Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Diffuse Intrinsic Pontine Glioma when undergoing chemotherapy or when you determine you have a genetic risk for developing Diffuse Intrinsic Pontine Glioma because of ACVR1 and IDH1 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Diffuse Intrinsic Pontine Glioma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Graviola” or “Include fruit Mulberry in my diet” or “Should I reduce consumption of vegetable Radish” or “Can I take Resveratrol and Mulberry supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO DIFFUSE INTRINSIC PONTINE GLIOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Diffuse Intrinsic Pontine Glioma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR DIFFUSE INTRINSIC PONTINE GLIOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Diffuse Intrinsic Pontine Glioma
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Diffuse Intrinsic Pontine Glioma from cBioPortal. From a patient sample size of 2; the top genes with mutations and other abnormalities for Diffuse Intrinsic Pontine Glioma include genes ACVR1, ATRX, IDH1, PIK3CA and STAG2. The occurrence frequency distribution for these genes respectively is 50.0%, 50.0%, 50.0%, 50.0% and 50.0%. These tumor genetic details of Diffuse Intrinsic Pontine Glioma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Diffuse Intrinsic Pontine Glioma.
Diffuse intrinsic pontine glioma (DIPG) is a lethal malignant pediatric tumor that grows diffusely in the pons, the lowermost region of the brain stem, near the bottom of the skull. This devastating disease has a median age at diagnosis of 6-7 years. DIPG is uncommon in adults and accounts for only 1-2% of intracranial gliomas. In adults, a low-grade phenotype predominates for DIPG or brainstem glioma, due to which they have a better prognosis compared to DIPG in children. Diffuse intrinsic pontine gliomas or brainstem gliomas in adults are associated with symptoms of visual disturbances, limb weakness and gait disorders. Treatment options for DIPG in adults include glucocorticoids, surgery and radiotherapy, supported by the right nutritious foods and natural supplements. (Reyes-Botero G et al, Oncologist, 2012; 17(3): 388-397; Srikanthan D et al, Chinese Neurosurgical J, 2021, 7:6)
Significance of Nutrition for Diffuse Intrinsic Pontine Glioma
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Diffuse Intrinsic Pontine Glioma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Graviola includes active ingredients Emodin, Daidzein, Lycopene, Vitamin C, Vitamin E and others. And Mulberry contains active ingredients Resveratrol, Morusin, Moracin P and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Diffuse Intrinsic Pontine Glioma, activation or inhibition of selected biochemical pathways like Hypoxia, PI3K-AKT-MTOR Signaling, TGFB Signaling, Oncogenic Cancer Epigenetics plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Diffuse Intrinsic Pontine Glioma, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR DIFFUSE INTRINSIC PONTINE GLIOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Diffuse Intrinsic Pontine Glioma undergoing chemotherapy treatment
In Diffuse Intrinsic Pontine Glioma – the genes ACVR1, ATRX, IDH1, PIK3CA and STAG2 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Diffuse Intrinsic Pontine Glioma are Hypoxia, PI3K-AKT-MTOR Signaling and others. Radiation is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Hypoxia, PI3K-AKT-MTOR Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Mung Bean or Soy Bean?
Pulses are an important part of many diets. The active ingredients contained in Mung Bean are Vitamin C, Oleic Acid, Linolenic Acid, Vitexin, Glucaric Acid among others. While the active ingredients contained in Soy Bean are Daidzein, Lupeol, Vitamin C, Vitamin E, Beta-sitosterol and others.
Vitamin C can manipulate biochemical pathways MYC Signaling, Hypoxia and PI3K-AKT-MTOR Signaling. Vitexin has biological action on biochemical pathways MYC Signaling, Hypoxia and PI3K-AKT-MTOR Signaling.
Lecithin can manipulate biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. Fisetin has biological action on biochemical pathways MYC Signaling. And so on.
When treating Diffuse Intrinsic Pontine Glioma with chemotherapy Radiation – Foods like Mung Bean are recommended compared to Soy Bean. This is because the active ingredients Lecithin and Fisetin in Soy Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Vitexin contained in Mung Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: MUNG BEAN IS RECOMMENDED OVER SOY BEAN FOR DIFFUSE INTRINSIC PONTINE GLIOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more vegetables, Arugula or Radish?
Vegetables are an important part of many diets. The active ingredients contained in Arugula are Esculin, Kaempferol, Vitamin A, Vitamin K, Erysolin among others. While the active ingredients contained in Radish are Isorhamnetin, Vitamin C, Beta-sitosterol, Oleic Acid, Linolenic Acid and others.
Kaempferol can manipulate biochemical pathways Hypoxia and PI3K-AKT-MTOR Signaling. Vitamin A has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling.
Pelargonidin can manipulate biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. And so on.
When treating Diffuse Intrinsic Pontine Glioma with chemotherapy Radiation – Foods like Arugula are recommended compared to Radish. This is because the active ingredients Pelargonidin and Folic Acid in Radish interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Kaempferol and Vitamin A contained in Arugula support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: ARUGULA IS RECOMMENDED OVER RADISH FOR DIFFUSE INTRINSIC PONTINE GLIOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more fruits, Mulberry or Graviola?
Fruits are an important part of many diets. The active ingredients contained in Mulberry are Resveratrol, Morusin, Moracin P among others. While the active ingredients contained in Graviola are Emodin, Daidzein, Lycopene, Vitamin C, Vitamin E and others.
Morusin can manipulate biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. Resveratrol has biological action on biochemical pathways Hypoxia, MYC Signaling and PI3K-AKT-MTOR Signaling.
Fisetin can manipulate biochemical pathways MYC Signaling. Folic Acid has biological action on biochemical pathways PI3K-AKT-MTOR Signaling and MYC Signaling. And so on.
When treating Diffuse Intrinsic Pontine Glioma with chemotherapy Radiation – Foods like Mulberry are recommended compared to Graviola. This is because the active ingredients Fisetin and Folic Acid in Graviola interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Morusin and Resveratrol contained in Mulberry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: MULBERRY IS RECOMMENDED OVER GRAVIOLA FOR DIFFUSE INTRINSIC PONTINE GLIOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more nuts, Almond or Brazil Nut?
Nuts are an important part of many diets. The active ingredients contained in Almond are Vitamin E, Beta-sitosterol, Oleic Acid, Linolenic Acid, Vitamin B3 among others. While the active ingredients contained in Brazil Nut are Vitamin E, Oleic Acid, Linolenic Acid, Lecithin, Folic Acid and others.
Beta-sitosterol can manipulate biochemical pathways MYC Signaling, Hypoxia and PI3K-AKT-MTOR Signaling. Vitamin E has biological action on biochemical pathways MYC Signaling, Hypoxia and PI3K-AKT-MTOR Signaling.
Lecithin can manipulate biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. And so on.
When treating Diffuse Intrinsic Pontine Glioma with chemotherapy Radiation – Foods like Almond are recommended compared to Brazil Nut. This is because the active ingredients Lecithin and Folic Acid in Brazil Nut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin E contained in Almond support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: ALMOND IS RECOMMENDED OVER BRAZIL NUT FOR DIFFUSE INTRINSIC PONTINE GLIOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Foods for Genetic Risk of Diffuse Intrinsic Pontine Glioma
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. ACVR1 and IDH1 are two genes whose abnormalities are risk factors for Diffuse Intrinsic Pontine Glioma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Diffuse Intrinsic Pontine Glioma can be used as a guide for coming up with a recommended personalized nutrition plan. For Diffuse Intrinsic Pontine Glioma gene ACVR1 has causative impact on biological pathways like TGFB Signaling and Hematopoiesis. And IDH1 has a causative impact on biological pathways like Oncogenic Cancer Epigenetics, Glutathione Metabolism and Hypoxia. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like ACVR1 and IDH1 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes ACVR1 and IDH1 should be avoided.
Eat more pulses, Common Pea or Common Bean?
The active ingredients contained in Common Pea are Lupeol, Daidzein, Vitamin C, Beta-sitosterol, Oleic Acid among others. While the active ingredients contained in Common Bean are Apigenin, Esculin, Vitamin C, Oleic Acid, Linolenic Acid and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and Cell Cycle Checkpoints. Beta-sitosterol has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, Oncogenic Cancer Epigenetics and Hypoxia.
Pelargonidin can manipulate biochemical pathways MYC Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and Cell Cycle Checkpoints. And so on.
For genetic risk of Diffuse Intrinsic Pontine Glioma due to abnormalities in genes ACVR1 and IDH1 – Foods like Common Pea are recommended compared to Common Bean. This is because the active ingredients Pelargonidin and Folic Acid in Common Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Common Pea together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER COMMON BEAN FOR REDUCING THE GENETIC RISK OF DIFFUSE INTRINSIC PONTINE GLIOMA DUE TO GENES ACVR1 AND IDH1
Eat more vegetables, Mexican Groundcherry or Chicory?
The active ingredients contained in Mexican Groundcherry are Vitamin C, Vitamin B3 among others. While the active ingredients contained in Chicory are Apigenin, Esculin, Lupeol, Vitamin C, Betulinic Acid and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and Cell Cycle Checkpoints. Vitamin B3 has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, Hypoxia and Apoptosis.
Luteolin can manipulate biochemical pathways MYC Signaling. Esculetin has biological action on biochemical pathways TGFB Signaling and Hypoxia. And so on.
For genetic risk of Diffuse Intrinsic Pontine Glioma due to abnormalities in genes ACVR1 and IDH1 – Foods like Mexican Groundcherry are recommended compared to Chicory. This is because the active ingredients Luteolin and Esculetin in Chicory further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Vitamin B3 contained in Mexican Groundcherry together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: MEXICAN GROUNDCHERRY IS RECOMMENDED OVER CHICORY FOR REDUCING THE GENETIC RISK OF DIFFUSE INTRINSIC PONTINE GLIOMA DUE TO GENES ACVR1 AND IDH1
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Feijoa or Cranberry?
The active ingredients contained in Feijoa are Vitamin C, Lycopene, Casuarinin, Folic Acid among others. While the active ingredients contained in Cranberry are Resveratrol, Ellagic Acid, Vitamin C, Quercetin, Hyperoside and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and Cell Cycle Checkpoints. Lycopene has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, Hypoxia and Apoptosis.
Ellagic Acid can manipulate biochemical pathways MYC Signaling. Myricetin has biological action on biochemical pathways Oncogenic Cancer Epigenetics. And so on.
For genetic risk of Diffuse Intrinsic Pontine Glioma due to abnormalities in genes ACVR1 and IDH1 – Foods like Feijoa are recommended compared to Cranberry. This is because the active ingredients Ellagic Acid and Myricetin in Cranberry further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Lycopene contained in Feijoa together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: FEIJOA IS RECOMMENDED OVER CRANBERRY FOR REDUCING THE GENETIC RISK OF DIFFUSE INTRINSIC PONTINE GLIOMA DUE TO GENES ACVR1 AND IDH1
Eat more nuts, Pine Nut or Peanut?
The active ingredients contained in Pine Nut are Vitamin E, Beta-sitosterol, Oleic Acid, Linolenic Acid, Linoleic Acid among others. While the active ingredients contained in Peanut are Vitamin C, Vitamin E, Beta-sitosterol, Quercetin, Oleic Acid and others.
Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and Cell Cycle Checkpoints. Vitamin K has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, MYC Signaling and Cell Cycle Checkpoints.
Lecithin can manipulate biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways Cell Cycle Checkpoints, Apoptosis and MYC Signaling. And so on.
For genetic risk of Diffuse Intrinsic Pontine Glioma due to abnormalities in genes ACVR1 and IDH1 – Foods like Pine Nut are recommended compared to Peanut. This is because the active ingredients Lecithin and Folic Acid in Peanut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin K contained in Pine Nut together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: PINE NUT IS RECOMMENDED OVER PEANUT FOR REDUCING THE GENETIC RISK OF DIFFUSE INTRINSIC PONTINE GLIOMA DUE TO GENES ACVR1 AND IDH1
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Diffuse Intrinsic Pontine Glioma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
- Msk Impact 2017
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- Effect of sodium nitrate loading on electrolyte transport by the renal tubule.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.