Which Foods are Recommended for Pituitary Neuroendocrine Tumors?

Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Pituitary Neuroendocrine Tumors when undergoing chemotherapy or when you determine you have a genetic risk for developing Pituitary Neuroendocrine Tumors because of USP8 and PRKDC gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Pituitary Neuroendocrine Tumors which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Mango” or “Include fruit Squashberry in my diet” or “Should I reduce consumption of vegetable Yardlong Bean” or “Can I take Dim and Neem Extract supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO PITUITARY NEUROENDOCRINE TUMORS, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Pituitary Neuroendocrine Tumors is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR PITUITARY NEUROENDOCRINE TUMORS, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.

About Pituitary Neuroendocrine Tumors

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Pituitary Neuroendocrine Tumors from cBioPortal. The top genes with mutations and other abnormalities for Pituitary Neuroendocrine Tumors include genes USP8, PRKDC, EGLN1, GNAS and KAT6A. The occurrence frequency distribution for these genes respectively is 11.8%, 6.8%, 5.9%, 5.9% and 5.6%. These tumor genetic details of Pituitary Neuroendocrine Tumors are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Pituitary Neuroendocrine Tumors.

Significance of Nutrition for Pituitary Neuroendocrine Tumors

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Pituitary Neuroendocrine Tumors. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Mango includes active ingredients Vitamin C, Lupeol, Beta-sitosterol, Oleic Acid, Delphinidin and others. And Squashberry contains active ingredients Vitamin C, Vitamin A and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Pituitary Neuroendocrine Tumors, activation or inhibition of selected biochemical pathways like Amino Acid Metabolism, Angiogenesis, PI3K-AKT-MTOR Signaling, DNA Repair plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Pituitary Neuroendocrine Tumors, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR PITUITARY NEUROENDOCRINE TUMORS – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Pituitary Neuroendocrine Tumors undergoing chemotherapy treatment

In Pituitary Neuroendocrine Tumors – the genes USP8, PRKDC, EGLN1, GNAS and KAT6A have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Pituitary Neuroendocrine Tumors are Amino Acid Metabolism, Angiogenesis, PI3K-AKT-MTOR Signaling and others. Fluorouracil is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Amino Acid Metabolism, Angiogenesis, PI3K-AKT-MTOR Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Common Pea or Lima Bean?

Pulses are an important part of many diets. The active ingredients contained in Common Pea are Vitamin C, Lupeol, Daidzein, Beta-sitosterol, Oleic Acid among others. While the active ingredients contained in Lima Bean are Vitamin C, Oleic Acid, Vitamin A, Linoleic Acid, Genistein and others.

Vitamin C can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Adherens junction and MYC Signaling. Beta-sitosterol has biological action on biochemical pathways NFKB Signaling, Microtubule Dynamics and DNA Repair.

Genistein can manipulate biochemical pathways DNA Repair and Oxidative Stress. Oleic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition and Netrin Signaling. And so on.

When treating Pituitary Neuroendocrine Tumors with chemotherapy Fluorouracil – Foods like Common Pea are recommended compared to Lima Bean. This is because the active ingredients Genistein and Oleic Acid in Lima Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Beta-sitosterol contained in Common Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER LIMA BEAN FOR PITUITARY NEUROENDOCRINE TUMORS ON TREATMENT WITH CHEMOTHERAPY FLUOROURACIL FOR SOME CONDITIONS.

Eat more vegetables, Cabbage or Yardlong Bean?

Vegetables are an important part of many diets. The active ingredients contained in Cabbage are Quercetin, Vitamin C, Benzyl Isothiocyanate, Beta-sitosterol, Isorhamnetin among others. While the active ingredients contained in Yardlong Bean are Vitamin C, Oleic Acid, Linolenic Acid, Vitamin A, Linoleic Acid and others.

Vitamin C can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Adherens junction and MYC Signaling. Glucaric Acid has biological action on biochemical pathways NFKB Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling.

Oleic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition and Netrin Signaling. Linolenic Acid has biological action on biochemical pathways Vitamin D Signaling and Oxidative Stress. And so on.

When treating Pituitary Neuroendocrine Tumors with chemotherapy Fluorouracil – Foods like Cabbage are recommended compared to Yardlong Bean. This is because the active ingredients Oleic Acid and Linolenic Acid in Yardlong Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Glucaric Acid contained in Cabbage support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: CABBAGE IS RECOMMENDED OVER YARDLONG BEAN FOR PITUITARY NEUROENDOCRINE TUMORS ON TREATMENT WITH CHEMOTHERAPY FLUOROURACIL FOR SOME CONDITIONS.

Eat more fruits, Squashberry or Mango?

Fruits are an important part of many diets. The active ingredients contained in Squashberry are Vitamin C, Vitamin A among others. While the active ingredients contained in Mango are Vitamin C, Lupeol, Beta-sitosterol, Oleic Acid, Delphinidin and others.

Vitamin A can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Adherens junction. Vitamin C has biological action on biochemical pathways MYC Signaling, WNT Beta Catenin Signaling and P53 Signaling.

Gallic Acid can manipulate biochemical pathways Vitamin D Signaling and Oxidative Stress. Citric Acid has biological action on biochemical pathways Oxidative Stress. And so on.

When treating Pituitary Neuroendocrine Tumors with chemotherapy Fluorouracil – Foods like Squashberry are recommended compared to Mango. This is because the active ingredients Gallic Acid and Citric Acid in Mango interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin A and Vitamin C contained in Squashberry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: SQUASHBERRY IS RECOMMENDED OVER MANGO FOR PITUITARY NEUROENDOCRINE TUMORS ON TREATMENT WITH CHEMOTHERAPY FLUOROURACIL FOR SOME CONDITIONS.

Eat more nuts, Pecan Nut or Acorn?

Nuts are an important part of many diets. The active ingredients contained in Pecan Nut are Vitamin E, Cianidanol, Oleic Acid, Delphinidin, Linolenic Acid among others. While the active ingredients contained in Acorn are Quercetin, Vitamin C, Beta-sitosterol, Gallic Acid, Beta-carotene and others.

Vitamin E can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and DNA Repair. Cianidanol has biological action on biochemical pathways Microtubule Dynamics, MYC Signaling and P53 Signaling.

Quercetin can manipulate biochemical pathways Oxidative Stress. Gallic Acid has biological action on biochemical pathways Vitamin D Signaling and Oxidative Stress. And so on.

When treating Pituitary Neuroendocrine Tumors with chemotherapy Fluorouracil – Foods like Pecan Nut are recommended compared to Acorn. This is because the active ingredients Quercetin and Gallic Acid in Acorn interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin E and Cianidanol contained in Pecan Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER ACORN FOR PITUITARY NEUROENDOCRINE TUMORS ON TREATMENT WITH CHEMOTHERAPY FLUOROURACIL FOR SOME CONDITIONS.

Foods for Genetic Risk of Pituitary Neuroendocrine Tumors

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. USP8 and PRKDC are two genes whose abnormalities are risk factors for Pituitary Neuroendocrine Tumors. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Pituitary Neuroendocrine Tumors can be used as a guide for coming up with a recommended personalized nutrition plan. For Pituitary Neuroendocrine Tumors gene USP8 has causative impact on biological pathways like Growth Factor Signaling, Growth Factor Signaling and Growth Factor Signaling. And PRKDC has a causative impact on biological pathways like DNA Repair, PI3K-AKT-MTOR Signaling and DNA Repair. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like USP8 and PRKDC should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes USP8 and PRKDC should be avoided.

Eat more pulses, Adzuki Bean or Common Bean?

The active ingredients contained in Adzuki Bean are Isoliquiritigenin, Glucaric Acid, Folic Acid, Genistein among others. While the active ingredients contained in Common Bean are Vitamin C, Esculin, Oleic Acid, Linoleic Acid, Folic Acid and others.

Glucaric Acid can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Isoliquiritigenin has biological action on biochemical pathways Chromatin Remodeling, Hypoxia and PI3K-AKT-MTOR Signaling.

Esculin can manipulate biochemical pathways Oxidative Stress. Gamma-linolenic Acid has biological action on biochemical pathways Oxidative Stress. And so on.

For genetic risk of Pituitary Neuroendocrine Tumors due to abnormalities in genes USP8 and PRKDC – Foods like Adzuki Bean are recommended compared to Common Bean. This is because the active ingredients Esculin and Gamma-linolenic Acid in Common Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Glucaric Acid and Isoliquiritigenin contained in Adzuki Bean together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: ADZUKI BEAN IS RECOMMENDED OVER COMMON BEAN FOR REDUCING THE GENETIC RISK OF PITUITARY NEUROENDOCRINE TUMORS DUE TO GENES USP8 AND PRKDC

Eat more vegetables, Turnip or Radish?

The active ingredients contained in Turnip are Vitamin C, Indole-3-carbinol, Sulforaphane, Folic Acid, Vitamin A among others. While the active ingredients contained in Radish are Isorhamnetin, Vitamin C, Quercetin, Caffeic Acid, Beta-sitosterol and others.

Indole-3-carbinol can manipulate biochemical pathways DNA Repair, PI3K-AKT-MTOR Signaling and Oxidative Stress. Sulforaphane has biological action on biochemical pathways Chromatin Remodeling, Hypoxia and Oxidative Stress.

Quercetin can manipulate biochemical pathways DNA Repair and Oxidative Stress. Pelargonidin has biological action on biochemical pathways PI3K-AKT-MTOR Signaling and Oxidative Stress. And so on.

For genetic risk of Pituitary Neuroendocrine Tumors due to abnormalities in genes USP8 and PRKDC – Foods like Turnip are recommended compared to Radish. This is because the active ingredients Quercetin and Pelargonidin in Radish further promote the effects of genes on the biochemical pathways. While the active ingredients Indole-3-carbinol and Sulforaphane contained in Turnip together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: TURNIP IS RECOMMENDED OVER RADISH FOR REDUCING THE GENETIC RISK OF PITUITARY NEUROENDOCRINE TUMORS DUE TO GENES USP8 AND PRKDC

Eat more fruits, Partridgeberry or Roselle?

The active ingredients contained in Partridgeberry are Resveratrol, Beta-sitosterol, Stigmasterol among others. While the active ingredients contained in Roselle are Vitamin C, Beta-sitosterol, Lutein, Oleic Acid, Linoleic Acid and others.

Resveratrol can manipulate biochemical pathways DNA Repair, Hypoxia and PI3K-AKT-MTOR Signaling. Beta-sitosterol has biological action on biochemical pathways Oxidative Stress and PI3K-AKT-MTOR Signaling.

Citric Acid can manipulate biochemical pathways Oxidative Stress. Oleic Acid has biological action on biochemical pathways DNA Repair. And so on.

For genetic risk of Pituitary Neuroendocrine Tumors due to abnormalities in genes USP8 and PRKDC – Foods like Partridgeberry are recommended compared to Roselle. This is because the active ingredients Citric Acid and Oleic Acid in Roselle further promote the effects of genes on the biochemical pathways. While the active ingredients Resveratrol and Beta-sitosterol contained in Partridgeberry together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: PARTRIDGEBERRY IS RECOMMENDED OVER ROSELLE FOR REDUCING THE GENETIC RISK OF PITUITARY NEUROENDOCRINE TUMORS DUE TO GENES USP8 AND PRKDC

Eat more nuts, Cashew Nut or Brazil Nut?

The active ingredients contained in Cashew Nut are Vitamin C, Beta-sitosterol, Butyric Acid, Lauric Acid, Folic Acid among others. While the active ingredients contained in Brazil Nut are Oleic Acid, Folic Acid, Vitamin E, Lecithin, Linolenic Acid and others.

Vitamin C can manipulate biochemical pathways Oxidative Stress, Hypoxia and PI3K-AKT-MTOR Signaling. Beta-sitosterol has biological action on biochemical pathways Oxidative Stress and PI3K-AKT-MTOR Signaling.

Lecithin can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Oleic Acid has biological action on biochemical pathways DNA Repair. And so on.

For genetic risk of Pituitary Neuroendocrine Tumors due to abnormalities in genes USP8 and PRKDC – Foods like Cashew Nut are recommended compared to Brazil Nut. This is because the active ingredients Lecithin and Oleic Acid in Brazil Nut further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Cashew Nut together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: CASHEW NUT IS RECOMMENDED OVER BRAZIL NUT FOR REDUCING THE GENETIC RISK OF PITUITARY NEUROENDOCRINE TUMORS DUE TO GENES USP8 AND PRKDC

In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Pituitary Neuroendocrine Tumors by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

References

• Regulated function of the prolyl-4-hydroxylase domain (PHD) oxygen sensor proteins.
• Reactive oxygen species-mediated activation of AMP-activated protein kinase and c-Jun N-terminal kinase plays a critical role in beta-sitosterol-induced apoptosis in multiple myeloma U266 cells.
• BRCA1 and BRCA2 as molecular targets for phytochemicals indole-3-carbinol and genistein in breast and prostate cancer cells.
• Anti-cancer targeting telomerase inhibitors: β-rubromycin and oleic acid.
• Retinol decreases beta-catenin protein levels in retinoic acid-resistant colon cancer cell lines.
• Cardioprotective effect of gallic acid on cardiac troponin-T, cardiac marker enzymes, lipid peroxidation products and antioxidants in experimentally induced myocardial infarction in Wistar rats.
• Preventive effects of butyric acid, nicotinamide, calcium glucarate alone or in combination during the 7, 12-dimethylbenz (a) anthracene induced mouse skin tumorigenesis via modulation of K-Ras-PI3K-AKTpathway and associated micro RNAs.
• Alpha-linolenic acid confers protection on mice renal cells against cisplatin-induced nephrotoxicity.
• Anti-IL-1 alpha autoantibodies in patients with rheumatic diseases and in healthy subjects.
• (+)-Catechin inhibits tumour angiogenesis and regulates the production of nitric oxide and TNF-alpha in LPS-stimulated macrophages.
• [Basic formulation of the tasks of special education in rehabilitating the physically handicapped].
• Bis(4-hydroxy-2H-chromen-2-one): synthesis and effects on leukemic cell lines proliferation and NF-κB regulation.
• Anti-oxidative and photo-protective effects of coumarins isolated from Fraxinus chinensis.
• Research on Rett syndrome: strategy and preliminary results.
• Spongiapyridine and related spongians isolated from an Indonesian Spongia sp.
• Sulforaphane modulates telomerase activity via epigenetic regulation in prostate cancer cell lines.
• [Metabolic changes in chronic uremia and their modification after low-protein diet, periodic dialysis and renal transplantation].
• New concepts in phospholipase D signaling in inflammation and cancer.
• HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods.
• Resveratrol, pterostilbene, and piceatannol in vaccinium berries.
• Sulforaphane and Other Nutrigenomic Nrf2 Activators: Can the Clinician’s Expectation Be Matched by the Reality?