Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Sarcomatoid Carcinoma Of The Urinary Bladder when undergoing chemotherapy or when you determine you have a genetic risk for developing Sarcomatoid Carcinoma Of The Urinary Bladder because of ERCC2 and LATS2 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Sarcomatoid Carcinoma Of The Urinary Bladder which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Strawberry” or “Include fruit Persimmon in my diet” or “Should I reduce consumption of vegetable Radish” or “Can I take D-limonene and Stevia supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO SARCOMATOID CARCINOMA OF THE URINARY BLADDER, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Sarcomatoid Carcinoma Of The Urinary Bladder is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR SARCOMATOID CARCINOMA OF THE URINARY BLADDER, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Sarcomatoid Carcinoma Of The Urinary Bladder
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Sarcomatoid Carcinoma Of The Urinary Bladder from cBioPortal. 40.0% of males and 60.0% of females were the distribution of gender in these clinical studies. From a patient sample size of 3; the top genes with mutations and other abnormalities for Sarcomatoid Carcinoma Of The Urinary Bladder include genes ERCC2, KRAS, LATS2, RHOA and TERT. The occurrence frequency distribution for these genes respectively is 33.3%, 33.3%, 33.3%, 33.3% and 33.3%. These tumor genetic details of Sarcomatoid Carcinoma Of The Urinary Bladder are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Sarcomatoid Carcinoma Of The Urinary Bladder.
Significance of Nutrition for Sarcomatoid Carcinoma Of The Urinary Bladder
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Sarcomatoid Carcinoma Of The Urinary Bladder. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Strawberry includes active ingredients Ellagic Acid, Lupeol, Vitamin C, Oleic Acid, Beta-sitosterol and others. And Persimmon contains active ingredients Lycopene, Quercetin, Lupeol, Betulinic Acid, Vitamin C and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Sarcomatoid Carcinoma Of The Urinary Bladder, activation or inhibition of selected biochemical pathways like Netrin Signaling, MAPK Signaling, RAS-RAF Signaling, Growth Factor Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Sarcomatoid Carcinoma Of The Urinary Bladder, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR SARCOMATOID CARCINOMA OF THE URINARY BLADDER – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Sarcomatoid Carcinoma Of The Urinary Bladder undergoing chemotherapy treatment
In Sarcomatoid Carcinoma Of The Urinary Bladder – the genes ERCC2, KRAS, LATS2, RHOA and TERT have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Sarcomatoid Carcinoma Of The Urinary Bladder are Netrin Signaling, MAPK Signaling, PI3K-AKT-MTOR Signaling and others. Gemcitabine is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Netrin Signaling, MAPK Signaling, PI3K-AKT-MTOR Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Winged Bean or Common Bean?
Pulses are an important part of many diets. The active ingredients contained in Winged Bean are Betulinic Acid, Vitamin C, Oleic Acid, Linolenic Acid, Linoleic Acid among others. While the active ingredients contained in Common Bean are Apigenin, Vitamin C, Oleic Acid, Linolenic Acid, Delphinidin and others.
Betulinic Acid can manipulate biochemical pathways MYC Signaling, PI3K-AKT-MTOR Signaling and MAPK Signaling. Vitamin C has biological action on biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling.
Pelargonidin can manipulate biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. Oleic Acid has biological action on biochemical pathways Netrin Signaling. And so on.
When treating Sarcomatoid Carcinoma Of The Urinary Bladder with chemotherapy Gemcitabine – Foods like Winged Bean are recommended compared to Common Bean. This is because the active ingredients Pelargonidin and Oleic Acid in Common Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Betulinic Acid and Vitamin C contained in Winged Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: WINGED BEAN IS RECOMMENDED OVER COMMON BEAN FOR SARCOMATOID CARCINOMA OF THE URINARY BLADDER ON TREATMENT WITH CHEMOTHERAPY GEMCITABINE FOR SOME CONDITIONS.
Eat more vegetables, Cauliflower or Radish?
Vegetables are an important part of many diets. The active ingredients contained in Cauliflower are Glucaric Acid, Sulforaphane, Vitamin C, Oleic Acid, Linolenic Acid among others. While the active ingredients contained in Radish are Quercetin, Caffeic Acid, Oleic Acid, Vitamin C, Beta-sitosterol and others.
Glucaric Acid can manipulate biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. Vitamin C has biological action on biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling.
Pelargonidin can manipulate biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. Oleic Acid has biological action on biochemical pathways Netrin Signaling. And so on.
When treating Sarcomatoid Carcinoma Of The Urinary Bladder with chemotherapy Gemcitabine – Foods like Cauliflower are recommended compared to Radish. This is because the active ingredients Pelargonidin and Oleic Acid in Radish interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Glucaric Acid and Vitamin C contained in Cauliflower support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: CAULIFLOWER IS RECOMMENDED OVER RADISH FOR SARCOMATOID CARCINOMA OF THE URINARY BLADDER ON TREATMENT WITH CHEMOTHERAPY GEMCITABINE FOR SOME CONDITIONS.
Eat more fruits, Persimmon or Strawberry?
Fruits are an important part of many diets. The active ingredients contained in Persimmon are Lycopene, Quercetin, Lupeol, Betulinic Acid, Vitamin C among others. While the active ingredients contained in Strawberry are Ellagic Acid, Lupeol, Vitamin C, Oleic Acid, Beta-sitosterol and others.
Lycopene can manipulate biochemical pathways MYC Signaling, PI3K-AKT-MTOR Signaling and MAPK Signaling. Vitamin C has biological action on biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling.
Fisetin can manipulate biochemical pathways MYC Signaling. Ellagic Acid has biological action on biochemical pathways MYC Signaling. And so on.
When treating Sarcomatoid Carcinoma Of The Urinary Bladder with chemotherapy Gemcitabine – Foods like Persimmon are recommended compared to Strawberry. This is because the active ingredients Fisetin and Ellagic Acid in Strawberry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Lycopene and Vitamin C contained in Persimmon support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PERSIMMON IS RECOMMENDED OVER STRAWBERRY FOR SARCOMATOID CARCINOMA OF THE URINARY BLADDER ON TREATMENT WITH CHEMOTHERAPY GEMCITABINE FOR SOME CONDITIONS.
Eat more nuts, Walnut or Acorn?
Nuts are an important part of many diets. The active ingredients contained in Walnut are D-limonene, Ellagic Acid, Protocatechuic Acid, Quercetin, Gallic Acid among others. While the active ingredients contained in Acorn are Quercetin, Gallic Acid, Vitamin C, Beta-sitosterol, Quercitrin and others.
D-limonene can manipulate biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. Juglone has biological action on biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling.
Beta-carotene can manipulate biochemical pathways MAPK Signaling. Folic Acid has biological action on biochemical pathways MYC Signaling, PI3K-AKT-MTOR Signaling and MAPK Signaling. And so on.
When treating Sarcomatoid Carcinoma Of The Urinary Bladder with chemotherapy Gemcitabine – Foods like Walnut are recommended compared to Acorn. This is because the active ingredients Beta-carotene and Folic Acid in Acorn interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients D-limonene and Juglone contained in Walnut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: WALNUT IS RECOMMENDED OVER ACORN FOR SARCOMATOID CARCINOMA OF THE URINARY BLADDER ON TREATMENT WITH CHEMOTHERAPY GEMCITABINE FOR SOME CONDITIONS.
Foods for Genetic Risk of Sarcomatoid Carcinoma Of The Urinary Bladder
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. ERCC2 and LATS2 are two genes whose abnormalities are risk factors for Sarcomatoid Carcinoma Of The Urinary Bladder. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Sarcomatoid Carcinoma Of The Urinary Bladder can be used as a guide for coming up with a recommended personalized nutrition plan. For Sarcomatoid Carcinoma Of The Urinary Bladder gene ERCC2 has causative impact on biological pathways like DNA Repair and Chromatin Remodeling. And LATS2 has a causative impact on biological pathways like Hippo Signaling. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like ERCC2 and LATS2 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes ERCC2 and LATS2 should be avoided.
Eat more pulses, Scarlet Bean or Pigeon Pea?
The active ingredients contained in Scarlet Bean are Oleic Acid, Vitamin C, Linolenic Acid, Beta-sitosterol, Stigmasterol among others. While the active ingredients contained in Pigeon Pea are Oleic Acid, Vitamin C, Linolenic Acid, Genistein, Linoleic Acid and others.
Vitamin C can manipulate biochemical pathways MYC Signaling, P53 Signaling and Cell Cycle Checkpoints. Beta-sitosterol has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, MYC Signaling and P53 Signaling.
Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways MYC Signaling, P53 Signaling and Cell Cycle Checkpoints. And so on.
For genetic risk of Sarcomatoid Carcinoma Of The Urinary Bladder due to abnormalities in genes ERCC2 and LATS2 – Foods like Scarlet Bean are recommended compared to Pigeon Pea. This is because the active ingredients Vitamin A and Folic Acid in Pigeon Pea further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Scarlet Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER PIGEON PEA FOR REDUCING THE GENETIC RISK OF SARCOMATOID CARCINOMA OF THE URINARY BLADDER DUE TO GENES ERCC2 AND LATS2
Eat more vegetables, Jicama or Endive?
The active ingredients contained in Jicama are Vitamin C, Vitamin B3, Beta-carotene, Vitamin A, Folic Acid among others. While the active ingredients contained in Endive are Quercetin, Kaempferol, Oleic Acid, Vitamin C, Linolenic Acid and others.
Vitamin C can manipulate biochemical pathways MYC Signaling, P53 Signaling and Cell Cycle Checkpoints. Vitamin B3 has biological action on biochemical pathways DNA Repair, PI3K-AKT-MTOR Signaling and Hypoxia.
Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways MYC Signaling, P53 Signaling and Cell Cycle Checkpoints. And so on.
For genetic risk of Sarcomatoid Carcinoma Of The Urinary Bladder due to abnormalities in genes ERCC2 and LATS2 – Foods like Jicama are recommended compared to Endive. This is because the active ingredients Vitamin A and Folic Acid in Endive further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Vitamin B3 contained in Jicama together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: JICAMA IS RECOMMENDED OVER ENDIVE FOR REDUCING THE GENETIC RISK OF SARCOMATOID CARCINOMA OF THE URINARY BLADDER DUE TO GENES ERCC2 AND LATS2
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Kiwi or Blackberry?
The active ingredients contained in Kiwi are Quercetin, Vitamin C, Fisetin, Chlorogenic Acid, Vitamin A among others. While the active ingredients contained in Blackberry are Quercetin, Ellagic Acid, Kaempferol, Myricetin, Cianidanol and others.
Vitamin C can manipulate biochemical pathways MYC Signaling, P53 Signaling and Cell Cycle Checkpoints. Quercetin has biological action on biochemical pathways MAPK Signaling, PI3K-AKT-MTOR Signaling and Hypoxia.
Scopoletin can manipulate biochemical pathways MYC Signaling and DNA Repair. Ellagic Acid has biological action on biochemical pathways MYC Signaling. And so on.
For genetic risk of Sarcomatoid Carcinoma Of The Urinary Bladder due to abnormalities in genes ERCC2 and LATS2 – Foods like Kiwi are recommended compared to Blackberry. This is because the active ingredients Scopoletin and Ellagic Acid in Blackberry further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Quercetin contained in Kiwi together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: KIWI IS RECOMMENDED OVER BLACKBERRY FOR REDUCING THE GENETIC RISK OF SARCOMATOID CARCINOMA OF THE URINARY BLADDER DUE TO GENES ERCC2 AND LATS2
Eat more nuts, Pine Nut or Peanut?
The active ingredients contained in Pine Nut are Oleic Acid, Vitamin E, Linolenic Acid, Beta-sitosterol, Linoleic Acid among others. While the active ingredients contained in Peanut are Quercetin, Oleic Acid, Vitamin E, Vitamin C, Linolenic Acid and others.
Beta-sitosterol can manipulate biochemical pathways MYC Signaling, P53 Signaling and Cell Cycle Checkpoints. Vitamin K has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, MYC Signaling and Cell Cycle Checkpoints.
Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Lecithin has biological action on biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Sarcomatoid Carcinoma Of The Urinary Bladder due to abnormalities in genes ERCC2 and LATS2 – Foods like Pine Nut are recommended compared to Peanut. This is because the active ingredients Vitamin A and Lecithin in Peanut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin K contained in Pine Nut together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: PINE NUT IS RECOMMENDED OVER PEANUT FOR REDUCING THE GENETIC RISK OF SARCOMATOID CARCINOMA OF THE URINARY BLADDER DUE TO GENES ERCC2 AND LATS2
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Sarcomatoid Carcinoma Of The Urinary Bladder by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
- Msk Impact 2017
- Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients.
- Cryptorchidism: a pediatrician’s view.
- Vitamin C enhances epigenetic modifications induced by 5-azacytidine and cell cycle arrest in the hepatocellular carcinoma cell lines HLE and Huh7.
- Pelargonidin reduces the TPA induced transformation of mouse epidermal cells -potential involvement of Nrf2 promoter demethylation.
- Oleic acid-induced ANGPTL4 enhances head and neck squamous cell carcinoma anoikis resistance and metastasis via up-regulation of fibronectin.
- Lycopene differentially induces quiescence and apoptosis in androgen-responsive and -independent prostate cancer cell lines.
- Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin.
- Identification of ellagic acid as potent inhibitor of protein kinase CK2: a successful example of a virtual screening application.
- Preventive effects of butyric acid, nicotinamide, calcium glucarate alone or in combination during the 7, 12-dimethylbenz (a) anthracene induced mouse skin tumorigenesis via modulation of K-Ras-PI3K-AKTpathway and associated micro RNAs.
- D-Limonene modulates inflammation, oxidative stress and Ras-ERK pathway to inhibit murine skin tumorigenesis.
- Mechanism of Juglone-Induced Cell Cycle Arrest and Apoptosis in Ishikawa Human Endometrial Cancer Cells.
- Growth stimulation of human pulmonary adenocarcinoma cells and small airway epithelial cells by beta-carotene via activation of cAMP, PKA, CREB and ERK1/2.
- Effects of folate deficiency on gene expression in the apoptosis and cancer pathways in colon cancer cells.
- β-Sitosterol targets Trx/Trx1 reductase to induce apoptosis in A549 cells via ROS mediated mitochondrial dysregulation and p53 activation.
- Vitamin A regulates Akt signaling through the phospholipid fatty acid composition.
- The endoperoxide ascaridol shows strong differential cytotoxicity in nucleotide excision repair-deficient cells.
- Concurrent acetylation of FoxO1/3a and p53 due to sirtuins inhibition elicit Bim/PUMA mediated mitochondrial dysfunction and apoptosis in berberine-treated HepG2 cells.
- Research progress on the anticancer effects of vitamin K2.
- The recruitment of Raf-1 to membranes is mediated by direct interaction with phosphatidic acid and is independent of association with Ras.
- HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods.
- Fisetin: a dietary antioxidant for health promotion.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.