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What Foods are Recommended for Cancer?
is a very common question. Personalized Nutrition Plans are foods and supplements which are personalized to a cancer indication, genes, any treatments and lifestyle conditions.

Which Foods are Recommended for Penile Squamous Cell Carcinoma?

Aug 11, 2022

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Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Penile Squamous Cell Carcinoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Penile Squamous Cell Carcinoma because of CARD11 and ALK gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Penile Squamous Cell Carcinoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Pummelo” or “Include fruit Cherimoya in my diet” or “Should I reduce consumption of vegetable Rhubarb” or “Can I take Birch and Dim supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO PENILE SQUAMOUS CELL CARCINOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Penile Squamous Cell Carcinoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR PENILE SQUAMOUS CELL CARCINOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.



About Penile Squamous Cell Carcinoma

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Penile Squamous Cell Carcinoma from cBioPortal. The patients enrolled in the studies for Penile Squamous Cell Carcinoma are in ages between 52 to 71 with an average age of 68.From a patient sample size of 16; the top genes with mutations and other abnormalities for Penile Squamous Cell Carcinoma include genes ATRX, CARD11, ALK, ALOX12B and APC. The occurrence frequency distribution for these genes respectively is 50.0%, 50.0%, 50.0%, 50.0% and 50.0%. These tumor genetic details of Penile Squamous Cell Carcinoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Penile Squamous Cell Carcinoma.

Significance of Nutrition for Penile Squamous Cell Carcinoma

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Penile Squamous Cell Carcinoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Pummelo includes active ingredients Naringin, Beta-sitosterol, Vitamin C, Linolenic Acid, Oleic Acid and others. And Cherimoya contains active ingredients Beta-sitosterol, Vitamin C, Linolenic Acid, Oleic Acid, Stigmasterol and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Penile Squamous Cell Carcinoma, activation or inhibition of selected biochemical pathways like Cell Cycle, C-type Lectin Receptor Signaling, PI3K-AKT-MTOR Signaling, MAPK Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Penile Squamous Cell Carcinoma, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

For cancers like Penile Squamous Cell Carcinoma, activation or inhibition of selected biochemical pathways like Cell Cycle, C-type Lectin Receptor Signaling, PI3K-AKT-MTOR Signaling, MAPK Signaling plays an important role in driving cancer growth.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR PENILE SQUAMOUS CELL CARCINOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Penile Squamous Cell Carcinoma undergoing chemotherapy treatment

In Penile Squamous Cell Carcinoma – the genes ATRX, CARD11, ALK, ALOX12B and APC have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Penile Squamous Cell Carcinoma are Cell Cycle, C-type Lectin Receptor Signaling, RUNX Signaling and others. Cisplatin is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Cell Cycle, C-type Lectin Receptor Signaling, RUNX Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Scarlet Bean or Fava Bean?

Pulses are an important part of many diets. The active ingredients contained in Scarlet Bean are Beta-sitosterol, Vitamin C, Linolenic Acid, Oleic Acid, Stigmasterol among others. While the active ingredients contained in Fava Bean are Quercetin, Daidzein, Caffeic Acid, Beta-sitosterol, Butein and others.

Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Apoptosis. Vitamin C has biological action on biochemical pathways Cell Cycle, MYC Signaling and WNT Beta Catenin Signaling.

Quercetin can manipulate biochemical pathways Oxidative Stress. Kaempferol has biological action on biochemical pathways Oxidative Stress. And so on.

When treating Penile Squamous Cell Carcinoma with chemotherapy Cisplatin – Foods like Scarlet Bean are recommended compared to Fava Bean. This is because the active ingredients Quercetin and Kaempferol in Fava Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Scarlet Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER FAVA BEAN FOR PENILE SQUAMOUS CELL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY CISPLATIN FOR SOME CONDITIONS.

Eat more vegetables, Amaranth or Rhubarb?

Vegetables are an important part of many diets. The active ingredients contained in Amaranth are Beta-sitosterol, Isoquercitrin, Vitamin C, Linolenic Acid, Oleic Acid among others. While the active ingredients contained in Rhubarb are Quercetin, Vitamin E, Gallic Acid, Vitamin C, Linolenic Acid and others.

Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Apoptosis. Vitamin C has biological action on biochemical pathways Cell Cycle, MYC Signaling and WNT Beta Catenin Signaling.

Rutin can manipulate biochemical pathways WNT Beta Catenin Signaling and Oxidative Stress. Quercetin has biological action on biochemical pathways Oxidative Stress. And so on.

When treating Penile Squamous Cell Carcinoma with chemotherapy Cisplatin – Foods like Amaranth are recommended compared to Rhubarb. This is because the active ingredients Rutin and Quercetin in Rhubarb interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Amaranth support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: AMARANTH IS RECOMMENDED OVER RHUBARB FOR PENILE SQUAMOUS CELL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY CISPLATIN FOR SOME CONDITIONS.

Which Foods are Recommended for Penile Squamous Cell Carcinoma?

Eat more fruits, Cherimoya or Pummelo?

Fruits are an important part of many diets. The active ingredients contained in Cherimoya are Beta-sitosterol, Vitamin C, Linolenic Acid, Oleic Acid, Stigmasterol among others. While the active ingredients contained in Pummelo are Naringin, Beta-sitosterol, Vitamin C, Linolenic Acid, Oleic Acid and others.

Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Apoptosis. Stigmasterol has biological action on biochemical pathways JAK-STAT Signaling, Cell Cycle and MYC Signaling.

Naringin can manipulate biochemical pathways Oxidative Stress. Naringenin has biological action on biochemical pathways Oxidative Stress. And so on.

When treating Penile Squamous Cell Carcinoma with chemotherapy Cisplatin – Foods like Cherimoya are recommended compared to Pummelo. This is because the active ingredients Naringin and Naringenin in Pummelo interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Stigmasterol contained in Cherimoya support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: CHERIMOYA IS RECOMMENDED OVER PUMMELO FOR PENILE SQUAMOUS CELL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY CISPLATIN FOR SOME CONDITIONS.

Eat more nuts, Pine Nut or Acorn?

Nuts are an important part of many diets. The active ingredients contained in Pine Nut are Beta-sitosterol, Vitamin E, Linolenic Acid, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Acorn are Quercetin, Beta-sitosterol, Gallic Acid, Vitamin C, Beta-carotene and others.

Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Apoptosis. Vitamin K has biological action on biochemical pathways Cell Cycle, MYC Signaling and Cell Cycle Checkpoints.

Quercetin can manipulate biochemical pathways Oxidative Stress. Gallic Acid has biological action on biochemical pathways Oxidative Stress. And so on.

When treating Penile Squamous Cell Carcinoma with chemotherapy Cisplatin – Foods like Pine Nut are recommended compared to Acorn. This is because the active ingredients Quercetin and Gallic Acid in Acorn interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin K contained in Pine Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: PINE NUT IS RECOMMENDED OVER ACORN FOR PENILE SQUAMOUS CELL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY CISPLATIN FOR SOME CONDITIONS.

Foods for Genetic Risk of Penile Squamous Cell Carcinoma

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. CARD11 and ALK are two genes whose abnormalities are risk factors for Penile Squamous Cell Carcinoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Penile Squamous Cell Carcinoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Penile Squamous Cell Carcinoma gene CARD11 has causative impact on biological pathways like T-Cell Receptor Signaling and NFKB Signaling. And ALK has a causative impact on biological pathways like Growth Factor Signaling, JAK-STAT Signaling and Immune Checkpoints. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like CARD11 and ALK should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes CARD11 and ALK should be avoided.

Eat more pulses, Winged Bean or Hyacinth Bean?

The active ingredients contained in Winged Bean are Betulinic Acid, Oleic Acid, Linolenic Acid, Vitamin C, Linoleic Acid among others. While the active ingredients contained in Hyacinth Bean are Genistein, Vitamin C, Myristic Acid, Palmitic Acid, Folic Acid and others.

Betulinic Acid can manipulate biochemical pathways NFKB Signaling, JAK-STAT Signaling and MYC Signaling. Vitamin C has biological action on biochemical pathways MAPK Signaling, PI3K-AKT-MTOR Signaling and Oncogenic Cancer Epigenetics.

Palmitic Acid can manipulate biochemical pathways NFKB Signaling, DNA Repair and MYC Signaling. Myristic Acid has biological action on biochemical pathways MAPK Signaling, RAS-RAF Signaling and MYC Signaling. And so on.

For genetic risk of Penile Squamous Cell Carcinoma due to abnormalities in genes CARD11 and ALK – Foods like Winged Bean are recommended compared to Hyacinth Bean. This is because the active ingredients Palmitic Acid and Myristic Acid in Hyacinth Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Betulinic Acid and Vitamin C contained in Winged Bean together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: WINGED BEAN IS RECOMMENDED OVER HYACINTH BEAN FOR REDUCING THE GENETIC RISK OF PENILE SQUAMOUS CELL CARCINOMA DUE TO GENES CARD11 AND ALK

Eat more vegetables, Brussels Sprout or Jute?

The active ingredients contained in Brussels Sprout are Brassinin, Oleic Acid, Linolenic Acid, Vitamin C, Sulforaphane among others. While the active ingredients contained in Jute are Quercetin, Kaempferol, Oleic Acid, Linolenic Acid, Vitamin C and others.

Brassinin can manipulate biochemical pathways NFKB Signaling, JAK-STAT Signaling and MYC Signaling. Vitamin C has biological action on biochemical pathways MAPK Signaling, PI3K-AKT-MTOR Signaling and Oncogenic Cancer Epigenetics.

Quercetin can manipulate biochemical pathways DNA Repair. Vitamin B3 has biological action on biochemical pathways PI3K-AKT-MTOR Signaling. And so on.

For genetic risk of Penile Squamous Cell Carcinoma due to abnormalities in genes CARD11 and ALK – Foods like Brussels Sprout are recommended compared to Jute. This is because the active ingredients Quercetin and Vitamin B3 in Jute further promote the effects of genes on the biochemical pathways. While the active ingredients Brassinin and Vitamin C contained in Brussels Sprout together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: BRUSSELS SPROUT IS RECOMMENDED OVER JUTE FOR REDUCING THE GENETIC RISK OF PENILE SQUAMOUS CELL CARCINOMA DUE TO GENES CARD11 AND ALK

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

Eat more fruits, Grape or Cranberry?

The active ingredients contained in Grape are Resveratrol, Lupeol, Pterostilbene, Chlorogenic Acid, Oleic Acid among others. While the active ingredients contained in Cranberry are Ellagic Acid, Quercetin, Myricetin, Resveratrol, Chlorogenic Acid and others.

Resveratrol can manipulate biochemical pathways NFKB Signaling, DNA Repair and JAK-STAT Signaling. Vitamin C has biological action on biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling.

Ellagic Acid can manipulate biochemical pathways MYC Signaling. Quercetin has biological action on biochemical pathways DNA Repair. And so on.

For genetic risk of Penile Squamous Cell Carcinoma due to abnormalities in genes CARD11 and ALK – Foods like Grape are recommended compared to Cranberry. This is because the active ingredients Ellagic Acid and Quercetin in Cranberry further promote the effects of genes on the biochemical pathways. While the active ingredients Resveratrol and Vitamin C contained in Grape together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: GRAPE IS RECOMMENDED OVER CRANBERRY FOR REDUCING THE GENETIC RISK OF PENILE SQUAMOUS CELL CARCINOMA DUE TO GENES CARD11 AND ALK

Eat more nuts, Pecan Nut or Brazil Nut?

The active ingredients contained in Pecan Nut are Oleic Acid, Linolenic Acid, Vitamin E, Delphinidin, Cianidanol among others. While the active ingredients contained in Brazil Nut are Oleic Acid, Linolenic Acid, Vitamin E, Lecithin, Folic Acid and others.

Vitamin E can manipulate biochemical pathways MYC Signaling, NFKB Signaling and MAPK Signaling. Delphinidin has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, RAS-RAF Signaling and NFKB Signaling.

Lecithin can manipulate biochemical pathways NFKB Signaling, JAK-STAT Signaling and MYC Signaling. Folic Acid has biological action on biochemical pathways MAPK Signaling, PI3K-AKT-MTOR Signaling and RAS-RAF Signaling. And so on.

For genetic risk of Penile Squamous Cell Carcinoma due to abnormalities in genes CARD11 and ALK – Foods like Pecan Nut are recommended compared to Brazil Nut. This is because the active ingredients Lecithin and Folic Acid in Brazil Nut further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin E and Delphinidin contained in Pecan Nut together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER BRAZIL NUT FOR REDUCING THE GENETIC RISK OF PENILE SQUAMOUS CELL CARCINOMA DUE TO GENES CARD11 AND ALK


In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Penile Squamous Cell Carcinoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

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References

Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.


Scientifically Reviewed by: Dr. Cogle

Christopher R. Cogle, M.D. is a tenured professor at the University of Florida, Chief Medical Officer of Florida Medicaid, and Director of the Florida Health Policy Leadership Academy at the Bob Graham Center for Public Service.

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