Foods for Endometrial Carcinoma!

Introduction

Foods for Endometrial Carcinoma should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.

Endometrial carcinoma, also known as endometrial cancer, is a type of cancer that affects the lining of the uterus. Accurate medical coding using the appropriate ICD-10 code is important for documentation. Staging of endometrial carcinoma determines the extent and spread of the cancer, guiding treatment decisions. Pathology outlines provide valuable information about the characteristics of endometrial carcinoma cells. Radiology assists in the diagnosis and evaluation of endometrial carcinoma, playing a crucial role in treatment planning. Recognizing the risk factors associated with endometrial carcinoma is important, as factors such as obesity, hormonal imbalances, and genetic mutations can increase the risk. Early diagnosis and management of endometrial carcinoma are vital for improved prognosis. Understanding the different types and subtypes of endometrial carcinoma aids in appropriate diagnosis and treatment strategies. Chemotherapy is one of the treatment options for endometrial carcinoma, often used in conjunction with surgery and/or radiation therapy. By adhering to treatment guidelines and seeking appropriate medical care, individuals with endometrial carcinoma can optimize their chances of successful outcomes and long-term survival.

For Endometrial Carcinoma does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Endometrial Carcinoma does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Endometrial Carcinoma?

For example does it matter if vegetable Globe Artichoke is consumed more compared to Arrowroot? Does it make any difference if fruit Sea-buckthornberry is preferred over Black Mulberry? Also if similar choices are made for nuts/seeds like Butternut over Chestnut and for pulses like Gram Bean over Mung Bean. And if what I eat matters – then how does one identify foods which are recommended for Endometrial Carcinoma and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Endometrial Carcinoma!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Sea-buckthornberry contains active ingredients Apigenin, Curcumin, Formononetin, Isoliquiritigenin, Lycopene. And Black Mulberry contains active ingredients Quercetin, Apigenin, Curcumin, Formononetin, Isoliquiritigenin and possibly others.

A common mistake made when deciding and choosing foods to eat for Endometrial Carcinoma – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Endometrial Carcinoma.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Endometrial Carcinoma?

Personalized nutrition for cancers like Endometrial Carcinoma consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Endometrial Carcinoma biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Characteristics of cancers like Endometrial Carcinoma

All cancers like Endometrial Carcinoma can be characterized by a unique set of biochemical pathways – the signature pathways of Endometrial Carcinoma. Biochemical pathways like Cell Cycle, Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling, MAPK Signaling are part of the signature definition of Endometrial Carcinoma. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Endometrial Carcinoma need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Endometrial Carcinoma when taking cancer treatment Anastrozole, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

PTEN, PIK3CA, ARID1A, PIK3R1 and KRAS are the top ranked reported genes for Endometrial Carcinoma. PTEN is reported in 62.0 % of the representative patients across all clinical trials. And PIK3CA is reported in 38.8 %. The combined population patient data cover ages from 38 to 90. 0.0 % of the patient data are identified as men. The Endometrial Carcinoma biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Food and Supplements for Endometrial Carcinoma

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable GLOBE ARTICHOKE or ARROWROOT?

Vegetable Globe Artichoke contains many active ingredients or bioactives such as Apigenin, Curcumin, Formononetin, Isoliquiritigenin, Caffeic Acid. These active ingredients manipulate various biochemical pathways like NFKB Signaling, JAK-STAT Signaling, PI3K-AKT-MTOR Signaling and Cell Cycle and others. Globe Artichoke is recommended for Endometrial Carcinoma when ongoing cancer treatment is Anastrozole. This is because Globe Artichoke modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Anastrozole.

Some of the active ingredients or bioactives in vegetable Arrowroot are Quercetin, Apigenin, Curcumin, Formononetin, Isoliquiritigenin. These active ingredients manipulate various biochemical pathways like Epithelial to Mesenchymal Transition, Cell Cycle, PI3K-AKT-MTOR Signaling and Cell Cycle Checkpoints and others. Arrowroot is not recommended for Endometrial Carcinoma when ongoing cancer treatment is Anastrozole because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE GLOBE ARTICHOKE IS RECOMMENDED OVER ARROWROOT FOR Endometrial Carcinoma AND TREATMENT Anastrozole.

Choose Fruit BLACK MULBERRY or SEA-BUCKTHORNBERRY?

Fruit Black Mulberry contains many active ingredients or bioactives such as Quercetin, Apigenin, Curcumin, Formononetin, Isoliquiritigenin. These active ingredients manipulate various biochemical pathways like Metastasis, NFKB Signaling, Epithelial to Mesenchymal Transition and Growth Factor Signaling and others. Black Mulberry is recommended for Endometrial Carcinoma when ongoing cancer treatment is Anastrozole. This is because Black Mulberry modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Anastrozole.

Some of the active ingredients or bioactives in fruit Sea-buckthornberry are Apigenin, Curcumin, Formononetin, Isoliquiritigenin, Lycopene. These active ingredients manipulate various biochemical pathways like Epithelial to Mesenchymal Transition, Cell Cycle, PI3K-AKT-MTOR Signaling and Cell Cycle Checkpoints and others. Sea-buckthornberry is not recommended for Endometrial Carcinoma when ongoing cancer treatment is Anastrozole because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT BLACK MULBERRY IS RECOMMENDED OVER SEA-BUCKTHORNBERRY FOR Endometrial Carcinoma AND TREATMENT Anastrozole.

Choose Nut BUTTERNUT or CHESTNUT?

Butternut contains many active ingredients or bioactives such as Apigenin, Curcumin, Formononetin, Isoliquiritigenin, Lycopene. These active ingredients manipulate various biochemical pathways like Reproductive Hormone Signaling and others. Butternut is recommended for Endometrial Carcinoma when ongoing cancer treatment is Anastrozole. This is because Butternut modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Anastrozole.

Some of the active ingredients or bioactives in Chestnut are Apigenin, Ellagic Acid, Curcumin, Formononetin, Isoliquiritigenin. These active ingredients manipulate various biochemical pathways like WNT Beta Catenin Signaling, Cell Cycle and Cell Cycle Checkpoints and others. Chestnut is not recommended for Endometrial Carcinoma when ongoing cancer treatment is Anastrozole because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

BUTTERNUT IS RECOMMENDED OVER CHESTNUT FOR Endometrial Carcinoma AND TREATMENT Anastrozole.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Endometrial Carcinoma or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable CAULIFLOWER or TURNIP?

Vegetable Cauliflower contains many active ingredients or bioactives such as Curcumin, Catechol, Lupeol, Formononetin, Daidzein. These active ingredients manipulate various biochemical pathways like Inositol Phosphate Signaling, Angiogenesis, PI3K-AKT-MTOR Signaling and P53 Signaling and others. Cauliflower is recommended for risk of Endometrial Carcinoma when associated genetic risk is ARID1A. This is because Cauliflower increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Turnip are Quercetin, Ellagic Acid, Curcumin, Catechol, Lupeol. These active ingredients manipulate various biochemical pathways like Insulin Signaling and MAPK Signaling and others. Turnip is not recommended when risk of Endometrial Carcinoma when associated genetic risk is ARID1A because it increases the signature pathways of it.

VEGETABLE CAULIFLOWER IS RECOMMENDED OVER TURNIP FOR ARID1A GENETIC RISK OF CANCER.

Choose Fruit RED RASPBERRY or PUMMELO?

Fruit Red Raspberry contains many active ingredients or bioactives such as Quercetin, Ellagic Acid, Curcumin, Catechol, Lupeol. These active ingredients manipulate various biochemical pathways like PI3K-AKT-MTOR Signaling, Angiogenesis, Insulin Signaling and Inositol Phosphate Signaling and others. Red Raspberry is recommended for risk of Endometrial Carcinoma when associated genetic risk is ARID1A. This is because Red Raspberry increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Pummelo are Quercetin, Curcumin, Catechol, Apigenin, Lupeol. These active ingredients manipulate various biochemical pathways like Cell Cycle Checkpoints and Insulin Signaling and others. Pummelo is not recommended when risk of Endometrial Carcinoma when associated genetic risk is ARID1A because it increases the signature pathways of it.

FRUIT RED RASPBERRY IS RECOMMENDED OVER PUMMELO FOR ARID1A GENETIC RISK OF CANCER.

Choose Nut COMMON HAZELNUT or EUROPEAN CHESTNUT?

Common Hazelnut contains many active ingredients or bioactives such as Quercetin, Curcumin, Catechol, Myricetin, Lupeol. These active ingredients manipulate various biochemical pathways like PI3K-AKT-MTOR Signaling, Angiogenesis, Insulin Signaling and Inositol Phosphate Signaling and others. Common Hazelnut is recommended for risk of Endometrial Carcinoma when associated genetic risk is ARID1A. This is because Common Hazelnut increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in European Chestnut are Quercetin, Ellagic Acid, Curcumin, Catechol, Apigenin. These active ingredients manipulate various biochemical pathways like Insulin Signaling and others. European Chestnut is not recommended when risk of Endometrial Carcinoma when associated genetic risk is ARID1A because it increases the signature pathways of it.

COMMON HAZELNUT IS RECOMMENDED OVER EUROPEAN CHESTNUT FOR ARID1A GENETIC RISK OF CANCER.

In Conclusion

Foods and Supplements chosen are important decisions for cancers like Endometrial Carcinoma. Endometrial Carcinoma patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Endometrial Carcinoma, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like Globe Artichoke contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Endometrial Carcinoma?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.

References

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