Which Foods are Recommended for Endometrial Carcinoma?

Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Endometrial Carcinoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Endometrial Carcinoma because of PTEN and ARID1A gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Endometrial Carcinoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Roselle” or “Include fruit Rowanberry in my diet” or “Should I reduce consumption of vegetable Endive” or “Can I take Hops and Maqui supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO ENDOMETRIAL CARCINOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Endometrial Carcinoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR ENDOMETRIAL CARCINOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.

About Endometrial Carcinoma

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Endometrial Carcinoma from cBioPortal. The patients enrolled in the studies for Endometrial Carcinoma are in ages between 38 to 90 with an average age of 64.From a patient sample size of 139; the top genes with mutations and other abnormalities for Endometrial Carcinoma include genes PTEN, PIK3CA, ARID1A, PIK3R1 and KRAS. The occurrence frequency distribution for these genes respectively is 62.0%, 38.8%, 35.5%, 29.8% and 25.6%. These tumor genetic details of Endometrial Carcinoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Endometrial Carcinoma.

Significance of Nutrition for Endometrial Carcinoma

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Endometrial Carcinoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Roselle includes active ingredients Beta-sitosterol, Vitamin E, Vitamin C, Linolenic Acid, Oleic Acid and others. And Rowanberry contains active ingredients Quercetin, Chlorogenic Acid and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Endometrial Carcinoma, activation or inhibition of selected biochemical pathways like Cell Cycle, Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling, MAPK Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Endometrial Carcinoma, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR ENDOMETRIAL CARCINOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Endometrial Carcinoma undergoing chemotherapy treatment

In Endometrial Carcinoma – the genes PTEN, PIK3CA, ARID1A, PIK3R1 and KRAS have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Endometrial Carcinoma are Cell Cycle, Cell Cycle Checkpoints, Microtubule Dynamics and others. Anastrozole is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Cell Cycle, Cell Cycle Checkpoints, Microtubule Dynamics so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Adzuki Bean or Pigeon Pea?

Pulses are an important part of many diets. The active ingredients contained in Adzuki Bean are Isoliquiritigenin, Genistein, Glucaric Acid, Folic Acid among others. While the active ingredients contained in Pigeon Pea are Genistein, Vitamin C, Linolenic Acid, Oleic Acid, Vitamin A and others.

Glucaric Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Cell Cycle. Isoliquiritigenin has biological action on biochemical pathways DCC Attractive Signaling, Adherens junction and Microtubule Dynamics.

Genistein can manipulate biochemical pathways Cell Cycle Checkpoints and Cell Cycle. Vitamin C has biological action on biochemical pathways Cell Cycle Checkpoints and Cell Cycle. And so on.

When treating Endometrial Carcinoma with chemotherapy Anastrozole – Foods like Adzuki Bean are recommended compared to Pigeon Pea. This is because the active ingredients Genistein and Vitamin C in Pigeon Pea interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Glucaric Acid and Isoliquiritigenin contained in Adzuki Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: ADZUKI BEAN IS RECOMMENDED OVER PIGEON PEA FOR ENDOMETRIAL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY ANASTROZOLE FOR SOME CONDITIONS.

Eat more vegetables, Jicama or Endive?

Vegetables are an important part of many diets. The active ingredients contained in Jicama are Vitamin C, Beta-carotene, Vitamin A, Vitamin B3, Folic Acid among others. While the active ingredients contained in Endive are Quercetin, Kaempferol, Vitamin C, Linolenic Acid, Oleic Acid and others.

Beta-carotene can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Adherens junction. Vitamin A has biological action on biochemical pathways TGFB Signaling, Cell Cycle and MYC Signaling.

Vitamin C can manipulate biochemical pathways Cell Cycle Checkpoints and Cell Cycle. Vitamin K has biological action on biochemical pathways Cell Cycle Checkpoints and Cell Cycle. And so on.

When treating Endometrial Carcinoma with chemotherapy Anastrozole – Foods like Jicama are recommended compared to Endive. This is because the active ingredients Vitamin C and Vitamin K in Endive interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-carotene and Vitamin A contained in Jicama support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: JICAMA IS RECOMMENDED OVER ENDIVE FOR ENDOMETRIAL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY ANASTROZOLE FOR SOME CONDITIONS.

Eat more fruits, Rowanberry or Roselle?

Fruits are an important part of many diets. The active ingredients contained in Rowanberry are Quercetin, Chlorogenic Acid among others. While the active ingredients contained in Roselle are Beta-sitosterol, Vitamin E, Vitamin C, Linolenic Acid, Oleic Acid and others.

Chlorogenic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Microtubule Dynamics. Quercetin has biological action on biochemical pathways DCC Attractive Signaling, Adherens junction and Reproductive Hormone Signaling.

Beta-sitosterol can manipulate biochemical pathways Cell Cycle Checkpoints and Cell Cycle. Vitamin E has biological action on biochemical pathways Cell Cycle Checkpoints and Cell Cycle. And so on.

When treating Endometrial Carcinoma with chemotherapy Anastrozole – Foods like Rowanberry are recommended compared to Roselle. This is because the active ingredients Beta-sitosterol and Vitamin E in Roselle interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Chlorogenic Acid and Quercetin contained in Rowanberry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: ROWANBERRY IS RECOMMENDED OVER ROSELLE FOR ENDOMETRIAL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY ANASTROZOLE FOR SOME CONDITIONS.

Eat more nuts, Pecan Nut or Peanut?

Nuts are an important part of many diets. The active ingredients contained in Pecan Nut are Vitamin E, Delphinidin, Linolenic Acid, Oleic Acid, Cianidanol among others. While the active ingredients contained in Peanut are Quercetin, Beta-sitosterol, Vitamin E, Vitamin C, Linolenic Acid and others.

Delphinidin can manipulate biochemical pathways NFKB Signaling, Growth Factor Signaling and MYC Signaling. Cianidanol has biological action on biochemical pathways Microtubule Dynamics, Cell Cycle Checkpoints and RUNX Signaling.

Beta-sitosterol can manipulate biochemical pathways Cell Cycle Checkpoints and Cell Cycle. Lecithin has biological action on biochemical pathways NFKB Signaling, JAK-STAT Signaling and MYC Signaling. And so on.

When treating Endometrial Carcinoma with chemotherapy Anastrozole – Foods like Pecan Nut are recommended compared to Peanut. This is because the active ingredients Beta-sitosterol and Lecithin in Peanut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Delphinidin and Cianidanol contained in Pecan Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER PEANUT FOR ENDOMETRIAL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY ANASTROZOLE FOR SOME CONDITIONS.

Foods for Genetic Risk of Endometrial Carcinoma

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. PTEN and ARID1A are two genes whose abnormalities are risk factors for Endometrial Carcinoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Endometrial Carcinoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Endometrial Carcinoma gene PTEN has causative impact on biological pathways like Autophagy and Focal Adhesion. And ARID1A has a causative impact on biological pathways like Androgen Signaling and Chromatin Remodeling. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like PTEN and ARID1A should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes PTEN and ARID1A should be avoided.

Eat more pulses, Scarlet Bean or Fava Bean?

The active ingredients contained in Scarlet Bean are Beta-sitosterol, Oleic Acid, Vitamin C, Linolenic Acid, Stigmasterol among others. While the active ingredients contained in Fava Bean are Beta-sitosterol, Daidzein, Oleic Acid, Vitamin C, P-coumaric Acid and others.

Stigmasterol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Liquiritigenin has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, Inositol Phosphate Signaling and MYC Signaling.

Ferulic Acid can manipulate biochemical pathways DNA Repair. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. And so on.

For genetic risk of Endometrial Carcinoma due to abnormalities in genes PTEN and ARID1A – Foods like Scarlet Bean are recommended compared to Fava Bean. This is because the active ingredients Ferulic Acid and Folic Acid in Fava Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Stigmasterol and Liquiritigenin contained in Scarlet Bean together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER FAVA BEAN FOR REDUCING THE GENETIC RISK OF ENDOMETRIAL CARCINOMA DUE TO GENES PTEN AND ARID1A

Eat more vegetables, Turnip or Chicory?

The active ingredients contained in Turnip are Indole-3-carbinol, Vitamin C, Sulforaphane, Vitamin A, Vitamin K among others. While the active ingredients contained in Chicory are Apigenin, Esculin, Lupeol, Betulinic Acid, Vitamin C and others.

Indole-3-carbinol can manipulate biochemical pathways Inositol Phosphate Signaling, Apoptosis and DNA Repair. Sulforaphane has biological action on biochemical pathways MYC Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.

Gallic Acid can manipulate biochemical pathways DNA Repair. Luteolin has biological action on biochemical pathways MYC Signaling. And so on.

For genetic risk of Endometrial Carcinoma due to abnormalities in genes PTEN and ARID1A – Foods like Turnip are recommended compared to Chicory. This is because the active ingredients Gallic Acid and Luteolin in Chicory further promote the effects of genes on the biochemical pathways. While the active ingredients Indole-3-carbinol and Sulforaphane contained in Turnip together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: TURNIP IS RECOMMENDED OVER CHICORY FOR REDUCING THE GENETIC RISK OF ENDOMETRIAL CARCINOMA DUE TO GENES PTEN AND ARID1A

Eat more fruits, Feijoa or Cranberry?

The active ingredients contained in Feijoa are Lycopene, Vitamin C, Casuarinin, Folic Acid among others. While the active ingredients contained in Cranberry are Resveratrol, Hyperoside, Vitamin C, P-coumaric Acid, Ellagic Acid and others.

Lycopene can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Casuarinin has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Apoptosis.

Resveratrol can manipulate biochemical pathways P53 Signaling. Ellagic Acid has biological action on biochemical pathways MYC Signaling and Cell Cycle Checkpoints. And so on.

For genetic risk of Endometrial Carcinoma due to abnormalities in genes PTEN and ARID1A – Foods like Feijoa are recommended compared to Cranberry. This is because the active ingredients Resveratrol and Ellagic Acid in Cranberry further promote the effects of genes on the biochemical pathways. While the active ingredients Lycopene and Casuarinin contained in Feijoa together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: FEIJOA IS RECOMMENDED OVER CRANBERRY FOR REDUCING THE GENETIC RISK OF ENDOMETRIAL CARCINOMA DUE TO GENES PTEN AND ARID1A

Eat more nuts, Hazelnut or Chestnut?

The active ingredients contained in Hazelnut are Vitamin E, Oleic Acid, Linolenic Acid, Quercetin, Linoleic Acid among others. While the active ingredients contained in Chestnut are Oleic Acid, Vitamin C, Linolenic Acid, Ellagic Acid, Quercetin and others.

Quercetin can manipulate biochemical pathways Inositol Phosphate Signaling, Apoptosis and MYC Signaling. Vitamin A has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and MYC Signaling.

Ellagic Acid can manipulate biochemical pathways MYC Signaling and Cell Cycle Checkpoints. Gallic Acid has biological action on biochemical pathways DNA Repair. And so on.

For genetic risk of Endometrial Carcinoma due to abnormalities in genes PTEN and ARID1A – Foods like Hazelnut are recommended compared to Chestnut. This is because the active ingredients Ellagic Acid and Gallic Acid in Chestnut further promote the effects of genes on the biochemical pathways. While the active ingredients Quercetin and Vitamin A contained in Hazelnut together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: HAZELNUT IS RECOMMENDED OVER CHESTNUT FOR REDUCING THE GENETIC RISK OF ENDOMETRIAL CARCINOMA DUE TO GENES PTEN AND ARID1A

In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Endometrial Carcinoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

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