Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Chromophobe Renal Cell Carcinoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Chromophobe Renal Cell Carcinoma because of BIRC6 and FAT4 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Chromophobe Renal Cell Carcinoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Apricot” or “Include fruit Partridgeberry in my diet” or “Should I reduce consumption of vegetable Okra” or “Can I take Thunder God and Dim supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO CHROMOPHOBE RENAL CELL CARCINOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Chromophobe Renal Cell Carcinoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR CHROMOPHOBE RENAL CELL CARCINOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Chromophobe Renal Cell Carcinoma
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Chromophobe Renal Cell Carcinoma from cBioPortal. The patients enrolled in the studies for Chromophobe Renal Cell Carcinoma are in ages between 17 to 86 with an average age of 50. 56.7% of males and 43.3% of females were the distribution of gender in these clinical studies. From a patient sample size of 208; the top genes with mutations and other abnormalities for Chromophobe Renal Cell Carcinoma include genes BIRC6, FAT4, LAMA1, TP53 and PIKFYVE. The occurrence frequency distribution for these genes respectively is 1.6%, 1.6%, 1.1%, 1.1% and 1.1%. These tumor genetic details of Chromophobe Renal Cell Carcinoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Chromophobe Renal Cell Carcinoma.
Significance of Nutrition for Chromophobe Renal Cell Carcinoma
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Chromophobe Renal Cell Carcinoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Apricot includes active ingredients Quercetin, Linolenic Acid, Beta-sitosterol, Vitamin C, Salicylic Acid and others. And Partridgeberry contains active ingredients Resveratrol, Beta-sitosterol, Stigmasterol and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Chromophobe Renal Cell Carcinoma, activation or inhibition of selected biochemical pathways like RAS-RAF Signaling, mRNA Splicing, PI3K-AKT-MTOR Signaling, Focal Adhesion plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Chromophobe Renal Cell Carcinoma, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR CHROMOPHOBE RENAL CELL CARCINOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Chromophobe Renal Cell Carcinoma undergoing chemotherapy treatment
In Chromophobe Renal Cell Carcinoma – the genes BIRC6, FAT4, LAMA1, TP53 and PIKFYVE have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Chromophobe Renal Cell Carcinoma are RAS-RAF Signaling, mRNA Splicing, Cell Cycle and others. Radiation is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers RAS-RAF Signaling, mRNA Splicing, Cell Cycle so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Common Pea or Common Bean?
Pulses are an important part of many diets. The active ingredients contained in Common Pea are Daidzein, Linolenic Acid, Lupeol, Beta-sitosterol, Kaempferol among others. While the active ingredients contained in Common Bean are Apigenin, Linolenic Acid, Kaempferol, Vitamin C, Oleic Acid and others.
Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Oxidative Stress. Vitamin C has biological action on biochemical pathways Cell Cycle, MYC Signaling and MAPK Signaling.
Vitamin A can manipulate biochemical pathways Extracellular Matrix Remodelling, Notch Signaling and Focal Adhesion. Apigenin has biological action on biochemical pathways Epithelial to Mesenchymal Transition, Stem Cell Signaling and DNA Repair. And so on.
When treating Chromophobe Renal Cell Carcinoma with chemotherapy Radiation – Foods like Common Pea are recommended compared to Common Bean. This is because the active ingredients Vitamin A and Apigenin in Common Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER COMMON BEAN FOR CHROMOPHOBE RENAL CELL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more vegetables, Cassava or Okra?
Vegetables are an important part of many diets. The active ingredients contained in Cassava are Linolenic Acid, Beta-sitosterol, Vitamin C, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Okra are Quercetin, Linolenic Acid, Beta-sitosterol, Vitamin C, Salicylic Acid and others.
Vitamin C can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Cell Cycle and MYC Signaling. Beta-sitosterol has biological action on biochemical pathways NFKB Signaling, Oxidative Stress and Microtubule Dynamics.
Vitamin A can manipulate biochemical pathways Extracellular Matrix Remodelling, Notch Signaling and Focal Adhesion. Quercetin has biological action on biochemical pathways Oxidative Stress. And so on.
When treating Chromophobe Renal Cell Carcinoma with chemotherapy Radiation – Foods like Cassava are recommended compared to Okra. This is because the active ingredients Vitamin A and Quercetin in Okra interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Beta-sitosterol contained in Cassava support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: CASSAVA IS RECOMMENDED OVER OKRA FOR CHROMOPHOBE RENAL CELL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more fruits, Partridgeberry or Apricot?
Fruits are an important part of many diets. The active ingredients contained in Partridgeberry are Resveratrol, Beta-sitosterol, Stigmasterol among others. While the active ingredients contained in Apricot are Quercetin, Linolenic Acid, Beta-sitosterol, Vitamin C, Salicylic Acid and others.
Resveratrol can manipulate biochemical pathways NFKB Signaling, Microtubule Dynamics and Cell Cycle. Beta-sitosterol has biological action on biochemical pathways Epithelial to Mesenchymal Transition, Oxidative Stress and MYC Signaling.
Rutin can manipulate biochemical pathways Oxidative Stress, Oncogenic Cancer Epigenetics and Focal Adhesion. Citric Acid has biological action on biochemical pathways Oxidative Stress. And so on.
When treating Chromophobe Renal Cell Carcinoma with chemotherapy Radiation – Foods like Partridgeberry are recommended compared to Apricot. This is because the active ingredients Rutin and Citric Acid in Apricot interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Resveratrol and Beta-sitosterol contained in Partridgeberry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PARTRIDGEBERRY IS RECOMMENDED OVER APRICOT FOR CHROMOPHOBE RENAL CELL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more nuts, Pine Nut or Pumpkin Seeds?
Nuts are an important part of many diets. The active ingredients contained in Pine Nut are Linolenic Acid, Beta-sitosterol, Vitamin E, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Pumpkin Seeds are Linolenic Acid, Beta-sitosterol, Salicylic Acid, Oleic Acid, Vitamin B3 and others.
Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Oxidative Stress. Vitamin K has biological action on biochemical pathways Cell Cycle, MYC Signaling and PI3K-AKT-MTOR Signaling.
Gamma-linolenic Acid can manipulate biochemical pathways Oxidative Stress. Lecithin has biological action on biochemical pathways NFKB Signaling, Cytoskeletal Dynamics and MYC Signaling. And so on.
When treating Chromophobe Renal Cell Carcinoma with chemotherapy Radiation – Foods like Pine Nut are recommended compared to Pumpkin Seeds. This is because the active ingredients Gamma-linolenic Acid and Lecithin in Pumpkin Seeds interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin K contained in Pine Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PINE NUT IS RECOMMENDED OVER PUMPKIN SEEDS FOR CHROMOPHOBE RENAL CELL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Foods for Genetic Risk of Chromophobe Renal Cell Carcinoma
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. BIRC6 and FAT4 are two genes whose abnormalities are risk factors for Chromophobe Renal Cell Carcinoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Chromophobe Renal Cell Carcinoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Chromophobe Renal Cell Carcinoma gene BIRC6 has causative impact on biological pathways like . And FAT4 has a causative impact on biological pathways like Cytoskeletal Dynamics and Adherens junction. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like BIRC6 and FAT4 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes BIRC6 and FAT4 should be avoided.
Eat more pulses, Hyacinth Bean or Pigeon Pea?
The active ingredients contained in Hyacinth Bean are Palmitic Acid, Vitamin C, Genistein, Folic Acid, Myristic Acid among others. While the active ingredients contained in Pigeon Pea are Linolenic Acid, Vitamin C, Oleic Acid, Linoleic Acid, Genistein and others.
Palmitic Acid can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin C has biological action on biochemical pathways Cell Cycle Checkpoints, MYC Signaling and P53 Signaling.
Linoleic Acid can manipulate biochemical pathways Extracellular Matrix Remodelling. Folic Acid has biological action on biochemical pathways MYC Signaling, P53 Signaling and Cell Cycle Checkpoints. And so on.
For genetic risk of Chromophobe Renal Cell Carcinoma due to abnormalities in genes BIRC6 and FAT4 – Foods like Hyacinth Bean are recommended compared to Pigeon Pea. This is because the active ingredients Linoleic Acid and Folic Acid in Pigeon Pea further promote the effects of genes on the biochemical pathways. While the active ingredients Palmitic Acid and Vitamin C contained in Hyacinth Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: HYACINTH BEAN IS RECOMMENDED OVER PIGEON PEA FOR REDUCING THE GENETIC RISK OF CHROMOPHOBE RENAL CELL CARCINOMA DUE TO GENES BIRC6 AND FAT4
Eat more vegetables, Arugula or Beetroot?
The active ingredients contained in Arugula are Esculin, Vitamin A, Kaempferol, Vitamin K, Erysolin among others. While the active ingredients contained in Beetroot are Beta-sitosterol, Vitamin E, Linolenic Acid, Vitamin C, Oleic Acid and others.
Kaempferol can manipulate biochemical pathways Cell Cycle Checkpoints. Vitamin K has biological action on biochemical pathways MYC Signaling, Calcium Signaling and Cell Cycle Checkpoints.
Linoleic Acid can manipulate biochemical pathways Extracellular Matrix Remodelling. Folic Acid has biological action on biochemical pathways MYC Signaling, P53 Signaling and Cell Cycle Checkpoints. And so on.
For genetic risk of Chromophobe Renal Cell Carcinoma due to abnormalities in genes BIRC6 and FAT4 – Foods like Arugula are recommended compared to Beetroot. This is because the active ingredients Linoleic Acid and Folic Acid in Beetroot further promote the effects of genes on the biochemical pathways. While the active ingredients Kaempferol and Vitamin K contained in Arugula together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: ARUGULA IS RECOMMENDED OVER BEETROOT FOR REDUCING THE GENETIC RISK OF CHROMOPHOBE RENAL CELL CARCINOMA DUE TO GENES BIRC6 AND FAT4
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Pomegranate or Raspberry?
The active ingredients contained in Pomegranate are Apigenin, Corilagin, Beta-sitosterol, Betulinic Acid, Maslinic Acid among others. While the active ingredients contained in Raspberry are Vitamin C, Quercetin, Resveratrol, Ellagic Acid, Gallic Acid and others.
Betulinic Acid can manipulate biochemical pathways MYC Signaling, P53 Signaling and Cell Cycle Checkpoints. Casuarinin has biological action on biochemical pathways Apoptosis, MYC Signaling and P53 Signaling.
Ellagic Acid can manipulate biochemical pathways MYC Signaling. Rutin has biological action on biochemical pathways Extracellular Matrix Remodelling. And so on.
For genetic risk of Chromophobe Renal Cell Carcinoma due to abnormalities in genes BIRC6 and FAT4 – Foods like Pomegranate are recommended compared to Raspberry. This is because the active ingredients Ellagic Acid and Rutin in Raspberry further promote the effects of genes on the biochemical pathways. While the active ingredients Betulinic Acid and Casuarinin contained in Pomegranate together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: POMEGRANATE IS RECOMMENDED OVER RASPBERRY FOR REDUCING THE GENETIC RISK OF CHROMOPHOBE RENAL CELL CARCINOMA DUE TO GENES BIRC6 AND FAT4
Eat more nuts, Pistachio or Cashew Nut?
The active ingredients contained in Pistachio are Beta-sitosterol, Vitamin E, Stigmasterol, Linolenic Acid, Oleic Acid among others. While the active ingredients contained in Cashew Nut are Beta-sitosterol, Palmitic Acid, Vitamin C, Gallic Acid, Butyric Acid and others.
Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin E has biological action on biochemical pathways Calcium Signaling, Cell Cycle Checkpoints and Apoptosis.
Lauric Acid can manipulate biochemical pathways MYC Signaling. Myristic Acid has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and Apoptosis. And so on.
For genetic risk of Chromophobe Renal Cell Carcinoma due to abnormalities in genes BIRC6 and FAT4 – Foods like Pistachio are recommended compared to Cashew Nut. This is because the active ingredients Lauric Acid and Myristic Acid in Cashew Nut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin E contained in Pistachio together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: PISTACHIO IS RECOMMENDED OVER CASHEW NUT FOR REDUCING THE GENETIC RISK OF CHROMOPHOBE RENAL CELL CARCINOMA DUE TO GENES BIRC6 AND FAT4
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Chromophobe Renal Cell Carcinoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
- Pan Origimed 2020
- Pan-cancer analysis of whole genomes.
- Beta-sitosterol induces anti-proliferation and apoptosis in human leukemic U937 cells through activation of caspase-3 and induction of Bax/Bcl-2 ratio.
- Vitamin C enhances epigenetic modifications induced by 5-azacytidine and cell cycle arrest in the hepatocellular carcinoma cell lines HLE and Huh7.
- Adhesion to the extracellular matrix is positively regulated by retinoic acid in HepG2 cells.
- Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin.
- Resveratrol induces autophagy by directly inhibiting mTOR through ATP competition.
- Flavonoids suppress human glioblastoma cell growth by inhibiting cell metabolism, migration, and by regulating extracellular matrix proteins and metalloproteinases expression.
- Small-molecule inhibitors of NADPH oxidase 4.
- Research progress on the anticancer effects of vitamin K2.
- Research on Rett syndrome: strategy and preliminary results.
- New concepts in phospholipase D signaling in inflammation and cancer.
- Functional lipidomics: Palmitic acid impairs hepatocellular carcinoma development by modulating membrane fluidity and glucose metabolism.
- Excess Linoleic Acid Increases Collagen I/III Ratio and Stiffens” the Heart Muscle Following High Fat Diets.”
- Effects of folate deficiency on gene expression in the apoptosis and cancer pathways in colon cancer cells.
- Betulinic acid induces DNA damage and apoptosis in SiHa cells.
- Induction of cell cycle arrest and apoptosis in human non-small cell lung cancer A549 cells by casuarinin from the bark of Terminalia arjuna Linn.
- Identification of ellagic acid as potent inhibitor of protein kinase CK2: a successful example of a virtual screening application.
- Down-regulation of telomerase activity in DLD-1 human colorectal adenocarcinoma cells by tocotrienol.
- Clinical pharmacodynamics of antihistamines.
- Saturated fatty acids modulate cell response to DNA damage: implication for their role in tumorigenesis.
- HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods.
- Resveratrol, pterostilbene, and piceatannol in vaccinium berries.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.