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What Foods are Recommended for Cancer?
is a very common question. Personalized Nutrition Plans are foods and supplements which are personalized to a cancer indication, genes, any treatments and lifestyle conditions.

Foods for Penile Squamous Cell Carcinoma!

Jul 26, 2023

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Introduction

Foods for Penile Squamous Cell Carcinoma should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.

Penile squamous cell carcinoma is a relatively rare form of cancer that occurs in the skin or tissues of the penis. Accurate diagnosis of penile squamous cell carcinoma is aided by pathology outlines and histological examination, which provide important insights into the characteristics of the tumor. Treatment options for squamous cell carcinoma of the penis can include surgery, radiation therapy, and chemotherapy. The appropriate approach is determined based on the stage and extent of the cancer. The ICD-10 coding system facilitates proper documentation of penile squamous cell carcinoma in medical records. Risk factors such as smoking, poor hygiene, human papillomavirus (HPV) infection, and lack of circumcision have been associated with an increased likelihood of developing the condition. Staging plays a role in determining the appropriate treatment plan for penile squamous cell carcinoma. The CAP (College of American Pathologists) protocol provides guidelines and recommendations for the comprehensive management of this cancer. Prognosis for penile squamous cell carcinoma varies depending on multiple factors, including the stage of the cancer and response to treatment. Awareness of the risk factors and the importance of regular check-ups can contribute to early detection and improved outcomes. Although penile squamous cell carcinoma is predominantly found in humans, it can also affect animals such as horses. Proper pathology examination and comprehensive understanding of this disease contribute to effective diagnosis, treatment, and patient care.



For Penile Squamous Cell Carcinoma does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Penile Squamous Cell Carcinoma does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Penile Squamous Cell Carcinoma?

For example does it matter if vegetable Yellow Zucchini is consumed more compared to Napa Cabbage? Does it make any difference if fruit Common Persimmon is preferred over Pomegranate? Also if similar choices are made for nuts/seeds like Black Walnut over Chestnut and for pulses like Moth Bean over Catjang Pea. And if what I eat matters – then how does one identify foods which are recommended for Penile Squamous Cell Carcinoma and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Penile Squamous Cell Carcinoma!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All cancers like Penile Squamous Cell Carcinoma can be characterized by a unique set of biochemical pathways - the signature pathways of Penile Squamous Cell Carcinoma. Biochemical pathways like MAPK Signaling, NFKB Signaling, PI3K-AKT-MTOR Signaling, RAS-RAF Signaling are part of the signature definition of Penile Squamous Cell Carcinoma.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Common Persimmon contains active ingredients Quercetin, Lupeol, Isoliquiritigenin, Apigenin, Curcumin. And Pomegranate contains active ingredients Quercetin, Ellagic Acid, Lupeol, Myricetin, Isoliquiritigenin and possibly others.

A common mistake made when deciding and choosing foods to eat for Penile Squamous Cell Carcinoma – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Penile Squamous Cell Carcinoma.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Penile Squamous Cell Carcinoma?

Personalized nutrition for cancers like Penile Squamous Cell Carcinoma consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Penile Squamous Cell Carcinoma biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

Characteristics of cancers like Penile Squamous Cell Carcinoma

All cancers like Penile Squamous Cell Carcinoma can be characterized by a unique set of biochemical pathways – the signature pathways of Penile Squamous Cell Carcinoma. Biochemical pathways like MAPK Signaling, NFKB Signaling, PI3K-AKT-MTOR Signaling, RAS-RAF Signaling are part of the signature definition of Penile Squamous Cell Carcinoma. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Penile Squamous Cell Carcinoma need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Penile Squamous Cell Carcinoma when taking cancer treatment Mitomycin, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

ATRX, CARD11, ALK, ALOX12B and APC are the top ranked reported genes for Penile Squamous Cell Carcinoma. ATRX is reported in 50.0 % of the representative patients across all clinical trials. And CARD11 is reported in 50.0 %. The combined population patient data cover ages from 52 to 71. 100.0 % of the patient data are identified as men. The Penile Squamous Cell Carcinoma biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Foods for Penile Squamous Cell Carcinoma!

Food and Supplements for Penile Squamous Cell Carcinoma

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable YELLOW ZUCCHINI or NAPA CABBAGE?

Vegetable Yellow Zucchini contains many active ingredients or bioactives such as Lupeol, Myricetin, Isoliquiritigenin, Apigenin, Curcumin. These active ingredients manipulate various biochemical pathways like Cell Cycle, Angiogenesis, WNT Beta Catenin Signaling and NFKB Signaling and others. Yellow Zucchini is recommended for Penile Squamous Cell Carcinoma when ongoing cancer treatment is Mitomycin. This is because Yellow Zucchini modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Mitomycin.

Some of the active ingredients or bioactives in vegetable Napa Cabbage are Lupeol, Isoliquiritigenin, Curcumin, Formononetin, Phloretin. These active ingredients manipulate various biochemical pathways like DNA Repair and Mismatch Repair and others. Napa Cabbage is not recommended for Penile Squamous Cell Carcinoma when ongoing cancer treatment is Mitomycin because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE YELLOW ZUCCHINI IS RECOMMENDED OVER NAPA CABBAGE FOR Penile Squamous Cell Carcinoma AND TREATMENT Mitomycin.

Choose Fruit POMEGRANATE or COMMON PERSIMMON?

Fruit Pomegranate contains many active ingredients or bioactives such as Quercetin, Ellagic Acid, Lupeol, Myricetin, Isoliquiritigenin. These active ingredients manipulate various biochemical pathways like Cell Cycle, Angiogenesis, DNA Repair and Cell Cycle Checkpoints and others. Pomegranate is recommended for Penile Squamous Cell Carcinoma when ongoing cancer treatment is Mitomycin. This is because Pomegranate modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Mitomycin.

Some of the active ingredients or bioactives in fruit Common Persimmon are Quercetin, Lupeol, Isoliquiritigenin, Apigenin, Curcumin. These active ingredients manipulate various biochemical pathways like DNA Repair, Extracellular Matrix Remodelling and WNT Beta Catenin Signaling and others. Common Persimmon is not recommended for Penile Squamous Cell Carcinoma when ongoing cancer treatment is Mitomycin because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT POMEGRANATE IS RECOMMENDED OVER COMMON PERSIMMON FOR Penile Squamous Cell Carcinoma AND TREATMENT Mitomycin.

Choose Nut BLACK WALNUT or CHESTNUT?

Black Walnut contains many active ingredients or bioactives such as Quercetin, Ellagic Acid, Lupeol, Myricetin, Isoliquiritigenin. These active ingredients manipulate various biochemical pathways like Cell Cycle, Angiogenesis, Cell Cycle Checkpoints and NFKB Signaling and others. Black Walnut is recommended for Penile Squamous Cell Carcinoma when ongoing cancer treatment is Mitomycin. This is because Black Walnut modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Mitomycin.

Some of the active ingredients or bioactives in Chestnut are Ellagic Acid, Lupeol, Myricetin, Isoliquiritigenin, Apigenin. These active ingredients manipulate various biochemical pathways like WNT Beta Catenin Signaling and Extracellular Matrix Remodelling and others. Chestnut is not recommended for Penile Squamous Cell Carcinoma when ongoing cancer treatment is Mitomycin because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

BLACK WALNUT IS RECOMMENDED OVER CHESTNUT FOR Penile Squamous Cell Carcinoma AND TREATMENT Mitomycin.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Penile Squamous Cell Carcinoma or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable BURDOCK or BROCCOLI?

Vegetable Burdock contains many active ingredients or bioactives such as Curcumin, Apigenin, Formononetin, Lupeol, Myricetin. These active ingredients manipulate various biochemical pathways like Apoptosis, P53 Signaling, Angiogenesis and Stem Cell Signaling and others. Burdock is recommended for risk of Penile Squamous Cell Carcinoma when associated genetic risk is ALK. This is because Burdock increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Broccoli are Curcumin, Quercetin, Formononetin, Lupeol, Resveratrol. These active ingredients manipulate various biochemical pathways like P53 Signaling and NFKB Signaling and others. Broccoli is not recommended when risk of Penile Squamous Cell Carcinoma when associated genetic risk is ALK because it increases the signature pathways of it.

VEGETABLE BURDOCK IS RECOMMENDED OVER BROCCOLI FOR ALK GENETIC RISK OF CANCER.

Choose Fruit SOUR CHERRY or PUMMELO?

Fruit Sour Cherry contains many active ingredients or bioactives such as Curcumin, Apigenin, Quercetin, Formononetin, Lupeol. These active ingredients manipulate various biochemical pathways like Apoptosis, Angiogenesis, P53 Signaling and MAPK Signaling and others. Sour Cherry is recommended for risk of Penile Squamous Cell Carcinoma when associated genetic risk is ALK. This is because Sour Cherry increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Pummelo are Curcumin, Apigenin, Quercetin, Formononetin, Lupeol. These active ingredients manipulate various biochemical pathways like Stem Cell Signaling and WNT Beta Catenin Signaling and others. Pummelo is not recommended when risk of Penile Squamous Cell Carcinoma when associated genetic risk is ALK because it increases the signature pathways of it.

FRUIT SOUR CHERRY IS RECOMMENDED OVER PUMMELO FOR ALK GENETIC RISK OF CANCER.

Choose Nut BUTTERNUT or EUROPEAN CHESTNUT?

Butternut contains many active ingredients or bioactives such as Curcumin, Apigenin, Formononetin, Lupeol, Lycopene. These active ingredients manipulate various biochemical pathways like Stem Cell Signaling, P53 Signaling, Angiogenesis and MYC Signaling and others. Butternut is recommended for risk of Penile Squamous Cell Carcinoma when associated genetic risk is ALK. This is because Butternut increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in European Chestnut are Curcumin, Apigenin, Quercetin, Ellagic Acid, Formononetin. These active ingredients manipulate various biochemical pathways like Stem Cell Signaling and WNT Beta Catenin Signaling and others. European Chestnut is not recommended when risk of Penile Squamous Cell Carcinoma when associated genetic risk is ALK because it increases the signature pathways of it.

BUTTERNUT IS RECOMMENDED OVER EUROPEAN CHESTNUT FOR ALK GENETIC RISK OF CANCER.


In Conclusion

Foods and Supplements chosen are important decisions for cancers like Penile Squamous Cell Carcinoma. Penile Squamous Cell Carcinoma patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Penile Squamous Cell Carcinoma, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like Yellow Zucchini contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Penile Squamous Cell Carcinoma?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.


Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.

References

Scientifically Reviewed by: Dr. Cogle

Christopher R. Cogle, M.D. is a tenured professor at the University of Florida, Chief Medical Officer of Florida Medicaid, and Director of the Florida Health Policy Leadership Academy at the Bob Graham Center for Public Service.

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