Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Diffuse Astrocytoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Diffuse Astrocytoma because of IDH1 and NF1 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Diffuse Astrocytoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Cranberry” or “Include fruit Blueberry in my diet” or “Should I reduce consumption of vegetable Onion” or “Can I take Caffeine and Tangerine supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO DIFFUSE ASTROCYTOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Diffuse Astrocytoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR DIFFUSE ASTROCYTOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Diffuse Astrocytoma
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Diffuse Astrocytoma from cBioPortal. The patients enrolled in the studies for Diffuse Astrocytoma are in ages between 14 to 80 with an average age of 34. 61.5% of males and 38.5% of females were the distribution of gender in these clinical studies. From a patient sample size of 110; the top genes with mutations and other abnormalities for Diffuse Astrocytoma include genes IDH1, TP53, ATRX, TERT and NF1. The occurrence frequency distribution for these genes respectively is 77.8%, 77.8%, 66.7%, 20.4% and 7.4%. These tumor genetic details of Diffuse Astrocytoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Diffuse Astrocytoma.
Significance of Nutrition for Diffuse Astrocytoma
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Diffuse Astrocytoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Cranberry includes active ingredients Ellagic Acid, Quercetin, Myricetin, Resveratrol, Hyperoside and others. And Blueberry contains active ingredients Quercetin, Vitamin E, Myricetin, Resveratrol, Hyperoside and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Diffuse Astrocytoma, activation or inhibition of selected biochemical pathways like RAS-RAF Signaling, Cell Cycle, Apoptosis, Hypoxia plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Diffuse Astrocytoma, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR DIFFUSE ASTROCYTOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Diffuse Astrocytoma undergoing chemotherapy treatment
In Diffuse Astrocytoma – the genes IDH1, TP53, ATRX, TERT and NF1 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Diffuse Astrocytoma are RAS-RAF Signaling, Cell Cycle, DNA Repair and others. Radiation is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers RAS-RAF Signaling, Cell Cycle, DNA Repair so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Scarlet Bean or Pigeon Pea?
Pulses are an important part of many diets. The active ingredients contained in Scarlet Bean are Beta-sitosterol, Vitamin C, Genistein, Oleic Acid, Linolenic Acid among others. While the active ingredients contained in Pigeon Pea are Vitamin C, Genistein, Oleic Acid, Linolenic Acid, Vitamin A and others.
Beta-sitosterol can manipulate biochemical pathways NFKB Signaling, Cell Cycle and MYC Signaling. Vitamin C has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, Hypoxia and RAS-RAF Signaling.
Genistein can manipulate biochemical pathways DNA Repair. Linoleic Acid has biological action on biochemical pathways TGFB Signaling. And so on.
When treating Diffuse Astrocytoma with chemotherapy Radiation – Foods like Scarlet Bean are recommended compared to Pigeon Pea. This is because the active ingredients Genistein and Linoleic Acid in Pigeon Pea interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Scarlet Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER PIGEON PEA FOR DIFFUSE ASTROCYTOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more vegetables, Cabbage or Onion?
Vegetables are an important part of many diets. The active ingredients contained in Cabbage are Quercetin, Benzyl Isothiocyanate, Isorhamnetin, Beta-sitosterol, Vitamin C among others. While the active ingredients contained in Onion are Quercetin, Myricetin, Isorhamnetin, Beta-sitosterol, Vitamin C and others.
Vitamin C can manipulate biochemical pathways Cell Cycle, MYC Signaling and PI3K-AKT-MTOR Signaling. Glucaric Acid has biological action on biochemical pathways NFKB Signaling, RAS-RAF Signaling and Cell Cycle.
Diallyl Disulfide can manipulate biochemical pathways DNA Repair. Pelargonidin has biological action on biochemical pathways MYC Signaling, NFKB Signaling and Cell Cycle. And so on.
When treating Diffuse Astrocytoma with chemotherapy Radiation – Foods like Cabbage are recommended compared to Onion. This is because the active ingredients Diallyl Disulfide and Pelargonidin in Onion interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Glucaric Acid contained in Cabbage support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: CABBAGE IS RECOMMENDED OVER ONION FOR DIFFUSE ASTROCYTOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more fruits, Blueberry or Cranberry?
Fruits are an important part of many diets. The active ingredients contained in Blueberry are Quercetin, Vitamin E, Myricetin, Resveratrol, Hyperoside among others. While the active ingredients contained in Cranberry are Ellagic Acid, Quercetin, Myricetin, Resveratrol, Hyperoside and others.
Gallic Acid can manipulate biochemical pathways NFKB Signaling, DNA Repair and Cell Cycle. Vitamin C has biological action on biochemical pathways MYC Signaling, PI3K-AKT-MTOR Signaling and Hypoxia.
Ellagic Acid can manipulate biochemical pathways MYC Signaling. Resveratrol has biological action on biochemical pathways DNA Repair. And so on.
When treating Diffuse Astrocytoma with chemotherapy Radiation – Foods like Blueberry are recommended compared to Cranberry. This is because the active ingredients Ellagic Acid and Resveratrol in Cranberry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Gallic Acid and Vitamin C contained in Blueberry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: BLUEBERRY IS RECOMMENDED OVER CRANBERRY FOR DIFFUSE ASTROCYTOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more nuts, Pecan Nut or Pumpkin Seeds?
Nuts are an important part of many diets. The active ingredients contained in Pecan Nut are Vitamin E, Cianidanol, Oleic Acid, Linolenic Acid, Delphinidin among others. While the active ingredients contained in Pumpkin Seeds are Salicylic Acid, Beta-sitosterol, Oleic Acid, Linolenic Acid, Gamma-linolenic Acid and others.
Vitamin E can manipulate biochemical pathways NFKB Signaling, DNA Repair and Cell Cycle. Cianidanol has biological action on biochemical pathways MYC Signaling, Hypoxia and PI3K-AKT-MTOR Signaling.
Lecithin can manipulate biochemical pathways MYC Signaling, NFKB Signaling and PI3K-AKT-MTOR Signaling. Cucurbitacin I has biological action on biochemical pathways MYC Signaling and NFKB Signaling. And so on.
When treating Diffuse Astrocytoma with chemotherapy Radiation – Foods like Pecan Nut are recommended compared to Pumpkin Seeds. This is because the active ingredients Lecithin and Cucurbitacin I in Pumpkin Seeds interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin E and Cianidanol contained in Pecan Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER PUMPKIN SEEDS FOR DIFFUSE ASTROCYTOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Foods for Genetic Risk of Diffuse Astrocytoma
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. IDH1 and NF1 are two genes whose abnormalities are risk factors for Diffuse Astrocytoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Diffuse Astrocytoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Diffuse Astrocytoma gene IDH1 has causative impact on biological pathways like Oncogenic Cancer Epigenetics, Glutathione Metabolism and Hypoxia. And NF1 has a causative impact on biological pathways like MAPK Signaling, PI3K-AKT-MTOR Signaling and RAS-RAF Signaling. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like IDH1 and NF1 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes IDH1 and NF1 should be avoided.
Eat more pulses, Common Pea or Lima Bean?
The active ingredients contained in Common Pea are Lupeol, Daidzein, Vitamin C, Beta-sitosterol, Oleic Acid among others. While the active ingredients contained in Lima Bean are Vitamin C, Oleic Acid, Genistein, Linoleic Acid, Vitamin A and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Beta-sitosterol has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Oncogenic Cancer Epigenetics.
Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. And so on.
For genetic risk of Diffuse Astrocytoma due to abnormalities in genes IDH1 and NF1 – Foods like Common Pea are recommended compared to Lima Bean. This is because the active ingredients Vitamin A and Folic Acid in Lima Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Common Pea together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER LIMA BEAN FOR REDUCING THE GENETIC RISK OF DIFFUSE ASTROCYTOMA DUE TO GENES IDH1 AND NF1
Eat more vegetables, Cassava or Endive?
The active ingredients contained in Cassava are Vitamin C, Beta-sitosterol, Oleic Acid, Linolenic Acid, Linoleic Acid among others. While the active ingredients contained in Endive are Quercetin, Vitamin C, Oleic Acid, Linolenic Acid, Kaempferol and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Beta-sitosterol has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Oncogenic Cancer Epigenetics.
Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. And so on.
For genetic risk of Diffuse Astrocytoma due to abnormalities in genes IDH1 and NF1 – Foods like Cassava are recommended compared to Endive. This is because the active ingredients Vitamin A and Folic Acid in Endive further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Cassava together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: CASSAVA IS RECOMMENDED OVER ENDIVE FOR REDUCING THE GENETIC RISK OF DIFFUSE ASTROCYTOMA DUE TO GENES IDH1 AND NF1
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Feijoa or Naranjilla?
The active ingredients contained in Feijoa are Vitamin C, Lycopene, Casuarinin, Folic Acid among others. While the active ingredients contained in Naranjilla are Zeaxanthin, Beta-carotene, Vitamin A and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Lycopene has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Hypoxia.
Beta-carotene can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Vitamin A has biological action on biochemical pathways PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Diffuse Astrocytoma due to abnormalities in genes IDH1 and NF1 – Foods like Feijoa are recommended compared to Naranjilla. This is because the active ingredients Beta-carotene and Vitamin A in Naranjilla further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Lycopene contained in Feijoa together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: FEIJOA IS RECOMMENDED OVER NARANJILLA FOR REDUCING THE GENETIC RISK OF DIFFUSE ASTROCYTOMA DUE TO GENES IDH1 AND NF1
Eat more nuts, Almond or Peanut?
The active ingredients contained in Almond are Quercetin, Beta-sitosterol, Vitamin E, Oleic Acid, Linolenic Acid among others. While the active ingredients contained in Peanut are Quercetin, Vitamin C, Beta-sitosterol, Vitamin E, Oleic Acid and others.
Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Quercetin has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Oncogenic Cancer Epigenetics.
Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Lecithin has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Diffuse Astrocytoma due to abnormalities in genes IDH1 and NF1 – Foods like Almond are recommended compared to Peanut. This is because the active ingredients Vitamin A and Lecithin in Peanut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Quercetin contained in Almond together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: ALMOND IS RECOMMENDED OVER PEANUT FOR REDUCING THE GENETIC RISK OF DIFFUSE ASTROCYTOMA DUE TO GENES IDH1 AND NF1
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Diffuse Astrocytoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
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- Activation of PPAR gamma and delta by conjugated linoleic acid mediates protection from experimental inflammatory bowel disease.
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- Inhibitory effect of tocotrienol on eukaryotic DNA polymerase lambda and angiogenesis.
- Cytotoxicity and apoptosis induction in human breast adenocarcinoma MCF-7 cells by (+)-cyanidan-3-ol.
- The recruitment of Raf-1 to membranes is mediated by direct interaction with phosphatidic acid and is independent of association with Ras.
- Cucurbitacin-I induces hypertrophy in H9c2 cardiomyoblasts through activation of autophagy via MEK/ERK1/2 signaling pathway.
- Vitamin A regulates Akt signaling through the phospholipid fatty acid composition.
- Effects of folate deficiency on gene expression in the apoptosis and cancer pathways in colon cancer cells.
- Lycopene metabolite, apo-10′-lycopenoic acid, inhibits diethylnitrosamine-initiated, high fat diet-promoted hepatic inflammation and tumorigenesis in mice.
- β-carotene Inhibits Expression of c-Myc and Cyclin E in Helicobacter pylori-infected Gastric Epithelial Cells.
- Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin.
- HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.