Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Breast Invasive Lobular Carcinoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Breast Invasive Lobular Carcinoma because of ARID1A and AKAP9 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Breast Invasive Lobular Carcinoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Apricot” or “Include fruit Mulberry in my diet” or “Should I reduce consumption of vegetable Okra” or “Can I take Dim and Fang Feng supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO BREAST INVASIVE LOBULAR CARCINOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Breast Invasive Lobular Carcinoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR BREAST INVASIVE LOBULAR CARCINOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Breast Invasive Lobular Carcinoma
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Breast Invasive Lobular Carcinoma from cBioPortal. The patients enrolled in the studies for Breast Invasive Lobular Carcinoma are in ages between 34 to 90 with an average age of 61.From a patient sample size of 1200; the top genes with mutations and other abnormalities for Breast Invasive Lobular Carcinoma include genes ARID1A, AKAP9, LAMA2, ALK and ESR1. The occurrence frequency distribution for these genes respectively is 1.6%, 1.2%, 1.1%, 1.1% and 0.9%. These tumor genetic details of Breast Invasive Lobular Carcinoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Breast Invasive Lobular Carcinoma.
Significance of Nutrition for Breast Invasive Lobular Carcinoma
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Breast Invasive Lobular Carcinoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Apricot includes active ingredients Quercetin, Beta-sitosterol, Salicylic Acid, Vitamin C, Modified Citrus Pectin and others. And Mulberry contains active ingredients Resveratrol, Morusin, Moracin P, Deoxynojirimycin and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Breast Invasive Lobular Carcinoma, activation or inhibition of selected biochemical pathways like Oncogenic Cancer Epigenetics, Suppressive Histone Methylation, PI3K-AKT-MTOR Signaling, MAPK Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Breast Invasive Lobular Carcinoma, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR BREAST INVASIVE LOBULAR CARCINOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Breast Invasive Lobular Carcinoma undergoing chemotherapy treatment
In Breast Invasive Lobular Carcinoma – the genes ARID1A, AKAP9, LAMA2, ALK and ESR1 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Breast Invasive Lobular Carcinoma are Oncogenic Cancer Epigenetics, Suppressive Histone Methylation, Noncoding RNA Signaling and others. Pembrolizumab is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Oncogenic Cancer Epigenetics, Suppressive Histone Methylation, Noncoding RNA Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Common Pea or Pigeon Pea?
Pulses are an important part of many diets. The active ingredients contained in Common Pea are Lupeol, Beta-sitosterol, Daidzein, Vitamin C, Kaempferol among others. While the active ingredients contained in Pigeon Pea are Vitamin C, Linolenic Acid, Oleic Acid, Genistein, Vitamin A and others.
Beta-sitosterol can manipulate biochemical pathways Myeloid-derived Suppressor Cells, MYC Signaling and WNT Beta Catenin Signaling. Vitamin C has biological action on biochemical pathways Suppressive Histone Methylation, Vitamin D Signaling and PI3K-AKT-MTOR Signaling.
Genistein can manipulate biochemical pathways Chromatin Remodeling and DNA Repair. Vitamin A has biological action on biochemical pathways Natural Killer Cell Activation. And so on.
When treating Breast Invasive Lobular Carcinoma with chemotherapy Pembrolizumab – Foods like Common Pea are recommended compared to Pigeon Pea. This is because the active ingredients Genistein and Vitamin A in Pigeon Pea interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER PIGEON PEA FOR BREAST INVASIVE LOBULAR CARCINOMA ON TREATMENT WITH CHEMOTHERAPY PEMBROLIZUMAB FOR SOME CONDITIONS.
Eat more vegetables, Cassava or Okra?
Vegetables are an important part of many diets. The active ingredients contained in Cassava are Beta-sitosterol, Vitamin C, Linolenic Acid, Oleic Acid, Vitamin A among others. While the active ingredients contained in Okra are Quercetin, Beta-sitosterol, Salicylic Acid, Vitamin C, Linolenic Acid and others.
Vitamin C can manipulate biochemical pathways Suppressive Histone Methylation, Myeloid-derived Suppressor Cells and MYC Signaling. Beta-sitosterol has biological action on biochemical pathways WNT Beta Catenin Signaling, Vitamin D Signaling and PI3K-AKT-MTOR Signaling.
Vitamin A can manipulate biochemical pathways Natural Killer Cell Activation. Quercetin has biological action on biochemical pathways Natural Killer Cell Activation. And so on.
When treating Breast Invasive Lobular Carcinoma with chemotherapy Pembrolizumab – Foods like Cassava are recommended compared to Okra. This is because the active ingredients Vitamin A and Quercetin in Okra interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Beta-sitosterol contained in Cassava support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: CASSAVA IS RECOMMENDED OVER OKRA FOR BREAST INVASIVE LOBULAR CARCINOMA ON TREATMENT WITH CHEMOTHERAPY PEMBROLIZUMAB FOR SOME CONDITIONS.
Eat more fruits, Mulberry or Apricot?
Fruits are an important part of many diets. The active ingredients contained in Mulberry are Resveratrol, Morusin, Moracin P, Deoxynojirimycin among others. While the active ingredients contained in Apricot are Quercetin, Beta-sitosterol, Salicylic Acid, Vitamin C, Modified Citrus Pectin and others.
Morusin can manipulate biochemical pathways Natural Killer Cell Activation, Myeloid-derived Suppressor Cells and JAK-STAT Signaling. Deoxynojirimycin has biological action on biochemical pathways Natural Killer Cell Activation.
Rutin can manipulate biochemical pathways WNT Beta Catenin Signaling. Quercetin has biological action on biochemical pathways Natural Killer Cell Activation. And so on.
When treating Breast Invasive Lobular Carcinoma with chemotherapy Pembrolizumab – Foods like Mulberry are recommended compared to Apricot. This is because the active ingredients Rutin and Quercetin in Apricot interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Morusin and Deoxynojirimycin contained in Mulberry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: MULBERRY IS RECOMMENDED OVER APRICOT FOR BREAST INVASIVE LOBULAR CARCINOMA ON TREATMENT WITH CHEMOTHERAPY PEMBROLIZUMAB FOR SOME CONDITIONS.
Eat more nuts, Pine Nut or Acorn?
Nuts are an important part of many diets. The active ingredients contained in Pine Nut are Vitamin E, Beta-sitosterol, Linolenic Acid, Oleic Acid, Vitamin A among others. While the active ingredients contained in Acorn are Quercetin, Beta-sitosterol, Beta-carotene, Vitamin C, Gallic Acid and others.
Beta-sitosterol can manipulate biochemical pathways Myeloid-derived Suppressor Cells, MYC Signaling and WNT Beta Catenin Signaling. Vitamin K has biological action on biochemical pathways Vitamin D Signaling, PI3K-AKT-MTOR Signaling and Amino Acid Metabolism.
Quercetin can manipulate biochemical pathways Natural Killer Cell Activation. Gallic Acid has biological action on biochemical pathways Vitamin D Signaling. And so on.
When treating Breast Invasive Lobular Carcinoma with chemotherapy Pembrolizumab – Foods like Pine Nut are recommended compared to Acorn. This is because the active ingredients Quercetin and Gallic Acid in Acorn interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin K contained in Pine Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PINE NUT IS RECOMMENDED OVER ACORN FOR BREAST INVASIVE LOBULAR CARCINOMA ON TREATMENT WITH CHEMOTHERAPY PEMBROLIZUMAB FOR SOME CONDITIONS.
Foods for Genetic Risk of Breast Invasive Lobular Carcinoma
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. ARID1A and AKAP9 are two genes whose abnormalities are risk factors for Breast Invasive Lobular Carcinoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Breast Invasive Lobular Carcinoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Breast Invasive Lobular Carcinoma gene ARID1A has causative impact on biological pathways like Androgen Signaling and Chromatin Remodeling. And AKAP9 has a causative impact on biological pathways like MAPK Signaling, MAPK Signaling and Cell Cycle. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like ARID1A and AKAP9 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes ARID1A and AKAP9 should be avoided.
Eat more pulses, Scarlet Bean or Fava Bean?
The active ingredients contained in Scarlet Bean are Beta-sitosterol, Vitamin C, Oleic Acid, Linolenic Acid, Stigmasterol among others. While the active ingredients contained in Fava Bean are Daidzein, Beta-sitosterol, Vitamin C, P-coumaric Acid, Oleic Acid and others.
Beta-sitosterol can manipulate biochemical pathways Inositol Phosphate Signaling, Apoptosis and MYC Signaling. Vitamin C has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.
Quercetin can manipulate biochemical pathways DNA Repair. Ferulic Acid has biological action on biochemical pathways DNA Repair. And so on.
For genetic risk of Breast Invasive Lobular Carcinoma due to abnormalities in genes ARID1A and AKAP9 – Foods like Scarlet Bean are recommended compared to Fava Bean. This is because the active ingredients Quercetin and Ferulic Acid in Fava Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin C contained in Scarlet Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER FAVA BEAN FOR REDUCING THE GENETIC RISK OF BREAST INVASIVE LOBULAR CARCINOMA DUE TO GENES ARID1A AND AKAP9
Eat more vegetables, Jicama or Beetroot?
The active ingredients contained in Jicama are Vitamin C, Beta-carotene, Vitamin B3, Vitamin A, Folic Acid among others. While the active ingredients contained in Beetroot are Beta-sitosterol, Vitamin E, Vitamin C, Oleic Acid, Linolenic Acid and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Beta-carotene has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Apoptosis.
Vitamin E can manipulate biochemical pathways DNA Repair. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. And so on.
For genetic risk of Breast Invasive Lobular Carcinoma due to abnormalities in genes ARID1A and AKAP9 – Foods like Jicama are recommended compared to Beetroot. This is because the active ingredients Vitamin E and Folic Acid in Beetroot further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-carotene contained in Jicama together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: JICAMA IS RECOMMENDED OVER BEETROOT FOR REDUCING THE GENETIC RISK OF BREAST INVASIVE LOBULAR CARCINOMA DUE TO GENES ARID1A AND AKAP9
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Feijoa or Cranberry?
The active ingredients contained in Feijoa are Lycopene, Vitamin C, Casuarinin, Folic Acid among others. While the active ingredients contained in Cranberry are Resveratrol, Vitamin C, P-coumaric Acid, Hyperoside, Quercetin and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Lycopene has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Apoptosis.
Resveratrol can manipulate biochemical pathways P53 Signaling. Quercetin has biological action on biochemical pathways DNA Repair. And so on.
For genetic risk of Breast Invasive Lobular Carcinoma due to abnormalities in genes ARID1A and AKAP9 – Foods like Feijoa are recommended compared to Cranberry. This is because the active ingredients Resveratrol and Quercetin in Cranberry further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Lycopene contained in Feijoa together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: FEIJOA IS RECOMMENDED OVER CRANBERRY FOR REDUCING THE GENETIC RISK OF BREAST INVASIVE LOBULAR CARCINOMA DUE TO GENES ARID1A AND AKAP9
Eat more nuts, Pecan Nut or Chestnut?
The active ingredients contained in Pecan Nut are Vitamin E, Oleic Acid, Linolenic Acid, Cianidanol, Linoleic Acid among others. While the active ingredients contained in Chestnut are Vitamin C, Oleic Acid, Linolenic Acid, Quercetin, Ellagic Acid and others.
Cianidanol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Delphinidin has biological action on biochemical pathways PI3K-AKT-MTOR Signaling and MYC Signaling.
Ellagic Acid can manipulate biochemical pathways MYC Signaling. Gallic Acid has biological action on biochemical pathways DNA Repair. And so on.
For genetic risk of Breast Invasive Lobular Carcinoma due to abnormalities in genes ARID1A and AKAP9 – Foods like Pecan Nut are recommended compared to Chestnut. This is because the active ingredients Ellagic Acid and Gallic Acid in Chestnut further promote the effects of genes on the biochemical pathways. While the active ingredients Cianidanol and Delphinidin contained in Pecan Nut together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER CHESTNUT FOR REDUCING THE GENETIC RISK OF BREAST INVASIVE LOBULAR CARCINOMA DUE TO GENES ARID1A AND AKAP9
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Breast Invasive Lobular Carcinoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
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Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.