Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Uterine Leiomyosarcoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Uterine Leiomyosarcoma because of BRCA1 and MED12 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Uterine Leiomyosarcoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Strawberry” or “Include fruit Raspberry in my diet” or “Should I reduce consumption of vegetable Yam” or “Can I take Birch and Dim supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO UTERINE LEIOMYOSARCOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Uterine Leiomyosarcoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR UTERINE LEIOMYOSARCOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Uterine Leiomyosarcoma
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Uterine Leiomyosarcoma from cBioPortal. The patients enrolled in the studies for Uterine Leiomyosarcoma are in ages between 35 to 75 with an average age of 57.From a patient sample size of 482; the top genes with mutations and other abnormalities for Uterine Leiomyosarcoma include genes MED12, TP53, ATRX, PTEN and BRCA1. The occurrence frequency distribution for these genes respectively is 7.5%, 6.0%, 3.0%, 2.0% and 1.5%. These tumor genetic details of Uterine Leiomyosarcoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Uterine Leiomyosarcoma.
Significance of Nutrition for Uterine Leiomyosarcoma
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Uterine Leiomyosarcoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Strawberry includes active ingredients Ellagic Acid, Lupeol, Beta-sitosterol, Fisetin, Oleic Acid and others. And Raspberry contains active ingredients Ellagic Acid, Quercetin, Gallic Acid, Resveratrol, Vitamin C and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Uterine Leiomyosarcoma, activation or inhibition of selected biochemical pathways like Cell Cycle Checkpoints, Cell Cycle, PI3K-AKT-MTOR Signaling, TGFB Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Uterine Leiomyosarcoma, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR UTERINE LEIOMYOSARCOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Uterine Leiomyosarcoma undergoing chemotherapy treatment
In Uterine Leiomyosarcoma – the genes MED12, TP53, ATRX, PTEN and BRCA1 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Uterine Leiomyosarcoma are Cell Cycle Checkpoints, Cell Cycle, Apoptosis and others. Dacarbazine is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Cell Cycle Checkpoints, Cell Cycle, Apoptosis so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Common Pea or Common Bean?
Pulses are an important part of many diets. The active ingredients contained in Common Pea are Lupeol, Daidzein, Beta-sitosterol, Oleic Acid, Linolenic Acid among others. While the active ingredients contained in Common Bean are Apigenin, Esculin, Ferulic Acid, Oleic Acid, Linolenic Acid and others.
Beta-sitosterol can manipulate biochemical pathways Inositol Phosphate Signaling, NFKB Signaling and Apoptosis. Vitamin C has biological action on biochemical pathways Cell Cycle, MYC Signaling and P53 Signaling.
Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Apigenin has biological action on biochemical pathways DNA Repair and Oxidative Stress. And so on.
When treating Uterine Leiomyosarcoma with chemotherapy Dacarbazine – Foods like Common Pea are recommended compared to Common Bean. This is because the active ingredients Vitamin A and Apigenin in Common Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER COMMON BEAN FOR UTERINE LEIOMYOSARCOMA ON TREATMENT WITH CHEMOTHERAPY DACARBAZINE FOR SOME CONDITIONS.
Eat more vegetables, Jicama or Yam?
Vegetables are an important part of many diets. The active ingredients contained in Jicama are Vitamin C, Beta-carotene, Vitamin B3, Vitamin A, Folic Acid among others. While the active ingredients contained in Yam are Beta-sitosterol, Oleic Acid, Linolenic Acid, Vitamin C, Dioscin and others.
Vitamin C can manipulate biochemical pathways Apoptosis, Cell Cycle and MYC Signaling. Beta-carotene has biological action on biochemical pathways NFKB Signaling, DNA Repair and P53 Signaling.
Citric Acid can manipulate biochemical pathways Oxidative Stress. Vitamin A has biological action on biochemical pathways PI3K-AKT-MTOR Signaling. And so on.
When treating Uterine Leiomyosarcoma with chemotherapy Dacarbazine – Foods like Jicama are recommended compared to Yam. This is because the active ingredients Citric Acid and Vitamin A in Yam interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Beta-carotene contained in Jicama support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: JICAMA IS RECOMMENDED OVER YAM FOR UTERINE LEIOMYOSARCOMA ON TREATMENT WITH CHEMOTHERAPY DACARBAZINE FOR SOME CONDITIONS.
Eat more fruits, Raspberry or Strawberry?
Fruits are an important part of many diets. The active ingredients contained in Raspberry are Ellagic Acid, Quercetin, Gallic Acid, Resveratrol, Vitamin C among others. While the active ingredients contained in Strawberry are Ellagic Acid, Lupeol, Beta-sitosterol, Fisetin, Oleic Acid and others.
Ellagic Acid can manipulate biochemical pathways NFKB Signaling, Apoptosis and Chemokine Signaling. Vitamin C has biological action on biochemical pathways Cell Cycle, MYC Signaling and P53 Signaling.
Fisetin can manipulate biochemical pathways MYC Signaling and Oxidative Stress. Urolithin B has biological action on biochemical pathways Oxidative Stress. And so on.
When treating Uterine Leiomyosarcoma with chemotherapy Dacarbazine – Foods like Raspberry are recommended compared to Strawberry. This is because the active ingredients Fisetin and Urolithin B in Strawberry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Ellagic Acid and Vitamin C contained in Raspberry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: RASPBERRY IS RECOMMENDED OVER STRAWBERRY FOR UTERINE LEIOMYOSARCOMA ON TREATMENT WITH CHEMOTHERAPY DACARBAZINE FOR SOME CONDITIONS.
Eat more nuts, Hazelnut or Acorn?
Nuts are an important part of many diets. The active ingredients contained in Hazelnut are Quercetin, Vitamin E, Oleic Acid, Linolenic Acid, Linoleic Acid among others. While the active ingredients contained in Acorn are Quercetin, Beta-sitosterol, Gallic Acid, Vitamin C, Beta-carotene and others.
Quercetin can manipulate biochemical pathways Inositol Phosphate Signaling, NFKB Signaling and Apoptosis. Vitamin E has biological action on biochemical pathways Chemokine Signaling, DNA Repair and Cell Cycle.
Gallic Acid can manipulate biochemical pathways Oxidative Stress. Quercitrin has biological action on biochemical pathways Oxidative Stress. And so on.
When treating Uterine Leiomyosarcoma with chemotherapy Dacarbazine – Foods like Hazelnut are recommended compared to Acorn. This is because the active ingredients Gallic Acid and Quercitrin in Acorn interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Quercetin and Vitamin E contained in Hazelnut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: HAZELNUT IS RECOMMENDED OVER ACORN FOR UTERINE LEIOMYOSARCOMA ON TREATMENT WITH CHEMOTHERAPY DACARBAZINE FOR SOME CONDITIONS.
Foods for Genetic Risk of Uterine Leiomyosarcoma
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. BRCA1 and MED12 are two genes whose abnormalities are risk factors for Uterine Leiomyosarcoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Uterine Leiomyosarcoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Uterine Leiomyosarcoma gene BRCA1 has causative impact on biological pathways like Androgen Signaling, DNA Repair and Cell Cycle. And MED12 has a causative impact on biological pathways like TGFB Signaling and Thyroid Hormone Signaling. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like BRCA1 and MED12 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes BRCA1 and MED12 should be avoided.
Eat more pulses, Scarlet Bean or Lima Bean?
The active ingredients contained in Scarlet Bean are Beta-sitosterol, Linolenic Acid, Oleic Acid, Vitamin C, Stigmasterol among others. While the active ingredients contained in Lima Bean are Oleic Acid, Vitamin C, Genistein, Linoleic Acid, Vitamin A and others.
Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin C has biological action on biochemical pathways Cell Cycle Checkpoints, MAPK Signaling and PI3K-AKT-MTOR Signaling.
Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Linoleic Acid has biological action on biochemical pathways TGFB Signaling. And so on.
For genetic risk of Uterine Leiomyosarcoma due to abnormalities in genes BRCA1 and MED12 – Foods like Scarlet Bean are recommended compared to Lima Bean. This is because the active ingredients Vitamin A and Linoleic Acid in Lima Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin C contained in Scarlet Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER LIMA BEAN FOR REDUCING THE GENETIC RISK OF UTERINE LEIOMYOSARCOMA DUE TO GENES BRCA1 AND MED12
Eat more vegetables, Giant Butterbur or Jute?
The active ingredients contained in Giant Butterbur are Beta-sitosterol, Vitamin C, Vitamin B3, Melatonin, Kaempferol among others. While the active ingredients contained in Jute are Quercetin, Linolenic Acid, Oleic Acid, Vitamin C, Vitamin B3 and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Beta-sitosterol has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Apoptosis.
Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. And so on.
For genetic risk of Uterine Leiomyosarcoma due to abnormalities in genes BRCA1 and MED12 – Foods like Giant Butterbur are recommended compared to Jute. This is because the active ingredients Vitamin A and Folic Acid in Jute further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Giant Butterbur together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: GIANT BUTTERBUR IS RECOMMENDED OVER JUTE FOR REDUCING THE GENETIC RISK OF UTERINE LEIOMYOSARCOMA DUE TO GENES BRCA1 AND MED12
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Feijoa or Lingonberry?
The active ingredients contained in Feijoa are Lycopene, Vitamin C, Casuarinin, Folic Acid among others. While the active ingredients contained in Lingonberry are Resveratrol, Hyperoside, Quercetin, Linolenic Acid, Oleic Acid and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Lycopene has biological action on biochemical pathways Cell Cycle Checkpoints, MAPK Signaling and PI3K-AKT-MTOR Signaling.
Resveratrol can manipulate biochemical pathways P53 Signaling. Caffeic Acid has biological action on biochemical pathways TGFB Signaling. And so on.
For genetic risk of Uterine Leiomyosarcoma due to abnormalities in genes BRCA1 and MED12 – Foods like Feijoa are recommended compared to Lingonberry. This is because the active ingredients Resveratrol and Caffeic Acid in Lingonberry further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Lycopene contained in Feijoa together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: FEIJOA IS RECOMMENDED OVER LINGONBERRY FOR REDUCING THE GENETIC RISK OF UTERINE LEIOMYOSARCOMA DUE TO GENES BRCA1 AND MED12
Eat more nuts, Pine Nut or Peanut?
The active ingredients contained in Pine Nut are Vitamin E, Beta-sitosterol, Linolenic Acid, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Peanut are Vitamin E, Quercetin, Beta-sitosterol, Linolenic Acid, Oleic Acid and others.
Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin K has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and MYC Signaling.
Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Lecithin has biological action on biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Uterine Leiomyosarcoma due to abnormalities in genes BRCA1 and MED12 – Foods like Pine Nut are recommended compared to Peanut. This is because the active ingredients Vitamin A and Lecithin in Peanut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin K contained in Pine Nut together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: PINE NUT IS RECOMMENDED OVER PEANUT FOR REDUCING THE GENETIC RISK OF UTERINE LEIOMYOSARCOMA DUE TO GENES BRCA1 AND MED12
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Uterine Leiomyosarcoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
- Msk Impact 2017
- Comprehensive and Integrated Genomic Characterization of Adult Soft Tissue Sarcomas.
- β-Sitosterol targets Trx/Trx1 reductase to induce apoptosis in A549 cells via ROS mediated mitochondrial dysregulation and p53 activation.
- Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH.
- Vitamin A regulates Akt signaling through the phospholipid fatty acid composition.
- Small-molecule inhibitors of NADPH oxidase 4.
- Specific pomegranate juice components as potential inhibitors of prostate cancer metastasis.
- Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin.
- The effect of Pasteurella haemolytica cytotoxin on bovine polymorphonuclear leukocytes can be attenuated by beta-adrenoceptor antagonists.
- Colloidal aggregation causes inhibition of G protein-coupled receptors.
- Anti-IL-1 alpha autoantibodies in patients with rheumatic diseases and in healthy subjects.
- Cardioprotective effect of gallic acid on cardiac troponin-T, cardiac marker enzymes, lipid peroxidation products and antioxidants in experimentally induced myocardial infarction in Wistar rats.
- Quercetin and quercitrin protect against cytokine‑induced injuries in RINm5F β-cells via the mitochondrial pathway and NF-κB signaling.
- Activation of PPAR gamma and delta by conjugated linoleic acid mediates protection from experimental inflammatory bowel disease.
- Lycopene differentially induces quiescence and apoptosis in androgen-responsive and -independent prostate cancer cell lines.
- Resveratrol, a remarkable inhibitor of ribonucleotide reductase.
- Synthesis and structure-activity relationship analysis of caffeic acid amides as selective matrix metalloproteinase inhibitors.
- Sequential protooncogene expression in regenerating kidney following acute renal injury.
- Research progress on the anticancer effects of vitamin K2.
- The recruitment of Raf-1 to membranes is mediated by direct interaction with phosphatidic acid and is independent of association with Ras.
- HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods.
- Fisetin: a dietary antioxidant for health promotion.
- Metabolic fate of strawberry polyphenols after chronic intake in healthy older adults.
- Strawberry processing does not affect the production and urinary excretion of urolithins, ellagic acid metabolites, in humans.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.