Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like T-cell Acute Lymphoid Leukemia when undergoing chemotherapy or when you determine you have a genetic risk for developing T-cell Acute Lymphoid Leukemia because of MED12 and PIK3R1 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as T-cell Acute Lymphoid Leukemia which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Cranberry” or “Include fruit Persimmon in my diet” or “Should I reduce consumption of vegetable Bell Pepper” or “Can I take D-limonene and Modified Citrus Pectin supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO T-CELL ACUTE LYMPHOID LEUKEMIA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for T-cell Acute Lymphoid Leukemia is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR T-CELL ACUTE LYMPHOID LEUKEMIA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About T-cell Acute Lymphoid Leukemia
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for T-cell Acute Lymphoid Leukemia from cBioPortal. The patients enrolled in the studies for T-cell Acute Lymphoid Leukemia are in ages between 2 to 18 with an average age of 6. 71.8% of males and 28.2% of females were the distribution of gender in these clinical studies. From a patient sample size of 40; the top genes with mutations and other abnormalities for T-cell Acute Lymphoid Leukemia include genes KRAS, MED12, NF1, NRAS and PIK3R1. The occurrence frequency distribution for these genes respectively is 25.0%, 25.0%, 25.0%, 25.0% and 25.0%. These tumor genetic details of T-cell Acute Lymphoid Leukemia are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of T-cell Acute Lymphoid Leukemia.
Significance of Nutrition for T-cell Acute Lymphoid Leukemia
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of T-cell Acute Lymphoid Leukemia. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Cranberry includes active ingredients Ellagic Acid, Resveratrol, Myricetin, Quercetin, Vitamin C and others. And Persimmon contains active ingredients Lycopene, Lupeol, Betulinic Acid, Quercetin, Vitamin C and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like T-cell Acute Lymphoid Leukemia, activation or inhibition of selected biochemical pathways like Hippo Signaling, MAPK Signaling, RAS-RAF Signaling, PI3K-AKT-MTOR Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of T-cell Acute Lymphoid Leukemia, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR T-CELL ACUTE LYMPHOID LEUKEMIA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for T-cell Acute Lymphoid Leukemia undergoing chemotherapy treatment
In T-cell Acute Lymphoid Leukemia – the genes KRAS, MED12, NF1, NRAS and PIK3R1 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for T-cell Acute Lymphoid Leukemia are Hippo Signaling, MAPK Signaling, PI3K-AKT-MTOR Signaling and others. Cyclophosphamide is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Hippo Signaling, MAPK Signaling, PI3K-AKT-MTOR Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Winged Bean or Adzuki Bean?
Pulses are an important part of many diets. The active ingredients contained in Winged Bean are Betulinic Acid, Oleic Acid, Vitamin C, Linolenic Acid, Linoleic Acid among others. While the active ingredients contained in Adzuki Bean are Glucaric Acid, Isoliquiritigenin, Genistein, Folic Acid and others.
Betulinic Acid can manipulate biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. Vitamin C has biological action on biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling.
Genistein can manipulate biochemical pathways Hippo Signaling. Folic Acid has biological action on biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. And so on.
When treating T-cell Acute Lymphoid Leukemia with chemotherapy Cyclophosphamide – Foods like Winged Bean are recommended compared to Adzuki Bean. This is because the active ingredients Genistein and Folic Acid in Adzuki Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Betulinic Acid and Vitamin C contained in Winged Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: WINGED BEAN IS RECOMMENDED OVER ADZUKI BEAN FOR T-CELL ACUTE LYMPHOID LEUKEMIA ON TREATMENT WITH CHEMOTHERAPY CYCLOPHOSPHAMIDE FOR SOME CONDITIONS.
Eat more vegetables, Cauliflower or Bell Pepper?
Vegetables are an important part of many diets. The active ingredients contained in Cauliflower are Glucaric Acid, Oleic Acid, Sulforaphane, Vitamin C, Linolenic Acid among others. While the active ingredients contained in Bell Pepper are Vitamin E, Oleic Acid, Vitamin C, Linolenic Acid, Isorhamnetin and others.
Glucaric Acid can manipulate biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. Vitamin C has biological action on biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling.
Capsaicin can manipulate biochemical pathways MYC Signaling and MAPK Signaling. Folic Acid has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, MYC Signaling and MAPK Signaling. And so on.
When treating T-cell Acute Lymphoid Leukemia with chemotherapy Cyclophosphamide – Foods like Cauliflower are recommended compared to Bell Pepper. This is because the active ingredients Capsaicin and Folic Acid in Bell Pepper interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Glucaric Acid and Vitamin C contained in Cauliflower support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: CAULIFLOWER IS RECOMMENDED OVER BELL PEPPER FOR T-CELL ACUTE LYMPHOID LEUKEMIA ON TREATMENT WITH CHEMOTHERAPY CYCLOPHOSPHAMIDE FOR SOME CONDITIONS.
Eat more fruits, Persimmon or Cranberry?
Fruits are an important part of many diets. The active ingredients contained in Persimmon are Lycopene, Lupeol, Betulinic Acid, Quercetin, Vitamin C among others. While the active ingredients contained in Cranberry are Ellagic Acid, Resveratrol, Myricetin, Quercetin, Vitamin C and others.
Lycopene can manipulate biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. Vitamin C has biological action on biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling.
Ellagic Acid can manipulate biochemical pathways MYC Signaling. Resveratrol has biological action on biochemical pathways Hippo Signaling. And so on.
When treating T-cell Acute Lymphoid Leukemia with chemotherapy Cyclophosphamide – Foods like Persimmon are recommended compared to Cranberry. This is because the active ingredients Ellagic Acid and Resveratrol in Cranberry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Lycopene and Vitamin C contained in Persimmon support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PERSIMMON IS RECOMMENDED OVER CRANBERRY FOR T-CELL ACUTE LYMPHOID LEUKEMIA ON TREATMENT WITH CHEMOTHERAPY CYCLOPHOSPHAMIDE FOR SOME CONDITIONS.
Eat more nuts, Pine Nut or Peanut?
Nuts are an important part of many diets. The active ingredients contained in Pine Nut are Vitamin E, Oleic Acid, Beta-sitosterol, Linolenic Acid, Linoleic Acid among others. While the active ingredients contained in Peanut are Vitamin E, Oleic Acid, Quercetin, Vitamin C, Linolenic Acid and others.
Beta-sitosterol can manipulate biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. Vitamin K has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling.
Lecithin can manipulate biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. And so on.
When treating T-cell Acute Lymphoid Leukemia with chemotherapy Cyclophosphamide – Foods like Pine Nut are recommended compared to Peanut. This is because the active ingredients Lecithin and Folic Acid in Peanut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin K contained in Pine Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PINE NUT IS RECOMMENDED OVER PEANUT FOR T-CELL ACUTE LYMPHOID LEUKEMIA ON TREATMENT WITH CHEMOTHERAPY CYCLOPHOSPHAMIDE FOR SOME CONDITIONS.
Foods for Genetic Risk of T-cell Acute Lymphoid Leukemia
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. MED12 and PIK3R1 are two genes whose abnormalities are risk factors for T-cell Acute Lymphoid Leukemia. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of T-cell Acute Lymphoid Leukemia can be used as a guide for coming up with a recommended personalized nutrition plan. For T-cell Acute Lymphoid Leukemia gene MED12 has causative impact on biological pathways like TGFB Signaling and Thyroid Hormone Signaling. And PIK3R1 has a causative impact on biological pathways like Hematopoiesis and Cytokine Signaling. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like MED12 and PIK3R1 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes MED12 and PIK3R1 should be avoided.
Eat more pulses, Mung Bean or Pigeon Pea?
The active ingredients contained in Mung Bean are Quercetin, Vitamin C, Oleic Acid, Linolenic Acid, Stigmasterol among others. While the active ingredients contained in Pigeon Pea are Vitamin C, Oleic Acid, Linolenic Acid, Linoleic Acid, Genistein and others.
Quercetin can manipulate biochemical pathways Apoptosis, TGFB Signaling and MYC Signaling. Vitamin C has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.
Linoleic Acid can manipulate biochemical pathways TGFB Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. And so on.
For genetic risk of T-cell Acute Lymphoid Leukemia due to abnormalities in genes MED12 and PIK3R1 – Foods like Mung Bean are recommended compared to Pigeon Pea. This is because the active ingredients Linoleic Acid and Folic Acid in Pigeon Pea further promote the effects of genes on the biochemical pathways. While the active ingredients Quercetin and Vitamin C contained in Mung Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: MUNG BEAN IS RECOMMENDED OVER PIGEON PEA FOR REDUCING THE GENETIC RISK OF T-CELL ACUTE LYMPHOID LEUKEMIA DUE TO GENES MED12 AND PIK3R1
Eat more vegetables, Cassava or Carob?
The active ingredients contained in Cassava are Beta-sitosterol, Vitamin C, Oleic Acid, Linolenic Acid, Linoleic Acid among others. While the active ingredients contained in Carob are Quercetin, Palmitic Acid, Myricetin, Phloroglucinol, Gallic Acid and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Beta-sitosterol has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Apoptosis.
Palmitic Acid can manipulate biochemical pathways TGFB Signaling, Chromatin Remodeling and PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. And so on.
For genetic risk of T-cell Acute Lymphoid Leukemia due to abnormalities in genes MED12 and PIK3R1 – Foods like Cassava are recommended compared to Carob. This is because the active ingredients Palmitic Acid and Folic Acid in Carob further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Cassava together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: CASSAVA IS RECOMMENDED OVER CAROB FOR REDUCING THE GENETIC RISK OF T-CELL ACUTE LYMPHOID LEUKEMIA DUE TO GENES MED12 AND PIK3R1
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Feijoa or Lingonberry?
The active ingredients contained in Feijoa are Lycopene, Vitamin C, Casuarinin, Folic Acid among others. While the active ingredients contained in Lingonberry are Quercetin, Resveratrol, Hyperoside, Vitamin C, Oleic Acid and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Lycopene has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and RAS-RAF Signaling.
Resveratrol can manipulate biochemical pathways P53 Signaling. Caffeic Acid has biological action on biochemical pathways TGFB Signaling. And so on.
For genetic risk of T-cell Acute Lymphoid Leukemia due to abnormalities in genes MED12 and PIK3R1 – Foods like Feijoa are recommended compared to Lingonberry. This is because the active ingredients Resveratrol and Caffeic Acid in Lingonberry further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Lycopene contained in Feijoa together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: FEIJOA IS RECOMMENDED OVER LINGONBERRY FOR REDUCING THE GENETIC RISK OF T-CELL ACUTE LYMPHOID LEUKEMIA DUE TO GENES MED12 AND PIK3R1
Eat more nuts, Almond or Macadamia Nut?
The active ingredients contained in Almond are Quercetin, Vitamin E, Beta-sitosterol, Oleic Acid, Linolenic Acid among others. While the active ingredients contained in Macadamia Nut are Beta-sitosterol, Palmitic Acid, Lauric Acid, Myristic Acid, Folic Acid and others.
Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Quercetin has biological action on biochemical pathways TGFB Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.
Palmitic Acid can manipulate biochemical pathways TGFB Signaling, Chromatin Remodeling and PI3K-AKT-MTOR Signaling. Lauric Acid has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of T-cell Acute Lymphoid Leukemia due to abnormalities in genes MED12 and PIK3R1 – Foods like Almond are recommended compared to Macadamia Nut. This is because the active ingredients Palmitic Acid and Lauric Acid in Macadamia Nut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Quercetin contained in Almond together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: ALMOND IS RECOMMENDED OVER MACADAMIA NUT FOR REDUCING THE GENETIC RISK OF T-CELL ACUTE LYMPHOID LEUKEMIA DUE TO GENES MED12 AND PIK3R1
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for T-cell Acute Lymphoid Leukemia by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
- Pptc 2019
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- Functional lipidomics: Palmitic acid impairs hepatocellular carcinoma development by modulating membrane fluidity and glucose metabolism.
- Clinical pharmacodynamics of antihistamines.
- HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.