Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Laryngeal Cancer when undergoing chemotherapy or when you determine you have a genetic risk for developing Laryngeal Cancer because of NOTCH1 and CDKN2A gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Laryngeal Cancer which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Naranjilla” or “Include fruit Partridgeberry in my diet” or “Should I reduce consumption of vegetable Garden Cress” or “Can I take Lycopene and Modified Citrus Pectin supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO LARYNGEAL CANCER, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Laryngeal Cancer is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR LARYNGEAL CANCER, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Laryngeal Cancer
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Laryngeal Cancer from cBioPortal. The patients enrolled in the studies for Laryngeal Cancer are in ages between 52 to 67 with an average age of 63. 84.7% of males and 15.3% of females were the distribution of gender in these clinical studies. From a patient sample size of 59; the top genes with mutations and other abnormalities for Laryngeal Cancer include genes TP53, NOTCH1, CDKN2A, KMT2D and NFE2L2. The occurrence frequency distribution for these genes respectively is 40.7%, 18.5%, 11.1%, 11.1% and 11.1%. These tumor genetic details of Laryngeal Cancer are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Laryngeal Cancer.
Significance of Nutrition for Laryngeal Cancer
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Laryngeal Cancer. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Naranjilla includes active ingredients Zeaxanthin, Beta-carotene, Vitamin A and others. And Partridgeberry contains active ingredients Resveratrol, Beta-sitosterol, Stigmasterol and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Laryngeal Cancer, activation or inhibition of selected biochemical pathways like RAS-RAF Signaling, NFKB Signaling, PI3K-AKT-MTOR Signaling, Cell Cycle Checkpoints plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Laryngeal Cancer, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR LARYNGEAL CANCER – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Laryngeal Cancer undergoing chemotherapy treatment
In Laryngeal Cancer – the genes TP53, NOTCH1, CDKN2A, KMT2D and NFE2L2 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Laryngeal Cancer are RAS-RAF Signaling, NFKB Signaling, Hypoxia and others. Docetaxel is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers RAS-RAF Signaling, NFKB Signaling, Hypoxia so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Scarlet Bean or Chickpea?
Pulses are an important part of many diets. The active ingredients contained in Scarlet Bean are Vitamin C, Beta-sitosterol, Linolenic Acid, Oleic Acid, Stigmasterol among others. While the active ingredients contained in Chickpea are Linolenic Acid, Oleic Acid, Genistein, Vitamin A, Folic Acid and others.
Vitamin C can manipulate biochemical pathways Apoptosis, Cell Cycle and MYC Signaling. Beta-sitosterol has biological action on biochemical pathways NFKB Signaling, Cell Survival and Heat Stress Response.
Vitamin A can manipulate biochemical pathways NFKB Signaling and TGFB Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, Growth Factor Signaling and JAK-STAT Signaling. And so on.
When treating Laryngeal Cancer with chemotherapy Docetaxel – Foods like Scarlet Bean are recommended compared to Chickpea. This is because the active ingredients Vitamin A and Folic Acid in Chickpea interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Beta-sitosterol contained in Scarlet Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER CHICKPEA FOR LARYNGEAL CANCER ON TREATMENT WITH CHEMOTHERAPY DOCETAXEL FOR SOME CONDITIONS.
Eat more vegetables, Asparagus or Garden Cress?
Vegetables are an important part of many diets. The active ingredients contained in Asparagus are Quercetin, Isorhamnetin, Vitamin C, Linolenic Acid, Oleic Acid among others. While the active ingredients contained in Garden Cress are Benzyl Isothiocyanate, Vitamin E, Isorhamnetin, Vitamin C, Beta-sitosterol and others.
Quercetin can manipulate biochemical pathways Apoptosis, Chemokine Signaling and Growth Factor Signaling. Isorhamnetin has biological action on biochemical pathways Cell Cycle, Cell Survival and MYC Signaling.
Vitamin A can manipulate biochemical pathways NFKB Signaling and TGFB Signaling. Linoleic Acid has biological action on biochemical pathways Chemokine Signaling, Heat Stress Response and TGFB Signaling. And so on.
When treating Laryngeal Cancer with chemotherapy Docetaxel – Foods like Asparagus are recommended compared to Garden Cress. This is because the active ingredients Vitamin A and Linoleic Acid in Garden Cress interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Quercetin and Isorhamnetin contained in Asparagus support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: ASPARAGUS IS RECOMMENDED OVER GARDEN CRESS FOR LARYNGEAL CANCER ON TREATMENT WITH CHEMOTHERAPY DOCETAXEL FOR SOME CONDITIONS.
Eat more fruits, Partridgeberry or Naranjilla?
Fruits are an important part of many diets. The active ingredients contained in Partridgeberry are Resveratrol, Beta-sitosterol, Stigmasterol among others. While the active ingredients contained in Naranjilla are Zeaxanthin, Beta-carotene, Vitamin A and others.
Resveratrol can manipulate biochemical pathways NFKB Signaling, Apoptosis and Chemokine Signaling. Beta-sitosterol has biological action on biochemical pathways Cell Cycle, Cell Survival and MYC Signaling.
Beta-carotene can manipulate biochemical pathways MAPK Signaling. Vitamin A has biological action on biochemical pathways NFKB Signaling and TGFB Signaling. And so on.
When treating Laryngeal Cancer with chemotherapy Docetaxel – Foods like Partridgeberry are recommended compared to Naranjilla. This is because the active ingredients Beta-carotene and Vitamin A in Naranjilla interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Resveratrol and Beta-sitosterol contained in Partridgeberry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PARTRIDGEBERRY IS RECOMMENDED OVER NARANJILLA FOR LARYNGEAL CANCER ON TREATMENT WITH CHEMOTHERAPY DOCETAXEL FOR SOME CONDITIONS.
Eat more nuts, Pine Nut or Acorn?
Nuts are an important part of many diets. The active ingredients contained in Pine Nut are Vitamin E, Beta-sitosterol, Linolenic Acid, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Acorn are Quercetin, Vitamin C, Beta-sitosterol, Gallic Acid, Beta-carotene and others.
Beta-sitosterol can manipulate biochemical pathways NFKB Signaling, Apoptosis and Cell Cycle. Vitamin K has biological action on biochemical pathways MYC Signaling, PI3K-AKT-MTOR Signaling and Cell Cycle.
Beta-carotene can manipulate biochemical pathways MAPK Signaling. Vitamin A has biological action on biochemical pathways NFKB Signaling and TGFB Signaling. And so on.
When treating Laryngeal Cancer with chemotherapy Docetaxel – Foods like Pine Nut are recommended compared to Acorn. This is because the active ingredients Beta-carotene and Vitamin A in Acorn interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin K contained in Pine Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PINE NUT IS RECOMMENDED OVER ACORN FOR LARYNGEAL CANCER ON TREATMENT WITH CHEMOTHERAPY DOCETAXEL FOR SOME CONDITIONS.

Foods for Genetic Risk of Laryngeal Cancer
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. NOTCH1 and CDKN2A are two genes whose abnormalities are risk factors for Laryngeal Cancer. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Laryngeal Cancer can be used as a guide for coming up with a recommended personalized nutrition plan. For Laryngeal Cancer gene NOTCH1 has causative impact on biological pathways like Notch Signaling and RUNX Signaling. And CDKN2A has a causative impact on biological pathways like Cell Cycle Checkpoints and Cell Cycle. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like NOTCH1 and CDKN2A should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes NOTCH1 and CDKN2A should be avoided.
Eat more pulses, Common Pea or Soy Bean?
The active ingredients contained in Common Pea are Lupeol, Beta-sitosterol, Daidzein, Linolenic Acid, Vitamin C among others. While the active ingredients contained in Soy Bean are Vitamin E, Lupeol, Beta-sitosterol, Daidzein, Linolenic Acid and others.
Beta-sitosterol can manipulate biochemical pathways Apoptosis, Cell Cycle and MYC Signaling. Vitamin C has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and Apoptosis.
Lecithin can manipulate biochemical pathways MYC Signaling. Aescin has biological action on biochemical pathways Cell Cycle Checkpoints and Cell Cycle. And so on.
For genetic risk of Laryngeal Cancer due to abnormalities in genes NOTCH1 and CDKN2A – Foods like Common Pea are recommended compared to Soy Bean. This is because the active ingredients Lecithin and Aescin in Soy Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER SOY BEAN FOR REDUCING THE GENETIC RISK OF LARYNGEAL CANCER DUE TO GENES NOTCH1 AND CDKN2A
Eat more vegetables, Milk Thistle or Celery?
The active ingredients contained in Milk Thistle are Vitamin E, Silibinin, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Celery are Apigenin, Linolenic Acid, Luteolin, Quercetin, Vitamin C and others.
Silibinin can manipulate biochemical pathways Apoptosis, Cell Cycle and Notch Signaling. Vitamin E has biological action on biochemical pathways MYC Signaling, P53 Signaling and Cell Cycle Checkpoints.
Luteolin can manipulate biochemical pathways MYC Signaling. Chrysin has biological action on biochemical pathways MYC Signaling. And so on.
For genetic risk of Laryngeal Cancer due to abnormalities in genes NOTCH1 and CDKN2A – Foods like Milk Thistle are recommended compared to Celery. This is because the active ingredients Luteolin and Chrysin in Celery further promote the effects of genes on the biochemical pathways. While the active ingredients Silibinin and Vitamin E contained in Milk Thistle together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: MILK THISTLE IS RECOMMENDED OVER CELERY FOR REDUCING THE GENETIC RISK OF LARYNGEAL CANCER DUE TO GENES NOTCH1 AND CDKN2A
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Roselle or Strawberry?
The active ingredients contained in Roselle are Vitamin E, Beta-sitosterol, Linolenic Acid, Stigmasterol, Vitamin C among others. While the active ingredients contained in Strawberry are Lupeol, Beta-sitosterol, Linolenic Acid, Fisetin, Ellagic Acid and others.
Vitamin E can manipulate biochemical pathways Apoptosis, Cell Cycle and Notch Signaling. Beta-sitosterol has biological action on biochemical pathways MYC Signaling, P53 Signaling and Cell Cycle Checkpoints.
Fisetin can manipulate biochemical pathways MYC Signaling. Ellagic Acid has biological action on biochemical pathways MYC Signaling. And so on.
For genetic risk of Laryngeal Cancer due to abnormalities in genes NOTCH1 and CDKN2A – Foods like Roselle are recommended compared to Strawberry. This is because the active ingredients Fisetin and Ellagic Acid in Strawberry further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin E and Beta-sitosterol contained in Roselle together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: ROSELLE IS RECOMMENDED OVER STRAWBERRY FOR REDUCING THE GENETIC RISK OF LARYNGEAL CANCER DUE TO GENES NOTCH1 AND CDKN2A
Eat more nuts, Pecan Nut or Peanut?
The active ingredients contained in Pecan Nut are Vitamin E, Linolenic Acid, Cianidanol, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Peanut are Vitamin E, Beta-sitosterol, Rhamnetin, Linolenic Acid, Ferulic Acid and others.
Vitamin E can manipulate biochemical pathways Apoptosis, Cell Cycle and Notch Signaling. Cianidanol has biological action on biochemical pathways MYC Signaling, P53 Signaling and Cell Cycle Checkpoints.
Lecithin can manipulate biochemical pathways MYC Signaling. Folic Acid has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and Apoptosis. And so on.
For genetic risk of Laryngeal Cancer due to abnormalities in genes NOTCH1 and CDKN2A – Foods like Pecan Nut are recommended compared to Peanut. This is because the active ingredients Lecithin and Folic Acid in Peanut further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin E and Cianidanol contained in Pecan Nut together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER PEANUT FOR REDUCING THE GENETIC RISK OF LARYNGEAL CANCER DUE TO GENES NOTCH1 AND CDKN2A

In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Laryngeal Cancer by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

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Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.