Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Cervical Adenosquamous Carcinoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Cervical Adenosquamous Carcinoma because of BCORL1 and EZH2 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Cervical Adenosquamous Carcinoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Coconut” or “Include fruit Partridgeberry in my diet” or “Should I reduce consumption of vegetable Beetroot” or “Can I take Resveratrol and Birch supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO CERVICAL ADENOSQUAMOUS CARCINOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Cervical Adenosquamous Carcinoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR CERVICAL ADENOSQUAMOUS CARCINOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Cervical Adenosquamous Carcinoma
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Cervical Adenosquamous Carcinoma from cBioPortal. From a patient sample size of 8; the top genes with mutations and other abnormalities for Cervical Adenosquamous Carcinoma include genes BCORL1, EZH2, KEAP1, KMT2A and NF1. The occurrence frequency distribution for these genes respectively is 33.3%, 33.3%, 33.3%, 33.3% and 33.3%. These tumor genetic details of Cervical Adenosquamous Carcinoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Cervical Adenosquamous Carcinoma.
Significance of Nutrition for Cervical Adenosquamous Carcinoma
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Cervical Adenosquamous Carcinoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Coconut includes active ingredients Palmitic Acid, Beta-sitosterol, Vitamin E, Capric Acid, Lauric Acid and others. And Partridgeberry contains active ingredients Resveratrol, Beta-sitosterol, Stigmasterol and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Cervical Adenosquamous Carcinoma, activation or inhibition of selected biochemical pathways like RAS-RAF Signaling, Oxidative Stress, PI3K-AKT-MTOR Signaling, Oncogenic Cancer Epigenetics plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Cervical Adenosquamous Carcinoma, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR CERVICAL ADENOSQUAMOUS CARCINOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Cervical Adenosquamous Carcinoma undergoing chemotherapy treatment
In Cervical Adenosquamous Carcinoma – the genes BCORL1, EZH2, KEAP1, KMT2A and NF1 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Cervical Adenosquamous Carcinoma are RAS-RAF Signaling, Oxidative Stress, PI3K-AKT-MTOR Signaling and others. Radiation is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers RAS-RAF Signaling, Oxidative Stress, PI3K-AKT-MTOR Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Common Pea or Common Bean?
Pulses are an important part of many diets. The active ingredients contained in Common Pea are Lupeol, Daidzein, Vitamin C, Beta-sitosterol, Oleic Acid among others. While the active ingredients contained in Common Bean are Apigenin, Esculin, Vitamin C, Oleic Acid, Ferulic Acid and others.
Vitamin C can manipulate biochemical pathways MYC Signaling, RAS-RAF Signaling and Oxidative Stress. Beta-sitosterol has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, MYC Signaling and Oxidative Stress.
Apigenin can manipulate biochemical pathways Oxidative Stress. Esculin has biological action on biochemical pathways Oxidative Stress. And so on.
When treating Cervical Adenosquamous Carcinoma with chemotherapy Radiation – Foods like Common Pea are recommended compared to Common Bean. This is because the active ingredients Apigenin and Esculin in Common Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Beta-sitosterol contained in Common Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER COMMON BEAN FOR CERVICAL ADENOSQUAMOUS CARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more vegetables, Cabbage or Beetroot?
Vegetables are an important part of many diets. The active ingredients contained in Cabbage are Benzyl Isothiocyanate, Isorhamnetin, Vitamin C, Beta-sitosterol, Quercetin among others. While the active ingredients contained in Beetroot are Vitamin C, Beta-sitosterol, Oleic Acid, Vitamin E, Linolenic Acid and others.
Vitamin C can manipulate biochemical pathways MYC Signaling, RAS-RAF Signaling and Oxidative Stress. Glucaric Acid has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, MYC Signaling and RAS-RAF Signaling.
Vitamin E can manipulate biochemical pathways Oxidative Stress. Citric Acid has biological action on biochemical pathways Oxidative Stress. And so on.
When treating Cervical Adenosquamous Carcinoma with chemotherapy Radiation – Foods like Cabbage are recommended compared to Beetroot. This is because the active ingredients Vitamin E and Citric Acid in Beetroot interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Glucaric Acid contained in Cabbage support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: CABBAGE IS RECOMMENDED OVER BEETROOT FOR CERVICAL ADENOSQUAMOUS CARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more fruits, Partridgeberry or Coconut?
Fruits are an important part of many diets. The active ingredients contained in Partridgeberry are Resveratrol, Beta-sitosterol, Stigmasterol among others. While the active ingredients contained in Coconut are Palmitic Acid, Beta-sitosterol, Vitamin E, Capric Acid, Lauric Acid and others.
Resveratrol can manipulate biochemical pathways MYC Signaling, RAS-RAF Signaling and PI3K-AKT-MTOR Signaling. Beta-sitosterol has biological action on biochemical pathways Oxidative Stress, MYC Signaling and PI3K-AKT-MTOR Signaling.
Lauric Acid can manipulate biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. Citric Acid has biological action on biochemical pathways Oxidative Stress. And so on.
When treating Cervical Adenosquamous Carcinoma with chemotherapy Radiation – Foods like Partridgeberry are recommended compared to Coconut. This is because the active ingredients Lauric Acid and Citric Acid in Coconut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Resveratrol and Beta-sitosterol contained in Partridgeberry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PARTRIDGEBERRY IS RECOMMENDED OVER COCONUT FOR CERVICAL ADENOSQUAMOUS CARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more nuts, Hazelnut or Cashew Nut?
Nuts are an important part of many diets. The active ingredients contained in Hazelnut are Oleic Acid, Quercetin, Vitamin E, Linolenic Acid, Linoleic Acid among others. While the active ingredients contained in Cashew Nut are Palmitic Acid, Vitamin C, Beta-sitosterol, Butyric Acid, Lauric Acid and others.
Quercetin can manipulate biochemical pathways MYC Signaling, RAS-RAF Signaling and PI3K-AKT-MTOR Signaling. Vitamin A has biological action on biochemical pathways Oxidative Stress, MYC Signaling and PI3K-AKT-MTOR Signaling.
Lauric Acid can manipulate biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. Myristic Acid has biological action on biochemical pathways RAS-RAF Signaling and MYC Signaling. And so on.
When treating Cervical Adenosquamous Carcinoma with chemotherapy Radiation – Foods like Hazelnut are recommended compared to Cashew Nut. This is because the active ingredients Lauric Acid and Myristic Acid in Cashew Nut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Quercetin and Vitamin A contained in Hazelnut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: HAZELNUT IS RECOMMENDED OVER CASHEW NUT FOR CERVICAL ADENOSQUAMOUS CARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Foods for Genetic Risk of Cervical Adenosquamous Carcinoma
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. BCORL1 and EZH2 are two genes whose abnormalities are risk factors for Cervical Adenosquamous Carcinoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Cervical Adenosquamous Carcinoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Cervical Adenosquamous Carcinoma gene BCORL1 has causative impact on biological pathways like Oncogenic Cancer Epigenetics. And EZH2 has a causative impact on biological pathways like Oncogenic Cancer Epigenetics, Suppressive Histone Methylation and Amino Acid Metabolism. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like BCORL1 and EZH2 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes BCORL1 and EZH2 should be avoided.
Eat more pulses, Mung Bean or Soy Bean?
The active ingredients contained in Mung Bean are Quercetin, Vitamin C, Linolenic Acid, Stigmasterol, Vitexin among others. While the active ingredients contained in Soy Bean are Lupeol, Daidzein, Quercetin, Vitamin C, Vitamin E and others.
Quercetin can manipulate biochemical pathways Apoptosis, Suppressive Histone Methylation and Noncoding RNA Signaling. Vitamin C has biological action on biochemical pathways MYC Signaling, P53 Signaling and Cell Cycle Checkpoints.
Aescin can manipulate biochemical pathways Cell Cycle Checkpoints. Lecithin has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Cervical Adenosquamous Carcinoma due to abnormalities in genes BCORL1 and EZH2 – Foods like Mung Bean are recommended compared to Soy Bean. This is because the active ingredients Aescin and Lecithin in Soy Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Quercetin and Vitamin C contained in Mung Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: MUNG BEAN IS RECOMMENDED OVER SOY BEAN FOR REDUCING THE GENETIC RISK OF CERVICAL ADENOSQUAMOUS CARCINOMA DUE TO GENES BCORL1 AND EZH2
Eat more vegetables, Cassava or Heart Of Palm?
The active ingredients contained in Cassava are Vitamin C, Beta-sitosterol, Linolenic Acid, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Heart Of Palm are Vitamin C, Palmitic Acid, Vitamin A, Folic Acid and others.
Vitamin C can manipulate biochemical pathways Apoptosis, Suppressive Histone Methylation and MYC Signaling. Beta-sitosterol has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.
Palmitic Acid can manipulate biochemical pathways Oncogenic Cancer Epigenetics. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. And so on.
For genetic risk of Cervical Adenosquamous Carcinoma due to abnormalities in genes BCORL1 and EZH2 – Foods like Cassava are recommended compared to Heart Of Palm. This is because the active ingredients Palmitic Acid and Folic Acid in Heart Of Palm further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Cassava together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: CASSAVA IS RECOMMENDED OVER HEART OF PALM FOR REDUCING THE GENETIC RISK OF CERVICAL ADENOSQUAMOUS CARCINOMA DUE TO GENES BCORL1 AND EZH2
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Feijoa or Cranberry?
The active ingredients contained in Feijoa are Lycopene, Vitamin C, Casuarinin, Folic Acid among others. While the active ingredients contained in Cranberry are Quercetin, Vitamin C, Resveratrol, Hyperoside, P-coumaric Acid and others.
Vitamin C can manipulate biochemical pathways Apoptosis, Suppressive Histone Methylation and MYC Signaling. Lycopene has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.
Ellagic Acid can manipulate biochemical pathways MYC Signaling. Myricetin has biological action on biochemical pathways Oncogenic Cancer Epigenetics. And so on.
For genetic risk of Cervical Adenosquamous Carcinoma due to abnormalities in genes BCORL1 and EZH2 – Foods like Feijoa are recommended compared to Cranberry. This is because the active ingredients Ellagic Acid and Myricetin in Cranberry further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Lycopene contained in Feijoa together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: FEIJOA IS RECOMMENDED OVER CRANBERRY FOR REDUCING THE GENETIC RISK OF CERVICAL ADENOSQUAMOUS CARCINOMA DUE TO GENES BCORL1 AND EZH2
Eat more nuts, Almond or Acorn?
The active ingredients contained in Almond are Quercetin, Vitamin E, Beta-sitosterol, Linolenic Acid, Stigmasterol among others. While the active ingredients contained in Acorn are Quercetin, Vitamin C, Beta-sitosterol, Beta-carotene, Vitamin B3 and others.
Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Quercetin has biological action on biochemical pathways Suppressive Histone Methylation, Noncoding RNA Signaling and Cell Cycle Checkpoints.
Vitamin B2 can manipulate biochemical pathways Oncogenic Cancer Epigenetics and Noncoding RNA Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. And so on.
For genetic risk of Cervical Adenosquamous Carcinoma due to abnormalities in genes BCORL1 and EZH2 – Foods like Almond are recommended compared to Acorn. This is because the active ingredients Vitamin B2 and Folic Acid in Acorn further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Quercetin contained in Almond together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: ALMOND IS RECOMMENDED OVER ACORN FOR REDUCING THE GENETIC RISK OF CERVICAL ADENOSQUAMOUS CARCINOMA DUE TO GENES BCORL1 AND EZH2
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Cervical Adenosquamous Carcinoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
- Pan Origimed 2020
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Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.