Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Colorectal Neuroendocrine Carcinoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Colorectal Neuroendocrine Carcinoma because of APC and AMER1 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Colorectal Neuroendocrine Carcinoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Lingonberry” or “Include fruit Graviola in my diet” or “Should I reduce consumption of vegetable Swede” or “Can I take Fisetin and Ellagic Acid supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO COLORECTAL NEUROENDOCRINE CARCINOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Colorectal Neuroendocrine Carcinoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR COLORECTAL NEUROENDOCRINE CARCINOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Colorectal Neuroendocrine Carcinoma
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Colorectal Neuroendocrine Carcinoma from cBioPortal. 48.1% of males and 51.9% of females were the distribution of gender in these clinical studies. From a patient sample size of 27; the top genes with mutations and other abnormalities for Colorectal Neuroendocrine Carcinoma include genes TP53, APC, AMER1, DOT1L and FAT3. The occurrence frequency distribution for these genes respectively is 28.6%, 21.4%, 14.3%, 14.3% and 7.1%. These tumor genetic details of Colorectal Neuroendocrine Carcinoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Colorectal Neuroendocrine Carcinoma.
Significance of Nutrition for Colorectal Neuroendocrine Carcinoma
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Colorectal Neuroendocrine Carcinoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Lingonberry includes active ingredients Resveratrol, Quercetin, Hyperoside, Oleic Acid, Caffeic Acid and others. And Graviola contains active ingredients Fisetin, Quercetin, Daidzein, Vitamin E, Beta-sitosterol and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Colorectal Neuroendocrine Carcinoma, activation or inhibition of selected biochemical pathways like Cell Cycle, MAPK Signaling, PI3K-AKT-MTOR Signaling, Cell Cycle Checkpoints plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Colorectal Neuroendocrine Carcinoma, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR COLORECTAL NEUROENDOCRINE CARCINOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Colorectal Neuroendocrine Carcinoma undergoing chemotherapy treatment
In Colorectal Neuroendocrine Carcinoma – the genes TP53, APC, AMER1, DOT1L and FAT3 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Colorectal Neuroendocrine Carcinoma are Cell Cycle, MAPK Signaling, PI3K-AKT-MTOR Signaling and others. Lanreotide is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Cell Cycle, MAPK Signaling, PI3K-AKT-MTOR Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Common Pea or Common Bean?
Pulses are an important part of many diets. The active ingredients contained in Common Pea are Lupeol, Daidzein, Beta-sitosterol, Oleic Acid, Vitamin C among others. While the active ingredients contained in Common Bean are Apigenin, Oleic Acid, Esculin, Gamma-linolenic Acid, Vitamin C and others.
Beta-sitosterol can manipulate biochemical pathways PI3K-AKT-MTOR Signaling, Angiogenesis and Cell Cycle. Vitamin C has biological action on biochemical pathways MAPK Signaling, PI3K-AKT-MTOR Signaling and Angiogenesis.
Apigenin can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Pelargonidin has biological action on biochemical pathways Cell Cycle and PI3K-AKT-MTOR Signaling. And so on.
When treating Colorectal Neuroendocrine Carcinoma with chemotherapy Lanreotide – Foods like Common Pea are recommended compared to Common Bean. This is because the active ingredients Apigenin and Pelargonidin in Common Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER COMMON BEAN FOR COLORECTAL NEUROENDOCRINE CARCINOMA ON TREATMENT WITH CHEMOTHERAPY LANREOTIDE FOR SOME CONDITIONS.
Eat more vegetables, Arugula or Swede?
Vegetables are an important part of many diets. The active ingredients contained in Arugula are Esculin, Kaempferol, Vitamin A, Vitamin K among others. While the active ingredients contained in Swede are Lycopene, Oleic Acid, Linolenic Acid, Linoleic Acid, Folic Acid and others.
Kaempferol can manipulate biochemical pathways PI3K-AKT-MTOR Signaling, Angiogenesis and Cell Cycle. Vitamin A has biological action on biochemical pathways Cell Cycle and PI3K-AKT-MTOR Signaling.
Linoleic Acid can manipulate biochemical pathways Angiogenesis. Folic Acid has biological action on biochemical pathways JAK-STAT Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. And so on.
When treating Colorectal Neuroendocrine Carcinoma with chemotherapy Lanreotide – Foods like Arugula are recommended compared to Swede. This is because the active ingredients Linoleic Acid and Folic Acid in Swede interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Kaempferol and Vitamin A contained in Arugula support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: ARUGULA IS RECOMMENDED OVER SWEDE FOR COLORECTAL NEUROENDOCRINE CARCINOMA ON TREATMENT WITH CHEMOTHERAPY LANREOTIDE FOR SOME CONDITIONS.
Eat more fruits, Graviola or Lingonberry?
Fruits are an important part of many diets. The active ingredients contained in Graviola are Fisetin, Quercetin, Daidzein, Vitamin E, Beta-sitosterol among others. While the active ingredients contained in Lingonberry are Resveratrol, Quercetin, Hyperoside, Oleic Acid, Caffeic Acid and others.
Fisetin can manipulate biochemical pathways PI3K-AKT-MTOR Signaling, Angiogenesis and MAPK Signaling. Emodin has biological action on biochemical pathways JAK-STAT Signaling, Cell Cycle and PI3K-AKT-MTOR Signaling.
Quercitrin can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Linoleic Acid has biological action on biochemical pathways Angiogenesis. And so on.
When treating Colorectal Neuroendocrine Carcinoma with chemotherapy Lanreotide – Foods like Graviola are recommended compared to Lingonberry. This is because the active ingredients Quercitrin and Linoleic Acid in Lingonberry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Fisetin and Emodin contained in Graviola support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: GRAVIOLA IS RECOMMENDED OVER LINGONBERRY FOR COLORECTAL NEUROENDOCRINE CARCINOMA ON TREATMENT WITH CHEMOTHERAPY LANREOTIDE FOR SOME CONDITIONS.
Eat more nuts, Pecan Nut or Brazil Nut?
Nuts are an important part of many diets. The active ingredients contained in Pecan Nut are Vitamin E, Oleic Acid, Linolenic Acid, Cianidanol, Delphinidin among others. While the active ingredients contained in Brazil Nut are Vitamin E, Oleic Acid, Linolenic Acid, Folic Acid, Lecithin and others.
Vitamin E can manipulate biochemical pathways PI3K-AKT-MTOR Signaling, Angiogenesis and MAPK Signaling. Cianidanol has biological action on biochemical pathways Angiogenesis, MAPK Signaling and PI3K-AKT-MTOR Signaling.
Lecithin can manipulate biochemical pathways Angiogenesis, MAPK Signaling and PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways JAK-STAT Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. And so on.
When treating Colorectal Neuroendocrine Carcinoma with chemotherapy Lanreotide – Foods like Pecan Nut are recommended compared to Brazil Nut. This is because the active ingredients Lecithin and Folic Acid in Brazil Nut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin E and Cianidanol contained in Pecan Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER BRAZIL NUT FOR COLORECTAL NEUROENDOCRINE CARCINOMA ON TREATMENT WITH CHEMOTHERAPY LANREOTIDE FOR SOME CONDITIONS.
Foods for Genetic Risk of Colorectal Neuroendocrine Carcinoma
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. APC and AMER1 are two genes whose abnormalities are risk factors for Colorectal Neuroendocrine Carcinoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Colorectal Neuroendocrine Carcinoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Colorectal Neuroendocrine Carcinoma gene APC has causative impact on biological pathways like Angiogenesis and Growth Factor Signaling. And AMER1 has a causative impact on biological pathways like . Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like APC and AMER1 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes APC and AMER1 should be avoided.
Eat more pulses, Scarlet Bean or Soy Bean?
The active ingredients contained in Scarlet Bean are Oleic Acid, Beta-sitosterol, Vitamin C, Linolenic Acid, Stigmasterol among others. While the active ingredients contained in Soy Bean are Lupeol, Daidzein, Vitamin E, Oleic Acid, Beta-sitosterol and others.
Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin C has biological action on biochemical pathways Cell Cycle Checkpoints, MAPK Signaling and PI3K-AKT-MTOR Signaling.
Aescin can manipulate biochemical pathways Cell Cycle Checkpoints. Lecithin has biological action on biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Colorectal Neuroendocrine Carcinoma due to abnormalities in genes APC and AMER1 – Foods like Scarlet Bean are recommended compared to Soy Bean. This is because the active ingredients Aescin and Lecithin in Soy Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin C contained in Scarlet Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER SOY BEAN FOR REDUCING THE GENETIC RISK OF COLORECTAL NEUROENDOCRINE CARCINOMA DUE TO GENES APC AND AMER1
Eat more vegetables, Giant Butterbur or Radish?
The active ingredients contained in Giant Butterbur are Beta-sitosterol, Vitamin C, Vitamin B3, Melatonin, Kaempferol among others. While the active ingredients contained in Radish are Oleic Acid, Beta-sitosterol, Vitamin C, Linolenic Acid, Quercetin and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Beta-sitosterol has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Apoptosis.
Pelargonidin can manipulate biochemical pathways MYC Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, P53 Signaling and MAPK Signaling. And so on.
For genetic risk of Colorectal Neuroendocrine Carcinoma due to abnormalities in genes APC and AMER1 – Foods like Giant Butterbur are recommended compared to Radish. This is because the active ingredients Pelargonidin and Folic Acid in Radish further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Giant Butterbur together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: GIANT BUTTERBUR IS RECOMMENDED OVER RADISH FOR REDUCING THE GENETIC RISK OF COLORECTAL NEUROENDOCRINE CARCINOMA DUE TO GENES APC AND AMER1
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Feijoa or Grape?
The active ingredients contained in Feijoa are Lycopene, Vitamin C, Casuarinin, Folic Acid among others. While the active ingredients contained in Grape are Lupeol, Resveratrol, Vitamin E, Oleic Acid, Beta-sitosterol and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Lycopene has biological action on biochemical pathways Cell Cycle Checkpoints, MAPK Signaling and PI3K-AKT-MTOR Signaling.
Resveratrol can manipulate biochemical pathways P53 Signaling. Pelargonidin has biological action on biochemical pathways MYC Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Colorectal Neuroendocrine Carcinoma due to abnormalities in genes APC and AMER1 – Foods like Feijoa are recommended compared to Grape. This is because the active ingredients Resveratrol and Pelargonidin in Grape further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Lycopene contained in Feijoa together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: FEIJOA IS RECOMMENDED OVER GRAPE FOR REDUCING THE GENETIC RISK OF COLORECTAL NEUROENDOCRINE CARCINOMA DUE TO GENES APC AND AMER1
Eat more nuts, Pine Nut or Peanut?
The active ingredients contained in Pine Nut are Vitamin E, Oleic Acid, Beta-sitosterol, Linolenic Acid, Linoleic Acid among others. While the active ingredients contained in Peanut are Vitamin E, Oleic Acid, Beta-sitosterol, Vitamin C, Linolenic Acid and others.
Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin K has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and MYC Signaling.
Lecithin can manipulate biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. Vanillic Acid has biological action on biochemical pathways MAPK Signaling. And so on.
For genetic risk of Colorectal Neuroendocrine Carcinoma due to abnormalities in genes APC and AMER1 – Foods like Pine Nut are recommended compared to Peanut. This is because the active ingredients Lecithin and Vanillic Acid in Peanut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin K contained in Pine Nut together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: PINE NUT IS RECOMMENDED OVER PEANUT FOR REDUCING THE GENETIC RISK OF COLORECTAL NEUROENDOCRINE CARCINOMA DUE TO GENES APC AND AMER1
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Colorectal Neuroendocrine Carcinoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
- Pan Origimed 2020
- Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients.
- β-Sitosterol targets Trx/Trx1 reductase to induce apoptosis in A549 cells via ROS mediated mitochondrial dysregulation and p53 activation.
- Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH.
- Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin.
- Pelargonidin suppresses adipogenesis in 3T3-L1 cells through inhibition of PPAR-γ signaling pathway.
- Fisetin targets YB-1/RSK axis independent of its effect on ERK signaling: insights from in vitro and in vivo melanoma models.
- Comparison of Myo-Monitor centric position to centric relation and centric occlusion.
- Identification of quercitrin as an inhibitor of the p90 S6 ribosomal kinase (RSK): structure of its complex with the N-terminal domain of RSK2 at 1.8 Å resolution.
- Linoleic acid enhances angiogenesis through suppression of angiostatin induced by plasminogen activator inhibitor 1.
- Small-molecule inhibitors of NADPH oxidase 4.
- The aberrant fusion proteins PML-RAR alpha and PLZF-RAR alpha contribute to the overexpression of cyclin A1 in acute promyelocytic leukemia.
- Sequential protooncogene expression in regenerating kidney following acute renal injury.
- Anti-IL-1 alpha autoantibodies in patients with rheumatic diseases and in healthy subjects.
- (+)-Catechin inhibits tumour angiogenesis and regulates the production of nitric oxide and TNF-alpha in LPS-stimulated macrophages.
- The recruitment of Raf-1 to membranes is mediated by direct interaction with phosphatidic acid and is independent of association with Ras.
- Lycopene differentially induces quiescence and apoptosis in androgen-responsive and -independent prostate cancer cell lines.
- Resveratrol, a remarkable inhibitor of ribonucleotide reductase.
- Research progress on the anticancer effects of vitamin K2.
- Vanillic acid exerts oestrogen-like activities in osteoblast-like UMR 106 cells through MAP kinase (MEK/ERK)-mediated ER signaling pathway.
- HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.