Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Salivary Duct Carcinoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Salivary Duct Carcinoma because of KDM5A and BRCA2 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Salivary Duct Carcinoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Currant” or “Include fruit Nance in my diet” or “Should I reduce consumption of vegetable Beetroot” or “Can I take Curcumin and Dim supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO SALIVARY DUCT CARCINOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Salivary Duct Carcinoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR SALIVARY DUCT CARCINOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Salivary Duct Carcinoma
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Salivary Duct Carcinoma from cBioPortal. The patients enrolled in the studies for Salivary Duct Carcinoma are in ages between 49 to 77 with an average age of 70. 45.8% of males and 54.2% of females were the distribution of gender in these clinical studies. From a patient sample size of 27; the top genes with mutations and other abnormalities for Salivary Duct Carcinoma include genes ARID1A, KDM5A, BRCA2, MAP2K4 and MST1R. The occurrence frequency distribution for these genes respectively is 16.7%, 16.7%, 16.7%, 16.7% and 16.7%. These tumor genetic details of Salivary Duct Carcinoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Salivary Duct Carcinoma.
Significance of Nutrition for Salivary Duct Carcinoma
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Salivary Duct Carcinoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Currant includes active ingredients Cianidanol, Linolenic Acid, Beta-sitosterol, Quercetin, Vitamin C and others. And Nance contains active ingredients Vitamin C, Betulin, Vitamin A and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Salivary Duct Carcinoma, activation or inhibition of selected biochemical pathways like MAPK Signaling, Apoptosis, DNA Repair, Epithelial to Mesenchymal Transition plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Salivary Duct Carcinoma, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR SALIVARY DUCT CARCINOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Salivary Duct Carcinoma undergoing chemotherapy treatment
In Salivary Duct Carcinoma – the genes ARID1A, KDM5A, BRCA2, MAP2K4 and MST1R have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Salivary Duct Carcinoma are MAPK Signaling, Apoptosis, DNA Repair and others. Carboplatin is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers MAPK Signaling, Apoptosis, DNA Repair so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Common Pea or Fava Bean?
Pulses are an important part of many diets. The active ingredients contained in Common Pea are Lupeol, Daidzein, Linolenic Acid, Beta-sitosterol, Vitamin C among others. While the active ingredients contained in Fava Bean are Cianidanol, Daidzein, Linolenic Acid, Beta-sitosterol, Quercetin and others.
Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and WNT Beta Catenin Signaling. Vitamin C has biological action on biochemical pathways P53 Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling.
Cianidanol can manipulate biochemical pathways Oxidative Stress. Quercetin has biological action on biochemical pathways Oxidative Stress. And so on.
When treating Salivary Duct Carcinoma with chemotherapy Carboplatin – Foods like Common Pea are recommended compared to Fava Bean. This is because the active ingredients Cianidanol and Quercetin in Fava Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER FAVA BEAN FOR SALIVARY DUCT CARCINOMA ON TREATMENT WITH CHEMOTHERAPY CARBOPLATIN FOR SOME CONDITIONS.
Eat more vegetables, Cabbage or Beetroot?
Vegetables are an important part of many diets. The active ingredients contained in Cabbage are Benzyl Isothiocyanate, Beta-sitosterol, Quercetin, Vitamin C, Brassinin among others. While the active ingredients contained in Beetroot are Linolenic Acid, Vitamin E, Beta-sitosterol, Vitamin C, Oleic Acid and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and WNT Beta Catenin Signaling. Glucaric Acid has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, MYC Signaling and Apoptosis.
Vitamin E can manipulate biochemical pathways Oxidative Stress. Citric Acid has biological action on biochemical pathways Oxidative Stress. And so on.
When treating Salivary Duct Carcinoma with chemotherapy Carboplatin – Foods like Cabbage are recommended compared to Beetroot. This is because the active ingredients Vitamin E and Citric Acid in Beetroot interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Glucaric Acid contained in Cabbage support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: CABBAGE IS RECOMMENDED OVER BEETROOT FOR SALIVARY DUCT CARCINOMA ON TREATMENT WITH CHEMOTHERAPY CARBOPLATIN FOR SOME CONDITIONS.
Eat more fruits, Nance or Currant?
Fruits are an important part of many diets. The active ingredients contained in Nance are Vitamin C, Betulin, Vitamin A among others. While the active ingredients contained in Currant are Cianidanol, Linolenic Acid, Beta-sitosterol, Quercetin, Vitamin C and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and WNT Beta Catenin Signaling. Betulin has biological action on biochemical pathways MAPK Signaling, PI3K-AKT-MTOR Signaling and Oxidative Stress.
Cianidanol can manipulate biochemical pathways Oxidative Stress. Gamma-linolenic Acid has biological action on biochemical pathways Oxidative Stress. And so on.
When treating Salivary Duct Carcinoma with chemotherapy Carboplatin – Foods like Nance are recommended compared to Currant. This is because the active ingredients Cianidanol and Gamma-linolenic Acid in Currant interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Betulin contained in Nance support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: NANCE IS RECOMMENDED OVER CURRANT FOR SALIVARY DUCT CARCINOMA ON TREATMENT WITH CHEMOTHERAPY CARBOPLATIN FOR SOME CONDITIONS.
Eat more nuts, Pistachio or Peanut?
Nuts are an important part of many diets. The active ingredients contained in Pistachio are Linolenic Acid, Vitamin E, Beta-sitosterol, Stigmasterol, Oleic Acid among others. While the active ingredients contained in Peanut are Linolenic Acid, Vitamin E, Beta-sitosterol, Quercetin, Vitamin C and others.
Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and WNT Beta Catenin Signaling. Stigmasterol has biological action on biochemical pathways JAK-STAT Signaling, P53 Signaling and MAPK Signaling.
Quercetin can manipulate biochemical pathways Oxidative Stress. Citric Acid has biological action on biochemical pathways Oxidative Stress. And so on.
When treating Salivary Duct Carcinoma with chemotherapy Carboplatin – Foods like Pistachio are recommended compared to Peanut. This is because the active ingredients Quercetin and Citric Acid in Peanut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Stigmasterol contained in Pistachio support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PISTACHIO IS RECOMMENDED OVER PEANUT FOR SALIVARY DUCT CARCINOMA ON TREATMENT WITH CHEMOTHERAPY CARBOPLATIN FOR SOME CONDITIONS.
Foods for Genetic Risk of Salivary Duct Carcinoma
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. KDM5A and BRCA2 are two genes whose abnormalities are risk factors for Salivary Duct Carcinoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Salivary Duct Carcinoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Salivary Duct Carcinoma gene KDM5A has causative impact on biological pathways like Oncogenic Histone Methylation. And BRCA2 has a causative impact on biological pathways like DNA Repair and DNA Repair. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like KDM5A and BRCA2 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes KDM5A and BRCA2 should be avoided.
Eat more pulses, Scarlet Bean or Lima Bean?
The active ingredients contained in Scarlet Bean are Linolenic Acid, Vitamin C, Oleic Acid, Beta-sitosterol, Stigmasterol among others. While the active ingredients contained in Lima Bean are Vitamin C, Oleic Acid, Linoleic Acid, Genistein, Vitamin A and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Beta-sitosterol has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Apoptosis.
Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. And so on.
For genetic risk of Salivary Duct Carcinoma due to abnormalities in genes KDM5A and BRCA2 – Foods like Scarlet Bean are recommended compared to Lima Bean. This is because the active ingredients Vitamin A and Folic Acid in Lima Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Scarlet Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER LIMA BEAN FOR REDUCING THE GENETIC RISK OF SALIVARY DUCT CARCINOMA DUE TO GENES KDM5A AND BRCA2
Eat more vegetables, Cassava or Celery?
The active ingredients contained in Cassava are Linolenic Acid, Vitamin C, Oleic Acid, Beta-sitosterol, Linoleic Acid among others. While the active ingredients contained in Celery are Apigenin, Quercetin, Linolenic Acid, Kaempferol, Vitamin C and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Beta-sitosterol has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Apoptosis.
Luteolin can manipulate biochemical pathways MYC Signaling. Chrysin has biological action on biochemical pathways MYC Signaling. And so on.
For genetic risk of Salivary Duct Carcinoma due to abnormalities in genes KDM5A and BRCA2 – Foods like Cassava are recommended compared to Celery. This is because the active ingredients Luteolin and Chrysin in Celery further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Cassava together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: CASSAVA IS RECOMMENDED OVER CELERY FOR REDUCING THE GENETIC RISK OF SALIVARY DUCT CARCINOMA DUE TO GENES KDM5A AND BRCA2
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Feijoa or Cranberry?
The active ingredients contained in Feijoa are Lycopene, Vitamin C, Casuarinin, Folic Acid among others. While the active ingredients contained in Cranberry are Quercetin, Resveratrol, Ellagic Acid, Vitamin C, Myricetin and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Lycopene has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Hypoxia.
Quercetin can manipulate biochemical pathways DNA Repair. Resveratrol has biological action on biochemical pathways P53 Signaling. And so on.
For genetic risk of Salivary Duct Carcinoma due to abnormalities in genes KDM5A and BRCA2 – Foods like Feijoa are recommended compared to Cranberry. This is because the active ingredients Quercetin and Resveratrol in Cranberry further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Lycopene contained in Feijoa together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: FEIJOA IS RECOMMENDED OVER CRANBERRY FOR REDUCING THE GENETIC RISK OF SALIVARY DUCT CARCINOMA DUE TO GENES KDM5A AND BRCA2
Eat more nuts, Pine Nut or Acorn?
The active ingredients contained in Pine Nut are Vitamin E, Linolenic Acid, Oleic Acid, Beta-sitosterol, Linoleic Acid among others. While the active ingredients contained in Acorn are Quercetin, Vitamin C, Beta-sitosterol, Vitamin B3, Quercitrin and others.
Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin K has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and MYC Signaling.
Quercetin can manipulate biochemical pathways DNA Repair. Beta-carotene has biological action on biochemical pathways PI3K-AKT-MTOR Signaling and DNA Repair. And so on.
For genetic risk of Salivary Duct Carcinoma due to abnormalities in genes KDM5A and BRCA2 – Foods like Pine Nut are recommended compared to Acorn. This is because the active ingredients Quercetin and Beta-carotene in Acorn further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin K contained in Pine Nut together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: PINE NUT IS RECOMMENDED OVER ACORN FOR REDUCING THE GENETIC RISK OF SALIVARY DUCT CARCINOMA DUE TO GENES KDM5A AND BRCA2
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Salivary Duct Carcinoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
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- Stigmasterol exhibits potent antitumor effects in human gastric cancer cells mediated via inhibition of cell migration, cell cycle arrest, mitochondrial mediated apoptosis and inhibition of JAK/STAT signalling pathway.
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- Resveratrol, a remarkable inhibitor of ribonucleotide reductase.
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- The effect of Pasteurella haemolytica cytotoxin on bovine polymorphonuclear leukocytes can be attenuated by beta-adrenoceptor antagonists.
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Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.