Foods for Laryngeal Cancer!

Introduction

Foods for Laryngeal Cancer should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.

For Laryngeal Cancer does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Laryngeal Cancer does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Laryngeal Cancer?

For example does it matter if vegetable Yellow Zucchini is consumed more compared to Swamp Cabbage? Does it make any difference if fruit Pitanga is preferred over Soursop? Also if similar choices are made for nuts/seeds like Butternut over European Chestnut and for pulses like Gram Bean over Lima Bean. And if what I eat matters – then how does one identify foods which are recommended for Laryngeal Cancer and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Laryngeal Cancer!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Pitanga contains active ingredients Quercetin, Apigenin, Curcumin, Lycopene, Lupeol. And Soursop contains active ingredients Apigenin, Curcumin, Lupeol, Emodin, Formononetin and possibly others.

A common mistake made when deciding and choosing foods to eat for Laryngeal Cancer – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Laryngeal Cancer.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Laryngeal Cancer?

Personalized nutrition for cancers like Laryngeal Cancer consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Laryngeal Cancer biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Characteristics of cancers like Laryngeal Cancer

All cancers like Laryngeal Cancer can be characterized by a unique set of biochemical pathways – the signature pathways of Laryngeal Cancer. Biochemical pathways like RAS-RAF Signaling, NFKB Signaling, PI3K-AKT-MTOR Signaling, Cell Cycle Checkpoints are part of the signature definition of Laryngeal Cancer. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Laryngeal Cancer need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Laryngeal Cancer when taking cancer treatment Docetaxel, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

TP53, NOTCH1, CDKN2A, KMT2D and NFE2L2 are the top ranked reported genes for Laryngeal Cancer. TP53 is reported in 40.7 % of the representative patients across all clinical trials. And NOTCH1 is reported in 18.5 %. The combined population patient data cover ages from 52 to 67. 84.7 % of the patient data are identified as men. The Laryngeal Cancer biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Food and Supplements for Laryngeal Cancer

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable YELLOW ZUCCHINI or SWAMP CABBAGE?

Vegetable Yellow Zucchini contains many active ingredients or bioactives such as Apigenin, Curcumin, Lupeol, Formononetin, Daidzein. These active ingredients manipulate various biochemical pathways like Hypoxia, NFKB Signaling and PI3K-AKT-MTOR Signaling and others. Yellow Zucchini is recommended for Laryngeal Cancer when ongoing cancer treatment is Docetaxel. This is because Yellow Zucchini modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Docetaxel.

Some of the active ingredients or bioactives in vegetable Swamp Cabbage are Curcumin, Lycopene, Lupeol, Formononetin, Daidzein. These active ingredients manipulate various biochemical pathways like Heat Stress Response and others. Swamp Cabbage is not recommended for Laryngeal Cancer when ongoing cancer treatment is Docetaxel because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE YELLOW ZUCCHINI IS RECOMMENDED OVER SWAMP CABBAGE FOR Laryngeal Cancer AND TREATMENT Docetaxel.

Choose Fruit SOURSOP or PITANGA?

Fruit Soursop contains many active ingredients or bioactives such as Apigenin, Curcumin, Lupeol, Emodin, Formononetin. These active ingredients manipulate various biochemical pathways like MAPK Signaling, MYC Signaling, NFKB Signaling and PI3K-AKT-MTOR Signaling and others. Soursop is recommended for Laryngeal Cancer when ongoing cancer treatment is Docetaxel. This is because Soursop modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Docetaxel.

Some of the active ingredients or bioactives in fruit Pitanga are Quercetin, Apigenin, Curcumin, Lycopene, Lupeol. These active ingredients manipulate various biochemical pathways like Heat Stress Response, TGFB Signaling and NFKB Signaling and others. Pitanga is not recommended for Laryngeal Cancer when ongoing cancer treatment is Docetaxel because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT SOURSOP IS RECOMMENDED OVER PITANGA FOR Laryngeal Cancer AND TREATMENT Docetaxel.

Choose Nut BUTTERNUT or EUROPEAN CHESTNUT?

Butternut contains many active ingredients or bioactives such as Apigenin, Curcumin, Lycopene, Lupeol, Formononetin. These active ingredients manipulate various biochemical pathways like MAPK Signaling, TGFB Signaling, NFKB Signaling and PI3K-AKT-MTOR Signaling and others. Butternut is recommended for Laryngeal Cancer when ongoing cancer treatment is Docetaxel. This is because Butternut modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Docetaxel.

Some of the active ingredients or bioactives in European Chestnut are Quercetin, Apigenin, Curcumin, Ellagic Acid, Lupeol. These active ingredients manipulate various biochemical pathways like Heat Stress Response and others. European Chestnut is not recommended for Laryngeal Cancer when ongoing cancer treatment is Docetaxel because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

BUTTERNUT IS RECOMMENDED OVER EUROPEAN CHESTNUT FOR Laryngeal Cancer AND TREATMENT Docetaxel.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Laryngeal Cancer or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable CALABASH or ARROWHEAD?

Vegetable Calabash contains many active ingredients or bioactives such as Apigenin, Curcumin, Lupeol, Daidzein, Beta-sitosterol. These active ingredients manipulate various biochemical pathways like MAPK Signaling, Oxidative Stress, Stem Cell Signaling and PI3K-AKT-MTOR Signaling and others. Calabash is recommended for risk of Laryngeal Cancer when associated genetic risk is CDKN2A. This is because Calabash increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Arrowhead are Apigenin, Curcumin, Lupeol, Daidzein, Beta-sitosterol. These active ingredients manipulate various biochemical pathways like Cell Cycle Checkpoints and Oxidative Stress and others. Arrowhead is not recommended when risk of Laryngeal Cancer when associated genetic risk is CDKN2A because it increases the signature pathways of it.

VEGETABLE CALABASH IS RECOMMENDED OVER ARROWHEAD FOR CDKN2A GENETIC RISK OF CANCER.

Choose Fruit NANCE or MUSCADINE GRAPE?

Fruit Nance contains many active ingredients or bioactives such as Apigenin, Curcumin, Lupeol, Daidzein, Beta-sitosterol. These active ingredients manipulate various biochemical pathways like MAPK Signaling, Oxidative Stress, Stem Cell Signaling and PI3K-AKT-MTOR Signaling and others. Nance is recommended for risk of Laryngeal Cancer when associated genetic risk is CDKN2A. This is because Nance increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Muscadine Grape are Apigenin, Curcumin, Lupeol, Ellagic Acid, Daidzein. These active ingredients manipulate various biochemical pathways like Cell Cycle Checkpoints and Stem Cell Signaling and others. Muscadine Grape is not recommended when risk of Laryngeal Cancer when associated genetic risk is CDKN2A because it increases the signature pathways of it.

FRUIT NANCE IS RECOMMENDED OVER MUSCADINE GRAPE FOR CDKN2A GENETIC RISK OF CANCER.

Choose Nut COMMON HAZELNUT or FLAXSEED?

Common Hazelnut contains many active ingredients or bioactives such as Curcumin, Lupeol, Daidzein, Quercetin, Beta-sitosterol. These active ingredients manipulate various biochemical pathways like MAPK Signaling, PI3K-AKT-MTOR Signaling, Stem Cell Signaling and Oxidative Stress and others. Common Hazelnut is recommended for risk of Laryngeal Cancer when associated genetic risk is CDKN2A. This is because Common Hazelnut increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in Flaxseed are Apigenin, Curcumin, Lupeol, Daidzein, Beta-sitosterol. These active ingredients manipulate various biochemical pathways like MAPK Signaling, PI3K-AKT-MTOR Signaling and Oxidative Stress and others. Flaxseed is not recommended when risk of Laryngeal Cancer when associated genetic risk is CDKN2A because it increases the signature pathways of it.

COMMON HAZELNUT IS RECOMMENDED OVER FLAXSEED FOR CDKN2A GENETIC RISK OF CANCER.

In Conclusion

Foods and Supplements chosen are important decisions for cancers like Laryngeal Cancer. Laryngeal Cancer patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Laryngeal Cancer, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like Yellow Zucchini contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Laryngeal Cancer?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.

References

• Hnc Mskcc 2016
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• L-Ascorbic Acid Inhibits Breast Cancer Growth by Inducing IRE/JNK/CHOP-Related Endoplasmic Reticulum Stress-Mediated p62/SQSTM1 Accumulation in the Nucleus.
• Negative regulation of signal transducer and activator of transcription-3 signalling cascade by lupeol inhibits growth and induces apoptosis in hepatocellular carcinoma cells.
• New concepts in phospholipase D signaling in inflammation and cancer.