Which Foods are Recommended for Pleural Mesothelioma?

Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Pleural Mesothelioma when undergoing chemotherapy or when you determine you have a genetic risk for developing Pleural Mesothelioma because of NF2 and BAP1 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Pleural Mesothelioma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Apricot” or “Include fruit Partridgeberry in my diet” or “Should I reduce consumption of vegetable Cauliflower” or “Can I take Dim and Artemisinine supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO PLEURAL MESOTHELIOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Pleural Mesothelioma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR PLEURAL MESOTHELIOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.

About Pleural Mesothelioma

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Pleural Mesothelioma from cBioPortal. The patients enrolled in the studies for Pleural Mesothelioma are in ages between 28 to 82 with an average age of 64. 78.1% of males and 21.9% of females were the distribution of gender in these clinical studies. From a patient sample size of 448; the top genes with mutations and other abnormalities for Pleural Mesothelioma include genes NF2, TP53, BAP1, LATS2 and TERT. The occurrence frequency distribution for these genes respectively is 5.0%, 3.6%, 3.6%, 2.9% and 2.9%. These tumor genetic details of Pleural Mesothelioma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Pleural Mesothelioma.

Pleural mesothelioma is a cancer of the lining of the lungs called the pleura. Construction workers, builders, miners and others who work around asbestos are at risk for pleural mesothelioma. Malignant pleural mesothelioma is 80-90% of all mesothelioma diagnosis. Symptoms of pleural mesothelioma include chest pain, dry cough, fatigue, and shortness of breath. A patient’s prognosis may vary based on the individual case, but the average life expectancy for patients diagnosed with pleural mesothelioma is about 18 month, and a 5-year survival rate is only 12%. Treatment options for pleural mesothelioma include a multimodal approach with surgery, chemotherapy, and radiation. Promising treatments such as immunotherapy, gene therapy and photodynamic therapy in clinical development have shown early success in extending life expectancy of patients with pleural mesothelioma in clinical trials. Additionally, the right nutrition (foods and natural supplements) as part of supportive care can help enhance the patients’ well-being. (Ref: https://www.mesothelioma.com/mesothelioma/types/pleural/ ; https://my.clevelandclinic.org/health/diseases/15044-pleural-mesothelioma ; Brims F, Cancers (Basel), 2021)

Significance of Nutrition for Pleural Mesothelioma

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Pleural Mesothelioma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Apricot includes active ingredients Quercetin, Beta-sitosterol, Modified Citrus Pectin, Vitamin C, Linolenic Acid and others. And Partridgeberry contains active ingredients Beta-sitosterol, Resveratrol, Stigmasterol and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Pleural Mesothelioma, activation or inhibition of selected biochemical pathways like Growth Factor Signaling, MAPK Signaling, PI3K-AKT-MTOR Signaling, Hippo Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Pleural Mesothelioma, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR PLEURAL MESOTHELIOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Pleural Mesothelioma undergoing chemotherapy treatment

In Pleural Mesothelioma – the genes NF2, TP53, BAP1, LATS2 and TERT have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Pleural Mesothelioma are Growth Factor Signaling, MAPK Signaling, Amino Acid Metabolism and others. Pemetrexed is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Growth Factor Signaling, MAPK Signaling, Amino Acid Metabolism so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Scarlet Bean or Adzuki Bean?

Pulses are an important part of many diets. The active ingredients contained in Scarlet Bean are Beta-sitosterol, Vitamin C, Linolenic Acid, Oleic Acid, Stigmasterol among others. While the active ingredients contained in Adzuki Bean are Isoliquiritigenin, Genistein, Glucaric Acid, Folic Acid and others.

Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Apoptosis. Vitamin C has biological action on biochemical pathways Adherens junction, Growth Factor Signaling and Cell Cycle.

Isoliquiritigenin can manipulate biochemical pathways Oxidative Stress. Genistein has biological action on biochemical pathways Oxidative Stress. And so on.

When treating Pleural Mesothelioma with chemotherapy Pemetrexed – Foods like Scarlet Bean are recommended compared to Adzuki Bean. This is because the active ingredients Isoliquiritigenin and Genistein in Adzuki Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Scarlet Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER ADZUKI BEAN FOR PLEURAL MESOTHELIOMA ON TREATMENT WITH CHEMOTHERAPY PEMETREXED FOR SOME CONDITIONS.

Eat more vegetables, Turnip or Cauliflower?

Vegetables are an important part of many diets. The active ingredients contained in Turnip are Vitamin C, Indole-3-carbinol, Sulforaphane, Vitamin A, Vitamin K among others. While the active ingredients contained in Cauliflower are Beta-sitosterol, Brassinin, Vitamin C, Indole-3-carbinol, Linolenic Acid and others.

Indole-3-carbinol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Apoptosis. Sulforaphane has biological action on biochemical pathways Microtubule Dynamics, Growth Factor Signaling and Cell Cycle.

Brassinin can manipulate biochemical pathways Oxidative Stress. Citric Acid has biological action on biochemical pathways Oxidative Stress. And so on.

When treating Pleural Mesothelioma with chemotherapy Pemetrexed – Foods like Turnip are recommended compared to Cauliflower. This is because the active ingredients Brassinin and Citric Acid in Cauliflower interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Indole-3-carbinol and Sulforaphane contained in Turnip support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: TURNIP IS RECOMMENDED OVER CAULIFLOWER FOR PLEURAL MESOTHELIOMA ON TREATMENT WITH CHEMOTHERAPY PEMETREXED FOR SOME CONDITIONS.

Eat more fruits, Partridgeberry or Apricot?

Fruits are an important part of many diets. The active ingredients contained in Partridgeberry are Beta-sitosterol, Resveratrol, Stigmasterol among others. While the active ingredients contained in Apricot are Quercetin, Beta-sitosterol, Modified Citrus Pectin, Vitamin C, Linolenic Acid and others.

Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Apoptosis. Resveratrol has biological action on biochemical pathways Inositol Phosphate Signaling, Microtubule Dynamics and JAK-STAT Signaling.

Rutin can manipulate biochemical pathways WNT Beta Catenin Signaling, Oxidative Stress and Microtubule Dynamics. Citric Acid has biological action on biochemical pathways Oxidative Stress. And so on.

When treating Pleural Mesothelioma with chemotherapy Pemetrexed – Foods like Partridgeberry are recommended compared to Apricot. This is because the active ingredients Rutin and Citric Acid in Apricot interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Resveratrol contained in Partridgeberry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: PARTRIDGEBERRY IS RECOMMENDED OVER APRICOT FOR PLEURAL MESOTHELIOMA ON TREATMENT WITH CHEMOTHERAPY PEMETREXED FOR SOME CONDITIONS.

Eat more nuts, Pecan Nut or Walnut?

Nuts are an important part of many diets. The active ingredients contained in Pecan Nut are Vitamin E, Linolenic Acid, Cianidanol, Oleic Acid, Delphinidin among others. While the active ingredients contained in Walnut are Ellagic Acid, D-limonene, Betulinic Acid, Quercetin, Beta-sitosterol and others.

Vitamin E can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Apoptosis. Cianidanol has biological action on biochemical pathways Microtubule Dynamics, Growth Factor Signaling and TWEAK Signaling.

Ellagic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition, TWEAK Signaling and MYC Signaling. D-limonene has biological action on biochemical pathways Oxidative Stress. And so on.

When treating Pleural Mesothelioma with chemotherapy Pemetrexed – Foods like Pecan Nut are recommended compared to Walnut. This is because the active ingredients Ellagic Acid and D-limonene in Walnut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin E and Cianidanol contained in Pecan Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER WALNUT FOR PLEURAL MESOTHELIOMA ON TREATMENT WITH CHEMOTHERAPY PEMETREXED FOR SOME CONDITIONS.

Foods for Genetic Risk of Pleural Mesothelioma

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. NF2 and BAP1 are two genes whose abnormalities are risk factors for Pleural Mesothelioma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Pleural Mesothelioma can be used as a guide for coming up with a recommended personalized nutrition plan. For Pleural Mesothelioma gene NF2 has causative impact on biological pathways like Hippo Signaling, Cytoskeletal Dynamics and Growth Factor Signaling. And BAP1 has a causative impact on biological pathways like DNA Repair. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like NF2 and BAP1 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes NF2 and BAP1 should be avoided.

Eat more pulses, Common Pea or Common Bean?

The active ingredients contained in Common Pea are Lupeol, Vitamin C, Daidzein, Beta-sitosterol, Oleic Acid among others. While the active ingredients contained in Common Bean are Apigenin, Esculin, Vitamin C, Oleic Acid, Linolenic Acid and others.

Vitamin C can manipulate biochemical pathways MYC Signaling, P53 Signaling and Cell Cycle Checkpoints. Beta-sitosterol has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, Oncogenic Cancer Epigenetics and MYC Signaling.

Pelargonidin can manipulate biochemical pathways MYC Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways P53 Signaling, MYC Signaling and Cell Cycle Checkpoints. And so on.

For genetic risk of Pleural Mesothelioma due to abnormalities in genes NF2 and BAP1 – Foods like Common Pea are recommended compared to Common Bean. This is because the active ingredients Pelargonidin and Folic Acid in Common Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Common Pea together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER COMMON BEAN FOR REDUCING THE GENETIC RISK OF PLEURAL MESOTHELIOMA DUE TO GENES NF2 AND BAP1

Eat more vegetables, Cassava or Celery?

The active ingredients contained in Cassava are Vitamin C, Beta-sitosterol, Oleic Acid, Linolenic Acid, Linoleic Acid among others. While the active ingredients contained in Celery are Apigenin, Vitamin C, Quercetin, Oleic Acid, Linolenic Acid and others.

Vitamin C can manipulate biochemical pathways MYC Signaling, P53 Signaling and Cell Cycle Checkpoints. Beta-sitosterol has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, Oncogenic Cancer Epigenetics and MYC Signaling.

Cynaroside can manipulate biochemical pathways Oncogenic Cancer Epigenetics. Chrysin has biological action on biochemical pathways MYC Signaling. And so on.

For genetic risk of Pleural Mesothelioma due to abnormalities in genes NF2 and BAP1 – Foods like Cassava are recommended compared to Celery. This is because the active ingredients Cynaroside and Chrysin in Celery further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Cassava together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: CASSAVA IS RECOMMENDED OVER CELERY FOR REDUCING THE GENETIC RISK OF PLEURAL MESOTHELIOMA DUE TO GENES NF2 AND BAP1

Eat more fruits, Feijoa or Cranberry?

The active ingredients contained in Feijoa are Vitamin C, Lycopene, Casuarinin, Folic Acid among others. While the active ingredients contained in Cranberry are Resveratrol, Vitamin C, Quercetin, Caffeic Acid, P-coumaric Acid and others.

Vitamin C can manipulate biochemical pathways MYC Signaling, P53 Signaling and Cell Cycle Checkpoints. Lycopene has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, Hypoxia and MYC Signaling.

Ellagic Acid can manipulate biochemical pathways MYC Signaling and Cell Cycle Checkpoints. Myricetin has biological action on biochemical pathways Oncogenic Cancer Epigenetics and Oncogenic Histone Methylation. And so on.

For genetic risk of Pleural Mesothelioma due to abnormalities in genes NF2 and BAP1 – Foods like Feijoa are recommended compared to Cranberry. This is because the active ingredients Ellagic Acid and Myricetin in Cranberry further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Lycopene contained in Feijoa together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: FEIJOA IS RECOMMENDED OVER CRANBERRY FOR REDUCING THE GENETIC RISK OF PLEURAL MESOTHELIOMA DUE TO GENES NF2 AND BAP1

Eat more nuts, Hazelnut or Acorn?

The active ingredients contained in Hazelnut are Quercetin, Vitamin E, Oleic Acid, Linolenic Acid, Linoleic Acid among others. While the active ingredients contained in Acorn are Vitamin C, Quercetin, Beta-sitosterol, Beta-carotene, Quercitrin and others.

Quercetin can manipulate biochemical pathways MYC Signaling, P53 Signaling and Cell Cycle Checkpoints. Vitamin E has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, Hypoxia and MYC Signaling.

Vitamin B3 can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Vitamin B2 has biological action on biochemical pathways Oncogenic Cancer Epigenetics. And so on.

For genetic risk of Pleural Mesothelioma due to abnormalities in genes NF2 and BAP1 – Foods like Hazelnut are recommended compared to Acorn. This is because the active ingredients Vitamin B3 and Vitamin B2 in Acorn further promote the effects of genes on the biochemical pathways. While the active ingredients Quercetin and Vitamin E contained in Hazelnut together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: HAZELNUT IS RECOMMENDED OVER ACORN FOR REDUCING THE GENETIC RISK OF PLEURAL MESOTHELIOMA DUE TO GENES NF2 AND BAP1

In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Pleural Mesothelioma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

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