Which Foods are Recommended for Epithelioid Hemangioendothelioma?

Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Epithelioid Hemangioendothelioma when undergoing chemotherapy or when you determine you have a genetic risk for developing Epithelioid Hemangioendothelioma because of CREBBP and ERBB4 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Epithelioid Hemangioendothelioma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Fig” or “Include fruit Partridgeberry in my diet” or “Should I reduce consumption of vegetable Carob” or “Can I take Calendula and Hesperidin supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO EPITHELIOID HEMANGIOENDOTHELIOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Epithelioid Hemangioendothelioma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR EPITHELIOID HEMANGIOENDOTHELIOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.

About Epithelioid Hemangioendothelioma

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Epithelioid Hemangioendothelioma from cBioPortal. 42.9% of males and 57.1% of females were the distribution of gender in these clinical studies. From a patient sample size of 31; the top genes with mutations and other abnormalities for Epithelioid Hemangioendothelioma include genes ATRX, CREBBP, ERBB4, MED12 and SDHAF2. The occurrence frequency distribution for these genes respectively is 13.3%, 6.7%, 6.7%, 6.7% and 6.7%. These tumor genetic details of Epithelioid Hemangioendothelioma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Epithelioid Hemangioendothelioma.

Epithelioid hemangioendothelioma is a rare and aggressive vascular tumor which most commonly occurs in older adults between 60-80 years of age. It forms in the cells that line the inside of blood vessels. It appears more frequently in females than males and seems to be more prevalent in young adults. Most common locations of epithelioid hemangioendothelioma are lungs, liver, and bones. Epithelioid hemangioendothelioma tumors have an aggressive clinical course with a tendency for both local recurrence and regional lymph node metastasis. In some cases, epithelioid hemangioendothelioma can be slow growing with mild to no symptoms for years. Surgery is considered the primary treatment for epithelioid hemangioendothelioma, especially in the soft tissue and skin. Other treatment strategies can include targeted therapy, radiation therapy, chemotherapy, and watchful waiting. In addition, supportive care with the optimal nutrition (foods and natural supplements) can enhance and improve patients’ well-being.
(ref: Liu Z and He S, J Oncol., 2022 ; https://fightehe.org/ehe-epithelioid-hemangioendothelioma/; https://my.clevelandclinic.org/health/diseases/23121-epithelioid-hemangioendothelioma )

Significance of Nutrition for Epithelioid Hemangioendothelioma

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Epithelioid Hemangioendothelioma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Fig includes active ingredients Angelicin, Lupeol, Psoralen, Vitamin C, Beta-sitosterol and others. And Partridgeberry contains active ingredients Resveratrol, Beta-sitosterol, Stigmasterol and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Epithelioid Hemangioendothelioma, activation or inhibition of selected biochemical pathways like MAPK Signaling, DNA Repair, PI3K-AKT-MTOR Signaling, TGFB Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Epithelioid Hemangioendothelioma, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR EPITHELIOID HEMANGIOENDOTHELIOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Epithelioid Hemangioendothelioma undergoing chemotherapy treatment

In Epithelioid Hemangioendothelioma – the genes ATRX, CREBBP, ERBB4, MED12 and SDHAF2 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Epithelioid Hemangioendothelioma are MAPK Signaling, DNA Repair, PI3K-AKT-MTOR Signaling and others. Dactinomycin is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers MAPK Signaling, DNA Repair, PI3K-AKT-MTOR Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Common Pea or Pigeon Pea?

Pulses are an important part of many diets. The active ingredients contained in Common Pea are Daidzein, Lupeol, Pelargonidin, Linolenic Acid, Oleic Acid among others. While the active ingredients contained in Pigeon Pea are Linolenic Acid, Oleic Acid, Vitamin C, Linoleic Acid, Genistein and others.

Beta-sitosterol can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Vitamin C has biological action on biochemical pathways MAPK Signaling and PI3K-AKT-MTOR Signaling.

Genistein can manipulate biochemical pathways DNA Repair. Folic Acid has biological action on biochemical pathways MAPK Signaling and PI3K-AKT-MTOR Signaling. And so on.

When treating Epithelioid Hemangioendothelioma with chemotherapy Dactinomycin – Foods like Common Pea are recommended compared to Pigeon Pea. This is because the active ingredients Genistein and Folic Acid in Pigeon Pea interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER PIGEON PEA FOR EPITHELIOID HEMANGIOENDOTHELIOMA ON TREATMENT WITH CHEMOTHERAPY DACTINOMYCIN FOR SOME CONDITIONS.

Eat more vegetables, Amaranth or Carob?

Vegetables are an important part of many diets. The active ingredients contained in Amaranth are Linolenic Acid, Oleic Acid, Isoquercitrin, Beta-sitosterol, Stigmasterol among others. While the active ingredients contained in Carob are Myricetin, Quercetin, Gallic Acid, Phloroglucinol, Folic Acid and others.

Beta-sitosterol can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Vitamin C has biological action on biochemical pathways MAPK Signaling and PI3K-AKT-MTOR Signaling.

Palmitic Acid can manipulate biochemical pathways MAPK Signaling. Myricetin has biological action on biochemical pathways PI3K-AKT-MTOR Signaling. And so on.

When treating Epithelioid Hemangioendothelioma with chemotherapy Dactinomycin – Foods like Amaranth are recommended compared to Carob. This is because the active ingredients Palmitic Acid and Myricetin in Carob interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Amaranth support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: AMARANTH IS RECOMMENDED OVER CAROB FOR EPITHELIOID HEMANGIOENDOTHELIOMA ON TREATMENT WITH CHEMOTHERAPY DACTINOMYCIN FOR SOME CONDITIONS.

Eat more fruits, Partridgeberry or Fig?

Fruits are an important part of many diets. The active ingredients contained in Partridgeberry are Resveratrol, Beta-sitosterol, Stigmasterol among others. While the active ingredients contained in Fig are Angelicin, Lupeol, Psoralen, Vitamin C, Beta-sitosterol and others.

Resveratrol can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Beta-sitosterol has biological action on biochemical pathways PI3K-AKT-MTOR Signaling.

Lauric Acid can manipulate biochemical pathways MAPK Signaling and PI3K-AKT-MTOR Signaling. Myristic Acid has biological action on biochemical pathways MAPK Signaling. And so on.

When treating Epithelioid Hemangioendothelioma with chemotherapy Dactinomycin – Foods like Partridgeberry are recommended compared to Fig. This is because the active ingredients Lauric Acid and Myristic Acid in Fig interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Resveratrol and Beta-sitosterol contained in Partridgeberry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: PARTRIDGEBERRY IS RECOMMENDED OVER FIG FOR EPITHELIOID HEMANGIOENDOTHELIOMA ON TREATMENT WITH CHEMOTHERAPY DACTINOMYCIN FOR SOME CONDITIONS.

Eat more nuts, Almond or Acorn?

Nuts are an important part of many diets. The active ingredients contained in Almond are Quercetin, Vitamin E, Oleic Acid, Linolenic Acid, Stigmasterol among others. While the active ingredients contained in Acorn are Quercetin, Gallic Acid, Vitamin C, Beta-sitosterol, Quercitrin and others.

Beta-sitosterol can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Quercetin has biological action on biochemical pathways DNA Repair, MAPK Signaling and PI3K-AKT-MTOR Signaling.

Beta-carotene can manipulate biochemical pathways MAPK Signaling. Folic Acid has biological action on biochemical pathways PI3K-AKT-MTOR Signaling and MAPK Signaling. And so on.

When treating Epithelioid Hemangioendothelioma with chemotherapy Dactinomycin – Foods like Almond are recommended compared to Acorn. This is because the active ingredients Beta-carotene and Folic Acid in Acorn interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Quercetin contained in Almond support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: ALMOND IS RECOMMENDED OVER ACORN FOR EPITHELIOID HEMANGIOENDOTHELIOMA ON TREATMENT WITH CHEMOTHERAPY DACTINOMYCIN FOR SOME CONDITIONS.

Foods for Genetic Risk of Epithelioid Hemangioendothelioma

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. CREBBP and ERBB4 are two genes whose abnormalities are risk factors for Epithelioid Hemangioendothelioma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Epithelioid Hemangioendothelioma can be used as a guide for coming up with a recommended personalized nutrition plan. For Epithelioid Hemangioendothelioma gene CREBBP has causative impact on biological pathways like G-protein-coupled Receptor Signaling and Immune Evasion Signaling. And ERBB4 has a causative impact on biological pathways like Growth Factor Signaling and MAPK Signaling. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like CREBBP and ERBB4 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes CREBBP and ERBB4 should be avoided.

Eat more pulses, Scarlet Bean or Fava Bean?

The active ingredients contained in Scarlet Bean are Beta-sitosterol, Linolenic Acid, Oleic Acid, Vitamin C, Stigmasterol among others. While the active ingredients contained in Fava Bean are Daidzein, Beta-sitosterol, Linolenic Acid, Oleic Acid, Vitamin C and others.

Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin C has biological action on biochemical pathways Growth Factor Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.

Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Linoleic Acid has biological action on biochemical pathways Growth Factor Signaling. And so on.

For genetic risk of Epithelioid Hemangioendothelioma due to abnormalities in genes CREBBP and ERBB4 – Foods like Scarlet Bean are recommended compared to Fava Bean. This is because the active ingredients Vitamin A and Linoleic Acid in Fava Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin C contained in Scarlet Bean together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER FAVA BEAN FOR REDUCING THE GENETIC RISK OF EPITHELIOID HEMANGIOENDOTHELIOMA DUE TO GENES CREBBP AND ERBB4

Eat more vegetables, Jicama or Chayote?

The active ingredients contained in Jicama are Vitamin C, Vitamin B3, Beta-carotene, Vitamin A, Folic Acid among others. While the active ingredients contained in Chayote are Linolenic Acid, Oleic Acid, Vitamin C, Linoleic Acid, Folic Acid and others.

Vitamin C can manipulate biochemical pathways Apoptosis, Growth Factor Signaling and MYC Signaling. Vitamin B3 has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and MYC Signaling.

Linoleic Acid can manipulate biochemical pathways Growth Factor Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. And so on.

For genetic risk of Epithelioid Hemangioendothelioma due to abnormalities in genes CREBBP and ERBB4 – Foods like Jicama are recommended compared to Chayote. This is because the active ingredients Linoleic Acid and Folic Acid in Chayote further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Vitamin B3 contained in Jicama together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: JICAMA IS RECOMMENDED OVER CHAYOTE FOR REDUCING THE GENETIC RISK OF EPITHELIOID HEMANGIOENDOTHELIOMA DUE TO GENES CREBBP AND ERBB4

Eat more fruits, Kiwi or Raspberry?

The active ingredients contained in Kiwi are Vitamin C, Quercetin, Fisetin, Chlorogenic Acid, Vitamin A among others. While the active ingredients contained in Raspberry are Resveratrol, Salicylic Acid, Vitamin C, Quercetin, Ellagic Acid and others.

Vitamin C can manipulate biochemical pathways Apoptosis, Growth Factor Signaling and MYC Signaling. Quercetin has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.

Ellagic Acid can manipulate biochemical pathways MYC Signaling and Cell Cycle Checkpoints. Vitamin A has biological action on biochemical pathways PI3K-AKT-MTOR Signaling. And so on.

For genetic risk of Epithelioid Hemangioendothelioma due to abnormalities in genes CREBBP and ERBB4 – Foods like Kiwi are recommended compared to Raspberry. This is because the active ingredients Ellagic Acid and Vitamin A in Raspberry further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Quercetin contained in Kiwi together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: KIWI IS RECOMMENDED OVER RASPBERRY FOR REDUCING THE GENETIC RISK OF EPITHELIOID HEMANGIOENDOTHELIOMA DUE TO GENES CREBBP AND ERBB4

Eat more nuts, Hazelnut or Chestnut?

The active ingredients contained in Hazelnut are Vitamin E, Linolenic Acid, Oleic Acid, Quercetin, Linoleic Acid among others. While the active ingredients contained in Chestnut are Linolenic Acid, Oleic Acid, Vitamin C, Quercetin, Ellagic Acid and others.

Vitamin E can manipulate biochemical pathways Apoptosis, Growth Factor Signaling and MYC Signaling. Quercetin has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.

Ellagic Acid can manipulate biochemical pathways MYC Signaling and Cell Cycle Checkpoints. Vitamin A has biological action on biochemical pathways PI3K-AKT-MTOR Signaling. And so on.

For genetic risk of Epithelioid Hemangioendothelioma due to abnormalities in genes CREBBP and ERBB4 – Foods like Hazelnut are recommended compared to Chestnut. This is because the active ingredients Ellagic Acid and Vitamin A in Chestnut further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin E and Quercetin contained in Hazelnut together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: HAZELNUT IS RECOMMENDED OVER CHESTNUT FOR REDUCING THE GENETIC RISK OF EPITHELIOID HEMANGIOENDOTHELIOMA DUE TO GENES CREBBP AND ERBB4

In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Epithelioid Hemangioendothelioma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

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