Which Foods are Recommended for Gallbladder Cancer?

Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Gallbladder Cancer when undergoing chemotherapy or when you determine you have a genetic risk for developing Gallbladder Cancer because of CTNNB1 and APC gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Gallbladder Cancer which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Cranberry” or “Include fruit Cherimoya in my diet” or “Should I reduce consumption of vegetable Rhubarb” or “Can I take Dim and Birch supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO GALLBLADDER CANCER, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Gallbladder Cancer is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR GALLBLADDER CANCER, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.

About Gallbladder Cancer

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Gallbladder Cancer from cBioPortal. The patients enrolled in the studies for Gallbladder Cancer are in ages between 37 to 86 with an average age of 61. 37.5% of males and 62.5% of females were the distribution of gender in these clinical studies. From a patient sample size of 314; the top genes with mutations and other abnormalities for Gallbladder Cancer include genes MUC16, KRAS, CTNNB1, KMT2C and APC. The occurrence frequency distribution for these genes respectively is 3.6%, 2.4%, 2.4%, 2.4% and 2.4%. These tumor genetic details of Gallbladder Cancer are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Gallbladder Cancer.

Significance of Nutrition for Gallbladder Cancer

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Gallbladder Cancer. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Cranberry includes active ingredients Ellagic Acid, Quercetin, Resveratrol, Delphinidin, Caffeic Acid and others. And Cherimoya contains active ingredients Beta-sitosterol, Vitamin C, Linolenic Acid, Oleic Acid, Stigmasterol and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Gallbladder Cancer, activation or inhibition of selected biochemical pathways like Nucleotide metabolism, Adherens junction, PI3K-AKT-MTOR Signaling, MAPK Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Gallbladder Cancer, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR GALLBLADDER CANCER – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Gallbladder Cancer undergoing chemotherapy treatment

In Gallbladder Cancer – the genes MUC16, KRAS, CTNNB1, KMT2C and APC have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Gallbladder Cancer are Nucleotide metabolism, Adherens junction, Cytokine Signaling and others. Gemcitabine is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Nucleotide metabolism, Adherens junction, Cytokine Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Adzuki Bean or Pigeon Pea?

Pulses are an important part of many diets. The active ingredients contained in Adzuki Bean are Isoliquiritigenin, Genistein, Glucaric Acid, Folic Acid among others. While the active ingredients contained in Pigeon Pea are Vitamin C, Linolenic Acid, Oleic Acid, Genistein, Vitamin A and others.

Glucaric Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and MYC Signaling. Isoliquiritigenin has biological action on biochemical pathways Adherens junction, Chemokine Signaling and Growth Factor Signaling.

Genistein can manipulate biochemical pathways DNA Repair and Oxidative Stress. Vitamin A has biological action on biochemical pathways Focal Adhesion. And so on.

When treating Gallbladder Cancer with chemotherapy Gemcitabine – Foods like Adzuki Bean are recommended compared to Pigeon Pea. This is because the active ingredients Genistein and Vitamin A in Pigeon Pea interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Glucaric Acid and Isoliquiritigenin contained in Adzuki Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: ADZUKI BEAN IS RECOMMENDED OVER PIGEON PEA FOR GALLBLADDER CANCER ON TREATMENT WITH CHEMOTHERAPY GEMCITABINE FOR SOME CONDITIONS.

Eat more vegetables, Kohlrabi or Rhubarb?

Vegetables are an important part of many diets. The active ingredients contained in Kohlrabi are Brassinin, Beta-sitosterol, Vitamin C, Linolenic Acid, Oleic Acid among others. While the active ingredients contained in Rhubarb are Quercetin, Vitamin E, Vitamin C, Linolenic Acid, Gallic Acid and others.

Brassinin can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Adherens junction. Vitamin C has biological action on biochemical pathways Growth Factor Signaling, MYC Signaling and WNT Beta Catenin Signaling.

Rutin can manipulate biochemical pathways WNT Beta Catenin Signaling and Oxidative Stress. Quercetin has biological action on biochemical pathways Oxidative Stress. And so on.

When treating Gallbladder Cancer with chemotherapy Gemcitabine – Foods like Kohlrabi are recommended compared to Rhubarb. This is because the active ingredients Rutin and Quercetin in Rhubarb interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Brassinin and Vitamin C contained in Kohlrabi support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: KOHLRABI IS RECOMMENDED OVER RHUBARB FOR GALLBLADDER CANCER ON TREATMENT WITH CHEMOTHERAPY GEMCITABINE FOR SOME CONDITIONS.

Eat more fruits, Cherimoya or Cranberry?

Fruits are an important part of many diets. The active ingredients contained in Cherimoya are Beta-sitosterol, Vitamin C, Linolenic Acid, Oleic Acid, Stigmasterol among others. While the active ingredients contained in Cranberry are Ellagic Acid, Quercetin, Resveratrol, Delphinidin, Caffeic Acid and others.

Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Adherens junction. Stigmasterol has biological action on biochemical pathways JAK-STAT Signaling, MYC Signaling and P53 Signaling.

Ellagic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition, WNT Beta Catenin Signaling and MYC Signaling. Quercetin has biological action on biochemical pathways Oxidative Stress. And so on.

When treating Gallbladder Cancer with chemotherapy Gemcitabine – Foods like Cherimoya are recommended compared to Cranberry. This is because the active ingredients Ellagic Acid and Quercetin in Cranberry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Stigmasterol contained in Cherimoya support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: CHERIMOYA IS RECOMMENDED OVER CRANBERRY FOR GALLBLADDER CANCER ON TREATMENT WITH CHEMOTHERAPY GEMCITABINE FOR SOME CONDITIONS.

Eat more nuts, Pine Nut or Acorn?

Nuts are an important part of many diets. The active ingredients contained in Pine Nut are Beta-sitosterol, Vitamin E, Linolenic Acid, Oleic Acid, Vitamin A among others. While the active ingredients contained in Acorn are Quercetin, Beta-sitosterol, Vitamin C, Gallic Acid, Beta-carotene and others.

Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Adherens junction. Vitamin K has biological action on biochemical pathways MYC Signaling, PI3K-AKT-MTOR Signaling and NFKB Signaling.

Quercetin can manipulate biochemical pathways Oxidative Stress. Gallic Acid has biological action on biochemical pathways Oxidative Stress. And so on.

When treating Gallbladder Cancer with chemotherapy Gemcitabine – Foods like Pine Nut are recommended compared to Acorn. This is because the active ingredients Quercetin and Gallic Acid in Acorn interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin K contained in Pine Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: PINE NUT IS RECOMMENDED OVER ACORN FOR GALLBLADDER CANCER ON TREATMENT WITH CHEMOTHERAPY GEMCITABINE FOR SOME CONDITIONS.

Foods for Genetic Risk of Gallbladder Cancer

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. CTNNB1 and APC are two genes whose abnormalities are risk factors for Gallbladder Cancer. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Gallbladder Cancer can be used as a guide for coming up with a recommended personalized nutrition plan. For Gallbladder Cancer gene CTNNB1 has causative impact on biological pathways like Adherens junction, Androgen Signaling and Cytoskeletal Dynamics. And APC has a causative impact on biological pathways like Angiogenesis and Growth Factor Signaling. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like CTNNB1 and APC should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes CTNNB1 and APC should be avoided.

Eat more pulses, Common Pea or Chickpea?

The active ingredients contained in Common Pea are Lupeol, Beta-sitosterol, Daidzein, Linolenic Acid, Vitamin C among others. While the active ingredients contained in Chickpea are Linolenic Acid, Oleic Acid, Vitamin A, Genistein, Folic Acid and others.

Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Apoptosis and Adherens junction. Vitamin C has biological action on biochemical pathways WNT Beta Catenin Signaling, MYC Signaling and P53 Signaling.

Oleic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. And so on.

For genetic risk of Gallbladder Cancer due to abnormalities in genes CTNNB1 and APC – Foods like Common Pea are recommended compared to Chickpea. This is because the active ingredients Oleic Acid and Folic Acid in Chickpea further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER CHICKPEA FOR REDUCING THE GENETIC RISK OF GALLBLADDER CANCER DUE TO GENES CTNNB1 AND APC

Eat more vegetables, Arugula or Eggplant?

The active ingredients contained in Arugula are Esculin, Vitamin A, Kaempferol, Vitamin K, Erysolin among others. While the active ingredients contained in Eggplant are Beta-sitosterol, Linolenic Acid, Vitamin C, Oleic Acid, Salicylic Acid and others.

Kaempferol can manipulate biochemical pathways WNT Beta Catenin Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling. Vitamin K has biological action on biochemical pathways MYC Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.

Oleic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition. Linoleic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition. And so on.

For genetic risk of Gallbladder Cancer due to abnormalities in genes CTNNB1 and APC – Foods like Arugula are recommended compared to Eggplant. This is because the active ingredients Oleic Acid and Linoleic Acid in Eggplant further promote the effects of genes on the biochemical pathways. While the active ingredients Kaempferol and Vitamin K contained in Arugula together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: ARUGULA IS RECOMMENDED OVER EGGPLANT FOR REDUCING THE GENETIC RISK OF GALLBLADDER CANCER DUE TO GENES CTNNB1 AND APC

Eat more fruits, Feijoa or Pummelo?

The active ingredients contained in Feijoa are Lycopene, Vitamin C, Casuarinin, Folic Acid among others. While the active ingredients contained in Pummelo are Naringin, Beta-sitosterol, Linolenic Acid, Vitamin C, Naringenin and others.

Vitamin C can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Apoptosis and Adherens junction. Lycopene has biological action on biochemical pathways WNT Beta Catenin Signaling, MYC Signaling and P53 Signaling.

Naringetol can manipulate biochemical pathways WNT Beta Catenin Signaling. Hesperetin has biological action on biochemical pathways WNT Beta Catenin Signaling. And so on.

For genetic risk of Gallbladder Cancer due to abnormalities in genes CTNNB1 and APC – Foods like Feijoa are recommended compared to Pummelo. This is because the active ingredients Naringetol and Hesperetin in Pummelo further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Lycopene contained in Feijoa together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: FEIJOA IS RECOMMENDED OVER PUMMELO FOR REDUCING THE GENETIC RISK OF GALLBLADDER CANCER DUE TO GENES CTNNB1 AND APC

Eat more nuts, Brazil Nut or Chestnut?

The active ingredients contained in Brazil Nut are Vitamin E, Linolenic Acid, Oleic Acid, Lecithin, Folic Acid among others. While the active ingredients contained in Chestnut are Quercetin, Linolenic Acid, Vitamin C, Oleic Acid, Ellagic Acid and others.

Vitamin E can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Apoptosis and MYC Signaling. Linolenic Acid has biological action on biochemical pathways Adherens junction, WNT Beta Catenin Signaling and P53 Signaling.

Ellagic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition, WNT Beta Catenin Signaling and MYC Signaling. Oleic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition. And so on.

For genetic risk of Gallbladder Cancer due to abnormalities in genes CTNNB1 and APC – Foods like Brazil Nut are recommended compared to Chestnut. This is because the active ingredients Ellagic Acid and Oleic Acid in Chestnut further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin E and Linolenic Acid contained in Brazil Nut together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: BRAZIL NUT IS RECOMMENDED OVER CHESTNUT FOR REDUCING THE GENETIC RISK OF GALLBLADDER CANCER DUE TO GENES CTNNB1 AND APC

In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Gallbladder Cancer by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

References

• Msk Impact 2017
• Regional differences in gallbladder cancer pathogenesis: Insights from a multi-institutional comparison of tumor mutations.
• Preventive effects of butyric acid, nicotinamide, calcium glucarate alone or in combination during the 7, 12-dimethylbenz (a) anthracene induced mouse skin tumorigenesis via modulation of K-Ras-PI3K-AKTpathway and associated micro RNAs.
• Isoliquiritigenin Inhibits Ovarian Cancer Metastasis by Reversing Epithelial-to-Mesenchymal Transition.
• BRCA1 and BRCA2 as molecular targets for phytochemicals indole-3-carbinol and genistein in breast and prostate cancer cells.
• Adhesion to the extracellular matrix is positively regulated by retinoic acid in HepG2 cells.
• β-Sitosterol and Gemcitabine Exhibit Synergistic Anti-pancreatic Cancer Activity by Modulating Apoptosis and Inhibiting Epithelial-Mesenchymal Transition by Deactivating Akt/GSK-3β Signaling.
• Stigmasterol Causes Ovarian Cancer Cell Apoptosis by Inducing Endoplasmic Reticulum and Mitochondrial Dysfunction.
• Identification of ellagic acid as potent inhibitor of protein kinase CK2: a successful example of a virtual screening application.
• Small-molecule inhibitors of NADPH oxidase 4.
• Brassinin Represses Invasive Potential of Lung Carcinoma Cells through Deactivation of PI3K/Akt/mTOR Signaling Cascade.
• Vitamin C enhances epigenetic modifications induced by 5-azacytidine and cell cycle arrest in the hepatocellular carcinoma cell lines HLE and Huh7.
• Association between paraoxonases gene expression and oxidative stress in hepatotoxicity induced by CCl4.
• Research progress on the anticancer effects of vitamin K2.
• Cardioprotective effect of gallic acid on cardiac troponin-T, cardiac marker enzymes, lipid peroxidation products and antioxidants in experimentally induced myocardial infarction in Wistar rats.
• Oleic acid-induced ANGPTL4 enhances head and neck squamous cell carcinoma anoikis resistance and metastasis via up-regulation of fibronectin.
• Effects of folate deficiency on gene expression in the apoptosis and cancer pathways in colon cancer cells.
• Lycopene metabolite, apo-10′-lycopenoic acid, inhibits diethylnitrosamine-initiated, high fat diet-promoted hepatic inflammation and tumorigenesis in mice.
• Structural Insight into the Interactions between Death-Associated Protein Kinase 1 and Natural Flavonoids.
• Role of phospholipase D in migration and invasion induced by linoleic acid in breast cancer cells.
• Gamma-tocotrienol inhibits nuclear factor-kappaB signaling pathway through inhibition of receptor-interacting protein and TAK1 leading to suppression of antiapoptotic gene products and potentiation of apoptosis.
• α-Linolenic acid inhibits the migration of human triple-negative breast cancer cells by attenuating Twist1 expression and suppressing Twist1-mediated epithelial-mesenchymal transition.