Which Foods are Recommended for Perivascular Epithelioid Cell Tumor?

Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Perivascular Epithelioid Cell Tumor when undergoing chemotherapy or when you determine you have a genetic risk for developing Perivascular Epithelioid Cell Tumor because of TSC2 and TSC1 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Perivascular Epithelioid Cell Tumor which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Peach” or “Include fruit Pomegranate in my diet” or “Should I reduce consumption of vegetable Radish” or “Can I take Diosmin and Mayapple supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO PERIVASCULAR EPITHELIOID CELL TUMOR, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Perivascular Epithelioid Cell Tumor is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR PERIVASCULAR EPITHELIOID CELL TUMOR, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.

About Perivascular Epithelioid Cell Tumor

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Perivascular Epithelioid Cell Tumor from cBioPortal. 30.3% of males and 69.7% of females were the distribution of gender in these clinical studies. From a patient sample size of 34; the top genes with mutations and other abnormalities for Perivascular Epithelioid Cell Tumor include genes TSC2, TP53, TERT, TSC1 and ATRX. The occurrence frequency distribution for these genes respectively is 18.8%, 12.5%, 12.5%, 12.5% and 12.5%. These tumor genetic details of Perivascular Epithelioid Cell Tumor are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Perivascular Epithelioid Cell Tumor.

Significance of Nutrition for Perivascular Epithelioid Cell Tumor

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Perivascular Epithelioid Cell Tumor. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Peach includes active ingredients Kaempferol, Beta-sitosterol, Oleic Acid, Vitamin C, Linolenic Acid and others. And Pomegranate contains active ingredients Apigenin, Betulinic Acid, Beta-sitosterol, Ellagic Acid, Vitamin C and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Perivascular Epithelioid Cell Tumor, activation or inhibition of selected biochemical pathways like JAK-STAT Signaling, DNA Repair, PI3K-AKT-MTOR Signaling, Apoptosis plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Perivascular Epithelioid Cell Tumor, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR PERIVASCULAR EPITHELIOID CELL TUMOR – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Perivascular Epithelioid Cell Tumor undergoing chemotherapy treatment

In Perivascular Epithelioid Cell Tumor – the genes TSC2, TP53, TERT, TSC1 and ATRX have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Perivascular Epithelioid Cell Tumor are JAK-STAT Signaling, DNA Repair, PI3K-AKT-MTOR Signaling and others. Gemcitabine is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers JAK-STAT Signaling, DNA Repair, PI3K-AKT-MTOR Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Mung Bean or Common Bean?

Pulses are an important part of many diets. The active ingredients contained in Mung Bean are Quercetin, Kaempferol, Oleic Acid, Linolenic Acid, Vitamin C among others. While the active ingredients contained in Common Bean are Apigenin, Kaempferol, Esculin, Oleic Acid, P-coumaric Acid and others.

Quercetin can manipulate biochemical pathways DNA Repair, JAK-STAT Signaling and TGFB Signaling. Kaempferol has biological action on biochemical pathways PI3K-AKT-MTOR Signaling and JAK-STAT Signaling.

Apigenin can manipulate biochemical pathways DNA Repair and TGFB Signaling. Esculin has biological action on biochemical pathways DNA Repair and TGFB Signaling. And so on.

When treating Perivascular Epithelioid Cell Tumor with chemotherapy Gemcitabine – Foods like Mung Bean are recommended compared to Common Bean. This is because the active ingredients Apigenin and Esculin in Common Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Quercetin and Kaempferol contained in Mung Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: MUNG BEAN IS RECOMMENDED OVER COMMON BEAN FOR PERIVASCULAR EPITHELIOID CELL TUMOR ON TREATMENT WITH CHEMOTHERAPY GEMCITABINE FOR SOME CONDITIONS.

Eat more vegetables, Arrowroot or Radish?

Vegetables are an important part of many diets. The active ingredients contained in Arrowroot are Quercetin, Beta-carotene, Protocatechuic Acid, Vitamin C, Chlorogenic Acid among others. While the active ingredients contained in Radish are Quercetin, Kaempferol, Beta-sitosterol, Oleic Acid, Linolenic Acid and others.

Quercetin can manipulate biochemical pathways DNA Repair, JAK-STAT Signaling and TGFB Signaling. Beta-carotene has biological action on biochemical pathways MYC Signaling, P53 Signaling and PI3K-AKT-MTOR Signaling.

Pelargonidin can manipulate biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. Caffeic Acid has biological action on biochemical pathways TGFB Signaling. And so on.

When treating Perivascular Epithelioid Cell Tumor with chemotherapy Gemcitabine – Foods like Arrowroot are recommended compared to Radish. This is because the active ingredients Pelargonidin and Caffeic Acid in Radish interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Quercetin and Beta-carotene contained in Arrowroot support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: ARROWROOT IS RECOMMENDED OVER RADISH FOR PERIVASCULAR EPITHELIOID CELL TUMOR ON TREATMENT WITH CHEMOTHERAPY GEMCITABINE FOR SOME CONDITIONS.

Eat more fruits, Pomegranate or Peach?

Fruits are an important part of many diets. The active ingredients contained in Pomegranate are Apigenin, Betulinic Acid, Beta-sitosterol, Ellagic Acid, Vitamin C among others. While the active ingredients contained in Peach are Kaempferol, Beta-sitosterol, Oleic Acid, Vitamin C, Linolenic Acid and others.

Betulinic Acid can manipulate biochemical pathways MYC Signaling, P53 Signaling and JAK-STAT Signaling. Gallic Acid has biological action on biochemical pathways DNA Repair, PI3K-AKT-MTOR Signaling and TGFB Signaling.

Caffeic Acid can manipulate biochemical pathways TGFB Signaling. Fisetin has biological action on biochemical pathways MYC Signaling. And so on.

When treating Perivascular Epithelioid Cell Tumor with chemotherapy Gemcitabine – Foods like Pomegranate are recommended compared to Peach. This is because the active ingredients Caffeic Acid and Fisetin in Peach interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Betulinic Acid and Gallic Acid contained in Pomegranate support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: POMEGRANATE IS RECOMMENDED OVER PEACH FOR PERIVASCULAR EPITHELIOID CELL TUMOR ON TREATMENT WITH CHEMOTHERAPY GEMCITABINE FOR SOME CONDITIONS.

Eat more nuts, Almond or Peanut?

Nuts are an important part of many diets. The active ingredients contained in Almond are Quercetin, Vitamin E, Beta-sitosterol, Oleic Acid, Linolenic Acid among others. While the active ingredients contained in Peanut are Quercetin, Vitamin E, Beta-sitosterol, Oleic Acid, Linolenic Acid and others.

Beta-sitosterol can manipulate biochemical pathways MYC Signaling, P53 Signaling and PI3K-AKT-MTOR Signaling. Quercetin has biological action on biochemical pathways DNA Repair, JAK-STAT Signaling and TGFB Signaling.

Lecithin can manipulate biochemical pathways MYC Signaling, JAK-STAT Signaling and PI3K-AKT-MTOR Signaling. Linoleic Acid has biological action on biochemical pathways TGFB Signaling. And so on.

When treating Perivascular Epithelioid Cell Tumor with chemotherapy Gemcitabine – Foods like Almond are recommended compared to Peanut. This is because the active ingredients Lecithin and Linoleic Acid in Peanut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Quercetin contained in Almond support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: ALMOND IS RECOMMENDED OVER PEANUT FOR PERIVASCULAR EPITHELIOID CELL TUMOR ON TREATMENT WITH CHEMOTHERAPY GEMCITABINE FOR SOME CONDITIONS.

Foods for Genetic Risk of Perivascular Epithelioid Cell Tumor

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. TSC2 and TSC1 are two genes whose abnormalities are risk factors for Perivascular Epithelioid Cell Tumor. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Perivascular Epithelioid Cell Tumor can be used as a guide for coming up with a recommended personalized nutrition plan. For Perivascular Epithelioid Cell Tumor gene TSC2 has causative impact on biological pathways like Nutrient sensing, Autophagy and PI3K-AKT-MTOR Signaling. And TSC1 has a causative impact on biological pathways like Nutrient sensing, Autophagy and PI3K-AKT-MTOR Signaling. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like TSC2 and TSC1 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes TSC2 and TSC1 should be avoided.

Eat more pulses, Scarlet Bean or Soy Bean?

The active ingredients contained in Scarlet Bean are Stigmasterol, Beta-sitosterol, Linolenic Acid, Vitamin C, Oleic Acid among others. While the active ingredients contained in Soy Bean are Lupeol, Stigmasterol, Daidzein, Vitamin E, Linolenic Acid and others.

Stigmasterol can manipulate biochemical pathways Apoptosis, JAK-STAT Signaling and MYC Signaling. Beta-sitosterol has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and MYC Signaling.

Genistein can manipulate biochemical pathways DNA Repair. Lecithin has biological action on biochemical pathways MYC Signaling and JAK-STAT Signaling. And so on.

For genetic risk of Perivascular Epithelioid Cell Tumor due to abnormalities in genes TSC2 and TSC1 – Foods like Scarlet Bean are recommended compared to Soy Bean. This is because the active ingredients Genistein and Lecithin in Soy Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Stigmasterol and Beta-sitosterol contained in Scarlet Bean together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER SOY BEAN FOR REDUCING THE GENETIC RISK OF PERIVASCULAR EPITHELIOID CELL TUMOR DUE TO GENES TSC2 AND TSC1

Eat more vegetables, Cassava or Heart Of Palm?

The active ingredients contained in Cassava are Beta-sitosterol, Linolenic Acid, Vitamin C, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Heart Of Palm are Palmitic Acid, Vitamin C, Vitamin A, Folic Acid and others.

Vitamin C can manipulate biochemical pathways MYC Signaling, P53 Signaling and Cell Cycle Checkpoints. Beta-sitosterol has biological action on biochemical pathways Apoptosis, MYC Signaling and P53 Signaling.

Palmitic Acid can manipulate biochemical pathways DNA Repair. Folic Acid has biological action on biochemical pathways Apoptosis, JAK-STAT Signaling and MYC Signaling. And so on.

For genetic risk of Perivascular Epithelioid Cell Tumor due to abnormalities in genes TSC2 and TSC1 – Foods like Cassava are recommended compared to Heart Of Palm. This is because the active ingredients Palmitic Acid and Folic Acid in Heart Of Palm further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Cassava together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: CASSAVA IS RECOMMENDED OVER HEART OF PALM FOR REDUCING THE GENETIC RISK OF PERIVASCULAR EPITHELIOID CELL TUMOR DUE TO GENES TSC2 AND TSC1

Eat more fruits, Feijoa or Grape?

The active ingredients contained in Feijoa are Lycopene, Vitamin C, Casuarinin, Folic Acid among others. While the active ingredients contained in Grape are Pterostilbene, Lupeol, Vitamin E, Linolenic Acid, Beta-sitosterol and others.

Vitamin C can manipulate biochemical pathways MYC Signaling, P53 Signaling and Cell Cycle Checkpoints. Lycopene has biological action on biochemical pathways Apoptosis, JAK-STAT Signaling and MYC Signaling.

Resveratrol can manipulate biochemical pathways P53 Signaling and DNA Repair. Pterostilbene has biological action on biochemical pathways DNA Repair. And so on.

For genetic risk of Perivascular Epithelioid Cell Tumor due to abnormalities in genes TSC2 and TSC1 – Foods like Feijoa are recommended compared to Grape. This is because the active ingredients Resveratrol and Pterostilbene in Grape further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Lycopene contained in Feijoa together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: FEIJOA IS RECOMMENDED OVER GRAPE FOR REDUCING THE GENETIC RISK OF PERIVASCULAR EPITHELIOID CELL TUMOR DUE TO GENES TSC2 AND TSC1

Eat more nuts, Hazelnut or Macadamia Nut?

The active ingredients contained in Hazelnut are Vitamin E, Linolenic Acid, Quercetin, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Macadamia Nut are Beta-sitosterol, Palmitic Acid, Lauric Acid, Folic Acid, Myristic Acid and others.

Vitamin E can manipulate biochemical pathways MYC Signaling, P53 Signaling and Cell Cycle Checkpoints. Quercetin has biological action on biochemical pathways Apoptosis, JAK-STAT Signaling and MYC Signaling.

Palmitic Acid can manipulate biochemical pathways DNA Repair. Lauric Acid has biological action on biochemical pathways MYC Signaling. And so on.

For genetic risk of Perivascular Epithelioid Cell Tumor due to abnormalities in genes TSC2 and TSC1 – Foods like Hazelnut are recommended compared to Macadamia Nut. This is because the active ingredients Palmitic Acid and Lauric Acid in Macadamia Nut further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin E and Quercetin contained in Hazelnut together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: HAZELNUT IS RECOMMENDED OVER MACADAMIA NUT FOR REDUCING THE GENETIC RISK OF PERIVASCULAR EPITHELIOID CELL TUMOR DUE TO GENES TSC2 AND TSC1

In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Perivascular Epithelioid Cell Tumor by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

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