Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Chronic Myelomonocytic Leukemia when undergoing chemotherapy or when you determine you have a genetic risk for developing Chronic Myelomonocytic Leukemia because of RUNX1 and CUX1 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Chronic Myelomonocytic Leukemia which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Cranberry” or “Include fruit Watermelon in my diet” or “Should I reduce consumption of vegetable Chicory” or “Can I take Stevia and Stigmasterol supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO CHRONIC MYELOMONOCYTIC LEUKEMIA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Chronic Myelomonocytic Leukemia is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR CHRONIC MYELOMONOCYTIC LEUKEMIA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Chronic Myelomonocytic Leukemia
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Chronic Myelomonocytic Leukemia from cBioPortal. The patients enrolled in the studies for Chronic Myelomonocytic Leukemia are in ages between 48 to 88 with an average age of 80. 62.5% of males and 37.5% of females were the distribution of gender in these clinical studies. From a patient sample size of 85; the top genes with mutations and other abnormalities for Chronic Myelomonocytic Leukemia include genes RUNX1, CUX1, JAK2, KMT2D and EP300. The occurrence frequency distribution for these genes respectively is 11.9%, 9.5%, 8.3%, 8.3% and 6.0%. These tumor genetic details of Chronic Myelomonocytic Leukemia are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Chronic Myelomonocytic Leukemia.
Significance of Nutrition for Chronic Myelomonocytic Leukemia
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Chronic Myelomonocytic Leukemia. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Cranberry includes active ingredients Quercetin, Resveratrol, Hyperoside, P-coumaric Acid, Vitamin C and others. And Watermelon contains active ingredients Cucurbitacin E, Lycopene, Linolenic Acid, Vitamin C, Oleic Acid and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Chronic Myelomonocytic Leukemia, activation or inhibition of selected biochemical pathways like Cytokine Signaling, JAK-STAT Signaling, Oncogenic Cancer Epigenetics, RAS-RAF Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Chronic Myelomonocytic Leukemia, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR CHRONIC MYELOMONOCYTIC LEUKEMIA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Chronic Myelomonocytic Leukemia undergoing chemotherapy treatment
In Chronic Myelomonocytic Leukemia – the genes RUNX1, CUX1, JAK2, KMT2D and EP300 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Chronic Myelomonocytic Leukemia are Cytokine Signaling, JAK-STAT Signaling, Cell Cycle Checkpoints and others. Hydroxyurea is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Cytokine Signaling, JAK-STAT Signaling, Cell Cycle Checkpoints so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Scarlet Bean or Adzuki Bean?
Pulses are an important part of many diets. The active ingredients contained in Scarlet Bean are Stigmasterol, Linolenic Acid, Beta-sitosterol, Vitamin C, Oleic Acid among others. While the active ingredients contained in Adzuki Bean are Isoliquiritigenin, Glucaric Acid, Genistein, Folic Acid and others.
Stigmasterol can manipulate biochemical pathways Apoptosis, JAK-STAT Signaling and MYC Signaling. Beta-sitosterol has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and MYC Signaling.
Genistein can manipulate biochemical pathways DNA Repair. Folic Acid has biological action on biochemical pathways Apoptosis, JAK-STAT Signaling and MYC Signaling. And so on.
When treating Chronic Myelomonocytic Leukemia with chemotherapy Hydroxyurea – Foods like Scarlet Bean are recommended compared to Adzuki Bean. This is because the active ingredients Genistein and Folic Acid in Adzuki Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Stigmasterol and Beta-sitosterol contained in Scarlet Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER ADZUKI BEAN FOR CHRONIC MYELOMONOCYTIC LEUKEMIA ON TREATMENT WITH CHEMOTHERAPY HYDROXYUREA FOR SOME CONDITIONS.
Eat more vegetables, Bitter Melon or Chicory?
Vegetables are an important part of many diets. The active ingredients contained in Bitter Melon are Cucurbitacin E, Cucurbitacin I, Linolenic Acid, Beta-sitosterol, Ferulic Acid among others. While the active ingredients contained in Chicory are Apigenin, Esculin, Betulinic Acid, Quercetin, Lupeol and others.
Vitamin C can manipulate biochemical pathways MYC Signaling, P53 Signaling and Cell Cycle Checkpoints. Cucurbitacin E has biological action on biochemical pathways Apoptosis, JAK-STAT Signaling and Cytokine Signaling.
Apigenin can manipulate biochemical pathways DNA Repair. Luteolin has biological action on biochemical pathways MYC Signaling. And so on.
When treating Chronic Myelomonocytic Leukemia with chemotherapy Hydroxyurea – Foods like Bitter Melon are recommended compared to Chicory. This is because the active ingredients Apigenin and Luteolin in Chicory interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Cucurbitacin E contained in Bitter Melon support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: BITTER MELON IS RECOMMENDED OVER CHICORY FOR CHRONIC MYELOMONOCYTIC LEUKEMIA ON TREATMENT WITH CHEMOTHERAPY HYDROXYUREA FOR SOME CONDITIONS.
Eat more fruits, Watermelon or Cranberry?
Fruits are an important part of many diets. The active ingredients contained in Watermelon are Cucurbitacin E, Lycopene, Linolenic Acid, Vitamin C, Oleic Acid among others. While the active ingredients contained in Cranberry are Quercetin, Resveratrol, Hyperoside, P-coumaric Acid, Vitamin C and others.
Lycopene can manipulate biochemical pathways Apoptosis, JAK-STAT Signaling and MYC Signaling. Cucurbitacin E has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and Cytokine Signaling.
Resveratrol can manipulate biochemical pathways P53 Signaling and DNA Repair. Ellagic Acid has biological action on biochemical pathways MYC Signaling. And so on.
When treating Chronic Myelomonocytic Leukemia with chemotherapy Hydroxyurea – Foods like Watermelon are recommended compared to Cranberry. This is because the active ingredients Resveratrol and Ellagic Acid in Cranberry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Lycopene and Cucurbitacin E contained in Watermelon support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: WATERMELON IS RECOMMENDED OVER CRANBERRY FOR CHRONIC MYELOMONOCYTIC LEUKEMIA ON TREATMENT WITH CHEMOTHERAPY HYDROXYUREA FOR SOME CONDITIONS.
Eat more nuts, Almond or Chestnut?
Nuts are an important part of many diets. The active ingredients contained in Almond are Stigmasterol, Quercetin, Vitamin E, Linolenic Acid, Beta-sitosterol among others. While the active ingredients contained in Chestnut are Quercetin, Linolenic Acid, Vitamin C, Oleic Acid, Linoleic Acid and others.
Beta-sitosterol can manipulate biochemical pathways MYC Signaling, P53 Signaling and Cell Cycle Checkpoints. Stigmasterol has biological action on biochemical pathways Apoptosis, JAK-STAT Signaling and Cytokine Signaling.
Ellagic Acid can manipulate biochemical pathways MYC Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, JAK-STAT Signaling and P53 Signaling. And so on.
When treating Chronic Myelomonocytic Leukemia with chemotherapy Hydroxyurea – Foods like Almond are recommended compared to Chestnut. This is because the active ingredients Ellagic Acid and Folic Acid in Chestnut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Stigmasterol contained in Almond support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: ALMOND IS RECOMMENDED OVER CHESTNUT FOR CHRONIC MYELOMONOCYTIC LEUKEMIA ON TREATMENT WITH CHEMOTHERAPY HYDROXYUREA FOR SOME CONDITIONS.
Foods for Genetic Risk of Chronic Myelomonocytic Leukemia
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. RUNX1 and CUX1 are two genes whose abnormalities are risk factors for Chronic Myelomonocytic Leukemia. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Chronic Myelomonocytic Leukemia can be used as a guide for coming up with a recommended personalized nutrition plan. For Chronic Myelomonocytic Leukemia gene RUNX1 has causative impact on biological pathways like NFKB Signaling, RUNX Signaling and TGFB Signaling. And CUX1 has a causative impact on biological pathways like DNA Repair. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like RUNX1 and CUX1 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes RUNX1 and CUX1 should be avoided.
Eat more pulses, Mung Bean or Soy Bean?
The active ingredients contained in Mung Bean are Quercetin, Vitamin C, Linolenic Acid, Oleic Acid, Kaempferol among others. While the active ingredients contained in Soy Bean are Lupeol, Quercetin, Beta-sitosterol, Vitamin C, Daidzein and others.
Quercetin can manipulate biochemical pathways Adherens junction, WNT Beta Catenin Signaling and MYC Signaling. Vitamin C has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.
Aescin can manipulate biochemical pathways Cell Cycle Checkpoints. Lecithin has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Chronic Myelomonocytic Leukemia due to abnormalities in genes RUNX1 and CUX1 – Foods like Mung Bean are recommended compared to Soy Bean. This is because the active ingredients Aescin and Lecithin in Soy Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Quercetin and Vitamin C contained in Mung Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: MUNG BEAN IS RECOMMENDED OVER SOY BEAN FOR REDUCING THE GENETIC RISK OF CHRONIC MYELOMONOCYTIC LEUKEMIA DUE TO GENES RUNX1 AND CUX1
Eat more vegetables, Jicama or Radish?
The active ingredients contained in Jicama are Vitamin C, Beta-carotene, Vitamin B3, Vitamin A, Folic Acid among others. While the active ingredients contained in Radish are Quercetin, Beta-sitosterol, Vitamin C, Linolenic Acid, Oleic Acid and others.
Vitamin C can manipulate biochemical pathways Adherens junction, WNT Beta Catenin Signaling and MYC Signaling. Beta-carotene has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.
Pelargonidin can manipulate biochemical pathways MYC Signaling, WNT Beta Catenin Signaling and Cell Cycle Checkpoints. Folic Acid has biological action on biochemical pathways P53 Signaling, PI3K-AKT-MTOR Signaling and RAS-RAF Signaling. And so on.
For genetic risk of Chronic Myelomonocytic Leukemia due to abnormalities in genes RUNX1 and CUX1 – Foods like Jicama are recommended compared to Radish. This is because the active ingredients Pelargonidin and Folic Acid in Radish further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-carotene contained in Jicama together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: JICAMA IS RECOMMENDED OVER RADISH FOR REDUCING THE GENETIC RISK OF CHRONIC MYELOMONOCYTIC LEUKEMIA DUE TO GENES RUNX1 AND CUX1
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Kiwi or Raspberry?
The active ingredients contained in Kiwi are Quercetin, Vitamin C, Vitamin A, Chlorogenic Acid, Fisetin among others. While the active ingredients contained in Raspberry are Quercetin, Vitamin C, Ellagic Acid, Resveratrol, Salicylic Acid and others.
Vitamin C can manipulate biochemical pathways Adherens junction, WNT Beta Catenin Signaling and MYC Signaling. Quercetin has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.
Ellagic Acid can manipulate biochemical pathways MYC Signaling and WNT Beta Catenin Signaling. Resveratrol has biological action on biochemical pathways P53 Signaling. And so on.
For genetic risk of Chronic Myelomonocytic Leukemia due to abnormalities in genes RUNX1 and CUX1 – Foods like Kiwi are recommended compared to Raspberry. This is because the active ingredients Ellagic Acid and Resveratrol in Raspberry further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Quercetin contained in Kiwi together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: KIWI IS RECOMMENDED OVER RASPBERRY FOR REDUCING THE GENETIC RISK OF CHRONIC MYELOMONOCYTIC LEUKEMIA DUE TO GENES RUNX1 AND CUX1
Eat more nuts, Pine Nut or Peanut?
The active ingredients contained in Pine Nut are Beta-sitosterol, Vitamin E, Linolenic Acid, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Peanut are Quercetin, Beta-sitosterol, Vitamin C, Vitamin E, Linolenic Acid and others.
Beta-sitosterol can manipulate biochemical pathways Adherens junction, WNT Beta Catenin Signaling and MYC Signaling. Vitamin K has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and MYC Signaling.
Lecithin can manipulate biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and RAS-RAF Signaling. And so on.
For genetic risk of Chronic Myelomonocytic Leukemia due to abnormalities in genes RUNX1 and CUX1 – Foods like Pine Nut are recommended compared to Peanut. This is because the active ingredients Lecithin and Folic Acid in Peanut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin K contained in Pine Nut together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: PINE NUT IS RECOMMENDED OVER PEANUT FOR REDUCING THE GENETIC RISK OF CHRONIC MYELOMONOCYTIC LEUKEMIA DUE TO GENES RUNX1 AND CUX1
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Chronic Myelomonocytic Leukemia by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
- Aml Ohsu 2018
- Functional genomic landscape of acute myeloid leukaemia.
- Stigmasterol isolated from marine microalgae Navicula incerta induces apoptosis in human hepatoma HepG2 cells.
- β-Sitosterol and Gemcitabine Exhibit Synergistic Anti-pancreatic Cancer Activity by Modulating Apoptosis and Inhibiting Epithelial-Mesenchymal Transition by Deactivating Akt/GSK-3β Signaling.
- BRCA1 and BRCA2 as molecular targets for phytochemicals indole-3-carbinol and genistein in breast and prostate cancer cells.
- Effects of folate deficiency on gene expression in the apoptosis and cancer pathways in colon cancer cells.
- Lycopene metabolite, apo-10′-lycopenoic acid, inhibits diethylnitrosamine-initiated, high fat diet-promoted hepatic inflammation and tumorigenesis in mice.
- Cucurbitacin E Induces G(2)/M Phase Arrest through STAT3/p53/p21 Signaling and Provokes Apoptosis via Fas/CD95 and Mitochondria-Dependent Pathways in Human Bladder Cancer T24 Cells.
- Resveratrol, a remarkable inhibitor of ribonucleotide reductase.
- Identification of ellagic acid as potent inhibitor of protein kinase CK2: a successful example of a virtual screening application.
- Vitamin C enhances epigenetic modifications induced by 5-azacytidine and cell cycle arrest in the hepatocellular carcinoma cell lines HLE and Huh7.
- Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin.
- Protein kinase and HDAC inhibitors from the endophytic fungus Epicoccum nigrum.
- The recruitment of Raf-1 to membranes is mediated by direct interaction with phosphatidic acid and is independent of association with Ras.
- β-carotene Inhibits Expression of c-Myc and Cyclin E in Helicobacter pylori-infected Gastric Epithelial Cells.
- Pelargonidin suppresses adipogenesis in 3T3-L1 cells through inhibition of PPAR-γ signaling pathway.
- Research progress on the anticancer effects of vitamin K2.
- HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods.
- Promise of bitter melon (Momordica charantia) bioactives in cancer prevention and therapy.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.