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What Foods are Recommended for Cancer?
is a very common question. Personalized Nutrition Plans are foods and supplements which are personalized to a cancer indication, genes, any treatments and lifestyle conditions.

Which Foods are Recommended for Fibrosarcoma?

Aug 13, 2022

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Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Fibrosarcoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Fibrosarcoma because of PREX2 and CYP17A1 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Fibrosarcoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Date” or “Include fruit Persimmon in my diet” or “Should I reduce consumption of vegetable Endive” or “Can I take Vitamin E and Sesamin supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO FIBROSARCOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Fibrosarcoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR FIBROSARCOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.



About Fibrosarcoma

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Fibrosarcoma from cBioPortal. 53.7% of males and 46.3% of females were the distribution of gender in these clinical studies. From a patient sample size of 41; the top genes with mutations and other abnormalities for Fibrosarcoma include genes TP53, ATRX, PREX2, CYP17A1 and BRAF. The occurrence frequency distribution for these genes respectively is 23.5%, 23.5%, 11.8%, 11.8% and 5.9%. These tumor genetic details of Fibrosarcoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Fibrosarcoma.

Significance of Nutrition for Fibrosarcoma

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Fibrosarcoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Date includes active ingredients Apigenin, Quercetin, Lupeol, Beta-sitosterol, Ferulic Acid and others. And Persimmon contains active ingredients Fisetin, Quercetin, Lycopene, Lupeol, Betulinic Acid and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Fibrosarcoma, activation or inhibition of selected biochemical pathways like Cell Cycle Checkpoints, Cell Cycle, MAPK Signaling, Apoptosis plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Fibrosarcoma, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

For cancers like Fibrosarcoma, activation or inhibition of selected biochemical pathways like Cell Cycle Checkpoints, Cell Cycle, MAPK Signaling, Apoptosis plays an important role in driving cancer growth.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR FIBROSARCOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Fibrosarcoma undergoing chemotherapy treatment

In Fibrosarcoma – the genes TP53, ATRX, PREX2, CYP17A1 and BRAF have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Fibrosarcoma are Cell Cycle Checkpoints, Cell Cycle, Growth Factor Signaling and others. Cyclophosphamide is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Cell Cycle Checkpoints, Cell Cycle, Growth Factor Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Winged Bean or Pigeon Pea?

Pulses are an important part of many diets. The active ingredients contained in Winged Bean are Betulinic Acid, Vitamin C, Linolenic Acid, Oleic Acid, Vitamin A among others. While the active ingredients contained in Pigeon Pea are Vitamin C, Linolenic Acid, Oleic Acid, Genistein, Vitamin A and others.

Betulinic Acid can manipulate biochemical pathways MAPK Signaling, Angiogenesis and Cell Cycle Checkpoints. Vitamin C has biological action on biochemical pathways MYC Signaling, Hypoxia and Epithelial to Mesenchymal Transition.

Genistein can manipulate biochemical pathways DNA Repair. Oleic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition. And so on.

When treating Fibrosarcoma with chemotherapy Cyclophosphamide – Foods like Winged Bean are recommended compared to Pigeon Pea. This is because the active ingredients Genistein and Oleic Acid in Pigeon Pea interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Betulinic Acid and Vitamin C contained in Winged Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: WINGED BEAN IS RECOMMENDED OVER PIGEON PEA FOR FIBROSARCOMA ON TREATMENT WITH CHEMOTHERAPY CYCLOPHOSPHAMIDE FOR SOME CONDITIONS.

Eat more vegetables, Arugula or Endive?

Vegetables are an important part of many diets. The active ingredients contained in Arugula are Esculin, Kaempferol, Vitamin A, Vitamin K, Erysolin among others. While the active ingredients contained in Endive are Quercetin, Vitamin C, Linolenic Acid, Oleic Acid, Kaempferol and others.

Kaempferol can manipulate biochemical pathways MAPK Signaling, Cell Cycle Checkpoints and NFKB Signaling. Vitamin A has biological action on biochemical pathways MYC Signaling, Epithelial to Mesenchymal Transition and PI3K-AKT-MTOR Signaling.

Oleic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition. Linoleic Acid has biological action on biochemical pathways Growth Factor Signaling and Epithelial to Mesenchymal Transition. And so on.

When treating Fibrosarcoma with chemotherapy Cyclophosphamide – Foods like Arugula are recommended compared to Endive. This is because the active ingredients Oleic Acid and Linoleic Acid in Endive interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Kaempferol and Vitamin A contained in Arugula support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: ARUGULA IS RECOMMENDED OVER ENDIVE FOR FIBROSARCOMA ON TREATMENT WITH CHEMOTHERAPY CYCLOPHOSPHAMIDE FOR SOME CONDITIONS.

Which Foods are Recommended for Fibrosarcoma?

Eat more fruits, Persimmon or Date?

Fruits are an important part of many diets. The active ingredients contained in Persimmon are Fisetin, Quercetin, Lycopene, Lupeol, Betulinic Acid among others. While the active ingredients contained in Date are Apigenin, Quercetin, Lupeol, Beta-sitosterol, Ferulic Acid and others.

Lycopene can manipulate biochemical pathways MAPK Signaling, Angiogenesis and Cell Cycle Checkpoints. Vitamin C has biological action on biochemical pathways MYC Signaling, Hypoxia and Epithelial to Mesenchymal Transition.

Apigenin can manipulate biochemical pathways Epithelial to Mesenchymal Transition and DNA Repair. Oleic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition. And so on.

When treating Fibrosarcoma with chemotherapy Cyclophosphamide – Foods like Persimmon are recommended compared to Date. This is because the active ingredients Apigenin and Oleic Acid in Date interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Lycopene and Vitamin C contained in Persimmon support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: PERSIMMON IS RECOMMENDED OVER DATE FOR FIBROSARCOMA ON TREATMENT WITH CHEMOTHERAPY CYCLOPHOSPHAMIDE FOR SOME CONDITIONS.

Eat more nuts, Almond or Cashew Nut?

Nuts are an important part of many diets. The active ingredients contained in Almond are Quercetin, Vitamin E, Beta-sitosterol, Linolenic Acid, Salicylic Acid among others. While the active ingredients contained in Cashew Nut are Beta-sitosterol, Vitamin C, Gallic Acid, Butyric Acid, Vitamin K and others.

Beta-sitosterol can manipulate biochemical pathways Angiogenesis, Cell Cycle Checkpoints and NFKB Signaling. Quercetin has biological action on biochemical pathways MAPK Signaling, MYC Signaling and Hypoxia.

Palmitic Acid can manipulate biochemical pathways MAPK Signaling, Growth Factor Signaling and Epithelial to Mesenchymal Transition. Lauric Acid has biological action on biochemical pathways NFKB Signaling, MYC Signaling and PI3K-AKT-MTOR Signaling. And so on.

When treating Fibrosarcoma with chemotherapy Cyclophosphamide – Foods like Almond are recommended compared to Cashew Nut. This is because the active ingredients Palmitic Acid and Lauric Acid in Cashew Nut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Quercetin contained in Almond support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: ALMOND IS RECOMMENDED OVER CASHEW NUT FOR FIBROSARCOMA ON TREATMENT WITH CHEMOTHERAPY CYCLOPHOSPHAMIDE FOR SOME CONDITIONS.

Foods for Genetic Risk of Fibrosarcoma

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. PREX2 and CYP17A1 are two genes whose abnormalities are risk factors for Fibrosarcoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Fibrosarcoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Fibrosarcoma gene PREX2 has causative impact on biological pathways like Inositol Phosphate Signaling. And CYP17A1 has a causative impact on biological pathways like Reproductive Hormone Signaling and Reproductive Hormone Signaling. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like PREX2 and CYP17A1 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes PREX2 and CYP17A1 should be avoided.

Eat more pulses, Mung Bean or Chickpea?

The active ingredients contained in Mung Bean are Quercetin, Vitamin C, Oleic Acid, Linolenic Acid, Stigmasterol among others. While the active ingredients contained in Chickpea are Oleic Acid, Linolenic Acid, Genistein, Vitamin A, Folic Acid and others.

Quercetin can manipulate biochemical pathways Cell Cycle Checkpoints, RAS-RAF Signaling and Reproductive Hormone Signaling. Vitamin C has biological action on biochemical pathways P53 Signaling, MYC Signaling and PI3K-AKT-MTOR Signaling.

Folic Acid can manipulate biochemical pathways Cell Cycle Checkpoints, RAS-RAF Signaling and P53 Signaling. And so on.

For genetic risk of Fibrosarcoma due to abnormalities in genes PREX2 and CYP17A1 – Foods like Mung Bean are recommended compared to Chickpea. This is because the active ingredients Folic Acid in Chickpea further promote the effects of genes on the biochemical pathways. While the active ingredients Quercetin and Vitamin C contained in Mung Bean together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: MUNG BEAN IS RECOMMENDED OVER CHICKPEA FOR REDUCING THE GENETIC RISK OF FIBROSARCOMA DUE TO GENES PREX2 AND CYP17A1

Eat more vegetables, Giant Butterbur or Okra?

The active ingredients contained in Giant Butterbur are Beta-sitosterol, Vitamin C, Kaempferol, Melatonin, Vitamin B3 among others. While the active ingredients contained in Okra are Quercetin, Beta-sitosterol, Vitamin C, Oleic Acid, Linolenic Acid and others.

Vitamin C can manipulate biochemical pathways Cell Cycle Checkpoints, RAS-RAF Signaling and P53 Signaling. Beta-sitosterol has biological action on biochemical pathways MYC Signaling, PI3K-AKT-MTOR Signaling and Apoptosis.

Folic Acid can manipulate biochemical pathways Cell Cycle Checkpoints, RAS-RAF Signaling and P53 Signaling. And so on.

For genetic risk of Fibrosarcoma due to abnormalities in genes PREX2 and CYP17A1 – Foods like Giant Butterbur are recommended compared to Okra. This is because the active ingredients Folic Acid in Okra further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Giant Butterbur together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: GIANT BUTTERBUR IS RECOMMENDED OVER OKRA FOR REDUCING THE GENETIC RISK OF FIBROSARCOMA DUE TO GENES PREX2 AND CYP17A1

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

Eat more fruits, Avocado or Huckleberry?

The active ingredients contained in Avocado are Quercetin, Beta-sitosterol, Vitamin C, Oleic Acid, Linolenic Acid among others. While the active ingredients contained in Huckleberry are Quercetin, Resveratrol, Vitamin C, P-coumaric Acid, Ferulic Acid and others.

Beta-sitosterol can manipulate biochemical pathways Cell Cycle Checkpoints, P53 Signaling and MYC Signaling. Quercetin has biological action on biochemical pathways RAS-RAF Signaling, Reproductive Hormone Signaling and PI3K-AKT-MTOR Signaling.

Resveratrol can manipulate biochemical pathways P53 Signaling. Pelargonidin has biological action on biochemical pathways MYC Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling. And so on.

For genetic risk of Fibrosarcoma due to abnormalities in genes PREX2 and CYP17A1 – Foods like Avocado are recommended compared to Huckleberry. This is because the active ingredients Resveratrol and Pelargonidin in Huckleberry further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Quercetin contained in Avocado together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: AVOCADO IS RECOMMENDED OVER HUCKLEBERRY FOR REDUCING THE GENETIC RISK OF FIBROSARCOMA DUE TO GENES PREX2 AND CYP17A1

Eat more nuts, Pistachio or Brazil Nut?

The active ingredients contained in Pistachio are Beta-sitosterol, Vitamin E, Resveratrol, Oleic Acid, Linolenic Acid among others. While the active ingredients contained in Brazil Nut are Vitamin E, Oleic Acid, Linolenic Acid, Lecithin, Folic Acid and others.

Beta-sitosterol can manipulate biochemical pathways Cell Cycle Checkpoints, P53 Signaling and MYC Signaling. Vitamin E has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, Apoptosis and Cell Cycle Checkpoints.

Lecithin can manipulate biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways Cell Cycle Checkpoints, RAS-RAF Signaling and P53 Signaling. And so on.

For genetic risk of Fibrosarcoma due to abnormalities in genes PREX2 and CYP17A1 – Foods like Pistachio are recommended compared to Brazil Nut. This is because the active ingredients Lecithin and Folic Acid in Brazil Nut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin E contained in Pistachio together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: PISTACHIO IS RECOMMENDED OVER BRAZIL NUT FOR REDUCING THE GENETIC RISK OF FIBROSARCOMA DUE TO GENES PREX2 AND CYP17A1


In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Fibrosarcoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

sample-report


References

Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.


Scientifically Reviewed by: Dr. Cogle

Christopher R. Cogle, M.D. is a tenured professor at the University of Florida, Chief Medical Officer of Florida Medicaid, and Director of the Florida Health Policy Leadership Academy at the Bob Graham Center for Public Service.

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