations and other abnormalities for Fibrolamellar Carcinoma include genes TERT, EIF4A2, EPHA5, NOTCH1 and RASA1. The occurrence frequency distribution for these genes respectively is 25.0%, 12.5%, 12.5%, 12.5% and 12.5%. These tumor genetic details of Fibrolamellar Carcinoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Fibrolamellar Carcinoma.
Significance of Nutrition for Fibrolamellar Carcinoma
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Fibrolamellar Carcinoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Elderberry includes active ingredients Quercetin, Lupeol, Betulinic Acid, Linolenic Acid, Vitamin C and others. And Rowanberry contains active ingredients Quercetin, Chlorogenic Acid and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Fibrolamellar Carcinoma, activation or inhibition of selected biochemical pathways like RAS-RAF Signaling, Focal Adhesion, MAPK Signaling, DNA Repair plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Fibrolamellar Carcinoma, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR FIBROLAMELLAR CARCINOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Fibrolamellar Carcinoma undergoing chemotherapy treatment
In Fibrolamellar Carcinoma – the genes TERT, EIF4A2, EPHA5, NOTCH1 and RASA1 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Fibrolamellar Carcinoma are RAS-RAF Signaling, Focal Adhesion, DNA Repair and others. Radiation is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers RAS-RAF Signaling, Focal Adhesion, DNA Repair so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Winged Bean or Black-eyed Pea?
Pulses are an important part of many diets. The active ingredients contained in Winged Bean are Betulinic Acid, Linolenic Acid, Vitamin C, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Black-eyed Pea are Daidzein, Linolenic Acid, Vitamin C, Oleic Acid, Genistein and others.
Betulinic Acid can manipulate biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. Vitamin C has biological action on biochemical pathways RAS-RAF Signaling, MYC Signaling and MAPK Signaling.
Vitamin A can manipulate biochemical pathways Focal Adhesion. Beta-carotene has biological action on biochemical pathways MAPK Signaling and Notch Signaling. And so on.
When treating Fibrolamellar Carcinoma with chemotherapy Radiation – Foods like Winged Bean are recommended compared to Black-eyed Pea. This is because the active ingredients Vitamin A and Beta-carotene in Black-eyed Pea interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Betulinic Acid and Vitamin C contained in Winged Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: WINGED BEAN IS RECOMMENDED OVER BLACK-EYED PEA FOR FIBROLAMELLAR CARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more vegetables, Cauliflower or Chinese Mustard?
Vegetables are an important part of many diets. The active ingredients contained in Cauliflower are Glucaric Acid, Linolenic Acid, Sulforaphane, Vitamin C, Oleic Acid among others. While the active ingredients contained in Chinese Mustard are Quercetin, Isorhamnetin, Kaempferol, Indole-3-carbinol, Vitamin A and others.
Glucaric Acid can manipulate biochemical pathways MYC Signaling, RAS-RAF Signaling and MAPK Signaling. Vitamin C has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, MYC Signaling and RAS-RAF Signaling.
Vitamin A can manipulate biochemical pathways Focal Adhesion. Indole-3-carbinol has biological action on biochemical pathways DNA Repair. And so on.
When treating Fibrolamellar Carcinoma with chemotherapy Radiation – Foods like Cauliflower are recommended compared to Chinese Mustard. This is because the active ingredients Vitamin A and Indole-3-carbinol in Chinese Mustard interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Glucaric Acid and Vitamin C contained in Cauliflower support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: CAULIFLOWER IS RECOMMENDED OVER CHINESE MUSTARD FOR FIBROLAMELLAR CARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more fruits, Rowanberry or Elderberry?
Fruits are an important part of many diets. The active ingredients contained in Rowanberry are Quercetin, Chlorogenic Acid among others. While the active ingredients contained in Elderberry are Quercetin, Lupeol, Betulinic Acid, Linolenic Acid, Vitamin C and others.
Chlorogenic Acid can manipulate biochemical pathways Notch Signaling, MYC Signaling and MAPK Signaling. Quercetin has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, Focal Adhesion and RAS-RAF Signaling.
Rutin can manipulate biochemical pathways Focal Adhesion. Vitamin A has biological action on biochemical pathways Focal Adhesion. And so on.
When treating Fibrolamellar Carcinoma with chemotherapy Radiation – Foods like Rowanberry are recommended compared to Elderberry. This is because the active ingredients Rutin and Vitamin A in Elderberry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Chlorogenic Acid and Quercetin contained in Rowanberry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: ROWANBERRY IS RECOMMENDED OVER ELDERBERRY FOR FIBROLAMELLAR CARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more nuts, Pistachio or Cashew Nut?
Nuts are an important part of many diets. The active ingredients contained in Pistachio are Vitamin E, Resveratrol, Linolenic Acid, Oleic Acid, Beta-sitosterol among others. While the active ingredients contained in Cashew Nut are Vitamin C, Beta-sitosterol, Gallic Acid, Butyric Acid, Vitamin K and others.
Beta-sitosterol can manipulate biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. Vitamin E has biological action on biochemical pathways MAPK Signaling, Notch Signaling and MYC Signaling.
Myristic Acid can manipulate biochemical pathways MYC Signaling, MAPK Signaling and RAS-RAF Signaling. Lauric Acid has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, MYC Signaling and MAPK Signaling. And so on.
When treating Fibrolamellar Carcinoma with chemotherapy Radiation – Foods like Pistachio are recommended compared to Cashew Nut. This is because the active ingredients Myristic Acid and Lauric Acid in Cashew Nut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin E contained in Pistachio support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PISTACHIO IS RECOMMENDED OVER CASHEW NUT FOR FIBROLAMELLAR CARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Foods for Genetic Risk of Fibrolamellar Carcinoma
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. EIF4A2 and EPHA5 are two genes whose abnormalities are risk factors for Fibrolamellar Carcinoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Fibrolamellar Carcinoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Fibrolamellar Carcinoma gene EIF4A2 has causative impact on biological pathways like PI3K-AKT-MTOR Signaling. And EPHA5 has a causative impact on biological pathways like . Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like EIF4A2 and EPHA5 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes EIF4A2 and EPHA5 should be avoided.
Eat more pulses, Mung Bean or Soy Bean?
The active ingredients contained in Mung Bean are Quercetin, Linolenic Acid, Vitamin C, Oleic Acid, Stigmasterol among others. While the active ingredients contained in Soy Bean are Lupeol, Quercetin, Vitamin E, Daidzein, Beta-sitosterol and others.
Quercetin can manipulate biochemical pathways Apoptosis, EPHRIN Signaling and MYC Signaling. Vitamin C has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and MAPK Signaling.
Aescin can manipulate biochemical pathways Cell Cycle Checkpoints. Lecithin has biological action on biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Fibrolamellar Carcinoma due to abnormalities in genes EIF4A2 and EPHA5 – Foods like Mung Bean are recommended compared to Soy Bean. This is because the active ingredients Aescin and Lecithin in Soy Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Quercetin and Vitamin C contained in Mung Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: MUNG BEAN IS RECOMMENDED OVER SOY BEAN FOR REDUCING THE GENETIC RISK OF FIBROLAMELLAR CARCINOMA DUE TO GENES EIF4A2 AND EPHA5
Eat more vegetables, Arugula or Radish?
The active ingredients contained in Arugula are Esculin, Kaempferol, Vitamin A, Vitamin K, Erysolin among others. While the active ingredients contained in Radish are Quercetin, Beta-sitosterol, Linolenic Acid, Vitamin C, Oleic Acid and others.
Kaempferol can manipulate biochemical pathways RAS-RAF Signaling, Cell Cycle Checkpoints and MAPK Signaling. Vitamin K has biological action on biochemical pathways MYC Signaling, PI3K-AKT-MTOR Signaling and Cell Cycle Checkpoints.
Pelargonidin can manipulate biochemical pathways MYC Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, P53 Signaling and MAPK Signaling. And so on.
For genetic risk of Fibrolamellar Carcinoma due to abnormalities in genes EIF4A2 and EPHA5 – Foods like Arugula are recommended compared to Radish. This is because the active ingredients Pelargonidin and Folic Acid in Radish further promote the effects of genes on the biochemical pathways. While the active ingredients Kaempferol and Vitamin K contained in Arugula together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: ARUGULA IS RECOMMENDED OVER RADISH FOR REDUCING THE GENETIC RISK OF FIBROLAMELLAR CARCINOMA DUE TO GENES EIF4A2 AND EPHA5
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Feijoa or Huckleberry?
The active ingredients contained in Feijoa are Lycopene, Vitamin C, Casuarinin, Folic Acid among others. While the active ingredients contained in Huckleberry are Quercetin, Vitamin C, Ferulic Acid, P-coumaric Acid, Resveratrol and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Lycopene has biological action on biochemical pathways Cell Cycle Checkpoints, MAPK Signaling and PI3K-AKT-MTOR Signaling.
Resveratrol can manipulate biochemical pathways P53 Signaling. Pelargonidin has biological action on biochemical pathways MYC Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Fibrolamellar Carcinoma due to abnormalities in genes EIF4A2 and EPHA5 – Foods like Feijoa are recommended compared to Huckleberry. This is because the active ingredients Resveratrol and Pelargonidin in Huckleberry further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Lycopene contained in Feijoa together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: FEIJOA IS RECOMMENDED OVER HUCKLEBERRY FOR REDUCING THE GENETIC RISK OF FIBROLAMELLAR CARCINOMA DUE TO GENES EIF4A2 AND EPHA5
Eat more nuts, Almond or Acorn?
The active ingredients contained in Almond are Quercetin, Vitamin E, Beta-sitosterol, Linolenic Acid, Oleic Acid among others. While the active ingredients contained in Acorn are Quercetin, Beta-sitosterol, Vitamin C, Quercitrin, Vitamin B3 and others.
Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Quercetin has biological action on biochemical pathways EPHRIN Signaling, Cell Cycle Checkpoints and MAPK Signaling.
Beta-carotene can manipulate biochemical pathways MAPK Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. And so on.
For genetic risk of Fibrolamellar Carcinoma due to abnormalities in genes EIF4A2 and EPHA5 – Foods like Almond are recommended compared to Acorn. This is because the active ingredients Beta-carotene and Folic Acid in Acorn further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Quercetin contained in Almond together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: ALMOND IS RECOMMENDED OVER ACORN FOR REDUCING THE GENETIC RISK OF FIBROLAMELLAR CARCINOMA DUE TO GENES EIF4A2 AND EPHA5
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Fibrolamellar Carcinoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
- Msk Impact 2017
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- Resveratrol, a remarkable inhibitor of ribonucleotide reductase.
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Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.