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What Foods are Recommended for Cancer?
is a very common question. Personalized Nutrition Plans are foods and supplements which are personalized to a cancer indication, genes, any treatments and lifestyle conditions.

Which Foods are Recommended for Extrahepatic Cholangiocarcinoma?

Aug 15, 2022

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Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Extrahepatic Cholangiocarcinoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Extrahepatic Cholangiocarcinoma because of SMAD4 and CDKN2A gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Extrahepatic Cholangiocarcinoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Gooseberry” or “Include fruit Cherimoya in my diet” or “Should I reduce consumption of vegetable Okra” or “Can I take Birch and Dim supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO EXTRAHEPATIC CHOLANGIOCARCINOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Extrahepatic Cholangiocarcinoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR EXTRAHEPATIC CHOLANGIOCARCINOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.



About Extrahepatic Cholangiocarcinoma

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Extrahepatic Cholangiocarcinoma from cBioPortal. The patients enrolled in the studies for Extrahepatic Cholangiocarcinoma are in ages between 29 to 79 with an average age of 64. 61.2% of males and 38.8% of females were the distribution of gender in these clinical studies. From a patient sample size of 432; the top genes with mutations and other abnormalities for Extrahepatic Cholangiocarcinoma include genes TP53, SMAD4, CDKN2A, ARID2 and KMT2C. The occurrence frequency distribution for these genes respectively is 44.2%, 14.7%, 9.4%, 5.6% and 5.6%. These tumor genetic details of Extrahepatic Cholangiocarcinoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Extrahepatic Cholangiocarcinoma.

Significance of Nutrition for Extrahepatic Cholangiocarcinoma

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Extrahepatic Cholangiocarcinoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Gooseberry includes active ingredients Beta-sitosterol, Vitamin C, Linolenic Acid, Modified Citrus Pectin, Gallic Acid and others. And Cherimoya contains active ingredients Beta-sitosterol, Vitamin C, Linolenic Acid, Stigmasterol, Oleic Acid and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Extrahepatic Cholangiocarcinoma, activation or inhibition of selected biochemical pathways like Angiogenesis, PI3K-AKT-MTOR Signaling, Cell Cycle Checkpoints, Apoptosis plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Extrahepatic Cholangiocarcinoma, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

For cancers like Extrahepatic Cholangiocarcinoma, activation or inhibition of selected biochemical pathways like Angiogenesis, PI3K-AKT-MTOR Signaling, Cell Cycle Checkpoints, Apoptosis plays an important role in driving cancer growth.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR EXTRAHEPATIC CHOLANGIOCARCINOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Extrahepatic Cholangiocarcinoma undergoing chemotherapy treatment

In Extrahepatic Cholangiocarcinoma – the genes TP53, SMAD4, CDKN2A, ARID2 and KMT2C have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Extrahepatic Cholangiocarcinoma are Angiogenesis, PI3K-AKT-MTOR Signaling, MAPK Signaling and others. Fluorouracil is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Angiogenesis, PI3K-AKT-MTOR Signaling, MAPK Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Black-eyed Pea or Yellow Wax Bean?

Pulses are an important part of many diets. The active ingredients contained in Black-eyed Pea are Daidzein, Vitamin C, Linolenic Acid, Beta-carotene, Stigmasterol among others. While the active ingredients contained in Yellow Wax Bean are Cianidanol, Vitamin C, Butyric Acid, Ferulic Acid, Vitamin A and others.

Daidzein can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Oxidative Stress. Vitamin C has biological action on biochemical pathways Adherens junction, MYC Signaling and WNT Beta Catenin Signaling.

Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling and Focal Adhesion. Palmitic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Microtubule Dynamics. And so on.

When treating Extrahepatic Cholangiocarcinoma with chemotherapy Fluorouracil – Foods like Black-eyed Pea are recommended compared to Yellow Wax Bean. This is because the active ingredients Vitamin A and Palmitic Acid in Yellow Wax Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Daidzein and Vitamin C contained in Black-eyed Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: BLACK-EYED PEA IS RECOMMENDED OVER YELLOW WAX BEAN FOR EXTRAHEPATIC CHOLANGIOCARCINOMA ON TREATMENT WITH CHEMOTHERAPY FLUOROURACIL FOR SOME CONDITIONS.

Eat more vegetables, Cabbage or Okra?

Vegetables are an important part of many diets. The active ingredients contained in Cabbage are Quercetin, Benzyl Isothiocyanate, Beta-sitosterol, Isorhamnetin, Vitamin C among others. While the active ingredients contained in Okra are Quercetin, Beta-sitosterol, Vitamin C, Linolenic Acid, Oleic Acid and others.

Vitamin C can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Adherens junction and MYC Signaling. Glucaric Acid has biological action on biochemical pathways NFKB Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling.

Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling and Focal Adhesion. Quercetin has biological action on biochemical pathways Oxidative Stress. And so on.

When treating Extrahepatic Cholangiocarcinoma with chemotherapy Fluorouracil – Foods like Cabbage are recommended compared to Okra. This is because the active ingredients Vitamin A and Quercetin in Okra interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Glucaric Acid contained in Cabbage support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: CABBAGE IS RECOMMENDED OVER OKRA FOR EXTRAHEPATIC CHOLANGIOCARCINOMA ON TREATMENT WITH CHEMOTHERAPY FLUOROURACIL FOR SOME CONDITIONS.

Which Foods are Recommended for Extrahepatic Cholangiocarcinoma?

Eat more fruits, Cherimoya or Gooseberry?

Fruits are an important part of many diets. The active ingredients contained in Cherimoya are Beta-sitosterol, Vitamin C, Linolenic Acid, Stigmasterol, Oleic Acid among others. While the active ingredients contained in Gooseberry are Beta-sitosterol, Vitamin C, Linolenic Acid, Modified Citrus Pectin, Gallic Acid and others.

Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Glucocorticoid Signaling. Stigmasterol has biological action on biochemical pathways DNA Repair, MYC Signaling and P53 Signaling.

Gallic Acid can manipulate biochemical pathways Oxidative Stress. Citric Acid has biological action on biochemical pathways Oxidative Stress. And so on.

When treating Extrahepatic Cholangiocarcinoma with chemotherapy Fluorouracil – Foods like Cherimoya are recommended compared to Gooseberry. This is because the active ingredients Gallic Acid and Citric Acid in Gooseberry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Stigmasterol contained in Cherimoya support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: CHERIMOYA IS RECOMMENDED OVER GOOSEBERRY FOR EXTRAHEPATIC CHOLANGIOCARCINOMA ON TREATMENT WITH CHEMOTHERAPY FLUOROURACIL FOR SOME CONDITIONS.

Eat more nuts, Walnut or Acorn?

Nuts are an important part of many diets. The active ingredients contained in Walnut are Quercetin, Ellagic Acid, Myricetin, Betulinic Acid, Beta-sitosterol among others. While the active ingredients contained in Acorn are Quercetin, Beta-sitosterol, Vitamin C, Beta-carotene, Gallic Acid and others.

Ellagic Acid can manipulate biochemical pathways NFKB Signaling, Glucocorticoid Signaling and Adherens junction. Myricetin has biological action on biochemical pathways Epithelial to Mesenchymal Transition, Microtubule Dynamics and DNA Repair.

Quercetin can manipulate biochemical pathways Oxidative Stress. Beta-carotene has biological action on biochemical pathways MAPK Signaling, PI3K-AKT-MTOR Signaling and Notch Signaling. And so on.

When treating Extrahepatic Cholangiocarcinoma with chemotherapy Fluorouracil – Foods like Walnut are recommended compared to Acorn. This is because the active ingredients Quercetin and Beta-carotene in Acorn interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Ellagic Acid and Myricetin contained in Walnut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: WALNUT IS RECOMMENDED OVER ACORN FOR EXTRAHEPATIC CHOLANGIOCARCINOMA ON TREATMENT WITH CHEMOTHERAPY FLUOROURACIL FOR SOME CONDITIONS.

Foods for Genetic Risk of Extrahepatic Cholangiocarcinoma

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. SMAD4 and CDKN2A are two genes whose abnormalities are risk factors for Extrahepatic Cholangiocarcinoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Extrahepatic Cholangiocarcinoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Extrahepatic Cholangiocarcinoma gene SMAD4 has causative impact on biological pathways like TGFB Signaling, Inflammation and Cell Cycle. And CDKN2A has a causative impact on biological pathways like Cell Cycle Checkpoints and Cell Cycle. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like SMAD4 and CDKN2A should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes SMAD4 and CDKN2A should be avoided.

Eat more pulses, Common Pea or Soy Bean?

The active ingredients contained in Common Pea are Lupeol, Daidzein, Beta-sitosterol, Linolenic Acid, Vitamin C among others. While the active ingredients contained in Soy Bean are Lupeol, Vitamin E, Daidzein, Quercetin, Beta-sitosterol and others.

Beta-sitosterol can manipulate biochemical pathways Apoptosis, Cell Cycle and MYC Signaling. Vitamin C has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and MAPK Signaling.

Aescin can manipulate biochemical pathways Cell Cycle Checkpoints and Cell Cycle. Lecithin has biological action on biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. And so on.

For genetic risk of Extrahepatic Cholangiocarcinoma due to abnormalities in genes SMAD4 and CDKN2A – Foods like Common Pea are recommended compared to Soy Bean. This is because the active ingredients Aescin and Lecithin in Soy Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER SOY BEAN FOR REDUCING THE GENETIC RISK OF EXTRAHEPATIC CHOLANGIOCARCINOMA DUE TO GENES SMAD4 AND CDKN2A

Eat more vegetables, Arugula or Carob?

The active ingredients contained in Arugula are Esculin, Kaempferol, Vitamin A, Vitamin K, Erysolin among others. While the active ingredients contained in Carob are Quercetin, Palmitic Acid, Myricetin, Gallic Acid, Phloroglucinol and others.

Kaempferol can manipulate biochemical pathways RAS-RAF Signaling, Cell Cycle Checkpoints and Cell Cycle. Vitamin K has biological action on biochemical pathways MYC Signaling, PI3K-AKT-MTOR Signaling and Cell Cycle Checkpoints.

Palmitic Acid can manipulate biochemical pathways MAPK Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. And so on.

For genetic risk of Extrahepatic Cholangiocarcinoma due to abnormalities in genes SMAD4 and CDKN2A – Foods like Arugula are recommended compared to Carob. This is because the active ingredients Palmitic Acid and Folic Acid in Carob further promote the effects of genes on the biochemical pathways. While the active ingredients Kaempferol and Vitamin K contained in Arugula together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: ARUGULA IS RECOMMENDED OVER CAROB FOR REDUCING THE GENETIC RISK OF EXTRAHEPATIC CHOLANGIOCARCINOMA DUE TO GENES SMAD4 AND CDKN2A

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

Eat more fruits, Feijoa or Grape?

The active ingredients contained in Feijoa are Lycopene, Vitamin C, Casuarinin, Folic Acid among others. While the active ingredients contained in Grape are Lupeol, Vitamin E, Beta-sitosterol, Pterostilbene, Linolenic Acid and others.

Vitamin C can manipulate biochemical pathways Apoptosis, Cell Cycle and MYC Signaling. Lycopene has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and MAPK Signaling.

Resveratrol can manipulate biochemical pathways P53 Signaling. Pelargonidin has biological action on biochemical pathways MYC Signaling, Cell Cycle Checkpoints and Cell Cycle. And so on.

For genetic risk of Extrahepatic Cholangiocarcinoma due to abnormalities in genes SMAD4 and CDKN2A – Foods like Feijoa are recommended compared to Grape. This is because the active ingredients Resveratrol and Pelargonidin in Grape further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Lycopene contained in Feijoa together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: FEIJOA IS RECOMMENDED OVER GRAPE FOR REDUCING THE GENETIC RISK OF EXTRAHEPATIC CHOLANGIOCARCINOMA DUE TO GENES SMAD4 AND CDKN2A

Eat more nuts, Pecan Nut or Peanut?

The active ingredients contained in Pecan Nut are Vitamin E, Cianidanol, Linolenic Acid, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Peanut are Vitamin E, Quercetin, Beta-sitosterol, Ferulic Acid, Linolenic Acid and others.

Vitamin E can manipulate biochemical pathways Apoptosis, Cell Cycle and MYC Signaling. Cianidanol has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and MAPK Signaling.

Lecithin can manipulate biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, P53 Signaling and Cell Cycle Checkpoints. And so on.

For genetic risk of Extrahepatic Cholangiocarcinoma due to abnormalities in genes SMAD4 and CDKN2A – Foods like Pecan Nut are recommended compared to Peanut. This is because the active ingredients Lecithin and Folic Acid in Peanut further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin E and Cianidanol contained in Pecan Nut together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER PEANUT FOR REDUCING THE GENETIC RISK OF EXTRAHEPATIC CHOLANGIOCARCINOMA DUE TO GENES SMAD4 AND CDKN2A


In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Extrahepatic Cholangiocarcinoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

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References

Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.


Scientifically Reviewed by: Dr. Cogle

Christopher R. Cogle, M.D. is a tenured professor at the University of Florida, Chief Medical Officer of Florida Medicaid, and Director of the Florida Health Policy Leadership Academy at the Bob Graham Center for Public Service.

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