Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Hodgkin Lymphoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Hodgkin Lymphoma because of ARID5B and B2M gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Hodgkin Lymphoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Strawberry” or “Include fruit Graviola in my diet” or “Should I reduce consumption of vegetable Radish” or “Can I take Buckthorn and Senna supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO HODGKIN LYMPHOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Hodgkin Lymphoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR HODGKIN LYMPHOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Hodgkin Lymphoma
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Hodgkin Lymphoma from cBioPortal. 60.0% of males and 40.0% of females were the distribution of gender in these clinical studies. From a patient sample size of 5; the top genes with mutations and other abnormalities for Hodgkin Lymphoma include genes ARID1A, ARID5B, B2M, CD79A and CTCF. The occurrence frequency distribution for these genes respectively is 25.0%, 25.0%, 25.0%, 25.0% and 25.0%. These tumor genetic details of Hodgkin Lymphoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Hodgkin Lymphoma.
Hodgkin lymphoma is a malignancy of the lymphatic system, especially seen in the cervical lymph nodes. It can be classified as classical Hodgkin lymphoma and nodular lymphocyte predominant Hodgkin lymphoma. Global incidence of Hodgkin lymphoma was 0.4% with 83,087 new cases reported in 2020 (Ref: GLOBOCAN database). Highest incidence was reported in Europe, Australia, and New Zealand, while the lowest incidence was found in Eastern and South-eastern Asia. Although relatively rare, it is the most common cancer among adolescents and young adults. Based on analysis of population data, higher incidence of Hodgkin lymphoma was found to be associated with prevalence of smoking, obesity and hypertension. The 5-year survival rate for patients with Hodgkin lymphoma in the United States is 88%. (Ref: American Cancer Society, ACS). Chemotherapy and radiation therapy are the main first line treatments of Hodgkin lymphoma, while novel treatment options including antibody therapy, vaccine therapies, checkpoint inhibitor immunotherapy and treatment with cytotoxic T lymphocytes have been used in advanced disease if other treatments have not worked. In addition, physician prescribed treatments supported by the right nutrition (food and supplements) aligned to the treatment can further enhance quality of life of the patient. (Ref: Huang J et al, J Hematol. & Oncol., 2022; https://www.cancer.org/cancer/hodgkin-lymphoma/treating.html)
Significance of Nutrition for Hodgkin Lymphoma
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Hodgkin Lymphoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Strawberry includes active ingredients Lupeol, Vitamin C, Beta-sitosterol, Linolenic Acid, Oleic Acid and others. And Graviola contains active ingredients Emodin, Lycopene, Quercetin, Vitamin E, Vitamin C and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Hodgkin Lymphoma, activation or inhibition of selected biochemical pathways like Chromatin Remodeling, Cell Cycle Checkpoints, Apoptosis, Epithelial to Mesenchymal Transition plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Hodgkin Lymphoma, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR HODGKIN LYMPHOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Hodgkin Lymphoma undergoing chemotherapy treatment
In Hodgkin Lymphoma – the genes ARID1A, ARID5B, B2M, CD79A and CTCF have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Hodgkin Lymphoma are and others. Bleomycin is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Winged Bean or Lima Bean?
Pulses are an important part of many diets. The active ingredients contained in Winged Bean are Betulinic Acid, Vitamin C, Linolenic Acid, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Lima Bean are Vitamin C, Oleic Acid, Genistein, Linoleic Acid, Vitamin A and others.
Betulinic Acid can manipulate biochemical pathways MYC Signaling. Vitamin C has biological action on biochemical pathways MYC Signaling.
Folic Acid can manipulate biochemical pathways MYC Signaling. And so on.
When treating Hodgkin Lymphoma with chemotherapy Bleomycin – Foods like Winged Bean are recommended compared to Lima Bean. This is because the active ingredients Folic Acid in Lima Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Betulinic Acid and Vitamin C contained in Winged Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: WINGED BEAN IS RECOMMENDED OVER LIMA BEAN FOR HODGKIN LYMPHOMA ON TREATMENT WITH CHEMOTHERAPY BLEOMYCIN FOR SOME CONDITIONS.
Eat more vegetables, Arugula or Radish?
Vegetables are an important part of many diets. The active ingredients contained in Arugula are Esculin, Vitamin A, Vitamin K, Erysolin among others. While the active ingredients contained in Radish are Quercetin, Vitamin C, Beta-sitosterol, Linolenic Acid, Oleic Acid and others.
Vitamin A can manipulate biochemical pathways MYC Signaling. Vitamin K has biological action on biochemical pathways MYC Signaling.
Pelargonidin can manipulate biochemical pathways MYC Signaling. Folic Acid has biological action on biochemical pathways MYC Signaling. And so on.
When treating Hodgkin Lymphoma with chemotherapy Bleomycin – Foods like Arugula are recommended compared to Radish. This is because the active ingredients Pelargonidin and Folic Acid in Radish interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin A and Vitamin K contained in Arugula support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: ARUGULA IS RECOMMENDED OVER RADISH FOR HODGKIN LYMPHOMA ON TREATMENT WITH CHEMOTHERAPY BLEOMYCIN FOR SOME CONDITIONS.
Eat more fruits, Graviola or Strawberry?
Fruits are an important part of many diets. The active ingredients contained in Graviola are Emodin, Lycopene, Quercetin, Vitamin E, Vitamin C among others. While the active ingredients contained in Strawberry are Lupeol, Vitamin C, Beta-sitosterol, Linolenic Acid, Oleic Acid and others.
Emodin can manipulate biochemical pathways MYC Signaling. Cinnamic Acid has biological action on biochemical pathways MYC Signaling.
Fisetin can manipulate biochemical pathways MYC Signaling. Ellagic Acid has biological action on biochemical pathways MYC Signaling. And so on.
When treating Hodgkin Lymphoma with chemotherapy Bleomycin – Foods like Graviola are recommended compared to Strawberry. This is because the active ingredients Fisetin and Ellagic Acid in Strawberry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Emodin and Cinnamic Acid contained in Graviola support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: GRAVIOLA IS RECOMMENDED OVER STRAWBERRY FOR HODGKIN LYMPHOMA ON TREATMENT WITH CHEMOTHERAPY BLEOMYCIN FOR SOME CONDITIONS.
Eat more nuts, Almond or Macadamia Nut?
Nuts are an important part of many diets. The active ingredients contained in Almond are Quercetin, Vitamin E, Beta-sitosterol, Linolenic Acid, Oleic Acid among others. While the active ingredients contained in Macadamia Nut are Beta-sitosterol, Palmitic Acid, Lauric Acid, Myristic Acid, Folic Acid and others.
Beta-sitosterol can manipulate biochemical pathways MYC Signaling. Quercetin has biological action on biochemical pathways MYC Signaling.
Lauric Acid can manipulate biochemical pathways MYC Signaling. Myristic Acid has biological action on biochemical pathways MYC Signaling. And so on.
When treating Hodgkin Lymphoma with chemotherapy Bleomycin – Foods like Almond are recommended compared to Macadamia Nut. This is because the active ingredients Lauric Acid and Myristic Acid in Macadamia Nut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Quercetin contained in Almond support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: ALMOND IS RECOMMENDED OVER MACADAMIA NUT FOR HODGKIN LYMPHOMA ON TREATMENT WITH CHEMOTHERAPY BLEOMYCIN FOR SOME CONDITIONS.
Foods for Genetic Risk of Hodgkin Lymphoma
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. ARID5B and B2M are two genes whose abnormalities are risk factors for Hodgkin Lymphoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Hodgkin Lymphoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Hodgkin Lymphoma gene ARID5B has causative impact on biological pathways like Suppressive Histone Methylation. And B2M has a causative impact on biological pathways like Antigen Presentation and Interferon Signaling. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like ARID5B and B2M should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes ARID5B and B2M should be avoided.
Eat more pulses, Mung Bean or Moth Bean?
The active ingredients contained in Mung Bean are Linolenic Acid, Stigmasterol, Quercetin, Vitamin C, Vitexin among others. While the active ingredients contained in Moth Bean are Linolenic Acid, Stigmasterol, Beta-sitosterol, Oleic Acid, Linoleic Acid and others.
Stigmasterol can manipulate biochemical pathways MAPK Signaling, Cell Cycle Checkpoints and P53 Signaling. Quercetin has biological action on biochemical pathways MYC Signaling, TGFB Signaling and EPHRIN Signaling.
Linoleic Acid can manipulate biochemical pathways TGFB Signaling. Folic Acid has biological action on biochemical pathways MAPK Signaling, Cell Cycle Checkpoints and P53 Signaling. And so on.
For genetic risk of Hodgkin Lymphoma due to abnormalities in genes ARID5B and B2M – Foods like Mung Bean are recommended compared to Moth Bean. This is because the active ingredients Linoleic Acid and Folic Acid in Moth Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Stigmasterol and Quercetin contained in Mung Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: MUNG BEAN IS RECOMMENDED OVER MOTH BEAN FOR REDUCING THE GENETIC RISK OF HODGKIN LYMPHOMA DUE TO GENES ARID5B AND B2M
Eat more vegetables, Cassava or Chicory?
The active ingredients contained in Cassava are Linolenic Acid, Vitamin C, Beta-sitosterol, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Chicory are Apigenin, Esculin, Protocatechuic Acid, Lupeol, Betulinic Acid and others.
Vitamin C can manipulate biochemical pathways MAPK Signaling, Cell Cycle Checkpoints and P53 Signaling. Beta-sitosterol has biological action on biochemical pathways MYC Signaling, Apoptosis and P53 Signaling.
Caffeic Acid can manipulate biochemical pathways TGFB Signaling. Apigenin has biological action on biochemical pathways TGFB Signaling. And so on.
For genetic risk of Hodgkin Lymphoma due to abnormalities in genes ARID5B and B2M – Foods like Cassava are recommended compared to Chicory. This is because the active ingredients Caffeic Acid and Apigenin in Chicory further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Cassava together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: CASSAVA IS RECOMMENDED OVER CHICORY FOR REDUCING THE GENETIC RISK OF HODGKIN LYMPHOMA DUE TO GENES ARID5B AND B2M
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Papaya or Cranberry?
The active ingredients contained in Papaya are Lycopene, Linalool, Benzyl Isothiocyanate, Linolenic Acid, Vitamin C among others. While the active ingredients contained in Cranberry are Ellagic Acid, Hyperoside, Myricetin, Quercetin, Vitamin C and others.
Lycopene can manipulate biochemical pathways MAPK Signaling, Cell Cycle Checkpoints and P53 Signaling. Zeaxanthin has biological action on biochemical pathways MYC Signaling, Apoptosis and MAPK Signaling.
Ellagic Acid can manipulate biochemical pathways MYC Signaling. Resveratrol has biological action on biochemical pathways P53 Signaling. And so on.
For genetic risk of Hodgkin Lymphoma due to abnormalities in genes ARID5B and B2M – Foods like Papaya are recommended compared to Cranberry. This is because the active ingredients Ellagic Acid and Resveratrol in Cranberry further promote the effects of genes on the biochemical pathways. While the active ingredients Lycopene and Zeaxanthin contained in Papaya together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: PAPAYA IS RECOMMENDED OVER CRANBERRY FOR REDUCING THE GENETIC RISK OF HODGKIN LYMPHOMA DUE TO GENES ARID5B AND B2M
Eat more nuts, Pistachio or Cashew Nut?
The active ingredients contained in Pistachio are Vitamin E, Linolenic Acid, Stigmasterol, Beta-sitosterol, Oleic Acid among others. While the active ingredients contained in Cashew Nut are Vitamin C, Beta-sitosterol, Gallic Acid, Palmitic Acid, Butyric Acid and others.
Beta-sitosterol can manipulate biochemical pathways P53 Signaling, MYC Signaling and Apoptosis. Vitamin E has biological action on biochemical pathways MAPK Signaling, Cell Cycle Checkpoints and P53 Signaling.
Palmitic Acid can manipulate biochemical pathways MAPK Signaling, Chromatin Remodeling and TGFB Signaling. Lauric Acid has biological action on biochemical pathways MYC Signaling and MAPK Signaling. And so on.
For genetic risk of Hodgkin Lymphoma due to abnormalities in genes ARID5B and B2M – Foods like Pistachio are recommended compared to Cashew Nut. This is because the active ingredients Palmitic Acid and Lauric Acid in Cashew Nut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin E contained in Pistachio together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: PISTACHIO IS RECOMMENDED OVER CASHEW NUT FOR REDUCING THE GENETIC RISK OF HODGKIN LYMPHOMA DUE TO GENES ARID5B AND B2M
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Hodgkin Lymphoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
- Msk Impact 2017
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- Lycopene differentially induces quiescence and apoptosis in androgen-responsive and -independent prostate cancer cell lines.
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- Resveratrol, a remarkable inhibitor of ribonucleotide reductase.
- Synthesis and structure-activity relationship analysis of caffeic acid amides as selective matrix metalloproteinase inhibitors.
- Gamma-tocotrienol-induced apoptosis in human gastric cancer SGC-7901 cells is associated with a suppression in mitogen-activated protein kinase signalling.
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- HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods.
- Fisetin: a dietary antioxidant for health promotion.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.