Foods for Endocervical Adenocarcinoma!

Introduction

Foods for Endocervical Adenocarcinoma should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.

Endocervical adenocarcinoma, a type of cancer originating in the cervical canal’s glandular cells, presents specific diagnostic and treatment challenges. The pathology outlines of endocervical adenocarcinoma, including its in situ variant, provide detailed insights into the tumor’s cellular structure and behavior. Cytology, often obtained through Pap smears, plays a crucial role in the early detection of this cancer, which can manifest with various symptoms (síntomas in Spanish). The ICD-10 code for endocervical adenocarcinoma, including its in situ form, facilitates standardized documentation and tracking in medical records. Treatment for endocervical adenocarcinoma typically involves a combination of surgery, radiation, and chemotherapy, depending on the cancer’s stage and the individual patient’s health. The survival rate for this cancer varies, with early detection and treatment being key factors in improving outcomes. A specific subtype, endocervical adenocarcinoma of the gastric type, presents unique histological features and may require a tailored treatment approach. The overall management of endocervical adenocarcinoma requires a comprehensive understanding of its pathology, an accurate diagnosis, and a well-coordinated treatment plan to maximize the chances of a favorable outcome.

For Endocervical Adenocarcinoma does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Endocervical Adenocarcinoma does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Endocervical Adenocarcinoma?

For example does it matter if vegetable Cauliflower is consumed more compared to Agave? Does it make any difference if fruit Pummelo is preferred over Red Raspberry? Also if similar choices are made for nuts/seeds like Walnut over Macadamia Nut and for pulses like Black-eyed Pea over Pigeon Pea. And if what I eat matters – then how does one identify foods which are recommended for Endocervical Adenocarcinoma and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Endocervical Adenocarcinoma!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Pummelo contains active ingredients Curcumin, Lycopene, Naringenin, Protocatechuic Acid, Apigenin. And Red Raspberry contains active ingredients Curcumin, Ellagic Acid, Protocatechuic Acid, Daidzein, Quercetin and possibly others.

A common mistake made when deciding and choosing foods to eat for Endocervical Adenocarcinoma – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Endocervical Adenocarcinoma.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Endocervical Adenocarcinoma?

Personalized nutrition for cancers like Endocervical Adenocarcinoma consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Endocervical Adenocarcinoma biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Characteristics of cancers like Endocervical Adenocarcinoma

All cancers like Endocervical Adenocarcinoma can be characterized by a unique set of biochemical pathways – the signature pathways of Endocervical Adenocarcinoma. Biochemical pathways like RAS-RAF Signaling, MAPK Signaling, PI3K-AKT-MTOR Signaling, TGFB Signaling are part of the signature definition of Endocervical Adenocarcinoma. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Endocervical Adenocarcinoma need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Endocervical Adenocarcinoma when taking cancer treatment Radiation, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

PIK3CA, KRAS, TP53, ERBB2 and KMT2C are the top ranked reported genes for Endocervical Adenocarcinoma. PIK3CA is reported in 37.5 % of the representative patients across all clinical trials. And KRAS is reported in 37.5 %. The combined population patient data cover ages from to . 0.0 % of the patient data are identified as men. The Endocervical Adenocarcinoma biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Food and Supplements for Endocervical Adenocarcinoma

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable CAULIFLOWER or AGAVE?

Vegetable Cauliflower contains many active ingredients or bioactives such as Curcumin, Daidzein, Glucaric Acid, Lupeol, Isoliquiritigenin. These active ingredients manipulate various biochemical pathways like NFKB Signaling, PI3K-AKT-MTOR Signaling, MAPK Signaling and MYC Signaling and others. Cauliflower is recommended for Endocervical Adenocarcinoma when ongoing cancer treatment is Radiation. This is because Cauliflower modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Radiation.

Some of the active ingredients or bioactives in vegetable Agave are Curcumin, Protocatechuic Acid, Apigenin, Daidzein, Lupeol. These active ingredients manipulate various biochemical pathways like NFKB Signaling, TGFB Signaling and Epithelial to Mesenchymal Transition and others. Agave is not recommended for Endocervical Adenocarcinoma when ongoing cancer treatment is Radiation because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE CAULIFLOWER IS RECOMMENDED OVER AGAVE FOR Endocervical Adenocarcinoma AND TREATMENT Radiation.

Choose Fruit RED RASPBERRY or PUMMELO?

Fruit Red Raspberry contains many active ingredients or bioactives such as Curcumin, Ellagic Acid, Protocatechuic Acid, Daidzein, Quercetin. These active ingredients manipulate various biochemical pathways like NFKB Signaling, Epithelial to Mesenchymal Transition, PI3K-AKT-MTOR Signaling and MAPK Signaling and others. Red Raspberry is recommended for Endocervical Adenocarcinoma when ongoing cancer treatment is Radiation. This is because Red Raspberry modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Radiation.

Some of the active ingredients or bioactives in fruit Pummelo are Curcumin, Lycopene, Naringenin, Protocatechuic Acid, Apigenin. These active ingredients manipulate various biochemical pathways like NFKB Signaling, TGFB Signaling and Epithelial to Mesenchymal Transition and others. Pummelo is not recommended for Endocervical Adenocarcinoma when ongoing cancer treatment is Radiation because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT RED RASPBERRY IS RECOMMENDED OVER PUMMELO FOR Endocervical Adenocarcinoma AND TREATMENT Radiation.

Choose Nut WALNUT or MACADAMIA NUT?

Walnut contains many active ingredients or bioactives such as Curcumin, D-limonene, Ellagic Acid, Protocatechuic Acid, Apigenin. These active ingredients manipulate various biochemical pathways like NFKB Signaling, TGFB Signaling, PI3K-AKT-MTOR Signaling and MAPK Signaling and others. Walnut is recommended for Endocervical Adenocarcinoma when ongoing cancer treatment is Radiation. This is because Walnut modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Radiation.

Some of the active ingredients or bioactives in Macadamia Nut are Curcumin, Protocatechuic Acid, Apigenin, Daidzein, Lupeol. These active ingredients manipulate various biochemical pathways like NFKB Signaling, TGFB Signaling, PI3K-AKT-MTOR Signaling and Epithelial to Mesenchymal Transition and others. Macadamia Nut is not recommended for Endocervical Adenocarcinoma when ongoing cancer treatment is Radiation because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

WALNUT IS RECOMMENDED OVER MACADAMIA NUT FOR Endocervical Adenocarcinoma AND TREATMENT Radiation.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Endocervical Adenocarcinoma or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable GIANT BUTTERBUR or BLACK CABBAGE?

Vegetable Giant Butterbur contains many active ingredients or bioactives such as Curcumin, Delphinidin, Apigenin, Myricetin, Catechol. These active ingredients manipulate various biochemical pathways like Oxidative Stress, Insulin Signaling, PI3K-AKT-MTOR Signaling and P53 Signaling and others. Giant Butterbur is recommended for risk of Endocervical Adenocarcinoma when associated genetic risk is ERBB2. This is because Giant Butterbur increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Black Cabbage are Curcumin, Delphinidin, Apigenin, Myricetin, Catechol. These active ingredients manipulate various biochemical pathways like Oxidative Stress and Insulin Signaling and others. Black Cabbage is not recommended when risk of Endocervical Adenocarcinoma when associated genetic risk is ERBB2 because it increases the signature pathways of it.

VEGETABLE GIANT BUTTERBUR IS RECOMMENDED OVER BLACK CABBAGE FOR ERBB2 GENETIC RISK OF CANCER.

Choose Fruit WATERMELON or JUJUBE?

Fruit Watermelon contains many active ingredients or bioactives such as Curcumin, Delphinidin, Catechol, Formononetin, Daidzein. These active ingredients manipulate various biochemical pathways like PI3K-AKT-MTOR Signaling, Insulin Signaling and P53 Signaling and others. Watermelon is recommended for risk of Endocervical Adenocarcinoma when associated genetic risk is ERBB2. This is because Watermelon increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Jujube are Quercetin, Curcumin, Delphinidin, Apigenin, Myricetin. These active ingredients manipulate various biochemical pathways like Oxidative Stress, Angiogenesis and PI3K-AKT-MTOR Signaling and others. Jujube is not recommended when risk of Endocervical Adenocarcinoma when associated genetic risk is ERBB2 because it increases the signature pathways of it.

FRUIT WATERMELON IS RECOMMENDED OVER JUJUBE FOR ERBB2 GENETIC RISK OF CANCER.

Choose Nut COMMON HAZELNUT or EUROPEAN CHESTNUT?

Common Hazelnut contains many active ingredients or bioactives such as Quercetin, Curcumin, Delphinidin, Myricetin, Catechol. These active ingredients manipulate various biochemical pathways like Angiogenesis, PI3K-AKT-MTOR Signaling, RAS-RAF Signaling and Insulin Signaling and others. Common Hazelnut is recommended for risk of Endocervical Adenocarcinoma when associated genetic risk is ERBB2. This is because Common Hazelnut increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in European Chestnut are Ellagic Acid, Quercetin, Curcumin, Delphinidin, Apigenin. These active ingredients manipulate various biochemical pathways like Oxidative Stress and Insulin Signaling and others. European Chestnut is not recommended when risk of Endocervical Adenocarcinoma when associated genetic risk is ERBB2 because it increases the signature pathways of it.

COMMON HAZELNUT IS RECOMMENDED OVER EUROPEAN CHESTNUT FOR ERBB2 GENETIC RISK OF CANCER.

In Conclusion

Foods and Supplements chosen are important decisions for cancers like Endocervical Adenocarcinoma. Endocervical Adenocarcinoma patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Endocervical Adenocarcinoma, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like Cauliflower contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Endocervical Adenocarcinoma?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.

References

• Summit 2018
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• Preventive effects of butyric acid, nicotinamide, calcium glucarate alone or in combination during the 7, 12-dimethylbenz (a) anthracene induced mouse skin tumorigenesis via modulation of K-Ras-PI3K-AKTpathway and associated micro RNAs.
• Brassinin Represses Invasive Potential of Lung Carcinoma Cells through Deactivation of PI3K/Akt/mTOR Signaling Cascade.
• D-Limonene modulates inflammation, oxidative stress and Ras-ERK pathway to inhibit murine skin tumorigenesis.