Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Wilms Tumor when undergoing chemotherapy or when you determine you have a genetic risk for developing Wilms Tumor because of HLA-DQB1 and MAP3K4 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Wilms Tumor which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Sapota” or “Include fruit Partridgeberry in my diet” or “Should I reduce consumption of vegetable Jute” or “Can I take Thunder God and Dim supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO WILMS TUMOR, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Wilms Tumor is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR WILMS TUMOR, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Wilms Tumor
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Wilms Tumor from cBioPortal. The patients enrolled in the studies for Wilms Tumor are in ages between 1 to 28 with an average age of 4. 45.3% of males and 54.7% of females were the distribution of gender in these clinical studies. From a patient sample size of 764; the top genes with mutations and other abnormalities for Wilms Tumor include genes HLA-DQB1, MAP3K4, EPHA5, ACTB and NFE2L1. The occurrence frequency distribution for these genes respectively is 4.2%, 2.4%, 1.8%, 1.8% and 1.2%. These tumor genetic details of Wilms Tumor are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Wilms Tumor.
Wilms tumor, also called nephroblastoma, is a rare type of kidney cancer that occurs in young children, that accounts for 95% of all malignant kidney tumors in patients under the age of 15 years. Wilms tumor can occur in one kidney or both kidneys and can spread to the rest of the body. There are about 650 new cases of Wilms tumor diagnosed in the United States each year, with the average age of diagnoses being 2 to 5 years. Incidence of Wilms tumor is slightly higher in girls when compared to boys. In younger children, the first sign of Wilms tumor is a large lump or mass in the abdomen, which can be associated with abdominal pain and swelling. In older children, symptoms may include pain, anemia, fever, blood in the urine, nausea, vomiting, constipation, loss of appetite, shortness of breath and high blood pressure. Staging of Wilms tumor is based on the spread of the tumor in the kidney or beyond the kidney. Mutations (genetic alterations) in genes such as WT1, CTNNB1 and WTX have been found to be altered in patients with Wilms tumor and changes in these genes could be responsible for the uncontrollable growth of the cells in the kidney. Treatment of Wilms tumor depends on the stage of the tumor and includes surgery, radiation therapy and combination chemotherapy regimens, that has improved the 5-year survival rate for Wilms tumor in the United States to 92%, but global rate of survival is only 78%. Supportive care with the right nutrition (foods and natural supplements) aligned with the treatment can enhance well-being of the patient. (Ref: https://www.ncbi.nlm.nih.gov/books/NBK442004/ ; https://rarediseases.org/rare-diseases/wilms-tumor/ )
Significance of Nutrition for Wilms Tumor
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Wilms Tumor. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Sapota includes active ingredients Lycopene, Beta-sitosterol, Oleic Acid, Linolenic Acid, Vitamin C and others. And Partridgeberry contains active ingredients Resveratrol, Beta-sitosterol, Stigmasterol and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Wilms Tumor, activation or inhibition of selected biochemical pathways like Cytoskeletal Dynamics, Adherens junction, MAPK Signaling, Focal Adhesion plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Wilms Tumor, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR WILMS TUMOR – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Wilms Tumor undergoing chemotherapy treatment
In Wilms Tumor – the genes HLA-DQB1, MAP3K4, EPHA5, ACTB and NFE2L1 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Wilms Tumor are Cytoskeletal Dynamics, Adherens junction, Epithelial to Mesenchymal Transition and others. Vincristine is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Cytoskeletal Dynamics, Adherens junction, Epithelial to Mesenchymal Transition so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Common Pea or Lima Bean?
Pulses are an important part of many diets. The active ingredients contained in Common Pea are Lupeol, Beta-sitosterol, Daidzein, Oleic Acid, Linolenic Acid among others. While the active ingredients contained in Lima Bean are Oleic Acid, Vitamin C, Vitamin A, Genistein, Linoleic Acid and others.
Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Apoptosis. Vitamin C has biological action on biochemical pathways Carbohydrate Metabolism, Adherens junction and Cell Cycle.
Genistein can manipulate biochemical pathways Oxidative Stress. Oleic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition and Cytoskeletal Dynamics. And so on.
When treating Wilms Tumor with chemotherapy Vincristine – Foods like Common Pea are recommended compared to Lima Bean. This is because the active ingredients Genistein and Oleic Acid in Lima Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER LIMA BEAN FOR WILMS TUMOR ON TREATMENT WITH CHEMOTHERAPY VINCRISTINE FOR SOME CONDITIONS.
Eat more vegetables, Jicama or Jute?
Vegetables are an important part of many diets. The active ingredients contained in Jicama are Beta-carotene, Vitamin C, Vitamin A, Vitamin B3, Folic Acid among others. While the active ingredients contained in Jute are Quercetin, Oleic Acid, Linolenic Acid, Vitamin C, Vitamin A and others.
Vitamin C can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Carbohydrate Metabolism and Apoptosis. Beta-carotene has biological action on biochemical pathways NFKB Signaling, Adherens junction and Microtubule Dynamics.
Quercetin can manipulate biochemical pathways Oxidative Stress. Kaempferol has biological action on biochemical pathways Oxidative Stress. And so on.
When treating Wilms Tumor with chemotherapy Vincristine – Foods like Jicama are recommended compared to Jute. This is because the active ingredients Quercetin and Kaempferol in Jute interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Beta-carotene contained in Jicama support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: JICAMA IS RECOMMENDED OVER JUTE FOR WILMS TUMOR ON TREATMENT WITH CHEMOTHERAPY VINCRISTINE FOR SOME CONDITIONS.
Eat more fruits, Partridgeberry or Sapota?
Fruits are an important part of many diets. The active ingredients contained in Partridgeberry are Resveratrol, Beta-sitosterol, Stigmasterol among others. While the active ingredients contained in Sapota are Lycopene, Beta-sitosterol, Oleic Acid, Linolenic Acid, Vitamin C and others.
Resveratrol can manipulate biochemical pathways Carbohydrate Metabolism, NFKB Signaling and Apoptosis. Beta-sitosterol has biological action on biochemical pathways Epithelial to Mesenchymal Transition, Adherens junction and Microtubule Dynamics.
Lycopene can manipulate biochemical pathways Oxidative Stress. Citric Acid has biological action on biochemical pathways Oxidative Stress. And so on.
When treating Wilms Tumor with chemotherapy Vincristine – Foods like Partridgeberry are recommended compared to Sapota. This is because the active ingredients Lycopene and Citric Acid in Sapota interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Resveratrol and Beta-sitosterol contained in Partridgeberry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PARTRIDGEBERRY IS RECOMMENDED OVER SAPOTA FOR WILMS TUMOR ON TREATMENT WITH CHEMOTHERAPY VINCRISTINE FOR SOME CONDITIONS.
Eat more nuts, Pecan Nut or Acorn?
Nuts are an important part of many diets. The active ingredients contained in Pecan Nut are Vitamin E, Oleic Acid, Linolenic Acid, Vitamin A, Cianidanol among others. While the active ingredients contained in Acorn are Quercetin, Beta-sitosterol, Beta-carotene, Vitamin C, Gallic Acid and others.
Vitamin E can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Apoptosis. Vitamin A has biological action on biochemical pathways Adherens junction, Cell Cycle and MYC Signaling.
Quercetin can manipulate biochemical pathways Oxidative Stress. Gallic Acid has biological action on biochemical pathways Oxidative Stress. And so on.
When treating Wilms Tumor with chemotherapy Vincristine – Foods like Pecan Nut are recommended compared to Acorn. This is because the active ingredients Quercetin and Gallic Acid in Acorn interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin E and Vitamin A contained in Pecan Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER ACORN FOR WILMS TUMOR ON TREATMENT WITH CHEMOTHERAPY VINCRISTINE FOR SOME CONDITIONS.
Foods for Genetic Risk of Wilms Tumor
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. HLA-DQB1 and MAP3K4 are two genes whose abnormalities are risk factors for Wilms Tumor. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Wilms Tumor can be used as a guide for coming up with a recommended personalized nutrition plan. For Wilms Tumor gene HLA-DQB1 has causative impact on biological pathways like Antigen Presentation. And MAP3K4 has a causative impact on biological pathways like MAPK Signaling, Growth Factor Signaling and G-protein-coupled Receptor Signaling. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like HLA-DQB1 and MAP3K4 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes HLA-DQB1 and MAP3K4 should be avoided.
Eat more pulses, Fava Bean or Pigeon Pea?
The active ingredients contained in Fava Bean are Quercetin, Beta-sitosterol, Ferulic Acid, Vitamin A, Caffeic Acid among others. While the active ingredients contained in Pigeon Pea are Vitamin A, Linolenic Acid, Vitamin C, Linoleic Acid, Oleic Acid and others.
Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, WNT Beta Catenin Signaling and Angiogenesis. Ferulic Acid has biological action on biochemical pathways MAPK Signaling, Adherens junction and Epithelial to Mesenchymal Transition.
Genistein can manipulate biochemical pathways G-protein-coupled Receptor Signaling. Linoleic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition. And so on.
For genetic risk of Wilms Tumor due to abnormalities in genes HLA-DQB1 and MAP3K4 – Foods like Fava Bean are recommended compared to Pigeon Pea. This is because the active ingredients Genistein and Linoleic Acid in Pigeon Pea further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Ferulic Acid contained in Fava Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: FAVA BEAN IS RECOMMENDED OVER PIGEON PEA FOR REDUCING THE GENETIC RISK OF WILMS TUMOR DUE TO GENES HLA-DQB1 AND MAP3K4
Eat more vegetables, Cassava or Yam?
The active ingredients contained in Cassava are Beta-sitosterol, Vitamin A, Linolenic Acid, Vitamin C, Linoleic Acid among others. While the active ingredients contained in Yam are Beta-sitosterol, Vitamin A, Linolenic Acid, Vitamin C, Dioscin and others.
Vitamin C can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Adherens junction and WNT Beta Catenin Signaling. Beta-sitosterol has biological action on biochemical pathways Angiogenesis, Epithelial to Mesenchymal Transition and WNT Beta Catenin Signaling.
Linoleic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition. Oleic Acid has biological action on biochemical pathways Cytoskeletal Dynamics, G-protein-coupled Receptor Signaling and Epithelial to Mesenchymal Transition. And so on.
For genetic risk of Wilms Tumor due to abnormalities in genes HLA-DQB1 and MAP3K4 – Foods like Cassava are recommended compared to Yam. This is because the active ingredients Linoleic Acid and Oleic Acid in Yam further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Cassava together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: CASSAVA IS RECOMMENDED OVER YAM FOR REDUCING THE GENETIC RISK OF WILMS TUMOR DUE TO GENES HLA-DQB1 AND MAP3K4
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Mango or Apricot?
The active ingredients contained in Mango are Beta-sitosterol, Lupeol, Vitamin A, Linolenic Acid, Gallic Acid among others. While the active ingredients contained in Apricot are Quercetin, Beta-sitosterol, Linolenic Acid, Vitamin C, Salicylic Acid and others.
Vitamin A can manipulate biochemical pathways Epithelial to Mesenchymal Transition, WNT Beta Catenin Signaling and Adherens junction. Vitamin C has biological action on biochemical pathways MAPK Signaling, Angiogenesis and Epithelial to Mesenchymal Transition.
Rutin can manipulate biochemical pathways WNT Beta Catenin Signaling. Quercetin has biological action on biochemical pathways G-protein-coupled Receptor Signaling. And so on.
For genetic risk of Wilms Tumor due to abnormalities in genes HLA-DQB1 and MAP3K4 – Foods like Mango are recommended compared to Apricot. This is because the active ingredients Rutin and Quercetin in Apricot further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin A and Vitamin C contained in Mango together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: MANGO IS RECOMMENDED OVER APRICOT FOR REDUCING THE GENETIC RISK OF WILMS TUMOR DUE TO GENES HLA-DQB1 AND MAP3K4
Eat more nuts, Walnut or Hazelnut?
The active ingredients contained in Walnut are Ellagic Acid, Quercetin, Betulinic Acid, Beta-sitosterol, Myricetin among others. While the active ingredients contained in Hazelnut are Quercetin, Vitamin A, Linolenic Acid, Vitamin E, Myricitrin and others.
Ellagic Acid can manipulate biochemical pathways Adherens junction, G-protein-coupled Receptor Signaling and EPHRIN Signaling. Beta-sitosterol has biological action on biochemical pathways Epithelial to Mesenchymal Transition, WNT Beta Catenin Signaling and Angiogenesis.
Quercetin can manipulate biochemical pathways G-protein-coupled Receptor Signaling. Linoleic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition. And so on.
For genetic risk of Wilms Tumor due to abnormalities in genes HLA-DQB1 and MAP3K4 – Foods like Walnut are recommended compared to Hazelnut. This is because the active ingredients Quercetin and Linoleic Acid in Hazelnut further promote the effects of genes on the biochemical pathways. While the active ingredients Ellagic Acid and Beta-sitosterol contained in Walnut together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: WALNUT IS RECOMMENDED OVER HAZELNUT FOR REDUCING THE GENETIC RISK OF WILMS TUMOR DUE TO GENES HLA-DQB1 AND MAP3K4
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Wilms Tumor by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
- Mixed Kunga Msk 2022
- Cancer therapy shapes the fitness landscape of clonal hematopoiesis.
- β-Sitosterol and Gemcitabine Exhibit Synergistic Anti-pancreatic Cancer Activity by Modulating Apoptosis and Inhibiting Epithelial-Mesenchymal Transition by Deactivating Akt/GSK-3β Signaling.
- Vitamin C enhances epigenetic modifications induced by 5-azacytidine and cell cycle arrest in the hepatocellular carcinoma cell lines HLE and Huh7.
- Oleic acid-induced ANGPTL4 enhances head and neck squamous cell carcinoma anoikis resistance and metastasis via up-regulation of fibronectin.
- The Repeated Administration of Resveratrol Has Measurable Effects on Circulating T-Cell Subsets in Humans.
- Effects of lycopene on protein expression in human primary prostatic epithelial cells.
- β-carotene Inhibits Expression of c-Myc and Cyclin E in Helicobacter pylori-infected Gastric Epithelial Cells.
- Quercetin induces rapid eNOS phosphorylation and vasodilation by an Akt-independent and PKA-dependent mechanism.
- Small-molecule inhibitors of NADPH oxidase 4.
- Anti-IL-1 alpha autoantibodies in patients with rheumatic diseases and in healthy subjects.
- Retinol decreases beta-catenin protein levels in retinoic acid-resistant colon cancer cell lines.
- Cardioprotective effect of gallic acid on cardiac troponin-T, cardiac marker enzymes, lipid peroxidation products and antioxidants in experimentally induced myocardial infarction in Wistar rats.
- Inhibitory effect of trans-ferulic acid on proliferation and migration of human lung cancer cells accompanied with increased endogenous reactive oxygen species and β-catenin instability.
- Role of phospholipase D in migration and invasion induced by linoleic acid in breast cancer cells.
- Indeno[1,2-b]indole derivatives as a novel class of potent human protein kinase CK2 inhibitors.
- HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods.
- Resveratrol, pterostilbene, and piceatannol in vaccinium berries.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.