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What Foods are Recommended for Cancer?
is a very common question. Personalized Nutrition Plans are foods and supplements which are personalized to a cancer indication, genes, any treatments and lifestyle conditions.

Which Foods are Recommended for Myeloproliferative Neoplasms?

Aug 12, 2022

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Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Myeloproliferative Neoplasms when undergoing chemotherapy or when you determine you have a genetic risk for developing Myeloproliferative Neoplasms because of JAK2 and CALR gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Myeloproliferative Neoplasms which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Malus (crab Apple)” or “Include fruit Pitanga in my diet” or “Should I reduce consumption of vegetable Lotus” or “Can I take Andrographis and Dim supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO MYELOPROLIFERATIVE NEOPLASMS, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Myeloproliferative Neoplasms is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR MYELOPROLIFERATIVE NEOPLASMS, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.



About Myeloproliferative Neoplasms

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Myeloproliferative Neoplasms from cBioPortal. From a patient sample size of 449; the top genes with mutations and other abnormalities for Myeloproliferative Neoplasms include genes JAK2, CALR, TET2, KMT2D and EP300. The occurrence frequency distribution for these genes respectively is 43.6%, 9.7%, 8.2%, 3.1% and 2.7%. These tumor genetic details of Myeloproliferative Neoplasms are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Myeloproliferative Neoplasms.

Significance of Nutrition for Myeloproliferative Neoplasms

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Myeloproliferative Neoplasms. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Malus (crab Apple) includes active ingredients Vitamin C, Linolenic Acid, Oleic Acid, Linoleic Acid, 7-4′-dihydroxyflavone and others. And Pitanga contains active ingredients Quercetin, Vitamin C, Vitamin A and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Myeloproliferative Neoplasms, activation or inhibition of selected biochemical pathways like Cell Cycle Checkpoints, Cell Cycle, JAK-STAT Signaling, Cytokine Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Myeloproliferative Neoplasms, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

For cancers like Myeloproliferative Neoplasms, activation or inhibition of selected biochemical pathways like Cell Cycle Checkpoints, Cell Cycle, JAK-STAT Signaling, Cytokine Signaling plays an important role in driving cancer growth.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR MYELOPROLIFERATIVE NEOPLASMS – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Myeloproliferative Neoplasms undergoing chemotherapy treatment

In Myeloproliferative Neoplasms – the genes JAK2, CALR, TET2, KMT2D and EP300 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Myeloproliferative Neoplasms are Cell Cycle Checkpoints, Cell Cycle, Growth Factor Signaling and others. Cyclophosphamide is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Cell Cycle Checkpoints, Cell Cycle, Growth Factor Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Mung Bean or Fava Bean?

Pulses are an important part of many diets. The active ingredients contained in Mung Bean are Quercetin, Kaempferol, Vitamin C, Linolenic Acid, Genistein among others. While the active ingredients contained in Fava Bean are Quercetin, Daidzein, Butein, Kaempferol, Vitamin C and others.

Quercetin can manipulate biochemical pathways Angiogenesis, MAPK Signaling and Cell Cycle Checkpoints. Kaempferol has biological action on biochemical pathways NFKB Signaling, JAK-STAT Signaling and Hypoxia.

Genistein can manipulate biochemical pathways Oxidative Stress and DNA Repair. P-coumaric Acid has biological action on biochemical pathways Oxidative Stress. And so on.

When treating Myeloproliferative Neoplasms with chemotherapy Cyclophosphamide – Foods like Mung Bean are recommended compared to Fava Bean. This is because the active ingredients Genistein and P-coumaric Acid in Fava Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Quercetin and Kaempferol contained in Mung Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: MUNG BEAN IS RECOMMENDED OVER FAVA BEAN FOR MYELOPROLIFERATIVE NEOPLASMS ON TREATMENT WITH CHEMOTHERAPY CYCLOPHOSPHAMIDE FOR SOME CONDITIONS.

Eat more vegetables, Arugula or Lotus?

Vegetables are an important part of many diets. The active ingredients contained in Arugula are Kaempferol, Esculin, Vitamin A, Vitamin K, Erysolin among others. While the active ingredients contained in Lotus are Quercetin, Kaempferol, Vitamin C, Beta-sitosterol, Fisetin and others.

Kaempferol can manipulate biochemical pathways MAPK Signaling, Angiogenesis and Cell Cycle Checkpoints. Vitamin A has biological action on biochemical pathways NFKB Signaling, Amino Acid Metabolism and MYC Signaling.

Citric Acid can manipulate biochemical pathways Oxidative Stress. Fisetin has biological action on biochemical pathways MYC Signaling, Epithelial to Mesenchymal Transition and Oxidative Stress. And so on.

When treating Myeloproliferative Neoplasms with chemotherapy Cyclophosphamide – Foods like Arugula are recommended compared to Lotus. This is because the active ingredients Citric Acid and Fisetin in Lotus interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Kaempferol and Vitamin A contained in Arugula support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: ARUGULA IS RECOMMENDED OVER LOTUS FOR MYELOPROLIFERATIVE NEOPLASMS ON TREATMENT WITH CHEMOTHERAPY CYCLOPHOSPHAMIDE FOR SOME CONDITIONS.

Which Foods are Recommended for Myeloproliferative Neoplasms?

Eat more fruits, Pitanga or Malus (crab Apple)?

Fruits are an important part of many diets. The active ingredients contained in Pitanga are Quercetin, Vitamin C, Vitamin A among others. While the active ingredients contained in Malus (crab Apple) are Vitamin C, Linolenic Acid, Oleic Acid, Linoleic Acid, 7-4′-dihydroxyflavone and others.

Vitamin C can manipulate biochemical pathways MAPK Signaling, Angiogenesis and Cell Cycle Checkpoints. Quercetin has biological action on biochemical pathways NFKB Signaling, JAK-STAT Signaling and MYC Signaling.

Linolenic Acid can manipulate biochemical pathways Vitamin D Signaling and Oxidative Stress. Oleic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition. And so on.

When treating Myeloproliferative Neoplasms with chemotherapy Cyclophosphamide – Foods like Pitanga are recommended compared to Malus (crab Apple). This is because the active ingredients Linolenic Acid and Oleic Acid in Malus (crab Apple) interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Quercetin contained in Pitanga support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: PITANGA IS RECOMMENDED OVER MALUS (CRAB APPLE) FOR MYELOPROLIFERATIVE NEOPLASMS ON TREATMENT WITH CHEMOTHERAPY CYCLOPHOSPHAMIDE FOR SOME CONDITIONS.

Eat more nuts, Almond or Macadamia Nut?

Nuts are an important part of many diets. The active ingredients contained in Almond are Quercetin, Vitamin E, Beta-sitosterol, Linolenic Acid, Salicylic Acid among others. While the active ingredients contained in Macadamia Nut are Beta-sitosterol, Myristic Acid, Lauric Acid, Palmitic Acid, Folic Acid and others.

Beta-sitosterol can manipulate biochemical pathways Angiogenesis, Cell Cycle Checkpoints and NFKB Signaling. Quercetin has biological action on biochemical pathways MAPK Signaling, JAK-STAT Signaling and MYC Signaling.

Myristic Acid can manipulate biochemical pathways MAPK Signaling, Angiogenesis and Cell Cycle Checkpoints. Lauric Acid has biological action on biochemical pathways NFKB Signaling, MYC Signaling and PI3K-AKT-MTOR Signaling. And so on.

When treating Myeloproliferative Neoplasms with chemotherapy Cyclophosphamide – Foods like Almond are recommended compared to Macadamia Nut. This is because the active ingredients Myristic Acid and Lauric Acid in Macadamia Nut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Quercetin contained in Almond support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: ALMOND IS RECOMMENDED OVER MACADAMIA NUT FOR MYELOPROLIFERATIVE NEOPLASMS ON TREATMENT WITH CHEMOTHERAPY CYCLOPHOSPHAMIDE FOR SOME CONDITIONS.

Foods for Genetic Risk of Myeloproliferative Neoplasms

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. JAK2 and CALR are two genes whose abnormalities are risk factors for Myeloproliferative Neoplasms. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Myeloproliferative Neoplasms can be used as a guide for coming up with a recommended personalized nutrition plan. For Myeloproliferative Neoplasms gene JAK2 has causative impact on biological pathways like AGE-RAGE Signaling, Chemokine Signaling and Hematopoiesis. And CALR has a causative impact on biological pathways like Antigen Presentation and Post Translation Modification. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like JAK2 and CALR should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes JAK2 and CALR should be avoided.

Eat more pulses, Winged Bean or Adzuki Bean?

The active ingredients contained in Winged Bean are Betulinic Acid, Oleic Acid, Vitamin C, Linolenic Acid, Linoleic Acid among others. While the active ingredients contained in Adzuki Bean are Isoliquiritigenin, Glucaric Acid, Genistein, Folic Acid and others.

Betulinic Acid can manipulate biochemical pathways JAK-STAT Signaling, Cytokine Signaling and Oncogenic Cancer Epigenetics. Vitamin C has biological action on biochemical pathways PI3K-AKT-MTOR Signaling and Oncogenic Cancer Epigenetics.

Folic Acid can manipulate biochemical pathways JAK-STAT Signaling and PI3K-AKT-MTOR Signaling. And so on.

For genetic risk of Myeloproliferative Neoplasms due to abnormalities in genes JAK2 and CALR – Foods like Winged Bean are recommended compared to Adzuki Bean. This is because the active ingredients Folic Acid in Adzuki Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Betulinic Acid and Vitamin C contained in Winged Bean together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: WINGED BEAN IS RECOMMENDED OVER ADZUKI BEAN FOR REDUCING THE GENETIC RISK OF MYELOPROLIFERATIVE NEOPLASMS DUE TO GENES JAK2 AND CALR

Eat more vegetables, Cucumber or Carob?

The active ingredients contained in Cucumber are Cucurbitacin I, Cucurbitacin E, Salicylic Acid, Lupeol, Caffeic Acid among others. While the active ingredients contained in Carob are Myricetin, Quercetin, Phloroglucinol, Gallic Acid, Palmitic Acid and others.

Cucurbitacin I can manipulate biochemical pathways JAK-STAT Signaling, Cytokine Signaling and PI3K-AKT-MTOR Signaling. Cucurbitacin E has biological action on biochemical pathways JAK-STAT Signaling, Cytokine Signaling and PI3K-AKT-MTOR Signaling.

Palmitic Acid can manipulate biochemical pathways Oncogenic Cancer Epigenetics. Myricetin has biological action on biochemical pathways Oncogenic Cancer Epigenetics. And so on.

For genetic risk of Myeloproliferative Neoplasms due to abnormalities in genes JAK2 and CALR – Foods like Cucumber are recommended compared to Carob. This is because the active ingredients Palmitic Acid and Myricetin in Carob further promote the effects of genes on the biochemical pathways. While the active ingredients Cucurbitacin I and Cucurbitacin E contained in Cucumber together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: CUCUMBER IS RECOMMENDED OVER CAROB FOR REDUCING THE GENETIC RISK OF MYELOPROLIFERATIVE NEOPLASMS DUE TO GENES JAK2 AND CALR

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

Eat more fruits, Watermelon or Papaya?

The active ingredients contained in Watermelon are Cucurbitacin E, Oleic Acid, Vitamin C, Lycopene, Linolenic Acid among others. While the active ingredients contained in Papaya are Benzyl Isothiocyanate, Salicylic Acid, Beta-sitosterol, Oleic Acid, Vitamin C and others.

Lycopene can manipulate biochemical pathways JAK-STAT Signaling and PI3K-AKT-MTOR Signaling. Cucurbitacin E has biological action on biochemical pathways Cytokine Signaling, JAK-STAT Signaling and PI3K-AKT-MTOR Signaling.

Myrcene can manipulate biochemical pathways Extracellular Matrix Remodelling. Folic Acid has biological action on biochemical pathways JAK-STAT Signaling and PI3K-AKT-MTOR Signaling. And so on.

For genetic risk of Myeloproliferative Neoplasms due to abnormalities in genes JAK2 and CALR – Foods like Watermelon are recommended compared to Papaya. This is because the active ingredients Myrcene and Folic Acid in Papaya further promote the effects of genes on the biochemical pathways. While the active ingredients Lycopene and Cucurbitacin E contained in Watermelon together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: WATERMELON IS RECOMMENDED OVER PAPAYA FOR REDUCING THE GENETIC RISK OF MYELOPROLIFERATIVE NEOPLASMS DUE TO GENES JAK2 AND CALR

Eat more nuts, Pumpkin Seeds or Brazil Nut?

The active ingredients contained in Pumpkin Seeds are Cucurbitacin I, Stigmasterol, Salicylic Acid, Beta-sitosterol, Oleic Acid among others. While the active ingredients contained in Brazil Nut are Oleic Acid, Vitamin E, Linolenic Acid, Folic Acid, Lecithin and others.

Gamma-linolenic Acid can manipulate biochemical pathways Extracellular Matrix Remodelling and PI3K-AKT-MTOR Signaling. Cucurbitacin I has biological action on biochemical pathways JAK-STAT Signaling, Cytokine Signaling and PI3K-AKT-MTOR Signaling.

Lecithin can manipulate biochemical pathways JAK-STAT Signaling and PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways JAK-STAT Signaling and PI3K-AKT-MTOR Signaling. And so on.

For genetic risk of Myeloproliferative Neoplasms due to abnormalities in genes JAK2 and CALR – Foods like Pumpkin Seeds are recommended compared to Brazil Nut. This is because the active ingredients Lecithin and Folic Acid in Brazil Nut further promote the effects of genes on the biochemical pathways. While the active ingredients Gamma-linolenic Acid and Cucurbitacin I contained in Pumpkin Seeds together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: PUMPKIN SEEDS IS RECOMMENDED OVER BRAZIL NUT FOR REDUCING THE GENETIC RISK OF MYELOPROLIFERATIVE NEOPLASMS DUE TO GENES JAK2 AND CALR


In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Myeloproliferative Neoplasms by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

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References

Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.


Scientifically Reviewed by: Dr. Cogle

Christopher R. Cogle, M.D. is a tenured professor at the University of Florida, Chief Medical Officer of Florida Medicaid, and Director of the Florida Health Policy Leadership Academy at the Bob Graham Center for Public Service.

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