Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Digital Papillary Adenocarcinoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Digital Papillary Adenocarcinoma because of JAK2 and PPM1D gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Digital Papillary Adenocarcinoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Pummelo” or “Include fruit Quince in my diet” or “Should I reduce consumption of vegetable Carob” or “Can I take Stevia and Modified Citrus Pectin supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO DIGITAL PAPILLARY ADENOCARCINOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Digital Papillary Adenocarcinoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR DIGITAL PAPILLARY ADENOCARCINOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Digital Papillary Adenocarcinoma
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Digital Papillary Adenocarcinoma from cBioPortal. The patients enrolled in the studies for Digital Papillary Adenocarcinoma are in ages between 10 to 97 with an average age of 69. 63.2% of males and 36.8% of females were the distribution of gender in these clinical studies. From a patient sample size of 228; the top genes with mutations and other abnormalities for Digital Papillary Adenocarcinoma include genes DNMT3A, TET2, PPM1D, TP53 and JAK2. The occurrence frequency distribution for these genes respectively is 49.4%, 19.3%, 8.4%, 7.2% and 6.0%. These tumor genetic details of Digital Papillary Adenocarcinoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Digital Papillary Adenocarcinoma.
Significance of Nutrition for Digital Papillary Adenocarcinoma
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Digital Papillary Adenocarcinoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Pummelo includes active ingredients Naringin, Linolenic Acid, Beta-sitosterol, Chlorogenic Acid, Vitamin C and others. And Quince contains active ingredients Modified Citrus Pectin, Chlorogenic Acid, Vitamin C, Oleic Acid, Quercitrin and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Digital Papillary Adenocarcinoma, activation or inhibition of selected biochemical pathways like RAS-RAF Signaling, mRNA Splicing, Oncogenic Cancer Epigenetics, DNA Repair plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Digital Papillary Adenocarcinoma, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR DIGITAL PAPILLARY ADENOCARCINOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Digital Papillary Adenocarcinoma undergoing chemotherapy treatment
In Digital Papillary Adenocarcinoma – the genes DNMT3A, TET2, PPM1D, TP53 and JAK2 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Digital Papillary Adenocarcinoma are RAS-RAF Signaling, mRNA Splicing, Cell Cycle and others. Radiation is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers RAS-RAF Signaling, mRNA Splicing, Cell Cycle so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Winged Bean or Adzuki Bean?
Pulses are an important part of many diets. The active ingredients contained in Winged Bean are Betulinic Acid, Linolenic Acid, Vitamin C, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Adzuki Bean are Isoliquiritigenin, Genistein, Glucaric Acid, Folic Acid and others.
Betulinic Acid can manipulate biochemical pathways Hedgehog Signaling, NFKB Signaling and JAK-STAT Signaling. Vitamin C has biological action on biochemical pathways Cell Cycle, MYC Signaling and MAPK Signaling.
Genistein can manipulate biochemical pathways DNA Repair. Folic Acid has biological action on biochemical pathways JAK-STAT Signaling, MYC Signaling and MAPK Signaling. And so on.
When treating Digital Papillary Adenocarcinoma with chemotherapy Radiation – Foods like Winged Bean are recommended compared to Adzuki Bean. This is because the active ingredients Genistein and Folic Acid in Adzuki Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Betulinic Acid and Vitamin C contained in Winged Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: WINGED BEAN IS RECOMMENDED OVER ADZUKI BEAN FOR DIGITAL PAPILLARY ADENOCARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more vegetables, Celeriac or Carob?
Vegetables are an important part of many diets. The active ingredients contained in Celeriac are Angelicin, Linolenic Acid, Vitamin C, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Carob are Quercetin, Myricetin, Gallic Acid, Phloroglucinol, Palmitic Acid and others.
Vitamin K can manipulate biochemical pathways MYC Signaling, NFKB Signaling and Cell Cycle. Angelicin has biological action on biochemical pathways Microtubule Dynamics, DNA Repair and JAK-STAT Signaling.
Palmitic Acid can manipulate biochemical pathways NFKB Signaling, mRNA Splicing and MAPK Signaling. Folic Acid has biological action on biochemical pathways JAK-STAT Signaling, MYC Signaling and PI3K-AKT-MTOR Signaling. And so on.
When treating Digital Papillary Adenocarcinoma with chemotherapy Radiation – Foods like Celeriac are recommended compared to Carob. This is because the active ingredients Palmitic Acid and Folic Acid in Carob interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin K and Angelicin contained in Celeriac support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: CELERIAC IS RECOMMENDED OVER CAROB FOR DIGITAL PAPILLARY ADENOCARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more fruits, Quince or Pummelo?
Fruits are an important part of many diets. The active ingredients contained in Quince are Modified Citrus Pectin, Chlorogenic Acid, Vitamin C, Oleic Acid, Quercitrin among others. While the active ingredients contained in Pummelo are Naringin, Linolenic Acid, Beta-sitosterol, Chlorogenic Acid, Vitamin C and others.
Quercitrin can manipulate biochemical pathways NFKB Signaling, Cell Cycle and MYC Signaling. Modified Citrus Pectin has biological action on biochemical pathways JAK-STAT Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling.
Naringetol can manipulate biochemical pathways Microtubule Dynamics. Hesperetin has biological action on biochemical pathways Microtubule Dynamics. And so on.
When treating Digital Papillary Adenocarcinoma with chemotherapy Radiation – Foods like Quince are recommended compared to Pummelo. This is because the active ingredients Naringetol and Hesperetin in Pummelo interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Quercitrin and Modified Citrus Pectin contained in Quince support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: QUINCE IS RECOMMENDED OVER PUMMELO FOR DIGITAL PAPILLARY ADENOCARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more nuts, Pecan Nut or Peanut?
Nuts are an important part of many diets. The active ingredients contained in Pecan Nut are Vitamin E, Linolenic Acid, Delphinidin, Oleic Acid, Cianidanol among others. While the active ingredients contained in Peanut are Quercetin, Vitamin E, Linolenic Acid, Ferulic Acid, Beta-sitosterol and others.
Vitamin E can manipulate biochemical pathways NFKB Signaling, DNA Repair and Cell Cycle. Delphinidin has biological action on biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling.
Lecithin can manipulate biochemical pathways NFKB Signaling, JAK-STAT Signaling and MYC Signaling. Folic Acid has biological action on biochemical pathways MAPK Signaling, PI3K-AKT-MTOR Signaling and RAS-RAF Signaling. And so on.
When treating Digital Papillary Adenocarcinoma with chemotherapy Radiation – Foods like Pecan Nut are recommended compared to Peanut. This is because the active ingredients Lecithin and Folic Acid in Peanut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin E and Delphinidin contained in Pecan Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER PEANUT FOR DIGITAL PAPILLARY ADENOCARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Foods for Genetic Risk of Digital Papillary Adenocarcinoma
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. JAK2 and PPM1D are two genes whose abnormalities are risk factors for Digital Papillary Adenocarcinoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Digital Papillary Adenocarcinoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Digital Papillary Adenocarcinoma gene JAK2 has causative impact on biological pathways like AGE-RAGE Signaling, Chemokine Signaling and Hematopoiesis. And PPM1D has a causative impact on biological pathways like DNA Repair. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like JAK2 and PPM1D should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes JAK2 and PPM1D should be avoided.
Eat more pulses, Scarlet Bean or Lentils?
The active ingredients contained in Scarlet Bean are Stigmasterol, Genistein, Beta-sitosterol, Oleic Acid, Vitamin C among others. While the active ingredients contained in Lentils are Ellagic Acid, Isoliquiritigenin, Genistein, Daidzein, Esculin and others.
Stigmasterol can manipulate biochemical pathways MYC Signaling, Cytokine Signaling and JAK-STAT Signaling. Beta-sitosterol has biological action on biochemical pathways Oncogenic Cancer Epigenetics, PI3K-AKT-MTOR Signaling and MYC Signaling.
Ellagic Acid can manipulate biochemical pathways MYC Signaling. Folic Acid has biological action on biochemical pathways JAK-STAT Signaling, PI3K-AKT-MTOR Signaling and MYC Signaling. And so on.
For genetic risk of Digital Papillary Adenocarcinoma due to abnormalities in genes JAK2 and PPM1D – Foods like Scarlet Bean are recommended compared to Lentils. This is because the active ingredients Ellagic Acid and Folic Acid in Lentils further promote the effects of genes on the biochemical pathways. While the active ingredients Stigmasterol and Beta-sitosterol contained in Scarlet Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER LENTILS FOR REDUCING THE GENETIC RISK OF DIGITAL PAPILLARY ADENOCARCINOMA DUE TO GENES JAK2 AND PPM1D
Eat more vegetables, Bitter Melon or Swede?
The active ingredients contained in Bitter Melon are Cucurbitacin E, Cucurbitacin I, Oleic Acid, Beta-sitosterol, Vitamin C among others. While the active ingredients contained in Swede are Lycopene, Oleic Acid, Linolenic Acid, Linoleic Acid, Folic Acid and others.
Vitamin C can manipulate biochemical pathways MYC Signaling, Oncogenic Cancer Epigenetics and PI3K-AKT-MTOR Signaling. Cucurbitacin E has biological action on biochemical pathways Cytokine Signaling, JAK-STAT Signaling and MYC Signaling.
Lycopene can manipulate biochemical pathways Extracellular Matrix Remodelling. Folic Acid has biological action on biochemical pathways MYC Signaling, JAK-STAT Signaling and PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Digital Papillary Adenocarcinoma due to abnormalities in genes JAK2 and PPM1D – Foods like Bitter Melon are recommended compared to Swede. This is because the active ingredients Lycopene and Folic Acid in Swede further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Cucurbitacin E contained in Bitter Melon together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: BITTER MELON IS RECOMMENDED OVER SWEDE FOR REDUCING THE GENETIC RISK OF DIGITAL PAPILLARY ADENOCARCINOMA DUE TO GENES JAK2 AND PPM1D
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Pomegranate or Fig?
The active ingredients contained in Pomegranate are Betulinic Acid, Apigenin, Ellagic Acid, Epigallocatechin Gallate, Beta-sitosterol among others. While the active ingredients contained in Fig are Bergapten, Lupeol, Beta-sitosterol, Vitamin C, Angelicin and others.
Betulinic Acid can manipulate biochemical pathways JAK-STAT Signaling, MYC Signaling and PI3K-AKT-MTOR Signaling. Gallic Acid has biological action on biochemical pathways Extracellular Matrix Remodelling, MYC Signaling and PI3K-AKT-MTOR Signaling.
Palmitic Acid can manipulate biochemical pathways Oncogenic Cancer Epigenetics. Lauric Acid has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Digital Papillary Adenocarcinoma due to abnormalities in genes JAK2 and PPM1D – Foods like Pomegranate are recommended compared to Fig. This is because the active ingredients Palmitic Acid and Lauric Acid in Fig further promote the effects of genes on the biochemical pathways. While the active ingredients Betulinic Acid and Gallic Acid contained in Pomegranate together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: POMEGRANATE IS RECOMMENDED OVER FIG FOR REDUCING THE GENETIC RISK OF DIGITAL PAPILLARY ADENOCARCINOMA DUE TO GENES JAK2 AND PPM1D
Eat more nuts, Almond or Acorn?
The active ingredients contained in Almond are Stigmasterol, Quercetin, Oleic Acid, Beta-sitosterol, Salicylic Acid among others. While the active ingredients contained in Acorn are Quercetin, Beta-sitosterol, Vitamin C, Beta-carotene, Gallic Acid and others.
Beta-sitosterol can manipulate biochemical pathways MYC Signaling, Oncogenic Cancer Epigenetics and PI3K-AKT-MTOR Signaling. Stigmasterol has biological action on biochemical pathways Cytokine Signaling, JAK-STAT Signaling and MYC Signaling.
Vitamin B2 can manipulate biochemical pathways Oncogenic Cancer Epigenetics. Folic Acid has biological action on biochemical pathways MYC Signaling, JAK-STAT Signaling and PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Digital Papillary Adenocarcinoma due to abnormalities in genes JAK2 and PPM1D – Foods like Almond are recommended compared to Acorn. This is because the active ingredients Vitamin B2 and Folic Acid in Acorn further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Stigmasterol contained in Almond together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: ALMOND IS RECOMMENDED OVER ACORN FOR REDUCING THE GENETIC RISK OF DIGITAL PAPILLARY ADENOCARCINOMA DUE TO GENES JAK2 AND PPM1D
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Digital Papillary Adenocarcinoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
- Msk Ch 2020
- Cancer therapy shapes the fitness landscape of clonal hematopoiesis.
- Helicteric Acid, Oleanic Acid, and Betulinic Acid, Three Triterpenes from Helicteres angustifolia L., Inhibit Proliferation and Induce Apoptosis in HT-29 Colorectal Cancer Cells via Suppressing NF-κB and STAT3 Signaling.
- The synergy of Vitamin C with decitabine activates TET2 in leukemic cells and significantly improves overall survival in elderly patients with acute myeloid leukemia.
- BRCA1 and BRCA2 as molecular targets for phytochemicals indole-3-carbinol and genistein in breast and prostate cancer cells.
- Folic acid mediates activation of the pro-oncogene STAT3 via the Folate Receptor alpha.
- Identification of quercitrin as an inhibitor of the p90 S6 ribosomal kinase (RSK): structure of its complex with the N-terminal domain of RSK2 at 1.8 Å resolution.
- Increased galectin-3 levels are associated with abdominal aortic aneurysm progression and inhibition of galectin-3 decreases elastase-induced AAA development.
- Research progress on the anticancer effects of vitamin K2.
- Angelicin regulates LPS-induced inflammation via inhibiting MAPK/NF-κB pathways.
- Functional lipidomics: Palmitic acid impairs hepatocellular carcinoma development by modulating membrane fluidity and glucose metabolism.
- Gamma-tocotrienol-induced apoptosis in human gastric cancer SGC-7901 cells is associated with a suppression in mitogen-activated protein kinase signalling.
- Delphinidin inhibits a broad spectrum of receptor tyrosine kinases of the ErbB and VEGFR family.
- The recruitment of Raf-1 to membranes is mediated by direct interaction with phosphatidic acid and is independent of association with Ras.
- Stigmasterol exhibits potent antitumor effects in human gastric cancer cells mediated via inhibition of cell migration, cell cycle arrest, mitochondrial mediated apoptosis and inhibition of JAK/STAT signalling pathway.
- Paederia foetida induces anticancer activity by modulating chromatin modification enzymes and altering pro-inflammatory cytokine gene expression in human prostate cancer cells.
- Identification of ellagic acid as potent inhibitor of protein kinase CK2: a successful example of a virtual screening application.
- Gallic acid, a phenolic compound, exerts anti-angiogenic effects via the PTEN/AKT/HIF-1α/VEGF signaling pathway in ovarian cancer cells.
- Clinical pharmacodynamics of antihistamines.
- Cucurbitacin E reduces obesity and related metabolic dysfunction in mice by targeting JAK-STAT5 signaling pathway.
- Lycopene and bone: an in vitro investigation and a pilot prospective clinical study.
- Methyl Donor Micronutrients that Modify DNA Methylation and Cancer Outcome.
- HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods.
- Pectin and Pectin-Based Composite Materials: Beyond Food Texture.
- Promise of bitter melon (Momordica charantia) bioactives in cancer prevention and therapy.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.