Foods for Pituitary Neuroendocrine Tumors!

Introduction

Foods for Pituitary Neuroendocrine Tumors should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.

For Pituitary Neuroendocrine Tumors does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Pituitary Neuroendocrine Tumors does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Pituitary Neuroendocrine Tumors?

For example does it matter if vegetable New Zealand Spinach is consumed more compared to Welsh Onion? Does it make any difference if fruit Fig is preferred over Pomegranate? Also if similar choices are made for nuts/seeds like Butternut over Chestnut and for pulses like Gram Bean over Lima Bean. And if what I eat matters – then how does one identify foods which are recommended for Pituitary Neuroendocrine Tumors and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Pituitary Neuroendocrine Tumors!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Fig contains active ingredients Quercetin, Curcumin, Formononetin, Phloretin, Daidzein. And Pomegranate contains active ingredients Quercetin, Ellagic Acid, Curcumin, Apigenin, Formononetin and possibly others.

A common mistake made when deciding and choosing foods to eat for Pituitary Neuroendocrine Tumors – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Pituitary Neuroendocrine Tumors.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Pituitary Neuroendocrine Tumors?

Personalized nutrition for cancers like Pituitary Neuroendocrine Tumors consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Pituitary Neuroendocrine Tumors biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Characteristics of cancers like Pituitary Neuroendocrine Tumors

All cancers like Pituitary Neuroendocrine Tumors can be characterized by a unique set of biochemical pathways – the signature pathways of Pituitary Neuroendocrine Tumors. Biochemical pathways like Apoptosis, Nutrient sensing, PI3K-AKT-MTOR Signaling, DNA Repair are part of the signature definition of Pituitary Neuroendocrine Tumors. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Pituitary Neuroendocrine Tumors need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Pituitary Neuroendocrine Tumors when taking cancer treatment Docetaxel, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

USP8, PRKDC, EGLN1, GNAS and KAT6A are the top ranked reported genes for Pituitary Neuroendocrine Tumors. USP8 is reported in 11.8 % of the representative patients across all clinical trials. And PRKDC is reported in 6.8 %. The combined population patient data cover ages from to . % of the patient data are identified as men. The Pituitary Neuroendocrine Tumors biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Food and Supplements for Pituitary Neuroendocrine Tumors

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable NEW ZEALAND SPINACH or WELSH ONION?

Vegetable New Zealand Spinach contains many active ingredients or bioactives such as Quercetin, Curcumin, Apigenin, Formononetin, Phloretin. These active ingredients manipulate various biochemical pathways like Cell Cycle, Epithelial to Mesenchymal Transition, TGFB Signaling and Angiogenesis and others. New Zealand Spinach is recommended for Pituitary Neuroendocrine Tumors when ongoing cancer treatment is Docetaxel. This is because New Zealand Spinach modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Docetaxel.

Some of the active ingredients or bioactives in vegetable Welsh Onion are Curcumin, Formononetin, Phloretin, Daidzein, Isoliquiritigenin. These active ingredients manipulate various biochemical pathways like WNT Beta Catenin Signaling and NFKB Signaling and others. Welsh Onion is not recommended for Pituitary Neuroendocrine Tumors when ongoing cancer treatment is Docetaxel because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE NEW ZEALAND SPINACH IS RECOMMENDED OVER WELSH ONION FOR Pituitary Neuroendocrine Tumors AND TREATMENT Docetaxel.

Choose Fruit POMEGRANATE or FIG?

Fruit Pomegranate contains many active ingredients or bioactives such as Quercetin, Ellagic Acid, Curcumin, Apigenin, Formononetin. These active ingredients manipulate various biochemical pathways like Cell Cycle, TGFB Signaling, Nutrient sensing and Microtubule Dynamics and others. Pomegranate is recommended for Pituitary Neuroendocrine Tumors when ongoing cancer treatment is Docetaxel. This is because Pomegranate modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Docetaxel.

Some of the active ingredients or bioactives in fruit Fig are Quercetin, Curcumin, Formononetin, Phloretin, Daidzein. These active ingredients manipulate various biochemical pathways like MAPK Signaling, WNT Beta Catenin Signaling, Microtubule Dynamics and MYC Signaling and others. Fig is not recommended for Pituitary Neuroendocrine Tumors when ongoing cancer treatment is Docetaxel because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT POMEGRANATE IS RECOMMENDED OVER FIG FOR Pituitary Neuroendocrine Tumors AND TREATMENT Docetaxel.

Choose Nut BUTTERNUT or CHESTNUT?

Butternut contains many active ingredients or bioactives such as Curcumin, Apigenin, Formononetin, Phloretin, Daidzein. These active ingredients manipulate various biochemical pathways like Cell Cycle, TGFB Signaling, Angiogenesis and MYC Signaling and others. Butternut is recommended for Pituitary Neuroendocrine Tumors when ongoing cancer treatment is Docetaxel. This is because Butternut modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Docetaxel.

Some of the active ingredients or bioactives in Chestnut are Ellagic Acid, Curcumin, Apigenin, Formononetin, Phloretin. These active ingredients manipulate various biochemical pathways like TGFB Signaling, Epithelial to Mesenchymal Transition, WNT Beta Catenin Signaling and NFKB Signaling and others. Chestnut is not recommended for Pituitary Neuroendocrine Tumors when ongoing cancer treatment is Docetaxel because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

BUTTERNUT IS RECOMMENDED OVER CHESTNUT FOR Pituitary Neuroendocrine Tumors AND TREATMENT Docetaxel.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Pituitary Neuroendocrine Tumors or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable GIANT BUTTERBUR or AVOCADO?

Vegetable Giant Butterbur contains many active ingredients or bioactives such as Curcumin, Apigenin, Lycopene, Protocatechuic Acid, Lupeol. These active ingredients manipulate various biochemical pathways like Small Molecule Transport, MAPK Signaling, Cell Cycle Checkpoints and MYC Signaling and others. Giant Butterbur is recommended for risk of Pituitary Neuroendocrine Tumors when associated genetic risk is EGLN1. This is because Giant Butterbur increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Avocado are Curcumin, Protocatechuic Acid, Quercetin, Lupeol, Psoralen. These active ingredients manipulate various biochemical pathways like Small Molecule Transport and others. Avocado is not recommended when risk of Pituitary Neuroendocrine Tumors when associated genetic risk is EGLN1 because it increases the signature pathways of it.

VEGETABLE GIANT BUTTERBUR IS RECOMMENDED OVER AVOCADO FOR EGLN1 GENETIC RISK OF CANCER.

Choose Fruit NANCE or PUMMELO?

Fruit Nance contains many active ingredients or bioactives such as Curcumin, Apigenin, Protocatechuic Acid, Lupeol, Vitamin C. These active ingredients manipulate various biochemical pathways like Hypoxia, MAPK Signaling and MYC Signaling and others. Nance is recommended for risk of Pituitary Neuroendocrine Tumors when associated genetic risk is EGLN1. This is because Nance increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Pummelo are Curcumin, Apigenin, Lycopene, Protocatechuic Acid, Quercetin. These active ingredients manipulate various biochemical pathways like DNA Repair, Extracellular Matrix Remodelling, Small Molecule Transport and Cell Cycle Checkpoints and others. Pummelo is not recommended when risk of Pituitary Neuroendocrine Tumors when associated genetic risk is EGLN1 because it increases the signature pathways of it.

FRUIT NANCE IS RECOMMENDED OVER PUMMELO FOR EGLN1 GENETIC RISK OF CANCER.

Choose Nut COMMON WALNUT or BRAZIL NUT?

Common Walnut contains many active ingredients or bioactives such as Curcumin, Ellagic Acid, Protocatechuic Acid, Quercetin, Lupeol. These active ingredients manipulate various biochemical pathways like Apoptosis, MAPK Signaling, Cell Cycle Checkpoints and MYC Signaling and others. Common Walnut is recommended for risk of Pituitary Neuroendocrine Tumors when associated genetic risk is EGLN1. This is because Common Walnut increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in Brazil Nut are Curcumin, Ellagic Acid, Protocatechuic Acid, Lupeol, Psoralen. These active ingredients manipulate various biochemical pathways like MAPK Signaling, DNA Repair and PI3K-AKT-MTOR Signaling and others. Brazil Nut is not recommended when risk of Pituitary Neuroendocrine Tumors when associated genetic risk is EGLN1 because it increases the signature pathways of it.

COMMON WALNUT IS RECOMMENDED OVER BRAZIL NUT FOR EGLN1 GENETIC RISK OF CANCER.

In Conclusion

Foods and Supplements chosen are important decisions for cancers like Pituitary Neuroendocrine Tumors. Pituitary Neuroendocrine Tumors patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Pituitary Neuroendocrine Tumors, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like New Zealand Spinach contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Pituitary Neuroendocrine Tumors?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.

References

• Betulinic acid inhibits stemness and EMT of pancreatic cancer cells via activation of AMPK signaling.
• Gallic acid, a phenolic compound, exerts anti-angiogenic effects via the PTEN/AKT/HIF-1α/VEGF signaling pathway in ovarian cancer cells.
• Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH.
• Myricetin arrests human telomeric G-quadruplex structure: a new mechanistic approach as an anticancer agent.