Which Foods are Recommended for Cutaneous T-cell Lymphoma?

Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Cutaneous T-cell Lymphoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Cutaneous T-cell Lymphoma because of PLCG1 and KIT gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Cutaneous T-cell Lymphoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Gooseberry” or “Include fruit Partridgeberry in my diet” or “Should I reduce consumption of vegetable Tomato” or “Can I take Curcumin and Alpha Lipoic Acid supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO CUTANEOUS T-CELL LYMPHOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Cutaneous T-cell Lymphoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR CUTANEOUS T-CELL LYMPHOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.

About Cutaneous T-cell Lymphoma

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Cutaneous T-cell Lymphoma from cBioPortal. From a patient sample size of 26; the top genes with mutations and other abnormalities for Cutaneous T-cell Lymphoma include genes TP53, PLCG1, KIT, TET2 and ADCYAP1R1. The occurrence frequency distribution for these genes respectively is 15.4%, 11.5%, 11.5%, 11.5% and 7.7%. These tumor genetic details of Cutaneous T-cell Lymphoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Cutaneous T-cell Lymphoma.

Cutaneous T-cell lymphoma (CTCL) is a group of rare blood cancers, a type of non-Hodgkin lymphoma, that affects the skin. Most cutaneous T-cell lymphomas grow very slowly and are not life-threatening. The T lymphocytes mutate to become cancerous and multiply uncontrollably in cutaneous T-cell lymphoma. These cancers cause symptoms like rash, very itchy skin (pruritis) or other skin issues that may appear like common skin disorders like psoriasis, eczema or even an allergic reaction. The two most common types of cutaneous T-cell lymphomas are mycosis fungoides and Sezary syndrome. In mycosis fungoides, very rarely (~10%) cases, the cancerous cells may spread from the skin to the lymph nodes or internal organs such as liver, spleen, or digestive system, and cause life-threatening medical complications. In Sezary syndrome, cancerous lymphocytes are in the skin and bloodstream and may cause widespread redness on the skin. CTCLs are two times as likely to affect men in the age group of 40-60 years. The treatment of CTCL varies depending on the stage and type of the cancer, but can include topical medications, light therapy, radiation therapy, chemotherapy, and biologic therapies. In severe cases, bone marrow transplantation may be necessary. The goals of treatment for CTCL are to control symptoms, improve quality of life, and prolong survival. It is important for patients to work closely with their healthcare provider to develop an individualized treatment plan that addresses their specific needs and goals. In addition, supportive care with the right nutrition (foods and natural supplements) can help improve the patients’ well-being. (Ref: https://my.clevelandclinic.org/health/diseases/17940-cutaneous-t-cell-lymphoma; https://emedicine.medscape.com/article/2139720-overview; https://www.clfoundation.org/cutaneous-t-cell-lymphoma)

Significance of Nutrition for Cutaneous T-cell Lymphoma

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Cutaneous T-cell Lymphoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Gooseberry includes active ingredients Vitamin C, Linolenic Acid, Gallic Acid, Beta-sitosterol, Oleic Acid and others. And Partridgeberry contains active ingredients Resveratrol, Beta-sitosterol, Stigmasterol and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Cutaneous T-cell Lymphoma, activation or inhibition of selected biochemical pathways like RAS-RAF Signaling, Cell Cycle, Extracellular Matrix Remodelling, Small Molecule Transport plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Cutaneous T-cell Lymphoma, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR CUTANEOUS T-CELL LYMPHOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Cutaneous T-cell Lymphoma undergoing chemotherapy treatment

In Cutaneous T-cell Lymphoma – the genes TP53, PLCG1, KIT, TET2 and ADCYAP1R1 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Cutaneous T-cell Lymphoma are RAS-RAF Signaling, Cell Cycle, DNA Repair and others. Radiation is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers RAS-RAF Signaling, Cell Cycle, DNA Repair so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Common Pea or Common Bean?

Pulses are an important part of many diets. The active ingredients contained in Common Pea are Daidzein, Lupeol, Vitamin C, Linolenic Acid, Beta-sitosterol among others. While the active ingredients contained in Common Bean are Apigenin, Esculin, Vitamin C, Linolenic Acid, Ferulic Acid and others.

Vitamin C can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Cell Cycle and MYC Signaling. Beta-sitosterol has biological action on biochemical pathways NFKB Signaling, Cell Survival and PI3K-AKT-MTOR Signaling.

Vitamin A can manipulate biochemical pathways Notch Signaling and Focal Adhesion. Apigenin has biological action on biochemical pathways Epithelial to Mesenchymal Transition, DNA Repair and Oxidative Stress. And so on.

When treating Cutaneous T-cell Lymphoma with chemotherapy Radiation – Foods like Common Pea are recommended compared to Common Bean. This is because the active ingredients Vitamin A and Apigenin in Common Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Beta-sitosterol contained in Common Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER COMMON BEAN FOR CUTANEOUS T-CELL LYMPHOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more vegetables, Jicama or Tomato?

Vegetables are an important part of many diets. The active ingredients contained in Jicama are Vitamin C, Beta-carotene, Vitamin A, Vitamin B3, Folic Acid among others. While the active ingredients contained in Tomato are Lupeol, Lycopene, Vitamin C, Linolenic Acid, Oleic Acid and others.

Vitamin C can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Cell Cycle and MYC Signaling. Beta-carotene has biological action on biochemical pathways NFKB Signaling, DNA Repair and Cell Survival.

Lycopene can manipulate biochemical pathways Oxidative Stress. Rutin has biological action on biochemical pathways Focal Adhesion and Oxidative Stress. And so on.

When treating Cutaneous T-cell Lymphoma with chemotherapy Radiation – Foods like Jicama are recommended compared to Tomato. This is because the active ingredients Lycopene and Rutin in Tomato interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Beta-carotene contained in Jicama support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: JICAMA IS RECOMMENDED OVER TOMATO FOR CUTANEOUS T-CELL LYMPHOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more fruits, Partridgeberry or Gooseberry?

Fruits are an important part of many diets. The active ingredients contained in Partridgeberry are Resveratrol, Beta-sitosterol, Stigmasterol among others. While the active ingredients contained in Gooseberry are Vitamin C, Linolenic Acid, Gallic Acid, Beta-sitosterol, Oleic Acid and others.

Resveratrol can manipulate biochemical pathways NFKB Signaling, JAK-STAT Signaling and Cell Cycle. Beta-sitosterol has biological action on biochemical pathways Epithelial to Mesenchymal Transition, Cell Survival and MYC Signaling.

Gallic Acid can manipulate biochemical pathways Oxidative Stress. Citric Acid has biological action on biochemical pathways Oxidative Stress. And so on.

When treating Cutaneous T-cell Lymphoma with chemotherapy Radiation – Foods like Partridgeberry are recommended compared to Gooseberry. This is because the active ingredients Gallic Acid and Citric Acid in Gooseberry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Resveratrol and Beta-sitosterol contained in Partridgeberry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: PARTRIDGEBERRY IS RECOMMENDED OVER GOOSEBERRY FOR CUTANEOUS T-CELL LYMPHOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more nuts, Pine Nut or Peanut?

Nuts are an important part of many diets. The active ingredients contained in Pine Nut are Vitamin E, Linolenic Acid, Beta-sitosterol, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Peanut are Quercetin, Vitamin E, Vitamin C, Linolenic Acid, Ferulic Acid and others.

Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Cell Cycle. Vitamin K has biological action on biochemical pathways MYC Signaling, PI3K-AKT-MTOR Signaling and NFKB Signaling.

Quercetin can manipulate biochemical pathways Oxidative Stress and Hypoxia. Vitamin A has biological action on biochemical pathways Notch Signaling and Focal Adhesion. And so on.

When treating Cutaneous T-cell Lymphoma with chemotherapy Radiation – Foods like Pine Nut are recommended compared to Peanut. This is because the active ingredients Quercetin and Vitamin A in Peanut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin K contained in Pine Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: PINE NUT IS RECOMMENDED OVER PEANUT FOR CUTANEOUS T-CELL LYMPHOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Foods for Genetic Risk of Cutaneous T-cell Lymphoma

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. PLCG1 and KIT are two genes whose abnormalities are risk factors for Cutaneous T-cell Lymphoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Cutaneous T-cell Lymphoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Cutaneous T-cell Lymphoma gene PLCG1 has causative impact on biological pathways like AGE-RAGE Signaling and Angiogenesis. And KIT has a causative impact on biological pathways like MAPK Signaling, Growth Factor Signaling and PI3K-AKT-MTOR Signaling. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like PLCG1 and KIT should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes PLCG1 and KIT should be avoided.

Eat more pulses, Scarlet Bean or Chickpea?

The active ingredients contained in Scarlet Bean are Beta-sitosterol, Oleic Acid, Vitamin C, Linolenic Acid, Stigmasterol among others. While the active ingredients contained in Chickpea are Oleic Acid, Linolenic Acid, Genistein, Vitamin A, Folic Acid and others.

Beta-sitosterol can manipulate biochemical pathways Inositol Phosphate Signaling, Apoptosis and MYC Signaling. Vitamin C has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and RAS-RAF Signaling.

Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and Cell Cycle Checkpoints. And so on.

For genetic risk of Cutaneous T-cell Lymphoma due to abnormalities in genes PLCG1 and KIT – Foods like Scarlet Bean are recommended compared to Chickpea. This is because the active ingredients Vitamin A and Folic Acid in Chickpea further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin C contained in Scarlet Bean together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER CHICKPEA FOR REDUCING THE GENETIC RISK OF CUTANEOUS T-CELL LYMPHOMA DUE TO GENES PLCG1 AND KIT

Eat more vegetables, Amaranth or Jute?

The active ingredients contained in Amaranth are Beta-sitosterol, Oleic Acid, Vitamin C, Linolenic Acid, Stigmasterol among others. While the active ingredients contained in Jute are Quercetin, Oleic Acid, Vitamin C, Linolenic Acid, Kaempferol and others.

Beta-sitosterol can manipulate biochemical pathways Inositol Phosphate Signaling, Apoptosis and MYC Signaling. Vitamin C has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and RAS-RAF Signaling.

Vitamin B3 can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Vitamin A has biological action on biochemical pathways PI3K-AKT-MTOR Signaling. And so on.

For genetic risk of Cutaneous T-cell Lymphoma due to abnormalities in genes PLCG1 and KIT – Foods like Amaranth are recommended compared to Jute. This is because the active ingredients Vitamin B3 and Vitamin A in Jute further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin C contained in Amaranth together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: AMARANTH IS RECOMMENDED OVER JUTE FOR REDUCING THE GENETIC RISK OF CUTANEOUS T-CELL LYMPHOMA DUE TO GENES PLCG1 AND KIT

Eat more fruits, Apricot or Cloudberry?

The active ingredients contained in Apricot are Quercetin, Beta-sitosterol, Modified Citrus Pectin, Oleic Acid, Vitamin C among others. While the active ingredients contained in Cloudberry are Ellagic Acid, Vitamin C, Urolithin B, Vitamin A and others.

Glucaric Acid can manipulate biochemical pathways Apoptosis, MYC Signaling and Calcium Signaling. Beta-sitosterol has biological action on biochemical pathways Inositol Phosphate Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.

Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Ellagic Acid has biological action on biochemical pathways MYC Signaling. And so on.

For genetic risk of Cutaneous T-cell Lymphoma due to abnormalities in genes PLCG1 and KIT – Foods like Apricot are recommended compared to Cloudberry. This is because the active ingredients Vitamin A and Ellagic Acid in Cloudberry further promote the effects of genes on the biochemical pathways. While the active ingredients Glucaric Acid and Beta-sitosterol contained in Apricot together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: APRICOT IS RECOMMENDED OVER CLOUDBERRY FOR REDUCING THE GENETIC RISK OF CUTANEOUS T-CELL LYMPHOMA DUE TO GENES PLCG1 AND KIT

Eat more nuts, Almond or Acorn?

The active ingredients contained in Almond are Quercetin, Beta-sitosterol, Vitamin E, Oleic Acid, Linolenic Acid among others. While the active ingredients contained in Acorn are Quercetin, Beta-sitosterol, Vitamin C, Quercitrin, Gallic Acid and others.

Beta-sitosterol can manipulate biochemical pathways Inositol Phosphate Signaling, Apoptosis and MYC Signaling. Vitamin E has biological action on biochemical pathways Calcium Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.

Vitamin B3 can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Vitamin A has biological action on biochemical pathways PI3K-AKT-MTOR Signaling. And so on.

For genetic risk of Cutaneous T-cell Lymphoma due to abnormalities in genes PLCG1 and KIT – Foods like Almond are recommended compared to Acorn. This is because the active ingredients Vitamin B3 and Vitamin A in Acorn further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin E contained in Almond together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: ALMOND IS RECOMMENDED OVER ACORN FOR REDUCING THE GENETIC RISK OF CUTANEOUS T-CELL LYMPHOMA DUE TO GENES PLCG1 AND KIT

In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Cutaneous T-cell Lymphoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

References

• Ctcl Columbia 2015
• The mutational landscape of cutaneous T cell lymphoma and Sézary syndrome.
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• Beta-sitosterol induces anti-proliferation and apoptosis in human leukemic U937 cells through activation of caspase-3 and induction of Bax/Bcl-2 ratio.
• Vitamin A regulates Akt signaling through the phospholipid fatty acid composition.
• Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin.
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• β-Carotene-induced apoptosis is mediated with loss of Ku proteins in gastric cancer AGS cells.
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