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What Foods are Recommended for Cancer?
is a very common question. Personalized Nutrition Plans are foods and supplements which are personalized to a cancer indication, genes, any treatments and lifestyle conditions.

Foods for Malt Lymphoma!

Jul 22, 2023

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Introduction

Foods for Malt Lymphoma should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.

MALT lymphoma, also known as extranodal marginal zone B-cell lymphoma of MALT type, is a type of cancer that primarily affects the mucosa-associated lymphoid tissue (MALT). Accurate medical coding using the appropriate ICD-10 code is crucial for documentation. Pathology outlines provide valuable information about the characteristics of MALT lymphoma cells. Diagnosis of MALT lymphoma may involve the recognition of specific symptoms, such as unexplained swelling or inflammation, or the identification of abnormal lymphoid tissue through radiology. Treatment options for MALT lymphoma may include the eradication of H. pylori bacteria, as it is a common cause of gastric MALT lymphoma. In cases where treatment is necessary, therapeutic approaches include radiation therapy, chemotherapy, and immunotherapy. The prognosis and survival rate for MALT lymphoma vary depending on factors such as the site and stage of the disease. Dietary modifications may also be recommended as part of supportive care during treatment. Staying informed about the latest research and seeking appropriate medical care are crucial for optimizing outcomes in individuals with MALT lymphoma. By doing so, patients can enhance their chances of successful treatment and long-term survival.



For Malt Lymphoma does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Malt Lymphoma does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Malt Lymphoma?

For example does it matter if vegetable Pepper (c. Frutescens) is consumed more compared to Welsh Onion? Does it make any difference if fruit Grapefruit is preferred over Red Raspberry? Also if similar choices are made for nuts/seeds like Almond over Walnut and for pulses like Broad Bean over Moth Bean. And if what I eat matters – then how does one identify foods which are recommended for Malt Lymphoma and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Malt Lymphoma!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All cancers like Malt Lymphoma can be characterized by a unique set of biochemical pathways - the signature pathways of Malt Lymphoma. Biochemical pathways like Cell Cycle Checkpoints, Apoptosis, Oncogenic Histone Methylation, NFKB Signaling are part of the signature definition of Malt Lymphoma.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Grapefruit contains active ingredients Curcumin, Formononetin, Phloretin, Lupeol, Daidzein. And Red Raspberry contains active ingredients Curcumin, Formononetin, Phloretin, Lupeol, Daidzein and possibly others.

A common mistake made when deciding and choosing foods to eat for Malt Lymphoma – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Malt Lymphoma.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Malt Lymphoma?

Personalized nutrition for cancers like Malt Lymphoma consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Malt Lymphoma biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

Characteristics of cancers like Malt Lymphoma

All cancers like Malt Lymphoma can be characterized by a unique set of biochemical pathways – the signature pathways of Malt Lymphoma. Biochemical pathways like Cell Cycle Checkpoints, Apoptosis, Oncogenic Histone Methylation, NFKB Signaling are part of the signature definition of Malt Lymphoma. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Malt Lymphoma need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Malt Lymphoma when taking cancer treatment Chlorambucil, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

KMT2C, TET2, KMT2D, CREBBP and SPEN are the top ranked reported genes for Malt Lymphoma. KMT2C is reported in 18.1 % of the representative patients across all clinical trials. And TET2 is reported in 13.9 %. The combined population patient data cover ages from to . % of the patient data are identified as men. The Malt Lymphoma biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Foods for Malt Lymphoma!

Food and Supplements for Malt Lymphoma

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable PEPPER (C. FRUTESCENS) or WELSH ONION?

Vegetable Pepper (c. Frutescens) contains many active ingredients or bioactives such as Apigenin, Curcumin, Formononetin, Phloretin, Lupeol. These active ingredients manipulate various biochemical pathways like PI3K-AKT-MTOR Signaling, MYC Signaling, NFKB Signaling and Oxidative Stress and others. Pepper (c. Frutescens) is recommended for Malt Lymphoma when ongoing cancer treatment is Chlorambucil. This is because Pepper (c. Frutescens) modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Chlorambucil.

Some of the active ingredients or bioactives in vegetable Welsh Onion are Curcumin, Formononetin, Phloretin, Lupeol, Daidzein. These active ingredients manipulate various biochemical pathways like Oxidative Stress and others. Welsh Onion is not recommended for Malt Lymphoma when ongoing cancer treatment is Chlorambucil because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE PEPPER (C. FRUTESCENS) IS RECOMMENDED OVER WELSH ONION FOR Malt Lymphoma AND TREATMENT Chlorambucil.

Choose Fruit RED RASPBERRY or GRAPEFRUIT?

Fruit Red Raspberry contains many active ingredients or bioactives such as Curcumin, Formononetin, Phloretin, Lupeol, Daidzein. These active ingredients manipulate various biochemical pathways like PI3K-AKT-MTOR Signaling, MYC Signaling, NFKB Signaling and Oxidative Stress and others. Red Raspberry is recommended for Malt Lymphoma when ongoing cancer treatment is Chlorambucil. This is because Red Raspberry modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Chlorambucil.

Some of the active ingredients or bioactives in fruit Grapefruit are Curcumin, Formononetin, Phloretin, Lupeol, Daidzein. These active ingredients manipulate various biochemical pathways like Oxidative Stress and others. Grapefruit is not recommended for Malt Lymphoma when ongoing cancer treatment is Chlorambucil because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT RED RASPBERRY IS RECOMMENDED OVER GRAPEFRUIT FOR Malt Lymphoma AND TREATMENT Chlorambucil.

Choose Nut ALMOND or WALNUT?

Almond contains many active ingredients or bioactives such as Curcumin, Formononetin, Phloretin, Lupeol, Daidzein. These active ingredients manipulate various biochemical pathways like PI3K-AKT-MTOR Signaling, MYC Signaling, NFKB Signaling and Oxidative Stress and others. Almond is recommended for Malt Lymphoma when ongoing cancer treatment is Chlorambucil. This is because Almond modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Chlorambucil.

Some of the active ingredients or bioactives in Walnut are Apigenin, Curcumin, Formononetin, Phloretin, Lupeol. These active ingredients manipulate various biochemical pathways like Oxidative Stress and others. Walnut is not recommended for Malt Lymphoma when ongoing cancer treatment is Chlorambucil because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

ALMOND IS RECOMMENDED OVER WALNUT FOR Malt Lymphoma AND TREATMENT Chlorambucil.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Malt Lymphoma or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable GIANT BUTTERBUR or RADISH?

Vegetable Giant Butterbur contains many active ingredients or bioactives such as Curcumin, Apigenin, Lupeol, Formononetin, Daidzein. These active ingredients manipulate various biochemical pathways like Cell Cycle Checkpoints, Histone/Protein Acetylation, TGFB Signaling and PI3K-AKT-MTOR Signaling and others. Giant Butterbur is recommended for risk of Malt Lymphoma when associated genetic risk is CREBBP. This is because Giant Butterbur increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Radish are Curcumin, Apigenin, Quercetin, Lupeol, Formononetin. These active ingredients manipulate various biochemical pathways like WNT Beta Catenin Signaling, TGFB Signaling and PI3K-AKT-MTOR Signaling and others. Radish is not recommended when risk of Malt Lymphoma when associated genetic risk is CREBBP because it increases the signature pathways of it.

VEGETABLE GIANT BUTTERBUR IS RECOMMENDED OVER RADISH FOR CREBBP GENETIC RISK OF CANCER.

Choose Fruit NANCE or MALABAR PLUM?

Fruit Nance contains many active ingredients or bioactives such as Curcumin, Apigenin, Lupeol, Formononetin, Daidzein. These active ingredients manipulate various biochemical pathways like Cell Cycle Checkpoints, Histone/Protein Acetylation, TGFB Signaling and PI3K-AKT-MTOR Signaling and others. Nance is recommended for risk of Malt Lymphoma when associated genetic risk is CREBBP. This is because Nance increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Malabar Plum are Curcumin, Apigenin, Lupeol, Formononetin, Daidzein. These active ingredients manipulate various biochemical pathways like Notch Signaling, WNT Beta Catenin Signaling, TGFB Signaling and PI3K-AKT-MTOR Signaling and others. Malabar Plum is not recommended when risk of Malt Lymphoma when associated genetic risk is CREBBP because it increases the signature pathways of it.

FRUIT NANCE IS RECOMMENDED OVER MALABAR PLUM FOR CREBBP GENETIC RISK OF CANCER.

Choose Nut BUTTERNUT or EUROPEAN CHESTNUT?

Butternut contains many active ingredients or bioactives such as Curcumin, Apigenin, Lupeol, Formononetin, Daidzein. These active ingredients manipulate various biochemical pathways like RAS-RAF Signaling, MYC Signaling, TGFB Signaling and PI3K-AKT-MTOR Signaling and others. Butternut is recommended for risk of Malt Lymphoma when associated genetic risk is CREBBP. This is because Butternut increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in European Chestnut are Curcumin, Apigenin, Quercetin, Lupeol, Ellagic Acid. These active ingredients manipulate various biochemical pathways like WNT Beta Catenin Signaling, TGFB Signaling and Oncogenic Cancer Epigenetics and others. European Chestnut is not recommended when risk of Malt Lymphoma when associated genetic risk is CREBBP because it increases the signature pathways of it.

BUTTERNUT IS RECOMMENDED OVER EUROPEAN CHESTNUT FOR CREBBP GENETIC RISK OF CANCER.


In Conclusion

Foods and Supplements chosen are important decisions for cancers like Malt Lymphoma. Malt Lymphoma patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Malt Lymphoma, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like Pepper (c. Frutescens) contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Malt Lymphoma?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.


Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.

References

Scientifically Reviewed by: Dr. Cogle

Christopher R. Cogle, M.D. is a tenured professor at the University of Florida, Chief Medical Officer of Florida Medicaid, and Director of the Florida Health Policy Leadership Academy at the Bob Graham Center for Public Service.

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