Foods for Perivascular Epithelioid Cell Tumor!

Introduction

Foods for Perivascular Epithelioid Cell Tumor should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.

Perivascular Epithelioid Cell Tumor (PEComa) is a unique type of tumor that originates from the perivascular epithelioid cells. This rare condition is characterized by a variety of pathological and radiological features, making its diagnosis and treatment challenging. According to ICD-10 classification, Perivascular Epithelioid Cell Tumors fall under a specific category due to their distinct nature. These tumors can be found in various parts of the body, including the uterus (uterine PEComa), bone, and endometrial regions. The survival rate for patients with PEComa can vary depending on several factors, including the location and malignancy of the tumor. Malignant Perivascular Epithelioid Cell Tumors represent a more aggressive form of this disease and require a different approach in terms of treatment and management. Everolimus has been studied as a potential treatment option for PEComa, showing promise in certain cases. Additionally, benign forms of this tumor also exist, which may have a more favorable prognosis compared to their malignant counterparts. Pathology outlines for PEComa are crucial for proper diagnosis and to guide appropriate treatment strategies.

For Perivascular Epithelioid Cell Tumor does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Perivascular Epithelioid Cell Tumor does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Perivascular Epithelioid Cell Tumor?

For example does it matter if vegetable New Zealand Spinach is consumed more compared to Mountain Yam? Does it make any difference if fruit Jostaberry is preferred over Rabbiteye Blueberry? Also if similar choices are made for nuts/seeds like Butternut over Japanese Chestnut and for pulses like Moth Bean over Adzuki Bean. And if what I eat matters – then how does one identify foods which are recommended for Perivascular Epithelioid Cell Tumor and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Perivascular Epithelioid Cell Tumor!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Jostaberry contains active ingredients Apigenin, Luteolin, Kaempferol, Isoliquiritigenin, Myricetin. And Rabbiteye Blueberry contains active ingredients Quercetin, Gallic Acid, Ferulic Acid, Epicatechin, Eugenol and possibly others.

A common mistake made when deciding and choosing foods to eat for Perivascular Epithelioid Cell Tumor – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Perivascular Epithelioid Cell Tumor.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Perivascular Epithelioid Cell Tumor?

Personalized nutrition for cancers like Perivascular Epithelioid Cell Tumor consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Perivascular Epithelioid Cell Tumor biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Characteristics of cancers like Perivascular Epithelioid Cell Tumor

All cancers like Perivascular Epithelioid Cell Tumor can be characterized by a unique set of biochemical pathways – the signature pathways of Perivascular Epithelioid Cell Tumor. Biochemical pathways like Cell Cycle Checkpoints, DNA Repair, PI3K-AKT-MTOR Signaling, Apoptosis are part of the signature definition of Perivascular Epithelioid Cell Tumor. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Perivascular Epithelioid Cell Tumor need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Perivascular Epithelioid Cell Tumor when taking cancer treatment Ifosfamide, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

TSC2, TP53, TERT, TSC1 and ATRX are the top ranked reported genes for Perivascular Epithelioid Cell Tumor. TSC2 is reported in 18.8 % of the representative patients across all clinical trials. And TP53 is reported in 12.5 %. The combined population patient data cover ages from to . 30.3 % of the patient data are identified as men. The Perivascular Epithelioid Cell Tumor biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Food and Supplements for Perivascular Epithelioid Cell Tumor

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable NEW ZEALAND SPINACH or MOUNTAIN YAM?

Vegetable New Zealand Spinach contains many active ingredients or bioactives such as Quercetin, Apigenin, Luteolin, Kaempferol, Beta-carotene. These active ingredients manipulate various biochemical pathways like DNA Repair, JAK-STAT Signaling and Cell Cycle Checkpoints and others. New Zealand Spinach is recommended for Perivascular Epithelioid Cell Tumor when ongoing cancer treatment is Ifosfamide. This is because New Zealand Spinach modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Ifosfamide.

Some of the active ingredients or bioactives in vegetable Mountain Yam are Apigenin, Luteolin, Kaempferol, Beta-carotene, Isoliquiritigenin. These active ingredients manipulate various biochemical pathways like DNA Repair and Cell Cycle Checkpoints and others. Mountain Yam is not recommended for Perivascular Epithelioid Cell Tumor when ongoing cancer treatment is Ifosfamide because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE NEW ZEALAND SPINACH IS RECOMMENDED OVER MOUNTAIN YAM FOR Perivascular Epithelioid Cell Tumor AND TREATMENT Ifosfamide.

Choose Fruit RABBITEYE BLUEBERRY or JOSTABERRY?

Fruit Rabbiteye Blueberry contains many active ingredients or bioactives such as Quercetin, Gallic Acid, Ferulic Acid, Epicatechin, Eugenol. These active ingredients manipulate various biochemical pathways like DNA Repair and Cell Cycle Checkpoints and others. Rabbiteye Blueberry is recommended for Perivascular Epithelioid Cell Tumor when ongoing cancer treatment is Ifosfamide. This is because Rabbiteye Blueberry modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Ifosfamide.

Some of the active ingredients or bioactives in fruit Jostaberry are Apigenin, Luteolin, Kaempferol, Isoliquiritigenin, Myricetin. These active ingredients manipulate various biochemical pathways like DNA Repair and Cell Cycle Checkpoints and others. Jostaberry is not recommended for Perivascular Epithelioid Cell Tumor when ongoing cancer treatment is Ifosfamide because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT RABBITEYE BLUEBERRY IS RECOMMENDED OVER JOSTABERRY FOR Perivascular Epithelioid Cell Tumor AND TREATMENT Ifosfamide.

Choose Nut BUTTERNUT or JAPANESE CHESTNUT?

Butternut contains many active ingredients or bioactives such as Apigenin, Luteolin, Kaempferol, Isoliquiritigenin, Myricetin. These active ingredients manipulate various biochemical pathways like JAK-STAT Signaling and Cell Cycle Checkpoints and others. Butternut is recommended for Perivascular Epithelioid Cell Tumor when ongoing cancer treatment is Ifosfamide. This is because Butternut modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Ifosfamide.

Some of the active ingredients or bioactives in Japanese Chestnut are Apigenin, Luteolin, Kaempferol, Isoliquiritigenin, Myricetin. These active ingredients manipulate various biochemical pathways like DNA Repair and Cell Cycle Checkpoints and others. Japanese Chestnut is not recommended for Perivascular Epithelioid Cell Tumor when ongoing cancer treatment is Ifosfamide because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

BUTTERNUT IS RECOMMENDED OVER JAPANESE CHESTNUT FOR Perivascular Epithelioid Cell Tumor AND TREATMENT Ifosfamide.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Perivascular Epithelioid Cell Tumor or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable GIANT BUTTERBUR or AGAVE?

Vegetable Giant Butterbur contains many active ingredients or bioactives such as Curcumin, Apigenin, Formononetin, Lupeol, Catechol. These active ingredients manipulate various biochemical pathways like Hypoxia, P53 Signaling, Nutrient sensing and MYC Signaling and others. Giant Butterbur is recommended for risk of Perivascular Epithelioid Cell Tumor when associated genetic risk is ATRX. This is because Giant Butterbur increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Agave are Curcumin, Apigenin, Formononetin, Lupeol, Catechol. These active ingredients manipulate various biochemical pathways like PI3K-AKT-MTOR Signaling and Oncogenic Cancer Epigenetics and others. Agave is not recommended when risk of Perivascular Epithelioid Cell Tumor when associated genetic risk is ATRX because it increases the signature pathways of it.

VEGETABLE GIANT BUTTERBUR IS RECOMMENDED OVER AGAVE FOR ATRX GENETIC RISK OF CANCER.

Choose Fruit JAVA PLUM or PUMMELO?

Fruit Java Plum contains many active ingredients or bioactives such as Curcumin, Apigenin, Formononetin, Lupeol, Ellagic Acid. These active ingredients manipulate various biochemical pathways like P53 Signaling, Nutrient sensing, Angiogenesis and MYC Signaling and others. Java Plum is recommended for risk of Perivascular Epithelioid Cell Tumor when associated genetic risk is ATRX. This is because Java Plum increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Pummelo are Curcumin, Apigenin, Quercetin, Formononetin, Lupeol. These active ingredients manipulate various biochemical pathways like PI3K-AKT-MTOR Signaling and Cell Cycle Checkpoints and others. Pummelo is not recommended when risk of Perivascular Epithelioid Cell Tumor when associated genetic risk is ATRX because it increases the signature pathways of it.

FRUIT JAVA PLUM IS RECOMMENDED OVER PUMMELO FOR ATRX GENETIC RISK OF CANCER.

Choose Nut COMMON WALNUT or CHESTNUT?

Common Walnut contains many active ingredients or bioactives such as Curcumin, Quercetin, Formononetin, Lupeol, Ellagic Acid. These active ingredients manipulate various biochemical pathways like Hypoxia, P53 Signaling, Angiogenesis and Cell Cycle Checkpoints and others. Common Walnut is recommended for risk of Perivascular Epithelioid Cell Tumor when associated genetic risk is ATRX. This is because Common Walnut increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in Chestnut are Curcumin, Apigenin, Formononetin, Lupeol, Ellagic Acid. These active ingredients manipulate various biochemical pathways like Stem Cell Signaling and Cell Cycle Checkpoints and others. Chestnut is not recommended when risk of Perivascular Epithelioid Cell Tumor when associated genetic risk is ATRX because it increases the signature pathways of it.

COMMON WALNUT IS RECOMMENDED OVER CHESTNUT FOR ATRX GENETIC RISK OF CANCER.

In Conclusion

Foods and Supplements chosen are important decisions for cancers like Perivascular Epithelioid Cell Tumor. Perivascular Epithelioid Cell Tumor patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Perivascular Epithelioid Cell Tumor, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like New Zealand Spinach contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Perivascular Epithelioid Cell Tumor?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.

References

• Msk Impact 2017
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• Eriodictyol exerts potent anticancer activity against A549 human lung cancer cell line by inducing mitochondrial-mediated apoptosis, G2/M cell cycle arrest and inhibition of m-TOR/PI3K/Akt signalling pathway.
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• Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH.