Which Foods are Recommended for Gastrointestinal Stromal Sarcoma?

Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Gastrointestinal Stromal Sarcoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Gastrointestinal Stromal Sarcoma because of KIT and TSC1 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Gastrointestinal Stromal Sarcoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Roselle” or “Include fruit Mulberry in my diet” or “Should I reduce consumption of vegetable Purslane” or “Can I take Naringin and Theaflavin supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO GASTROINTESTINAL STROMAL SARCOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Gastrointestinal Stromal Sarcoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR GASTROINTESTINAL STROMAL SARCOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.

About Gastrointestinal Stromal Sarcoma

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Gastrointestinal Stromal Sarcoma from cBioPortal. The patients enrolled in the studies for Gastrointestinal Stromal Sarcoma are in ages between 16 to 90 with an average age of 59. 55.2% of males and 44.8% of females were the distribution of gender in these clinical studies. From a patient sample size of 1269; the top genes with mutations and other abnormalities for Gastrointestinal Stromal Sarcoma include genes KIT, TSC1, SETD2, MAX and PDGFRA. The occurrence frequency distribution for these genes respectively is 5.2%, 1.1%, 1.1%, 1.0% and 0.7%. These tumor genetic details of Gastrointestinal Stromal Sarcoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Gastrointestinal Stromal Sarcoma.

Significance of Nutrition for Gastrointestinal Stromal Sarcoma

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Gastrointestinal Stromal Sarcoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Roselle includes active ingredients Vitamin E, Beta-sitosterol, Vitamin C, Linolenic Acid, Stigmasterol and others. And Mulberry contains active ingredients Morusin, Resveratrol, Moracin P, Deoxynojirimycin and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Gastrointestinal Stromal Sarcoma, activation or inhibition of selected biochemical pathways like RAS-RAF Signaling, PI3K-AKT-MTOR Signaling, Growth Factor Signaling, MAPK Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Gastrointestinal Stromal Sarcoma, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR GASTROINTESTINAL STROMAL SARCOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Gastrointestinal Stromal Sarcoma undergoing chemotherapy treatment

In Gastrointestinal Stromal Sarcoma – the genes KIT, TSC1, SETD2, MAX and PDGFRA have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Gastrointestinal Stromal Sarcoma are RAS-RAF Signaling, PI3K-AKT-MTOR Signaling, Amino Acid Metabolism and others. Everolimus is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers RAS-RAF Signaling, PI3K-AKT-MTOR Signaling, Amino Acid Metabolism so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Scarlet Bean or Pigeon Pea?

Pulses are an important part of many diets. The active ingredients contained in Scarlet Bean are Beta-sitosterol, Vitamin C, Linolenic Acid, Stigmasterol, Genistein among others. While the active ingredients contained in Pigeon Pea are Vitamin C, Linolenic Acid, Genistein, Oleic Acid, Vitamin A and others.

Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Adherens junction and Microtubule Dynamics. Vitamin C has biological action on biochemical pathways Growth Factor Signaling, Cell Cycle and MYC Signaling.

Genistein can manipulate biochemical pathways RAS-RAF Signaling. Vitamin A has biological action on biochemical pathways Oxidative Stress. And so on.

When treating Gastrointestinal Stromal Sarcoma with chemotherapy Everolimus – Foods like Scarlet Bean are recommended compared to Pigeon Pea. This is because the active ingredients Genistein and Vitamin A in Pigeon Pea interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Scarlet Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER PIGEON PEA FOR GASTROINTESTINAL STROMAL SARCOMA ON TREATMENT WITH CHEMOTHERAPY EVEROLIMUS FOR SOME CONDITIONS.

Eat more vegetables, Jicama or Purslane?

Vegetables are an important part of many diets. The active ingredients contained in Jicama are Vitamin C, Beta-carotene, Vitamin A, Vitamin B3, Folic Acid among others. While the active ingredients contained in Purslane are Vitamin C, Linolenic Acid, Oleic Acid, Vitamin A, Linoleic Acid and others.

Vitamin C can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Adherens junction and Growth Factor Signaling. Beta-carotene has biological action on biochemical pathways Microtubule Dynamics, Cell Cycle and Cell Survival.

Vitamin A can manipulate biochemical pathways Oxidative Stress. Linolenic Acid has biological action on biochemical pathways Vitamin D Signaling. And so on.

When treating Gastrointestinal Stromal Sarcoma with chemotherapy Everolimus – Foods like Jicama are recommended compared to Purslane. This is because the active ingredients Vitamin A and Linolenic Acid in Purslane interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Beta-carotene contained in Jicama support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: JICAMA IS RECOMMENDED OVER PURSLANE FOR GASTROINTESTINAL STROMAL SARCOMA ON TREATMENT WITH CHEMOTHERAPY EVEROLIMUS FOR SOME CONDITIONS.

Eat more fruits, Mulberry or Roselle?

Fruits are an important part of many diets. The active ingredients contained in Mulberry are Morusin, Resveratrol, Moracin P, Deoxynojirimycin among others. While the active ingredients contained in Roselle are Vitamin E, Beta-sitosterol, Vitamin C, Linolenic Acid, Stigmasterol and others.

Morusin can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Adherens junction and Growth Factor Signaling. Deoxynojirimycin has biological action on biochemical pathways Cell Survival, Epithelial to Mesenchymal Transition and Growth Factor Signaling.

Stigmasterol can manipulate biochemical pathways Oxidative Stress. Vitamin A has biological action on biochemical pathways Oxidative Stress. And so on.

When treating Gastrointestinal Stromal Sarcoma with chemotherapy Everolimus – Foods like Mulberry are recommended compared to Roselle. This is because the active ingredients Stigmasterol and Vitamin A in Roselle interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Morusin and Deoxynojirimycin contained in Mulberry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: MULBERRY IS RECOMMENDED OVER ROSELLE FOR GASTROINTESTINAL STROMAL SARCOMA ON TREATMENT WITH CHEMOTHERAPY EVEROLIMUS FOR SOME CONDITIONS.

Eat more nuts, Pine Nut or Acorn?

Nuts are an important part of many diets. The active ingredients contained in Pine Nut are Vitamin E, Beta-sitosterol, Linolenic Acid, Oleic Acid, Vitamin A among others. While the active ingredients contained in Acorn are Quercetin, Beta-sitosterol, Vitamin C, Gallic Acid, Beta-carotene and others.

Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Adherens junction and Microtubule Dynamics. Vitamin K has biological action on biochemical pathways Cell Cycle, MYC Signaling and Vitamin D Signaling.

Quercetin can manipulate biochemical pathways RAS-RAF Signaling. Gallic Acid has biological action on biochemical pathways Vitamin D Signaling. And so on.

When treating Gastrointestinal Stromal Sarcoma with chemotherapy Everolimus – Foods like Pine Nut are recommended compared to Acorn. This is because the active ingredients Quercetin and Gallic Acid in Acorn interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin K contained in Pine Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: PINE NUT IS RECOMMENDED OVER ACORN FOR GASTROINTESTINAL STROMAL SARCOMA ON TREATMENT WITH CHEMOTHERAPY EVEROLIMUS FOR SOME CONDITIONS.

Foods for Genetic Risk of Gastrointestinal Stromal Sarcoma

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. KIT and TSC1 are two genes whose abnormalities are risk factors for Gastrointestinal Stromal Sarcoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Gastrointestinal Stromal Sarcoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Gastrointestinal Stromal Sarcoma gene KIT has causative impact on biological pathways like MAPK Signaling, Growth Factor Signaling and PI3K-AKT-MTOR Signaling. And TSC1 has a causative impact on biological pathways like Nutrient sensing, Autophagy and PI3K-AKT-MTOR Signaling. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like KIT and TSC1 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes KIT and TSC1 should be avoided.

Eat more pulses, Common Pea or Lima Bean?

The active ingredients contained in Common Pea are Lupeol, Daidzein, Beta-sitosterol, Oleic Acid, Vitamin C among others. While the active ingredients contained in Lima Bean are Oleic Acid, Vitamin C, Genistein, Linoleic Acid, Vitamin A and others.

Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin C has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and RAS-RAF Signaling.

Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. And so on.

For genetic risk of Gastrointestinal Stromal Sarcoma due to abnormalities in genes KIT and TSC1 – Foods like Common Pea are recommended compared to Lima Bean. This is because the active ingredients Vitamin A and Folic Acid in Lima Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER LIMA BEAN FOR REDUCING THE GENETIC RISK OF GASTROINTESTINAL STROMAL SARCOMA DUE TO GENES KIT AND TSC1

Eat more vegetables, Giant Butterbur or Celery?

The active ingredients contained in Giant Butterbur are Beta-sitosterol, Vitamin C, Kaempferol, Vitamin B3, Melatonin among others. While the active ingredients contained in Celery are Apigenin, Quercetin, Oleic Acid, Vitamin C, Linolenic Acid and others.

Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Beta-sitosterol has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Apoptosis.

Luteolin can manipulate biochemical pathways MYC Signaling. Chrysin has biological action on biochemical pathways MYC Signaling. And so on.

For genetic risk of Gastrointestinal Stromal Sarcoma due to abnormalities in genes KIT and TSC1 – Foods like Giant Butterbur are recommended compared to Celery. This is because the active ingredients Luteolin and Chrysin in Celery further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Giant Butterbur together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: GIANT BUTTERBUR IS RECOMMENDED OVER CELERY FOR REDUCING THE GENETIC RISK OF GASTROINTESTINAL STROMAL SARCOMA DUE TO GENES KIT AND TSC1

Eat more fruits, Kiwi or Huckleberry?

The active ingredients contained in Kiwi are Quercetin, Vitamin C, Chlorogenic Acid, Fisetin, Vitamin A among others. While the active ingredients contained in Huckleberry are Resveratrol, Quercetin, Vitamin C, P-coumaric Acid, Ferulic Acid and others.

Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Chlorogenic Acid has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, Growth Factor Signaling and MYC Signaling.

Resveratrol can manipulate biochemical pathways P53 Signaling. Quercetin has biological action on biochemical pathways DNA Repair. And so on.

For genetic risk of Gastrointestinal Stromal Sarcoma due to abnormalities in genes KIT and TSC1 – Foods like Kiwi are recommended compared to Huckleberry. This is because the active ingredients Resveratrol and Quercetin in Huckleberry further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Chlorogenic Acid contained in Kiwi together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: KIWI IS RECOMMENDED OVER HUCKLEBERRY FOR REDUCING THE GENETIC RISK OF GASTROINTESTINAL STROMAL SARCOMA DUE TO GENES KIT AND TSC1

Eat more nuts, Pecan Nut or Peanut?

The active ingredients contained in Pecan Nut are Vitamin E, Cianidanol, Oleic Acid, Linolenic Acid, Linoleic Acid among others. While the active ingredients contained in Peanut are Quercetin, Beta-sitosterol, Vitamin E, Oleic Acid, Vitamin C and others.

Vitamin E can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Cianidanol has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Apoptosis.

Quercetin can manipulate biochemical pathways DNA Repair. Vitamin A has biological action on biochemical pathways PI3K-AKT-MTOR Signaling. And so on.

For genetic risk of Gastrointestinal Stromal Sarcoma due to abnormalities in genes KIT and TSC1 – Foods like Pecan Nut are recommended compared to Peanut. This is because the active ingredients Quercetin and Vitamin A in Peanut further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin E and Cianidanol contained in Pecan Nut together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER PEANUT FOR REDUCING THE GENETIC RISK OF GASTROINTESTINAL STROMAL SARCOMA DUE TO GENES KIT AND TSC1

In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Gastrointestinal Stromal Sarcoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

References

• Msk Impact 2017
• Cancer therapy shapes the fitness landscape of clonal hematopoiesis.
• β-Sitosterol targets Trx/Trx1 reductase to induce apoptosis in A549 cells via ROS mediated mitochondrial dysregulation and p53 activation.
• Vitamin C enhances epigenetic modifications induced by 5-azacytidine and cell cycle arrest in the hepatocellular carcinoma cell lines HLE and Huh7.
• Vitamin A regulates Akt signaling through the phospholipid fatty acid composition.
• Morusin induces cell death through inactivating STAT3 signaling in prostate cancer cells.
• Intake of mulberry 1-deoxynojirimycin prevents colorectal cancer in mice.
• Stigmasterol Causes Ovarian Cancer Cell Apoptosis by Inducing Endoplasmic Reticulum and Mitochondrial Dysfunction.
• β-carotene Inhibits Expression of c-Myc and Cyclin E in Helicobacter pylori-infected Gastric Epithelial Cells.
• Research progress on the anticancer effects of vitamin K2.
• [Basic formulation of the tasks of special education in rehabilitating the physically handicapped].
• Effects of folate deficiency on gene expression in the apoptosis and cancer pathways in colon cancer cells.
• Chlorogenic acid inhibits proliferation and induces apoptosis in A498 human kidney cancer cells via inactivating PI3K/Akt/mTOR signalling pathway.
• Resveratrol, a remarkable inhibitor of ribonucleotide reductase.
• Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin.
• Gamma- and delta-tocotrienols exert a more potent anticancer effect than alpha-tocopheryl succinate on breast cancer cell lines irrespective of HER-2/neu expression.
• Cytotoxicity and apoptosis induction in human breast adenocarcinoma MCF-7 cells by (+)-cyanidan-3-ol.
• Determination of 1-deoxynojirimycin in mulberry leaves using hydrophilic interaction chromatography with evaporative light scattering detection.
• 1-Deoxynojirimycin in Mulberry (Morus indica L.) Leaves Ameliorates Stable Angina Pectoris in Patients With Coronary Heart Disease by Improving Antioxidant and Anti-inflammatory Capacities.
• Effects of mulberry leaf extract rich in 1-deoxynojirimycin on blood lipid profiles in humans.
• Effect of sodium nitrate loading on electrolyte transport by the renal tubule.
• Phenolic Profiles, Antioxidant Capacities, and Inhibitory Effects on Digestive Enzymes of Different Kiwifruits.
• HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods.