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What Foods are Recommended for Cancer?
is a very common question. Personalized Nutrition Plans are foods and supplements which are personalized to a cancer indication, genes, any treatments and lifestyle conditions.

Foods for Bladder Squamous Cell Carcinoma!

Aug 4, 2023

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Introduction

Foods for Bladder Squamous Cell Carcinoma should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.

Squamous cell carcinoma of the urinary bladder is a distinct type of bladder cancer characterized by its pathology and clinical behavior. It presents specific challenges in diagnosis and treatment, as evident in radiology and detailed in bladder squamous cell carcinoma pathology outlines. The staging of this cancer is critical for determining appropriate treatment, which often involves a combination of chemotherapy, radiation therapy, and surgery. The survival rate of squamous cell carcinoma bladder cancer depends significantly on the stage at diagnosis and the effectiveness of the chosen treatment strategy. Bladder squamous cell carcinoma treatment guidelines emphasize the importance of addressing individual patient factors, including the presence of risk factors like bladder stones, bladder exstrophy, and infections such as schistosomiasis. Advanced cases, such as metastatic bladder squamous cell carcinoma, require more aggressive treatment approaches. Studies have explored the role of biomarkers like GATA3 in the prognosis and treatment of this disease. Understanding squamous cell carcinoma bladder symptoms early on is crucial for timely diagnosis and intervention, improving the overall prognosis for patients.



For Bladder Squamous Cell Carcinoma does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Bladder Squamous Cell Carcinoma does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Bladder Squamous Cell Carcinoma?

For example does it matter if vegetable Rocket Salad is consumed more compared to Winter Squash? Does it make any difference if fruit Grapefruit is preferred over Bayberry? Also if similar choices are made for nuts/seeds like Almond over Pistachio and for pulses like Broad Bean over Mung Bean. And if what I eat matters – then how does one identify foods which are recommended for Bladder Squamous Cell Carcinoma and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Bladder Squamous Cell Carcinoma!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All cancers like Bladder Squamous Cell Carcinoma can be characterized by a unique set of biochemical pathways - the signature pathways of Bladder Squamous Cell Carcinoma. Biochemical pathways like Vitamin Metabolism, Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling, MAPK Signaling are part of the signature definition of Bladder Squamous Cell Carcinoma.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Grapefruit contains active ingredients Luteolin, Lupeol, Eugenol, Phloretin, Linolenic Acid. And Bayberry contains active ingredients Myricetin, Luteolin, Lupeol, Eugenol, Phloretin and possibly others.

A common mistake made when deciding and choosing foods to eat for Bladder Squamous Cell Carcinoma – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Bladder Squamous Cell Carcinoma.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Bladder Squamous Cell Carcinoma?

Personalized nutrition for cancers like Bladder Squamous Cell Carcinoma consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Bladder Squamous Cell Carcinoma biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

Characteristics of cancers like Bladder Squamous Cell Carcinoma

All cancers like Bladder Squamous Cell Carcinoma can be characterized by a unique set of biochemical pathways – the signature pathways of Bladder Squamous Cell Carcinoma. Biochemical pathways like Vitamin Metabolism, Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling, MAPK Signaling are part of the signature definition of Bladder Squamous Cell Carcinoma. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Bladder Squamous Cell Carcinoma need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Bladder Squamous Cell Carcinoma when taking cancer treatment Ifosfamide, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

TP53, KDM6A, ARID1A, KMT2C and FGFR3 are the top ranked reported genes for Bladder Squamous Cell Carcinoma. TP53 is reported in 38.5 % of the representative patients across all clinical trials. And KDM6A is reported in 34.6 %. The combined population patient data cover ages from 34 to 84. 63.0 % of the patient data are identified as men. The Bladder Squamous Cell Carcinoma biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Foods for Bladder Squamous Cell Carcinoma!

Food and Supplements for Bladder Squamous Cell Carcinoma

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable ROCKET SALAD or WINTER SQUASH?

Vegetable Rocket Salad contains many active ingredients or bioactives such as Quercetin, Myricetin, Luteolin, Lupeol, Eugenol. These active ingredients manipulate various biochemical pathways like Extracellular Matrix Remodelling, Cell Cycle and Cell Cycle Checkpoints and others. Rocket Salad is recommended for Bladder Squamous Cell Carcinoma when ongoing cancer treatment is Ifosfamide. This is because Rocket Salad modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Ifosfamide.

Some of the active ingredients or bioactives in vegetable Winter Squash are Myricetin, Luteolin, Lupeol, Eugenol, Phloretin. These active ingredients manipulate various biochemical pathways like Oxidative Stress and Hippo Signaling and others. Winter Squash is not recommended for Bladder Squamous Cell Carcinoma when ongoing cancer treatment is Ifosfamide because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE ROCKET SALAD IS RECOMMENDED OVER WINTER SQUASH FOR Bladder Squamous Cell Carcinoma AND TREATMENT Ifosfamide.

Choose Fruit BAYBERRY or GRAPEFRUIT?

Fruit Bayberry contains many active ingredients or bioactives such as Myricetin, Luteolin, Lupeol, Eugenol, Phloretin. These active ingredients manipulate various biochemical pathways like Vitamin Metabolism, Cell Cycle, JAK-STAT Signaling and Epithelial to Mesenchymal Transition and others. Bayberry is recommended for Bladder Squamous Cell Carcinoma when ongoing cancer treatment is Ifosfamide. This is because Bayberry modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Ifosfamide.

Some of the active ingredients or bioactives in fruit Grapefruit are Luteolin, Lupeol, Eugenol, Phloretin, Linolenic Acid. These active ingredients manipulate various biochemical pathways like Oxidative Stress and DNA Repair and others. Grapefruit is not recommended for Bladder Squamous Cell Carcinoma when ongoing cancer treatment is Ifosfamide because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT BAYBERRY IS RECOMMENDED OVER GRAPEFRUIT FOR Bladder Squamous Cell Carcinoma AND TREATMENT Ifosfamide.

Choose Nut ALMOND or PISTACHIO?

Almond contains many active ingredients or bioactives such as Lupeol, Eugenol, Phloretin, Linolenic Acid, Beta-sitosterol. These active ingredients manipulate various biochemical pathways like JAK-STAT Signaling, Cell Cycle, Epithelial to Mesenchymal Transition and Cell Cycle Checkpoints and others. Almond is recommended for Bladder Squamous Cell Carcinoma when ongoing cancer treatment is Ifosfamide. This is because Almond modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Ifosfamide.

Some of the active ingredients or bioactives in Pistachio are Quercetin, Lupeol, Eugenol, Phloretin, Linolenic Acid. These active ingredients manipulate various biochemical pathways like Oxidative Stress and Hippo Signaling and others. Pistachio is not recommended for Bladder Squamous Cell Carcinoma when ongoing cancer treatment is Ifosfamide because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

ALMOND IS RECOMMENDED OVER PISTACHIO FOR Bladder Squamous Cell Carcinoma AND TREATMENT Ifosfamide.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Bladder Squamous Cell Carcinoma or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable GIANT BUTTERBUR or ALLIUM?

Vegetable Giant Butterbur contains many active ingredients or bioactives such as Curcumin, Apigenin, Lycopene, Lupeol, Daidzein. These active ingredients manipulate various biochemical pathways like RAS-RAF Signaling, Cell Cycle, Epithelial to Mesenchymal Transition and P53 Signaling and others. Giant Butterbur is recommended for risk of Bladder Squamous Cell Carcinoma when associated genetic risk is ARID1A. This is because Giant Butterbur increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Allium are Curcumin, Quercetin, Lupeol, Daidzein, Phloretin. These active ingredients manipulate various biochemical pathways like WNT Beta Catenin Signaling and PI3K-AKT-MTOR Signaling and others. Allium is not recommended when risk of Bladder Squamous Cell Carcinoma when associated genetic risk is ARID1A because it increases the signature pathways of it.

VEGETABLE GIANT BUTTERBUR IS RECOMMENDED OVER ALLIUM FOR ARID1A GENETIC RISK OF CANCER.

Choose Fruit NANCE or PUMMELO?

Fruit Nance contains many active ingredients or bioactives such as Curcumin, Apigenin, Lupeol, Daidzein, Myricetin. These active ingredients manipulate various biochemical pathways like RAS-RAF Signaling, Cell Cycle, Epithelial to Mesenchymal Transition and P53 Signaling and others. Nance is recommended for risk of Bladder Squamous Cell Carcinoma when associated genetic risk is ARID1A. This is because Nance increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Pummelo are Curcumin, Apigenin, Quercetin, Lycopene, Lupeol. These active ingredients manipulate various biochemical pathways like WNT Beta Catenin Signaling and Epithelial to Mesenchymal Transition and others. Pummelo is not recommended when risk of Bladder Squamous Cell Carcinoma when associated genetic risk is ARID1A because it increases the signature pathways of it.

FRUIT NANCE IS RECOMMENDED OVER PUMMELO FOR ARID1A GENETIC RISK OF CANCER.

Choose Nut COMMON HAZELNUT or CHESTNUT?

Common Hazelnut contains many active ingredients or bioactives such as Curcumin, Quercetin, Lycopene, Lupeol, Daidzein. These active ingredients manipulate various biochemical pathways like RAS-RAF Signaling, Cell Cycle, Epithelial to Mesenchymal Transition and P53 Signaling and others. Common Hazelnut is recommended for risk of Bladder Squamous Cell Carcinoma when associated genetic risk is ARID1A. This is because Common Hazelnut increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in Chestnut are Curcumin, Apigenin, Ellagic Acid, Lycopene, Lupeol. These active ingredients manipulate various biochemical pathways like WNT Beta Catenin Signaling and Epithelial to Mesenchymal Transition and others. Chestnut is not recommended when risk of Bladder Squamous Cell Carcinoma when associated genetic risk is ARID1A because it increases the signature pathways of it.

COMMON HAZELNUT IS RECOMMENDED OVER CHESTNUT FOR ARID1A GENETIC RISK OF CANCER.


In Conclusion

Foods and Supplements chosen are important decisions for cancers like Bladder Squamous Cell Carcinoma. Bladder Squamous Cell Carcinoma patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Bladder Squamous Cell Carcinoma, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like Rocket Salad contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Bladder Squamous Cell Carcinoma?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.


Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.

References

Scientifically Reviewed by: Dr. Cogle

Christopher R. Cogle, M.D. is a tenured professor at the University of Florida, Chief Medical Officer of Florida Medicaid, and Director of the Florida Health Policy Leadership Academy at the Bob Graham Center for Public Service.

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