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What Foods are Recommended for Cancer?
is a very common question. Personalized Nutrition Plans are foods and supplements which are personalized to a cancer indication, genes, any treatments and lifestyle conditions.

Foods for Pleural Mesothelioma!

Jul 28, 2023

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Introduction

Foods for Pleural Mesothelioma should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.

Pleural mesothelioma is a cancer of the lining of the lungs called the pleura. Construction workers, builders, miners and others who work around asbestos are at risk for pleural mesothelioma. Malignant pleural mesothelioma is 80-90% of all mesothelioma diagnosis. Symptoms of pleural mesothelioma include chest pain, dry cough, fatigue, and shortness of breath. A patient’s prognosis may vary based on the individual case, but the average life expectancy for patients diagnosed with pleural mesothelioma is about 18 month, and a 5-year survival rate is only 12%. Treatment options for pleural mesothelioma include a multimodal approach with surgery, chemotherapy, and radiation. Promising treatments such as immunotherapy, gene therapy and photodynamic therapy in clinical development have shown early success in extending life expectancy of patients with pleural mesothelioma in clinical trials. Additionally, the right nutrition (foods and natural supplements) as part of supportive care can help enhance the patients’ well-being.



For Pleural Mesothelioma does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Pleural Mesothelioma does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Pleural Mesothelioma?

For example does it matter if vegetable Rocket Salad is consumed more compared to Yam? Does it make any difference if fruit Grapefruit is preferred over Grapefruit/pummelo Hybrid? Also if similar choices are made for nuts/seeds like Chia over Japanese Walnut and for pulses like Adzuki Bean over Catjang Pea. And if what I eat matters – then how does one identify foods which are recommended for Pleural Mesothelioma and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Pleural Mesothelioma!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All cancers like Pleural Mesothelioma can be characterized by a unique set of biochemical pathways - the signature pathways of Pleural Mesothelioma. Biochemical pathways like Growth Factor Signaling, MAPK Signaling, PI3K-AKT-MTOR Signaling, Hippo Signaling are part of the signature definition of Pleural Mesothelioma.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Grapefruit contains active ingredients Curcumin, Lupeol, Formononetin, Lycopene, Phloretin. And Grapefruit/pummelo Hybrid contains active ingredients Curcumin, Apigenin, Lupeol, Formononetin, Lycopene and possibly others.

A common mistake made when deciding and choosing foods to eat for Pleural Mesothelioma – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Pleural Mesothelioma.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Pleural Mesothelioma?

Personalized nutrition for cancers like Pleural Mesothelioma consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Pleural Mesothelioma biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

Characteristics of cancers like Pleural Mesothelioma

All cancers like Pleural Mesothelioma can be characterized by a unique set of biochemical pathways – the signature pathways of Pleural Mesothelioma. Biochemical pathways like Growth Factor Signaling, MAPK Signaling, PI3K-AKT-MTOR Signaling, Hippo Signaling are part of the signature definition of Pleural Mesothelioma. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Pleural Mesothelioma need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Pleural Mesothelioma when taking cancer treatment Pemetrexed, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

NF2, TP53, BAP1, LATS2 and TERT are the top ranked reported genes for Pleural Mesothelioma. NF2 is reported in 5.0 % of the representative patients across all clinical trials. And TP53 is reported in 3.6 %. The combined population patient data cover ages from 28 to 82. 78.1 % of the patient data are identified as men. The Pleural Mesothelioma biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Foods for Pleural Mesothelioma!

Food and Supplements for Pleural Mesothelioma

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable ROCKET SALAD or YAM?

Vegetable Rocket Salad contains many active ingredients or bioactives such as Curcumin, Apigenin, Quercetin, Lupeol, Formononetin. These active ingredients manipulate various biochemical pathways like Cell Cycle, Adherens junction, Epithelial to Mesenchymal Transition and TWEAK Signaling and others. Rocket Salad is recommended for Pleural Mesothelioma when ongoing cancer treatment is Pemetrexed. This is because Rocket Salad modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Pemetrexed.

Some of the active ingredients or bioactives in vegetable Yam are Curcumin, Apigenin, Lupeol, Formononetin, Phloretin. These active ingredients manipulate various biochemical pathways like Epithelial to Mesenchymal Transition, Heat Stress Response and Oxidative Stress and others. Yam is not recommended for Pleural Mesothelioma when ongoing cancer treatment is Pemetrexed because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE ROCKET SALAD IS RECOMMENDED OVER YAM FOR Pleural Mesothelioma AND TREATMENT Pemetrexed.

Choose Fruit GRAPEFRUIT/PUMMELO HYBRID or GRAPEFRUIT?

Fruit Grapefruit/pummelo Hybrid contains many active ingredients or bioactives such as Curcumin, Apigenin, Lupeol, Formononetin, Lycopene. These active ingredients manipulate various biochemical pathways like Cell Cycle, P53 Signaling, Microtubule Dynamics and TWEAK Signaling and others. Grapefruit/pummelo Hybrid is recommended for Pleural Mesothelioma when ongoing cancer treatment is Pemetrexed. This is because Grapefruit/pummelo Hybrid modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Pemetrexed.

Some of the active ingredients or bioactives in fruit Grapefruit are Curcumin, Lupeol, Formononetin, Lycopene, Phloretin. These active ingredients manipulate various biochemical pathways like WNT Beta Catenin Signaling, Heat Stress Response, Microtubule Dynamics and Oxidative Stress and others. Grapefruit is not recommended for Pleural Mesothelioma when ongoing cancer treatment is Pemetrexed because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT GRAPEFRUIT/PUMMELO HYBRID IS RECOMMENDED OVER GRAPEFRUIT FOR Pleural Mesothelioma AND TREATMENT Pemetrexed.

Choose Nut CHIA or JAPANESE WALNUT?

Chia contains many active ingredients or bioactives such as Curcumin, Apigenin, Lupeol, Formononetin, Lycopene. These active ingredients manipulate various biochemical pathways like Cell Cycle, P53 Signaling, Microtubule Dynamics and TWEAK Signaling and others. Chia is recommended for Pleural Mesothelioma when ongoing cancer treatment is Pemetrexed. This is because Chia modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Pemetrexed.

Some of the active ingredients or bioactives in Japanese Walnut are Curcumin, Apigenin, Ellagic Acid, Lupeol, Formononetin. These active ingredients manipulate various biochemical pathways like Epithelial to Mesenchymal Transition, WNT Beta Catenin Signaling and Heat Stress Response and others. Japanese Walnut is not recommended for Pleural Mesothelioma when ongoing cancer treatment is Pemetrexed because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

CHIA IS RECOMMENDED OVER JAPANESE WALNUT FOR Pleural Mesothelioma AND TREATMENT Pemetrexed.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Pleural Mesothelioma or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable GIANT BUTTERBUR or MEXICAN GROUNDCHERRY?

Vegetable Giant Butterbur contains many active ingredients or bioactives such as Apigenin, Curcumin, Formononetin, Myricetin, Kaempferol. These active ingredients manipulate various biochemical pathways like Stem Cell Signaling, P53 Signaling, Angiogenesis and MYC Signaling and others. Giant Butterbur is recommended for risk of Pleural Mesothelioma when associated genetic risk is BAP1. This is because Giant Butterbur increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Mexican Groundcherry are Apigenin, Curcumin, Formononetin, Myricetin, Kaempferol. These active ingredients manipulate various biochemical pathways like Stem Cell Signaling and Oncogenic Cancer Epigenetics and others. Mexican Groundcherry is not recommended when risk of Pleural Mesothelioma when associated genetic risk is BAP1 because it increases the signature pathways of it.

VEGETABLE GIANT BUTTERBUR IS RECOMMENDED OVER MEXICAN GROUNDCHERRY FOR BAP1 GENETIC RISK OF CANCER.

Choose Fruit NANCE or PUMMELO?

Fruit Nance contains many active ingredients or bioactives such as Apigenin, Curcumin, Formononetin, Myricetin, Kaempferol. These active ingredients manipulate various biochemical pathways like Stem Cell Signaling, P53 Signaling, Angiogenesis and MYC Signaling and others. Nance is recommended for risk of Pleural Mesothelioma when associated genetic risk is BAP1. This is because Nance increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Pummelo are Apigenin, Quercetin, Curcumin, Formononetin, Lupeol. These active ingredients manipulate various biochemical pathways like Stem Cell Signaling and Cell Cycle Checkpoints and others. Pummelo is not recommended when risk of Pleural Mesothelioma when associated genetic risk is BAP1 because it increases the signature pathways of it.

FRUIT NANCE IS RECOMMENDED OVER PUMMELO FOR BAP1 GENETIC RISK OF CANCER.

Choose Nut BUTTERNUT or EUROPEAN CHESTNUT?

Butternut contains many active ingredients or bioactives such as Apigenin, Curcumin, Formononetin, Myricetin, Kaempferol. These active ingredients manipulate various biochemical pathways like Stem Cell Signaling, P53 Signaling, MAPK Signaling and MYC Signaling and others. Butternut is recommended for risk of Pleural Mesothelioma when associated genetic risk is BAP1. This is because Butternut increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in European Chestnut are Apigenin, Quercetin, Curcumin, Ellagic Acid, Formononetin. These active ingredients manipulate various biochemical pathways like Stem Cell Signaling and Cell Cycle Checkpoints and others. European Chestnut is not recommended when risk of Pleural Mesothelioma when associated genetic risk is BAP1 because it increases the signature pathways of it.

BUTTERNUT IS RECOMMENDED OVER EUROPEAN CHESTNUT FOR BAP1 GENETIC RISK OF CANCER.


In Conclusion

Foods and Supplements chosen are important decisions for cancers like Pleural Mesothelioma. Pleural Mesothelioma patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Pleural Mesothelioma, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like Rocket Salad contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Pleural Mesothelioma?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.


Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.

References

Scientifically Reviewed by: Dr. Cogle

Christopher R. Cogle, M.D. is a tenured professor at the University of Florida, Chief Medical Officer of Florida Medicaid, and Director of the Florida Health Policy Leadership Academy at the Bob Graham Center for Public Service.

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