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What Foods are Recommended for Cancer?
is a very common question. Personalized Nutrition Plans are foods and supplements which are personalized to a cancer indication, genes, any treatments and lifestyle conditions.

Which Foods are Recommended for Hepatocellular Carcinoma?

Aug 12, 2022

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Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Hepatocellular Carcinoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Hepatocellular Carcinoma because of CTNNB1 and ALB gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Hepatocellular Carcinoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Date” or “Include fruit Partridgeberry in my diet” or “Should I reduce consumption of vegetable Cauliflower” or “Can I take Neem Extract and Dim supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO HEPATOCELLULAR CARCINOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Hepatocellular Carcinoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR HEPATOCELLULAR CARCINOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.



About Hepatocellular Carcinoma

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Hepatocellular Carcinoma from cBioPortal. The patients enrolled in the studies for Hepatocellular Carcinoma are in ages between 2 to 91 with an average age of 65. 81.2% of males and 18.8% of females were the distribution of gender in these clinical studies. From a patient sample size of 2305; the top genes with mutations and other abnormalities for Hepatocellular Carcinoma include genes TERT, CTNNB1, TP53, MUC16 and ALB. The occurrence frequency distribution for these genes respectively is 21.5%, 13.6%, 8.3%, 4.3% and 4.2%. These tumor genetic details of Hepatocellular Carcinoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Hepatocellular Carcinoma.

Significance of Nutrition for Hepatocellular Carcinoma

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Hepatocellular Carcinoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Date includes active ingredients Quercetin, Apigenin, Lupeol, Beta-sitosterol, Linolenic Acid and others. And Partridgeberry contains active ingredients Resveratrol, Beta-sitosterol, Stigmasterol and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Hepatocellular Carcinoma, activation or inhibition of selected biochemical pathways like MAPK Signaling, RAS-RAF Signaling, Epithelial to Mesenchymal Transition, Focal Adhesion plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Hepatocellular Carcinoma, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

For cancers like Hepatocellular Carcinoma, activation or inhibition of selected biochemical pathways like MAPK Signaling, RAS-RAF Signaling, Epithelial to Mesenchymal Transition, Focal Adhesion plays an important role in driving cancer growth.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR HEPATOCELLULAR CARCINOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Hepatocellular Carcinoma undergoing chemotherapy treatment

In Hepatocellular Carcinoma – the genes TERT, CTNNB1, TP53, MUC16 and ALB have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Hepatocellular Carcinoma are MAPK Signaling, RAS-RAF Signaling, Cell Cycle and others. Sorafenib is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers MAPK Signaling, RAS-RAF Signaling, Cell Cycle so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Common Pea or Pigeon Pea?

Pulses are an important part of many diets. The active ingredients contained in Common Pea are Genistein, Lupeol, Daidzein, Beta-sitosterol, Linolenic Acid among others. While the active ingredients contained in Pigeon Pea are Genistein, Linolenic Acid, Oleic Acid, Vitamin C, Vitamin A and others.

Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Glucocorticoid Signaling and Apoptosis. Vitamin C has biological action on biochemical pathways Growth Factor Signaling, Cell Cycle and MYC Signaling.

Genistein can manipulate biochemical pathways Oxidative Stress. Vitamin A has biological action on biochemical pathways Chemokine Signaling. And so on.

When treating Hepatocellular Carcinoma with chemotherapy Sorafenib – Foods like Common Pea are recommended compared to Pigeon Pea. This is because the active ingredients Genistein and Vitamin A in Pigeon Pea interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER PIGEON PEA FOR HEPATOCELLULAR CARCINOMA ON TREATMENT WITH CHEMOTHERAPY SORAFENIB FOR SOME CONDITIONS.

Eat more vegetables, Cassava or Cauliflower?

Vegetables are an important part of many diets. The active ingredients contained in Cassava are Beta-sitosterol, Linolenic Acid, Oleic Acid, Vitamin C, Vitamin A among others. While the active ingredients contained in Cauliflower are Sulforaphane, Beta-sitosterol, Indole-3-carbinol, Linolenic Acid, Brassinin and others.

Vitamin C can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Growth Factor Signaling and Cell Cycle. Beta-sitosterol has biological action on biochemical pathways Glucocorticoid Signaling, Apoptosis and Oxidative Stress.

Brassinin can manipulate biochemical pathways Oxidative Stress. Citric Acid has biological action on biochemical pathways Oxidative Stress. And so on.

When treating Hepatocellular Carcinoma with chemotherapy Sorafenib – Foods like Cassava are recommended compared to Cauliflower. This is because the active ingredients Brassinin and Citric Acid in Cauliflower interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Beta-sitosterol contained in Cassava support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: CASSAVA IS RECOMMENDED OVER CAULIFLOWER FOR HEPATOCELLULAR CARCINOMA ON TREATMENT WITH CHEMOTHERAPY SORAFENIB FOR SOME CONDITIONS.

Which Foods are Recommended for Hepatocellular Carcinoma?

Eat more fruits, Partridgeberry or Date?

Fruits are an important part of many diets. The active ingredients contained in Partridgeberry are Resveratrol, Beta-sitosterol, Stigmasterol among others. While the active ingredients contained in Date are Quercetin, Apigenin, Lupeol, Beta-sitosterol, Linolenic Acid and others.

Resveratrol can manipulate biochemical pathways Microtubule Dynamics, Chemokine Signaling and Hippo Signaling. Beta-sitosterol has biological action on biochemical pathways Epithelial to Mesenchymal Transition, Glucocorticoid Signaling and Apoptosis.

Quercetin can manipulate biochemical pathways Oxidative Stress. Apigenin has biological action on biochemical pathways Epithelial to Mesenchymal Transition, Heat Stress Response and PI3K-AKT-MTOR Signaling. And so on.

When treating Hepatocellular Carcinoma with chemotherapy Sorafenib – Foods like Partridgeberry are recommended compared to Date. This is because the active ingredients Quercetin and Apigenin in Date interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Resveratrol and Beta-sitosterol contained in Partridgeberry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: PARTRIDGEBERRY IS RECOMMENDED OVER DATE FOR HEPATOCELLULAR CARCINOMA ON TREATMENT WITH CHEMOTHERAPY SORAFENIB FOR SOME CONDITIONS.

Eat more nuts, Pecan Nut or Pumpkin Seeds?

Nuts are an important part of many diets. The active ingredients contained in Pecan Nut are Vitamin E, Linolenic Acid, Delphinidin, Cianidanol, Oleic Acid among others. While the active ingredients contained in Pumpkin Seeds are Beta-sitosterol, Linolenic Acid, Oleic Acid, Gamma-linolenic Acid, Stigmasterol and others.

Vitamin E can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Apoptosis and Chemokine Signaling. Delphinidin has biological action on biochemical pathways Growth Factor Signaling, MYC Signaling and MAPK Signaling.

Gamma-linolenic Acid can manipulate biochemical pathways Oxidative Stress. Lecithin has biological action on biochemical pathways Chemokine Signaling, JAK-STAT Signaling and MYC Signaling. And so on.

When treating Hepatocellular Carcinoma with chemotherapy Sorafenib – Foods like Pecan Nut are recommended compared to Pumpkin Seeds. This is because the active ingredients Gamma-linolenic Acid and Lecithin in Pumpkin Seeds interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin E and Delphinidin contained in Pecan Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER PUMPKIN SEEDS FOR HEPATOCELLULAR CARCINOMA ON TREATMENT WITH CHEMOTHERAPY SORAFENIB FOR SOME CONDITIONS.

Foods for Genetic Risk of Hepatocellular Carcinoma

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. CTNNB1 and ALB are two genes whose abnormalities are risk factors for Hepatocellular Carcinoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Hepatocellular Carcinoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Hepatocellular Carcinoma gene CTNNB1 has causative impact on biological pathways like Adherens junction, Androgen Signaling and Cytoskeletal Dynamics. And ALB has a causative impact on biological pathways like . Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like CTNNB1 and ALB should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes CTNNB1 and ALB should be avoided.

Eat more pulses, Scarlet Bean or Fava Bean?

The active ingredients contained in Scarlet Bean are Beta-sitosterol, Linolenic Acid, Vitamin C, Oleic Acid, Stigmasterol among others. While the active ingredients contained in Fava Bean are Beta-sitosterol, Daidzein, Quercetin, Ferulic Acid, Linolenic Acid and others.

Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Apoptosis and Adherens junction. Vitamin C has biological action on biochemical pathways WNT Beta Catenin Signaling, MYC Signaling and P53 Signaling.

Oleic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition. Linoleic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition. And so on.

For genetic risk of Hepatocellular Carcinoma due to abnormalities in genes CTNNB1 and ALB – Foods like Scarlet Bean are recommended compared to Fava Bean. This is because the active ingredients Oleic Acid and Linoleic Acid in Fava Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin C contained in Scarlet Bean together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER FAVA BEAN FOR REDUCING THE GENETIC RISK OF HEPATOCELLULAR CARCINOMA DUE TO GENES CTNNB1 AND ALB

Eat more vegetables, Arugula or Carrot?

The active ingredients contained in Arugula are Esculin, Vitamin A, Kaempferol, Vitamin K, Erysolin among others. While the active ingredients contained in Carrot are Lupeol, Beta-sitosterol, Lycopene, Eugenol, D-limonene and others.

Kaempferol can manipulate biochemical pathways WNT Beta Catenin Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling. Vitamin K has biological action on biochemical pathways MYC Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.

Osthole can manipulate biochemical pathways WNT Beta Catenin Signaling and Adherens junction. Luteolin has biological action on biochemical pathways MYC Signaling and WNT Beta Catenin Signaling. And so on.

For genetic risk of Hepatocellular Carcinoma due to abnormalities in genes CTNNB1 and ALB – Foods like Arugula are recommended compared to Carrot. This is because the active ingredients Osthole and Luteolin in Carrot further promote the effects of genes on the biochemical pathways. While the active ingredients Kaempferol and Vitamin K contained in Arugula together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: ARUGULA IS RECOMMENDED OVER CARROT FOR REDUCING THE GENETIC RISK OF HEPATOCELLULAR CARCINOMA DUE TO GENES CTNNB1 AND ALB

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

Eat more fruits, Feijoa or Pummelo?

The active ingredients contained in Feijoa are Lycopene, Vitamin C, Casuarinin, Folic Acid among others. While the active ingredients contained in Pummelo are Naringin, Beta-sitosterol, Naringenin, Linolenic Acid, Vitamin C and others.

Vitamin C can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Apoptosis and Adherens junction. Lycopene has biological action on biochemical pathways WNT Beta Catenin Signaling, MYC Signaling and P53 Signaling.

Naringetol can manipulate biochemical pathways WNT Beta Catenin Signaling. Hesperetin has biological action on biochemical pathways WNT Beta Catenin Signaling. And so on.

For genetic risk of Hepatocellular Carcinoma due to abnormalities in genes CTNNB1 and ALB – Foods like Feijoa are recommended compared to Pummelo. This is because the active ingredients Naringetol and Hesperetin in Pummelo further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Lycopene contained in Feijoa together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: FEIJOA IS RECOMMENDED OVER PUMMELO FOR REDUCING THE GENETIC RISK OF HEPATOCELLULAR CARCINOMA DUE TO GENES CTNNB1 AND ALB

Eat more nuts, Brazil Nut or Chestnut?

The active ingredients contained in Brazil Nut are Vitamin E, Linolenic Acid, Oleic Acid, Lecithin, Folic Acid among others. While the active ingredients contained in Chestnut are Quercetin, Linolenic Acid, Vitamin C, Oleic Acid, Ellagic Acid and others.

Vitamin E can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Apoptosis and MYC Signaling. Linolenic Acid has biological action on biochemical pathways Adherens junction, WNT Beta Catenin Signaling and P53 Signaling.

Ellagic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition, WNT Beta Catenin Signaling and MYC Signaling. Oleic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition. And so on.

For genetic risk of Hepatocellular Carcinoma due to abnormalities in genes CTNNB1 and ALB – Foods like Brazil Nut are recommended compared to Chestnut. This is because the active ingredients Ellagic Acid and Oleic Acid in Chestnut further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin E and Linolenic Acid contained in Brazil Nut together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: BRAZIL NUT IS RECOMMENDED OVER CHESTNUT FOR REDUCING THE GENETIC RISK OF HEPATOCELLULAR CARCINOMA DUE TO GENES CTNNB1 AND ALB


In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Hepatocellular Carcinoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

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References

Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.


Scientifically Reviewed by: Dr. Cogle

Christopher R. Cogle, M.D. is a tenured professor at the University of Florida, Chief Medical Officer of Florida Medicaid, and Director of the Florida Health Policy Leadership Academy at the Bob Graham Center for Public Service.

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