Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Bladder Squamous Cell Carcinoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Bladder Squamous Cell Carcinoma because of KDM6A and ARID1A gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Bladder Squamous Cell Carcinoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Strawberry” or “Include fruit Saskatoon Berry in my diet” or “Should I reduce consumption of vegetable Lotus” or “Can I take Alpha Lipoic Acid and Dim supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO BLADDER SQUAMOUS CELL CARCINOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Bladder Squamous Cell Carcinoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR BLADDER SQUAMOUS CELL CARCINOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Bladder Squamous Cell Carcinoma
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Bladder Squamous Cell Carcinoma from cBioPortal. The patients enrolled in the studies for Bladder Squamous Cell Carcinoma are in ages between 34 to 84 with an average age of 65. 63.0% of males and 37.0% of females were the distribution of gender in these clinical studies. From a patient sample size of 27; the top genes with mutations and other abnormalities for Bladder Squamous Cell Carcinoma include genes TP53, KDM6A, ARID1A, KMT2C and FGFR3. The occurrence frequency distribution for these genes respectively is 38.5%, 34.6%, 23.1%, 23.1% and 23.1%. These tumor genetic details of Bladder Squamous Cell Carcinoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Bladder Squamous Cell Carcinoma.
Significance of Nutrition for Bladder Squamous Cell Carcinoma
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Bladder Squamous Cell Carcinoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Strawberry includes active ingredients Ellagic Acid, Cianidanol, Lupeol, Beta-sitosterol, Vitamin C and others. And Saskatoon Berry contains active ingredients Quercetin, Delphinidin and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Bladder Squamous Cell Carcinoma, activation or inhibition of selected biochemical pathways like Adherens junction, Growth Factor Signaling, PI3K-AKT-MTOR Signaling, MAPK Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Bladder Squamous Cell Carcinoma, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR BLADDER SQUAMOUS CELL CARCINOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Bladder Squamous Cell Carcinoma undergoing chemotherapy treatment
In Bladder Squamous Cell Carcinoma – the genes TP53, KDM6A, ARID1A, KMT2C and FGFR3 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Bladder Squamous Cell Carcinoma are Adherens junction, Growth Factor Signaling, Chemokine Signaling and others. Gemcitabine is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Adherens junction, Growth Factor Signaling, Chemokine Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Common Bean or Soy Bean?
Pulses are an important part of many diets. The active ingredients contained in Common Bean are Vitamin C, Pelargonidin, Linolenic Acid, Delphinidin, Gamma-linolenic Acid among others. While the active ingredients contained in Soy Bean are Quercetin, Daidzein, Vitamin E, Lupeol, Beta-sitosterol and others.
Vitamin A can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Adherens junction and TGFB Signaling. Vitamin C has biological action on biochemical pathways Growth Factor Signaling, MYC Signaling and WNT Beta Catenin Signaling.
Genistein can manipulate biochemical pathways DNA Repair and Oxidative Stress. Lecithin has biological action on biochemical pathways Chemokine Signaling, JAK-STAT Signaling and MYC Signaling. And so on.
When treating Bladder Squamous Cell Carcinoma with chemotherapy Gemcitabine – Foods like Common Bean are recommended compared to Soy Bean. This is because the active ingredients Genistein and Lecithin in Soy Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin A and Vitamin C contained in Common Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: COMMON BEAN IS RECOMMENDED OVER SOY BEAN FOR BLADDER SQUAMOUS CELL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY GEMCITABINE FOR SOME CONDITIONS.
Eat more vegetables, Cassava or Lotus?
Vegetables are an important part of many diets. The active ingredients contained in Cassava are Beta-sitosterol, Vitamin C, Linolenic Acid, Oleic Acid, Vitamin A among others. While the active ingredients contained in Lotus are Quercetin, Beta-sitosterol, Vitamin C, Linolenic Acid, Oleic Acid and others.
Vitamin C can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Adherens junction and Growth Factor Signaling. Beta-sitosterol has biological action on biochemical pathways MYC Signaling, WNT Beta Catenin Signaling and P53 Signaling.
Citric Acid can manipulate biochemical pathways Oxidative Stress. Fisetin has biological action on biochemical pathways Epithelial to Mesenchymal Transition, MYC Signaling and Oxidative Stress. And so on.
When treating Bladder Squamous Cell Carcinoma with chemotherapy Gemcitabine – Foods like Cassava are recommended compared to Lotus. This is because the active ingredients Citric Acid and Fisetin in Lotus interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Beta-sitosterol contained in Cassava support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: CASSAVA IS RECOMMENDED OVER LOTUS FOR BLADDER SQUAMOUS CELL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY GEMCITABINE FOR SOME CONDITIONS.
Eat more fruits, Saskatoon Berry or Strawberry?
Fruits are an important part of many diets. The active ingredients contained in Saskatoon Berry are Quercetin, Delphinidin among others. While the active ingredients contained in Strawberry are Ellagic Acid, Cianidanol, Lupeol, Beta-sitosterol, Vitamin C and others.
Delphinidin can manipulate biochemical pathways Growth Factor Signaling, MYC Signaling and PI3K-AKT-MTOR Signaling. Quercetin has biological action on biochemical pathways Epithelial to Mesenchymal Transition, DCC Attractive Signaling and Adherens junction.
Fisetin can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Oxidative Stress and MYC Signaling. Ellagic Acid has biological action on biochemical pathways Vitamin D Signaling, Epithelial to Mesenchymal Transition and MYC Signaling. And so on.
When treating Bladder Squamous Cell Carcinoma with chemotherapy Gemcitabine – Foods like Saskatoon Berry are recommended compared to Strawberry. This is because the active ingredients Fisetin and Ellagic Acid in Strawberry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Delphinidin and Quercetin contained in Saskatoon Berry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: SASKATOON BERRY IS RECOMMENDED OVER STRAWBERRY FOR BLADDER SQUAMOUS CELL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY GEMCITABINE FOR SOME CONDITIONS.
Eat more nuts, Pistachio or Peanut?
Nuts are an important part of many diets. The active ingredients contained in Pistachio are Vitamin E, Beta-sitosterol, Resveratrol, Linolenic Acid, Stigmasterol among others. While the active ingredients contained in Peanut are Quercetin, Vitamin E, Beta-sitosterol, Vitamin C, Linolenic Acid and others.
Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Adherens junction and MYC Signaling. Vitamin E has biological action on biochemical pathways DCC Attractive Signaling, Chemokine Signaling and DNA Repair.
Citric Acid can manipulate biochemical pathways Oxidative Stress. Lecithin has biological action on biochemical pathways Chemokine Signaling, JAK-STAT Signaling and MYC Signaling. And so on.
When treating Bladder Squamous Cell Carcinoma with chemotherapy Gemcitabine – Foods like Pistachio are recommended compared to Peanut. This is because the active ingredients Citric Acid and Lecithin in Peanut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin E contained in Pistachio support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PISTACHIO IS RECOMMENDED OVER PEANUT FOR BLADDER SQUAMOUS CELL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY GEMCITABINE FOR SOME CONDITIONS.
Foods for Genetic Risk of Bladder Squamous Cell Carcinoma
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. KDM6A and ARID1A are two genes whose abnormalities are risk factors for Bladder Squamous Cell Carcinoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Bladder Squamous Cell Carcinoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Bladder Squamous Cell Carcinoma gene KDM6A has causative impact on biological pathways like Suppressive Histone Methylation. And ARID1A has a causative impact on biological pathways like Androgen Signaling and Chromatin Remodeling. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like KDM6A and ARID1A should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes KDM6A and ARID1A should be avoided.
Eat more pulses, Common Pea or Pigeon Pea?
The active ingredients contained in Common Pea are Lupeol, Beta-sitosterol, Daidzein, Vitamin C, Linolenic Acid among others. While the active ingredients contained in Pigeon Pea are Vitamin C, Linolenic Acid, Oleic Acid, Linoleic Acid, Vitamin A and others.
Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Apoptosis and MYC Signaling. Vitamin C has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.
Oleic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition. Linoleic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition. And so on.
For genetic risk of Bladder Squamous Cell Carcinoma due to abnormalities in genes KDM6A and ARID1A – Foods like Common Pea are recommended compared to Pigeon Pea. This is because the active ingredients Oleic Acid and Linoleic Acid in Pigeon Pea further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER PIGEON PEA FOR REDUCING THE GENETIC RISK OF BLADDER SQUAMOUS CELL CARCINOMA DUE TO GENES KDM6A AND ARID1A
Eat more vegetables, Arugula or Spinach?
The active ingredients contained in Arugula are Esculin, Vitamin A, Kaempferol, Vitamin K, Erysolin among others. While the active ingredients contained in Spinach are Apigenin, Beta-sitosterol, Vitamin C, Linolenic Acid, Quercetin and others.
Vitamin A can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Apoptosis and MYC Signaling. Kaempferol has biological action on biochemical pathways RAS-RAF Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.
Apigenin can manipulate biochemical pathways Epithelial to Mesenchymal Transition. Oleic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition. And so on.
For genetic risk of Bladder Squamous Cell Carcinoma due to abnormalities in genes KDM6A and ARID1A – Foods like Arugula are recommended compared to Spinach. This is because the active ingredients Apigenin and Oleic Acid in Spinach further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin A and Kaempferol contained in Arugula together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: ARUGULA IS RECOMMENDED OVER SPINACH FOR REDUCING THE GENETIC RISK OF BLADDER SQUAMOUS CELL CARCINOMA DUE TO GENES KDM6A AND ARID1A
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Feijoa or Date?
The active ingredients contained in Feijoa are Lycopene, Vitamin C, Casuarinin, Folic Acid among others. While the active ingredients contained in Date are Apigenin, Lupeol, Beta-sitosterol, Vitamin C, Protocatechuic Acid and others.
Vitamin C can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Apoptosis and MYC Signaling. Lycopene has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.
Apigenin can manipulate biochemical pathways Epithelial to Mesenchymal Transition. Oleic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition. And so on.
For genetic risk of Bladder Squamous Cell Carcinoma due to abnormalities in genes KDM6A and ARID1A – Foods like Feijoa are recommended compared to Date. This is because the active ingredients Apigenin and Oleic Acid in Date further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Lycopene contained in Feijoa together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: FEIJOA IS RECOMMENDED OVER DATE FOR REDUCING THE GENETIC RISK OF BLADDER SQUAMOUS CELL CARCINOMA DUE TO GENES KDM6A AND ARID1A
Eat more nuts, Hazelnut or Chestnut?
The active ingredients contained in Hazelnut are Vitamin E, Linolenic Acid, Quercetin, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Chestnut are Vitamin C, Linolenic Acid, Quercetin, Ellagic Acid, Oleic Acid and others.
Vitamin E can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Apoptosis and MYC Signaling. Quercetin has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.
Ellagic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition and MYC Signaling. Oleic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition. And so on.
For genetic risk of Bladder Squamous Cell Carcinoma due to abnormalities in genes KDM6A and ARID1A – Foods like Hazelnut are recommended compared to Chestnut. This is because the active ingredients Ellagic Acid and Oleic Acid in Chestnut further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin E and Quercetin contained in Hazelnut together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: HAZELNUT IS RECOMMENDED OVER CHESTNUT FOR REDUCING THE GENETIC RISK OF BLADDER SQUAMOUS CELL CARCINOMA DUE TO GENES KDM6A AND ARID1A
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Bladder Squamous Cell Carcinoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
- Msk Impact 2017
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- β-Sitosterol and Gemcitabine Exhibit Synergistic Anti-pancreatic Cancer Activity by Modulating Apoptosis and Inhibiting Epithelial-Mesenchymal Transition by Deactivating Akt/GSK-3β Signaling.
- Gamma-tocotrienol inhibits nuclear factor-kappaB signaling pathway through inhibition of receptor-interacting protein and TAK1 leading to suppression of antiapoptotic gene products and potentiation of apoptosis.
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- Lycopene metabolite, apo-10′-lycopenoic acid, inhibits diethylnitrosamine-initiated, high fat diet-promoted hepatic inflammation and tumorigenesis in mice.
- HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods.
- Fisetin: a dietary antioxidant for health promotion.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.