Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Endocervical Adenocarcinoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Endocervical Adenocarcinoma because of ERBB2 and PIK3CA gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Endocervical Adenocarcinoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Malus (crab Apple)” or “Include fruit Salmonberry in my diet” or “Should I reduce consumption of vegetable Celery” or “Can I take Modified Citrus Pectin and Stevia supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO ENDOCERVICAL ADENOCARCINOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Endocervical Adenocarcinoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR ENDOCERVICAL ADENOCARCINOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Endocervical Adenocarcinoma
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Endocervical Adenocarcinoma from cBioPortal. From a patient sample size of 20; the top genes with mutations and other abnormalities for Endocervical Adenocarcinoma include genes PIK3CA, KRAS, TP53, ERBB2 and KMT2C. The occurrence frequency distribution for these genes respectively is 37.5%, 37.5%, 37.5%, 25.0% and 25.0%. These tumor genetic details of Endocervical Adenocarcinoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Endocervical Adenocarcinoma.
Significance of Nutrition for Endocervical Adenocarcinoma
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Endocervical Adenocarcinoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Malus (crab Apple) includes active ingredients Linolenic Acid, Vitamin C, Oleic Acid, Linoleic Acid, 7-4′-dihydroxyflavone and others. And Salmonberry contains active ingredients Protocatechuic Acid, P-coumaric Acid, Vanillic Acid, Vitamin A and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Endocervical Adenocarcinoma, activation or inhibition of selected biochemical pathways like RAS-RAF Signaling, MAPK Signaling, PI3K-AKT-MTOR Signaling, TGFB Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Endocervical Adenocarcinoma, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR ENDOCERVICAL ADENOCARCINOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Endocervical Adenocarcinoma undergoing chemotherapy treatment
In Endocervical Adenocarcinoma – the genes PIK3CA, KRAS, TP53, ERBB2 and KMT2C have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Endocervical Adenocarcinoma are RAS-RAF Signaling, MAPK Signaling, TGFB Signaling and others. Radiation is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers RAS-RAF Signaling, MAPK Signaling, TGFB Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Winged Bean or Fava Bean?
Pulses are an important part of many diets. The active ingredients contained in Winged Bean are Betulinic Acid, Linolenic Acid, Vitamin C, Oleic Acid, Vitamin A among others. While the active ingredients contained in Fava Bean are Daidzein, Cianidanol, Quercetin, Linolenic Acid, Beta-sitosterol and others.
Betulinic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and MYC Signaling. Vitamin C has biological action on biochemical pathways MAPK Signaling, PI3K-AKT-MTOR Signaling and RAS-RAF Signaling.
Caffeic Acid can manipulate biochemical pathways TGFB Signaling. Oleic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition. And so on.
When treating Endocervical Adenocarcinoma with chemotherapy Radiation – Foods like Winged Bean are recommended compared to Fava Bean. This is because the active ingredients Caffeic Acid and Oleic Acid in Fava Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Betulinic Acid and Vitamin C contained in Winged Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: WINGED BEAN IS RECOMMENDED OVER FAVA BEAN FOR ENDOCERVICAL ADENOCARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more vegetables, Brussels Sprout or Celery?
Vegetables are an important part of many diets. The active ingredients contained in Brussels Sprout are Glucaric Acid, Linolenic Acid, Beta-sitosterol, Brassinin, Vitamin C among others. While the active ingredients contained in Celery are Apigenin, Quercetin, Glucaric Acid, Linolenic Acid, Vitamin C and others.
Glucaric Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and MYC Signaling. Brassinin has biological action on biochemical pathways MAPK Signaling, PI3K-AKT-MTOR Signaling and Epithelial to Mesenchymal Transition.
Luteolin can manipulate biochemical pathways MYC Signaling. Chrysin has biological action on biochemical pathways Epithelial to Mesenchymal Transition and MYC Signaling. And so on.
When treating Endocervical Adenocarcinoma with chemotherapy Radiation – Foods like Brussels Sprout are recommended compared to Celery. This is because the active ingredients Luteolin and Chrysin in Celery interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Glucaric Acid and Brassinin contained in Brussels Sprout support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: BRUSSELS SPROUT IS RECOMMENDED OVER CELERY FOR ENDOCERVICAL ADENOCARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more fruits, Salmonberry or Malus (crab Apple)?
Fruits are an important part of many diets. The active ingredients contained in Salmonberry are Protocatechuic Acid, P-coumaric Acid, Vanillic Acid, Vitamin A among others. While the active ingredients contained in Malus (crab Apple) are Linolenic Acid, Vitamin C, Oleic Acid, Linoleic Acid, 7-4′-dihydroxyflavone and others.
Protocatechuic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and MYC Signaling. P-coumaric Acid has biological action on biochemical pathways TGFB Signaling, PI3K-AKT-MTOR Signaling and MYC Signaling.
Oleic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition. Linoleic Acid has biological action on biochemical pathways TGFB Signaling and Epithelial to Mesenchymal Transition. And so on.
When treating Endocervical Adenocarcinoma with chemotherapy Radiation – Foods like Salmonberry are recommended compared to Malus (crab Apple). This is because the active ingredients Oleic Acid and Linoleic Acid in Malus (crab Apple) interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Protocatechuic Acid and P-coumaric Acid contained in Salmonberry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: SALMONBERRY IS RECOMMENDED OVER MALUS (CRAB APPLE) FOR ENDOCERVICAL ADENOCARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more nuts, Pine Nut or Peanut?
Nuts are an important part of many diets. The active ingredients contained in Pine Nut are Vitamin E, Linolenic Acid, Beta-sitosterol, Oleic Acid, Vitamin A among others. While the active ingredients contained in Peanut are Quercetin, Gamma-linolenic Acid, Vitamin E, Linolenic Acid, Beta-sitosterol and others.
Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and MYC Signaling. Vitamin K has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, MYC Signaling and NFKB Signaling.
Lecithin can manipulate biochemical pathways MYC Signaling, NFKB Signaling and MAPK Signaling. Oleic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition. And so on.
When treating Endocervical Adenocarcinoma with chemotherapy Radiation – Foods like Pine Nut are recommended compared to Peanut. This is because the active ingredients Lecithin and Oleic Acid in Peanut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin K contained in Pine Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PINE NUT IS RECOMMENDED OVER PEANUT FOR ENDOCERVICAL ADENOCARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Foods for Genetic Risk of Endocervical Adenocarcinoma
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. ERBB2 and PIK3CA are two genes whose abnormalities are risk factors for Endocervical Adenocarcinoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Endocervical Adenocarcinoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Endocervical Adenocarcinoma gene ERBB2 has causative impact on biological pathways like Growth Factor Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. And PIK3CA has a causative impact on biological pathways like Angiogenesis and Hematopoiesis. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like ERBB2 and PIK3CA should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes ERBB2 and PIK3CA should be avoided.
Eat more pulses, Scarlet Bean or Moth Bean?
The active ingredients contained in Scarlet Bean are Oleic Acid, Linolenic Acid, Beta-sitosterol, Vitamin C, Stigmasterol among others. While the active ingredients contained in Moth Bean are Oleic Acid, Linolenic Acid, Beta-sitosterol, Stigmasterol, Linoleic Acid and others.
Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin C has biological action on biochemical pathways Growth Factor Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.
Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Linoleic Acid has biological action on biochemical pathways Growth Factor Signaling. And so on.
For genetic risk of Endocervical Adenocarcinoma due to abnormalities in genes ERBB2 and PIK3CA – Foods like Scarlet Bean are recommended compared to Moth Bean. This is because the active ingredients Vitamin A and Linoleic Acid in Moth Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin C contained in Scarlet Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER MOTH BEAN FOR REDUCING THE GENETIC RISK OF ENDOCERVICAL ADENOCARCINOMA DUE TO GENES ERBB2 AND PIK3CA
Eat more vegetables, Jicama or Chayote?
The active ingredients contained in Jicama are Vitamin C, Vitamin B3, Beta-carotene, Vitamin A, Folic Acid among others. While the active ingredients contained in Chayote are Oleic Acid, Linolenic Acid, Vitamin C, Linoleic Acid, Folic Acid and others.
Vitamin C can manipulate biochemical pathways Apoptosis, Growth Factor Signaling and MYC Signaling. Vitamin B3 has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.
Linoleic Acid can manipulate biochemical pathways Growth Factor Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. And so on.
For genetic risk of Endocervical Adenocarcinoma due to abnormalities in genes ERBB2 and PIK3CA – Foods like Jicama are recommended compared to Chayote. This is because the active ingredients Linoleic Acid and Folic Acid in Chayote further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Vitamin B3 contained in Jicama together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: JICAMA IS RECOMMENDED OVER CHAYOTE FOR REDUCING THE GENETIC RISK OF ENDOCERVICAL ADENOCARCINOMA DUE TO GENES ERBB2 AND PIK3CA
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Currant or Peach?
The active ingredients contained in Currant are Cianidanol, Quercetin, Delphinidin, Oleic Acid, Gamma-linolenic Acid among others. While the active ingredients contained in Peach are Oleic Acid, Modified Citrus Pectin, Linolenic Acid, Beta-sitosterol, Vitamin C and others.
Cianidanol can manipulate biochemical pathways Apoptosis, Growth Factor Signaling and MYC Signaling. Delphinidin has biological action on biochemical pathways RAS-RAF Signaling, PI3K-AKT-MTOR Signaling and MYC Signaling.
Fisetin can manipulate biochemical pathways MYC Signaling. Vitamin A has biological action on biochemical pathways PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Endocervical Adenocarcinoma due to abnormalities in genes ERBB2 and PIK3CA – Foods like Currant are recommended compared to Peach. This is because the active ingredients Fisetin and Vitamin A in Peach further promote the effects of genes on the biochemical pathways. While the active ingredients Cianidanol and Delphinidin contained in Currant together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: CURRANT IS RECOMMENDED OVER PEACH FOR REDUCING THE GENETIC RISK OF ENDOCERVICAL ADENOCARCINOMA DUE TO GENES ERBB2 AND PIK3CA
Eat more nuts, Hazelnut or Acorn?
The active ingredients contained in Hazelnut are Quercetin, Vitamin E, Oleic Acid, Linolenic Acid, Linoleic Acid among others. While the active ingredients contained in Acorn are Quercetin, Beta-sitosterol, Vitamin C, Vitamin B3, Quercitrin and others.
Quercetin can manipulate biochemical pathways Apoptosis, Growth Factor Signaling and MYC Signaling. Vitamin E has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.
Beta-carotene can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Vitamin A has biological action on biochemical pathways PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Endocervical Adenocarcinoma due to abnormalities in genes ERBB2 and PIK3CA – Foods like Hazelnut are recommended compared to Acorn. This is because the active ingredients Beta-carotene and Vitamin A in Acorn further promote the effects of genes on the biochemical pathways. While the active ingredients Quercetin and Vitamin E contained in Hazelnut together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: HAZELNUT IS RECOMMENDED OVER ACORN FOR REDUCING THE GENETIC RISK OF ENDOCERVICAL ADENOCARCINOMA DUE TO GENES ERBB2 AND PIK3CA
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Endocervical Adenocarcinoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
- Summit 2018
- HER kinase inhibition in patients with HER2- and HER3-mutant cancers.
- Betulinic Acid Suppresses Breast Cancer Metastasis by Targeting GRP78-Mediated Glycolysis and ER Stress Apoptotic Pathway.
- Vitamin C enhances epigenetic modifications induced by 5-azacytidine and cell cycle arrest in the hepatocellular carcinoma cell lines HLE and Huh7.
- Synthesis and structure-activity relationship analysis of caffeic acid amides as selective matrix metalloproteinase inhibitors.
- Oleic acid-induced ANGPTL4 enhances head and neck squamous cell carcinoma anoikis resistance and metastasis via up-regulation of fibronectin.
- Protocatechuic acid inhibits lung cancer cells by modulating FAK, MAPK, and NF-κB pathways.
- Inhibition of histone-deacetylase activity by short-chain fatty acids and some polyphenol metabolites formed in the colon.
- Role of phospholipase D in migration and invasion induced by linoleic acid in breast cancer cells.
- Preventive effects of butyric acid, nicotinamide, calcium glucarate alone or in combination during the 7, 12-dimethylbenz (a) anthracene induced mouse skin tumorigenesis via modulation of K-Ras-PI3K-AKTpathway and associated micro RNAs.
- Brassinin Represses Invasive Potential of Lung Carcinoma Cells through Deactivation of PI3K/Akt/mTOR Signaling Cascade.
- Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin.
- β-Sitosterol targets Trx/Trx1 reductase to induce apoptosis in A549 cells via ROS mediated mitochondrial dysregulation and p53 activation.
- Research progress on the anticancer effects of vitamin K2.
- The recruitment of Raf-1 to membranes is mediated by direct interaction with phosphatidic acid and is independent of association with Ras.
- Vitamin A regulates Akt signaling through the phospholipid fatty acid composition.
- Molecular docking analysis of Cianidanol fromGinkgo biloba with HER2+ breast cancer target.
- Identification of new potent phthalazine derivatives with VEGFR-2 and EGFR kinase inhibitory activity.
- Concurrent acetylation of FoxO1/3a and p53 due to sirtuins inhibition elicit Bim/PUMA mediated mitochondrial dysfunction and apoptosis in berberine-treated HepG2 cells.
- Effects of folate deficiency on gene expression in the apoptosis and cancer pathways in colon cancer cells.
- Protein kinase and HDAC inhibitors from the endophytic fungus Epicoccum nigrum.
- Gamma- and delta-tocotrienols exert a more potent anticancer effect than alpha-tocopheryl succinate on breast cancer cell lines irrespective of HER-2/neu expression.
- β-carotene Inhibits Expression of c-Myc and Cyclin E in Helicobacter pylori-infected Gastric Epithelial Cells.
- HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods.
- Fisetin: a dietary antioxidant for health promotion.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.