Which Foods are Recommended for Oligoastrocytoma?

Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Oligoastrocytoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Oligoastrocytoma because of ABL1 and ARID2 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Oligoastrocytoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Huckleberry” or “Include fruit Grape in my diet” or “Should I reduce consumption of vegetable Radish” or “Can I take Chapparal and Senna supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO OLIGOASTROCYTOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Oligoastrocytoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR OLIGOASTROCYTOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.

About Oligoastrocytoma

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Oligoastrocytoma from cBioPortal. 50.0% of males and 50.0% of females were the distribution of gender in these clinical studies. From a patient sample size of 4; the top genes with mutations and other abnormalities for Oligoastrocytoma include genes IDH1, ATRX, ABL1, ARID2 and ASXL1. The occurrence frequency distribution for these genes respectively is 100.0%, 50.0%, 25.0%, 25.0% and 25.0%. These tumor genetic details of Oligoastrocytoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Oligoastrocytoma.

Significance of Nutrition for Oligoastrocytoma

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Oligoastrocytoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Huckleberry includes active ingredients Resveratrol, Vitamin C, Chlorogenic Acid, Quercetin, Caffeic Acid and others. And Grape contains active ingredients Resveratrol, Vitamin E, Lupeol, Vitamin C, Chlorogenic Acid and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Oligoastrocytoma, activation or inhibition of selected biochemical pathways like Hypoxia, Notch Signaling, Oncogenic Cancer Epigenetics, Energy Metabolism plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Oligoastrocytoma, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR OLIGOASTROCYTOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Oligoastrocytoma undergoing chemotherapy treatment

In Oligoastrocytoma – the genes IDH1, ATRX, ABL1, ARID2 and ASXL1 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Oligoastrocytoma are Hypoxia, Notch Signaling, PI3K-AKT-MTOR Signaling and others. Procarbazine is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Hypoxia, Notch Signaling, PI3K-AKT-MTOR Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Mung Bean or Common Bean?

Pulses are an important part of many diets. The active ingredients contained in Mung Bean are Vitamin C, Quercetin, Glucaric Acid, Kaempferol, Linolenic Acid among others. While the active ingredients contained in Common Bean are Apigenin, Vitamin C, Esculin, Kaempferol, Gamma-linolenic Acid and others.

Vitamin C can manipulate biochemical pathways Hypoxia and PI3K-AKT-MTOR Signaling. Quercetin has biological action on biochemical pathways Hypoxia and PI3K-AKT-MTOR Signaling.

Pelargonidin can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways PI3K-AKT-MTOR Signaling. And so on.

When treating Oligoastrocytoma with chemotherapy Procarbazine – Foods like Mung Bean are recommended compared to Common Bean. This is because the active ingredients Pelargonidin and Folic Acid in Common Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Quercetin contained in Mung Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: MUNG BEAN IS RECOMMENDED OVER COMMON BEAN FOR OLIGOASTROCYTOMA ON TREATMENT WITH CHEMOTHERAPY PROCARBAZINE FOR SOME CONDITIONS.

Eat more vegetables, Cauliflower or Radish?

Vegetables are an important part of many diets. The active ingredients contained in Cauliflower are Vitamin C, Glucaric Acid, Beta-sitosterol, Linolenic Acid, Oleic Acid among others. While the active ingredients contained in Radish are Isorhamnetin, Vitamin C, Quercetin, Kaempferol, Beta-sitosterol and others.

Vitamin C can manipulate biochemical pathways Hypoxia and PI3K-AKT-MTOR Signaling. Glucaric Acid has biological action on biochemical pathways PI3K-AKT-MTOR Signaling.

Pelargonidin can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways PI3K-AKT-MTOR Signaling. And so on.

When treating Oligoastrocytoma with chemotherapy Procarbazine – Foods like Cauliflower are recommended compared to Radish. This is because the active ingredients Pelargonidin and Folic Acid in Radish interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Glucaric Acid contained in Cauliflower support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: CAULIFLOWER IS RECOMMENDED OVER RADISH FOR OLIGOASTROCYTOMA ON TREATMENT WITH CHEMOTHERAPY PROCARBAZINE FOR SOME CONDITIONS.

Eat more fruits, Grape or Huckleberry?

Fruits are an important part of many diets. The active ingredients contained in Grape are Resveratrol, Vitamin E, Lupeol, Vitamin C, Chlorogenic Acid among others. While the active ingredients contained in Huckleberry are Resveratrol, Vitamin C, Chlorogenic Acid, Quercetin, Caffeic Acid and others.

Resveratrol can manipulate biochemical pathways Hypoxia and PI3K-AKT-MTOR Signaling. Vitamin C has biological action on biochemical pathways Hypoxia and PI3K-AKT-MTOR Signaling.

Pelargonidin can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. And so on.

When treating Oligoastrocytoma with chemotherapy Procarbazine – Foods like Grape are recommended compared to Huckleberry. This is because the active ingredients Pelargonidin in Huckleberry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Resveratrol and Vitamin C contained in Grape support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: GRAPE IS RECOMMENDED OVER HUCKLEBERRY FOR OLIGOASTROCYTOMA ON TREATMENT WITH CHEMOTHERAPY PROCARBAZINE FOR SOME CONDITIONS.

Eat more nuts, Hazelnut or Brazil Nut?

Nuts are an important part of many diets. The active ingredients contained in Hazelnut are Vitamin E, Quercetin, Linolenic Acid, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Brazil Nut are Vitamin E, Linolenic Acid, Oleic Acid, Folic Acid, Lecithin and others.

Vitamin E can manipulate biochemical pathways Hypoxia, Notch Signaling and PI3K-AKT-MTOR Signaling. Quercetin has biological action on biochemical pathways Hypoxia and PI3K-AKT-MTOR Signaling.

Lecithin can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways PI3K-AKT-MTOR Signaling. And so on.

When treating Oligoastrocytoma with chemotherapy Procarbazine – Foods like Hazelnut are recommended compared to Brazil Nut. This is because the active ingredients Lecithin and Folic Acid in Brazil Nut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin E and Quercetin contained in Hazelnut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: HAZELNUT IS RECOMMENDED OVER BRAZIL NUT FOR OLIGOASTROCYTOMA ON TREATMENT WITH CHEMOTHERAPY PROCARBAZINE FOR SOME CONDITIONS.

Foods for Genetic Risk of Oligoastrocytoma

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. ABL1 and ARID2 are two genes whose abnormalities are risk factors for Oligoastrocytoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Oligoastrocytoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Oligoastrocytoma gene ABL1 has causative impact on biological pathways like Growth Factor Signaling, DNA Repair and Cell Cycle Checkpoints. And ARID2 has a causative impact on biological pathways like Chromatin Remodeling. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like ABL1 and ARID2 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes ABL1 and ARID2 should be avoided.

Eat more pulses, Winged Bean or Fava Bean?

The active ingredients contained in Winged Bean are Betulinic Acid, Vitamin C, Oleic Acid, Linolenic Acid, Linoleic Acid among others. While the active ingredients contained in Fava Bean are Quercetin, Daidzein, Beta-sitosterol, Vitamin C, Oleic Acid and others.

Betulinic Acid can manipulate biochemical pathways Cell Cycle Checkpoints, P53 Signaling and MYC Signaling. Vitamin C has biological action on biochemical pathways RAS-RAF Signaling, Oncogenic Cancer Epigenetics and PI3K-AKT-MTOR Signaling.

Ferulic Acid can manipulate biochemical pathways DNA Repair. Folic Acid has biological action on biochemical pathways Cell Cycle Checkpoints, RAS-RAF Signaling and P53 Signaling. And so on.

For genetic risk of Oligoastrocytoma due to abnormalities in genes ABL1 and ARID2 – Foods like Winged Bean are recommended compared to Fava Bean. This is because the active ingredients Ferulic Acid and Folic Acid in Fava Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Betulinic Acid and Vitamin C contained in Winged Bean together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: WINGED BEAN IS RECOMMENDED OVER FAVA BEAN FOR REDUCING THE GENETIC RISK OF OLIGOASTROCYTOMA DUE TO GENES ABL1 AND ARID2

Eat more vegetables, Cassava or Chicory?

The active ingredients contained in Cassava are Beta-sitosterol, Vitamin C, Oleic Acid, Linolenic Acid, Linoleic Acid among others. While the active ingredients contained in Chicory are Apigenin, Esculin, Lupeol, Quercetin, Betulinic Acid and others.

Vitamin C can manipulate biochemical pathways Cell Cycle Checkpoints, RAS-RAF Signaling and P53 Signaling. Beta-sitosterol has biological action on biochemical pathways MYC Signaling, Oncogenic Cancer Epigenetics and PI3K-AKT-MTOR Signaling.

Luteolin can manipulate biochemical pathways MYC Signaling. Gallic Acid has biological action on biochemical pathways DNA Repair. And so on.

For genetic risk of Oligoastrocytoma due to abnormalities in genes ABL1 and ARID2 – Foods like Cassava are recommended compared to Chicory. This is because the active ingredients Luteolin and Gallic Acid in Chicory further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Cassava together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: CASSAVA IS RECOMMENDED OVER CHICORY FOR REDUCING THE GENETIC RISK OF OLIGOASTROCYTOMA DUE TO GENES ABL1 AND ARID2

Eat more fruits, Star Fruit or Strawberry?

The active ingredients contained in Star Fruit are Epigallocatechin Gallate, Beta-sitosterol, Vitamin C, Oleic Acid, Linolenic Acid among others. While the active ingredients contained in Strawberry are Ellagic Acid, Lupeol, Beta-sitosterol, Vitamin C, Oleic Acid and others.

Vitamin C can manipulate biochemical pathways Cell Cycle Checkpoints, RAS-RAF Signaling and P53 Signaling. Epigallocatechin Gallate has biological action on biochemical pathways Oncogenic Cancer Epigenetics, PI3K-AKT-MTOR Signaling and Apoptosis.

Fisetin can manipulate biochemical pathways MYC Signaling. Ellagic Acid has biological action on biochemical pathways MYC Signaling. And so on.

For genetic risk of Oligoastrocytoma due to abnormalities in genes ABL1 and ARID2 – Foods like Star Fruit are recommended compared to Strawberry. This is because the active ingredients Fisetin and Ellagic Acid in Strawberry further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Epigallocatechin Gallate contained in Star Fruit together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: STAR FRUIT IS RECOMMENDED OVER STRAWBERRY FOR REDUCING THE GENETIC RISK OF OLIGOASTROCYTOMA DUE TO GENES ABL1 AND ARID2

Eat more nuts, Almond or Macadamia Nut?

The active ingredients contained in Almond are Quercetin, Beta-sitosterol, Vitamin E, Oleic Acid, Linolenic Acid among others. While the active ingredients contained in Macadamia Nut are Beta-sitosterol, Palmitic Acid, Lauric Acid, Myristic Acid, Folic Acid and others.

Beta-sitosterol can manipulate biochemical pathways Cell Cycle Checkpoints, P53 Signaling and MYC Signaling. Quercetin has biological action on biochemical pathways RAS-RAF Signaling, Oncogenic Cancer Epigenetics and PI3K-AKT-MTOR Signaling.

Palmitic Acid can manipulate biochemical pathways DNA Repair, Oncogenic Cancer Epigenetics and PI3K-AKT-MTOR Signaling. Lauric Acid has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. And so on.

For genetic risk of Oligoastrocytoma due to abnormalities in genes ABL1 and ARID2 – Foods like Almond are recommended compared to Macadamia Nut. This is because the active ingredients Palmitic Acid and Lauric Acid in Macadamia Nut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Quercetin contained in Almond together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: ALMOND IS RECOMMENDED OVER MACADAMIA NUT FOR REDUCING THE GENETIC RISK OF OLIGOASTROCYTOMA DUE TO GENES ABL1 AND ARID2

In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Oligoastrocytoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

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